Publications - Ruvkun - 2024
Yanagi KS, Jochim B, Kunjo SO, Breen P, Ruvkun G, Lehrbach N Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans. PLoS Biol. 2024;22(7):e3002720 - PMID: 38991033 - PMCID: PMC11265709 - DOI: 10.1371/journal.pbio.3002720
Seetharaman A, Galagali H, Linarte E, Liu MHX, Cohen JD, Chetal K, Sadreyev R, Tate AJ, Montgomery TA, Ruvkun G Caenorhabditis elegans SynMuv B gene activity is down-regulated during a viral infection to enhance RNA interference. bioRxiv. 2024;:ePub - PMID: 39071373 - PMCID: PMC11275910 - DOI: 10.1101/2024.07.12.603258
Meisel JD, Wiesenthal PP, Mootha VK, Ruvkun G CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene. Curr Biol. 2024;34(12):2728-2738.e6 - PMID: 38810637 - PMCID: PMC11265314 - DOI: 10.1016/j.cub.2024.04.079
Warnhoff K, Bhattacharya S, Snoozy J, Breen PC, Ruvkun G Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans. Elife. 2024;12:ePub - PMID: 38349720 - PMCID: PMC10942545 - DOI: 10.7554/eLife.89173
Meisel JD, Miranda M, Skinner OS, Wiesenthal PP, Wellner SM, Jourdain AA, Ruvkun G, Mootha VK Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism. Cell. 2024;187(3):659-675.e18 - PMID: 38215760 - PMCID: PMC10919891 - DOI: 10.1016/j.cell.2023.12.010