Govindan JA, Jayamani E, Zhang X, Mylonakis E, Ruvkun G Dialogue between E. coli free radical pathways and the mitochondria of C. elegans. Proc Natl Acad Sci U S A. 2015;112(40):12456-61 - PMID: 26392561 - PMCID: PMC4603447 - DOI: 10.1073/pnas.1517448112

Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans. Nat Cell Biol. 2015;17(10):1294-303 - PMID: 26322678 - PMCID: PMC4589496 - DOI: 10.1038/ncb3229

Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway. Dev Cell. 2015;34(4):457-465 - PMID: 26279487 - PMCID: PMC4550515 - DOI: 10.1016/j.devcel.2015.07.009

Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles. Nucleic Acids Res. 2015;43(W1):W154-W159 - PMID: 25958392 - PMCID: PMC4489270 - DOI: 10.1093/nar/gkv452

Kirienko NV, Ausubel FM, Ruvkun G Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2015;112(6):1821-6 - PMID: 25624506 - PMCID: PMC4330731 - DOI: 10.1073/pnas.1424954112

O'Rourke EJ, Ruvkun G Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2014;17(1):104 - PMID: 25534088

Govindan JA, Ruvkun G Pathogens. Virulence. 2014;5(7):695-696 - PMID: 25513769 - PMCID: PMC4189874 - DOI: 10.4161/viru.36667

Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence. PLoS Genet. 2014;10(12):e1004752 - PMID: 25474471 - PMCID: PMC4256158 - DOI: 10.1371/journal.pgen.1004752

Govindan JA, Ruvkun G Pathogens. Virulence. 2014;5(7):ePub - PMID: 25290904 - PMCID: PMC4189874

Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans. Nat Struct Mol Biol. 2014;21(8):712-720 - PMID: 25038802 - PMCID: PMC4125460 - DOI: 10.1038/nsmb.2858

Liu Y, Samuel BS, Breen PC, Ruvkun G Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature. 2014;508(7496):406-10 - PMID: 24695221 - PMCID: PMC4102179 - DOI: 10.1038/nature13204

Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation. Curr Biol. 2014;24(8):839-44 - PMID: 24684932 - PMCID: PMC4010136 - DOI: 10.1016/j.cub.2014.02.060

Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev. 2013;27(24):2678-95 - PMID: 24352423 - PMCID: PMC3877757 - DOI: 10.1101/gad.233254.113

Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis. Cell. 2013;155(6):1409-21 - PMID: 24269006 - PMCID: PMC3956118 - DOI: 10.1016/j.cell.2013.10.047

Soukas AA, Carr CE, Ruvkun G Genetic Regulation of Caenorhabditis elegans Lysosome Related Organelle Function. PLoS Genet. 2013;9(10):e1003908 - PMID: 24204312 - PMCID: PMC3812091 - DOI: 10.1371/journal.pgen.1003908

Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Mol Syst Biol. 2013;9:692 - PMID: 24084807 - PMCID: PMC3817400 - DOI: 10.1038/msb.2013.50

Shi Z, Hayes G, Ruvkun G Dual Regulation of the lin-14 Target mRNA by the lin-4 miRNA. PLoS One. 2013;8(9):e75475 - PMID: 24058689 - PMCID: PMC3772890 - DOI: 10.1371/journal.pone.0075475

Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, Ruvkun G Radiation Resistance of Sequencing Chips for in situ Life Detection. Astrobiology. 2013;13(6):560-9 - PMID: 23734755 - DOI: 10.1089/ast.2012.0923

Shore DE, Ruvkun G A cytoprotective perspective on longevity regulation. Trends Cell Biol. 2013;23(9):409-20 - PMID: 23726168 - PMCID: PMC4057428 - DOI: 10.1016/j.tcb.2013.04.007

Montgomery TA, Ruvkun G MicroRNAs Visit the ER. Cell. 2013;153(3):511-2 - PMID: 23622236 - DOI: 10.1016/j.cell.2013.04.014

Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol. 2013;15(5):491-501 - PMID: 23604319 - PMCID: PMC3748955 - DOI: 10.1038/ncb2720

O'Rourke EJ, Ruvkun G MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2013;15(6):668-676 - PMID: 23604316 - PMCID: PMC3723461 - DOI: 10.1038/ncb2741

Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death. Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003

Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death. Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003

O'Rourke EJ, Kuballa P, Xavier R, Ruvkun G ?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev. 2013;27(4):429-40 - PMID: 23392608 - PMCID: PMC3589559 - DOI: 10.1101/gad.205294.112

Shi Z, Montgomery TA, Qi Y, Ruvkun G High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes. Genome Res. 2013;23(3):497-508 - PMID: 23363624 - PMCID: PMC3589538 - DOI: 10.1101/gr.149112.112

Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature. 2013;493(7434):694-8 - PMID: 23364702 - PMCID: PMC3762460 - DOI: 10.1038/nature11779

Carr CE, Rowedder H, Vafadari C, Lui CS, Cascio E, Zuber MT, Ruvkun G Radiation resistance of biological reagents for in situ life detection. Astrobiology. 2013;13(1):68-78 - PMID: 23330963 - DOI: 10.1089/ast.2012.0869

Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks. PLoS One. 2012;7(10):e48282 - PMID: 23144747 - PMCID: PMC3483217 - DOI: 10.1371/journal.pone.0048282

Zhang C, Ruvkun G New insights into siRNA amplification and RNAi. RNA Biol. 2012;9(8):1045-9 - PMID: 22858672 - PMCID: PMC3551858 - DOI: 10.4161/rna.21246

Shore DE, Carr CE, Ruvkun G Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet. 2012;8(7):e1002792 - PMID: 22829775 - PMCID: PMC3400582 - DOI: 10.1371/journal.pgen.1002792

Phillips CM, Montgomery TA, Breen PC, Ruvkun G MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline. Genes Dev. 2012;26(13):1433-44 - PMID: 22713602 - PMCID: PMC3403012 - DOI: 10.1101/gad.193904.112

Zhang C, Montgomery TA, Fischer SE, Garcia SM, Riedel CG, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G The Caenorhabditis elegans RDE-10/RDE-11 Complex Regulates RNAi by Promoting Secondary siRNA Amplification. Curr Biol. 2012;22(10):881-90 - PMID: 22542102 - PMCID: PMC3371361 - DOI: 10.1016/j.cub.2012.04.011

Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G PIWI Associated siRNAs and piRNAs Specifically Require the Caenorhabditis elegans HEN1 Ortholog henn-1. PLoS Genet. 2012;8(4):e1002616 - PMID: 22536158 - PMCID: PMC3334881 - DOI: 10.1371/journal.pgen.1002616

Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE An image analysis toolbox for high-throughput C. elegans assays. Nat Methods. 2012;9(7):714-6 - PMID: 22522656 - PMCID: PMC3433711 - DOI: 10.1038/nmeth.1984

Melo JA, Ruvkun G Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses. Cell. 2012;149(2):452-66 - PMID: 22500807 - PMCID: PMC3613046 - DOI: 10.1016/j.cell.2012.02.050

Shi Z, Ruvkun G The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2012;109(12):4568-73 - PMID: 22396595 - PMCID: PMC3311396 - DOI: 10.1073/pnas.1202421109

Wu X, Shi Z, Cui M, Han M, Ruvkun G Repression of Germline RNAi Pathways in Somatic Cells by Retinoblastoma Pathway Chromatin Complexes. PLoS Genet. 2012;8(3):e1002542 - PMID: 22412383 - PMCID: PMC3297578 - DOI: 10.1371/journal.pgen.1002542

Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods. 2011;8(2):135-8 - PMID: 21240281 - PMCID: PMC3061290 - DOI: 10.1038/nmeth.1556

Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2011;108(4):1201-8 - PMID: 21245313 - PMCID: PMC3029761 - DOI: 10.1073/pnas.1018695108

Hayes GD, Riedel CG, Ruvkun G The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev. 2011;25(19):2079-92 - PMID: 21979920 - PMCID: PMC3197206 - DOI: 10.1101/gad.17153811

Russel S, Frand AR, Ruvkun G Regulation of the C. elegans molt by pqn-47. Dev Biol. 2011;360(2):297-309 - PMID: 21989027 - PMCID: PMC3618673 - DOI: 10.1016/j.ydbio.2011.09.025

Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet. 2011;7(11):e1002369 - PMID: 22102828 - PMCID: PMC3213143 - DOI: 10.1371/journal.pgen.1002369

Kimura KD, Riddle DL, Ruvkun G The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status. Cold Spring Harb Symp Quant Biol. 2011;76:113-20 - PMID: 22123849 - DOI: 10.1101/sqb.2011.76.010660

Meli VS, Osuna B, Ruvkun G, Frand AR MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Mol Biol Cell. 2010;21(10):1648-61 - PMID: 20335506 - PMCID: PMC2869372 - DOI: 10.1091/mbc.E08-07-0708

Wu X, Ruvkun G Cancer. Germ cell genes and cancer. Science. 2010;330(6012):1761-2 - PMID: 21205660 - DOI: 10.1126/science.1200772

Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A. 2009;106(6):1875-9 - PMID: 19174521 - PMCID: PMC2631283 - DOI: 10.1073/pnas.0810338106

Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009;23(4):496-511 - PMID: 19240135 - PMCID: PMC2648650 - DOI: 10.1101/gad.1775409

Curran SP, Wu X, Riedel CG, Ruvkun G A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009;459(7250):1079-84 - PMID: 19506556 - PMCID: PMC2716045 - DOI: 10.1038/nature08106

O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 2009;10(5):430-5 - PMID: 19883620 - PMCID: PMC2921818 - DOI: 10.1016/j.cmet.2009.10.002

Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One. 2009;4(12):e8210 - PMID: 20011587 - PMCID: PMC2788130 - DOI: 10.1371/journal.pone.0008210

Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol Dev. 2008;10(1):106-13 - PMID: 18184361 - PMCID: PMC2637451 - DOI: 10.1111/j.1525-142X.2007.00217.x

Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Cold Spring Harb Symp Quant Biol. 2008;72:489-97 - PMID: 18419309 - DOI: 10.1101/sqb.2007.72.068

Gabel HW, Ruvkun G The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol. 2008;15(5):531-3 - PMID: 18438419 - PMCID: PMC2910399 - DOI: 10.1038/nsmb.1411

Patel DS, Fang LL, Svy DK, Ruvkun G, Li W Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans. Development. 2008;135(13):2239-49 - PMID: 18495818 - DOI: 10.1242/dev.016972

Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell. 2008;133(5):903-15 - PMID: 18510933 - PMCID: PMC2553566 - DOI: 10.1016/j.cell.2008.04.035

Ruvkun G Tiny RNA: Where do we come from? What are we? Where are we going?. Trends Plant Sci. 2008;13(7):313-6 - PMID: 18562240 - DOI: 10.1016/j.tplants.2008.05.005

Fischer SE, Butler MD, Pan Q, Ruvkun G Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature. 2008;455(7212):491-6 - PMID: 18784652 - PMCID: PMC2756026 - DOI: 10.1038/nature07274

Ruvkun G The perfect storm of tiny RNAs. Nat Med. 2008;14(10):1041-5 - PMID: 18841145 - DOI: 10.1038/nm1008-1041

Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G The most conserved genome segments for life detection on Earth and other planets. Orig Life Evol Biosph. 2008;38(6):517-33 - PMID: 18853276 - DOI: 10.1007/s11084-008-9148-z

Wang MC, O'Rourke EJ, Ruvkun G Fat metabolism links germline stem cells and longevity in C. elegans. Science. 2008;322(5903):957-60 - PMID: 18988854 - PMCID: PMC2760269 - DOI: 10.1126/science.1162011

Hayes GD, Ruvkun G Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Cold Spring Harb Symp Quant Biol. 2007;71:21-7 - PMID: 17381276 - DOI: 10.1101/sqb.2006.71.018

Curran SP, Ruvkun G Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 2007;3(4):e56 - PMID: 17411345 - PMCID: PMC1847696 - DOI: 10.1371/journal.pgen.0030056

Kim N, Dempsey CM, Kuan CJ, Zoval JV, O'Rourke E, Ruvkun G, Madou MJ, Sze JY Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Genetics. 2007;177(2):835-45 - PMID: 17720915 - PMCID: PMC2034647 - DOI: 10.1534/genetics.107.076901

Samuelson AV, Carr CE, Ruvkun G Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev. 2007;21(22):2976-94 - PMID: 18006689 - PMCID: PMC2049198 - DOI: 10.1101/gad.1588907

Parry DH, Xu J, Ruvkun G A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol. 2007;17(23):2013-22 - PMID: 18023351 - PMCID: PMC2211719 - DOI: 10.1016/j.cub.2007.10.058

Ruvkun G Clarifications on miRNA and cancer. Science. 2006;311(5757):36-7 - PMID: 16400132 - DOI: 10.1126/science.311.5757.36d

Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 2006;124(2):343-54 - PMID: 16439208 - DOI: 10.1016/j.cell.2005.11.036

Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G Polygenic control of Caenorhabditis elegans fat storage. Nat Genet. 2006;38(3):363-8 - PMID: 16462744 - DOI: 10.1038/ng1739

Sandoval GM, Duerr JS, Hodgkin J, Rand JB, Ruvkun G A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nat Neurosci. 2006;9(5):599-601 - PMID: 16604067 - DOI: 10.1038/nn1685

Hu PJ, Xu J, Ruvkun G Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006;2(7):e99 - PMID: 16839187 - PMCID: PMC1487177 - DOI: 10.1371/journal.pgen.0020099

Hayes GD, Frand AR, Ruvkun G The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development. 2006;133(23):4631-41 - PMID: 17065234 - DOI: 10.1242/dev.02655

Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G Functional genomic analysis of RNA interference in C. elegans. Science. 2005;308(5725):1164-7 - PMID: 15790806 - DOI: 10.1126/science.1109267

Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P Analysis of xbx genes in C. elegans. Development. 2005;132(8):1923-34 - PMID: 15790967 - DOI: 10.1242/dev.01775

Ruvkun GB The tiny RNA world. Harvey Lect. 2005;99:1-21 - PMID: 15984549

Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 2005;19(13):1544-55 - PMID: 15998808 - PMCID: PMC1172061 - DOI: 10.1101/gad.1308205

Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM Systematic analysis of genes required for synapse structure and function. Nature. 2005;436(7050):510-7 - PMID: 16049479 - DOI: 10.1038/nature03809

Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 2005;436(7050):593-7 - PMID: 16049496 - DOI: 10.1038/nature04010

Wang D, Ruvkun G Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway. Cold Spring Harb Symp Quant Biol. 2005;69:429-31 - PMID: 16117677 - DOI: 10.1101/sqb.2004.69.429

Frand AR, Russel S, Ruvkun G Functional genomic analysis of C. elegans molting. PLoS Biol. 2005;3(10):e312 - PMID: 16122351 - PMCID: PMC1233573 - DOI: 10.1371/journal.pbio.0030312

Kennedy S, Wang D, Ruvkun G A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 2004;427(6975):645-9 - PMID: 14961122 - DOI: 10.1038/nature02302

Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Mol Cell. 2004;13(4):469-82 - PMID: 14992718 - DOI: 10.1016/s1097-2765(04)00033-4

Ruvkun G, Wightman B, Ha I The 20 years it took to recognize the importance of tiny RNAs. Cell. 2004;116(2 Suppl):S93-6, 2 p following S96 - PMID: 15055593 - DOI: 10.1016/s0092-8674(04)00034-0

Mak HY, Ruvkun G Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Development. 2004;131(8):1777-86 - PMID: 15084462 - DOI: 10.1242/dev.01069

Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004;36(10):1079-83 - PMID: 15361871 - DOI: 10.1038/ng1421

Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 2003;421(6920):268-72 - PMID: 12529643 - DOI: 10.1038/nature01279

Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T A uniform system for microRNA annotation. RNA. 2003;9(3):277-9 - PMID: 12592000 - PMCID: PMC1370393 - DOI: 10.1261/rna.2183803

Li W, Kennedy SG, Ruvkun G daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev. 2003;17(7):844-58 - PMID: 12654727 - PMCID: PMC196030 - DOI: 10.1101/gad.1066503

Lee SS, Kennedy S, Tolonen AC, Ruvkun G DAF-16 target genes that control C. elegans life-span and metabolism. Science. 2003;300(5619):644-7 - PMID: 12690206 - DOI: 10.1126/science.1083614

Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J Computational and experimental identification of C. elegans microRNAs. Mol Cell. 2003;11(5):1253-63 - PMID: 12769849 - DOI: 10.1016/s1097-2765(03)00153-9

Aspöck G, Ruvkun G, Bürglin TR The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development. 2003;130(15):3369-78 - PMID: 12810585 - DOI: 10.1242/dev.00551

Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol. 2003;259(1):1-8 - PMID: 12812783 - DOI: 10.1016/s0012-1606(03)00063-0

Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 2003;300(5627):1921 - PMID: 12817143 - DOI: 10.1126/science.1080147

Pasquinelli AE, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?. Evol Dev. 2003;5(4):372-8 - PMID: 12823453 - DOI: 10.1046/j.1525-142x.2003.03044.x

Sze JY, Ruvkun G Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity. Proc Natl Acad Sci U S A. 2003;100(16):9560-5 - PMID: 12883006 - PMCID: PMC170957 - DOI: 10.1073/pnas.1530752100

Ruvinsky I, Ruvkun G Functional tests of enhancer conservation between distantly related species. Development. 2003;130(21):5133-42 - PMID: 12944426 - DOI: 10.1242/dev.00711

Komaroff AL, Ruvkun G Unraveling the secrets of the cell. Newsweek. 2003;142(23):96 - PMID: 14712576

Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 2003;300(5627):1921 - PMID: 12817143 - DOI: 10.1126/science.1080147

Lee SS, Ruvkun G Longevity: don't hold your breath. Nature. 2002;418(6895):287-8 - PMID: 12124610 - DOI: 10.1038/418287a

Sze JY, Zhang S, Li J, Ruvkun G The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development. 2002;129(16):3901-11 - PMID: 12135927 - DOI: 10.1242/dev.129.16.3901

Pasquinelli AE, Ruvkun G Control of developmental timing by micrornas and their targets. Annu Rev Cell Dev Biol. 2002;18:495-513 - PMID: 12142272 - DOI: 10.1146/annurev.cellbio.18.012502.105832

Wolkow CA, Muñoz MJ, Riddle DL, Ruvkun G Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem. 2002;277(51):49591-7 - PMID: 12393910 - DOI: 10.1074/jbc.M207866200

Reinhart BJ, Ruvkun G Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics. 2001;157(1):199-209 - PMID: 11139502 - PMCID: PMC1461488 - DOI: 10.1093/genetics/157.1.199

Bürglin TR, Ruvkun G Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6. Development. 2001;128(5):779-90 - PMID: 11171402 - DOI: 10.1242/dev.128.5.779

Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 2001;15(6):672-86 - PMID: 11274053 - PMCID: PMC312654 - DOI: 10.1101/gad.867301

Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001;106(1):23-34 - PMID: 11461699 - DOI: 10.1016/s0092-8674(01)00431-7

Ruvkun G Molecular biology. Glimpses of a tiny RNA world. Science. 2001;294(5543):797-9 - PMID: 11679654 - DOI: 10.1126/science.1066315

Finch CE, Ruvkun G The genetics of aging. Annu Rev Genomics Hum Genet. 2001;2:435-62 - PMID: 11701657 - DOI: 10.1146/annurev.genom.2.1.435

Lee RY, Hench J, Ruvkun G Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol. 2001;11(24):1950-7 - PMID: 11747821 - DOI: 10.1016/s0960-9822(01)00595-4

Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc Natl Acad Sci U S A. 2000;97(1):460-5 - PMID: 10618440 - PMCID: PMC26685 - DOI: 10.1073/pnas.97.1.460

Sze JY, Victor M, Loer C, Shi Y, Ruvkun G Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature. 2000;403(6769):560-4 - PMID: 10676966 - DOI: 10.1038/35000609

Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000;403(6772):901-6 - PMID: 10706289 - DOI: 10.1038/35002607

Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell. 2000;5(4):659-69 - PMID: 10882102 - DOI: 10.1016/s1097-2765(00)80245-2

Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc Natl Acad Sci U S A. 2000;97(19):10412-7 - PMID: 10973497 - PMCID: PMC27038 - DOI: 10.1073/pnas.190326997

Wolkow CA, Kimura KD, Lee MS, Ruvkun G Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science. 2000;290(5489):147-50 - PMID: 11021802 - DOI: 10.1126/science.290.5489.147

Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000;408(6808):86-9 - PMID: 11081512 - DOI: 10.1038/35040556

Kagoshima H, Sommer R, Reinhart BJ, Cassata G, Ruvkun G, Bürglin TR Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal. Dev Genes Evol. 2000;210(11):564-9 - PMID: 11180807 - DOI: 10.1007/s004270000099

Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol. 1999;144(1):45-57 - PMID: 9885243 - PMCID: PMC2148118 - DOI: 10.1083/jcb.144.1.45

Hobert O, Tessmar K, Ruvkun G The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development. 1999;126(7):1547-62 - PMID: 10068647 - DOI: 10.1242/dev.126.7.1547

Hobert O, Ruvkun G Pax genes in Caenorhabditis elegans: a new twist. Trends Genet. 1999;15(6):214-6 - PMID: 10354580 - DOI: 10.1016/s0168-9525(99)01731-x

Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 1999;13(11):1438-52 - PMID: 10364160 - PMCID: PMC316759 - DOI: 10.1101/gad.13.11.1438

Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes Dev. 1999;13(14):1794-806 - PMID: 10421632 - PMCID: PMC316880 - DOI: 10.1101/gad.13.14.1794

Davidson EH, Ruvkun G Themes from a NASA workshop on gene regulatory processes in development and evolution. J Exp Zool. 1999;285(2):104-15 - PMID: 10440721 - DOI: 10.1002/(sici)1097-010x(19990815)285:2<104::aid-jez2>3.0.co;2-z

Slack F, Ruvkun G Temporal pattern formation by heterochronic genes. Annu Rev Genet. 1998;31:611-34 - PMID: 9442909 - DOI: 10.1146/annurev.genet.31.1.611

Tissenbaum HA, Ruvkun G An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics. 1998;148(2):703-17 - PMID: 9504918 - PMCID: PMC1459840 - DOI: 10.1093/genetics/148.2.703

Hobert O, D'Alberti T, Liu Y, Ruvkun G Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11. J Neurosci. 1998;18(6):2084-96 - PMID: 9482795 - PMCID: PMC6792926 - DOI: 10.1523/JNEUROSCI.18-06-02084.1998

Paradis S, Ruvkun G Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 1998;12(16):2488-98 - PMID: 9716402 - PMCID: PMC317081 - DOI: 10.1101/gad.12.16.2488

Guarente L, Ruvkun G, Amasino R Aging, life span, and senescence. Proc Natl Acad Sci U S A. 1998;95(19):11034-6 - PMID: 9736682 - PMCID: PMC33892 - DOI: 10.1073/pnas.95.19.11034

Ruvkun G, Hobert O The taxonomy of developmental control in Caenorhabditis elegans. Science. 1998;282(5396):2033-41 - PMID: 9851920 - DOI: 10.1126/science.282.5396.2033

Slack FJ, Ruvkun G A novel repeat domain that is often associated with RING finger and B-box motifs. Trends Biochem Sci. 1998;23(12):474-5 - PMID: 9868369 - DOI: 10.1016/s0968-0004(98)01299-7

Ogg S, Ruvkun G The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell. 1998;2(6):887-93 - PMID: 9885576 - DOI: 10.1016/s1097-2765(00)80303-2

Slack F, Ruvkun G Heterochronic genes in development and evolution. Biol Bull. 1998;195(3):375-6 - PMID: 9924779 - DOI: 10.2307/1543152

Hobert O, Ruvkun G A common theme for LIM homeobox gene function across phylogeny?. Biol Bull. 1998;195(3):377-80 - PMID: 9924780 - DOI: 10.2307/1543153

Sze JY, Liu Y, Ruvkun G VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth. Development. 1997;124(6):1159-68 - PMID: 9102303 - DOI: 10.1242/dev.124.6.1159

Sluder AE, Lindblom T, Ruvkun G The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development. Dev Biol. 1997;184(2):303-19 - PMID: 9133437 - DOI: 10.1006/dbio.1997.8544

Hobert O, Mori I, Yamashita Y, Honda H, Ohshima Y, Liu Y, Ruvkun G Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron. 1997;19(2):345-57 - PMID: 9292724 - DOI: 10.1016/s0896-6273(00)80944-7

Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997;277(5328):942-6 - PMID: 9252323 - DOI: 10.1126/science.277.5328.942

Patterson GI, Koweek A, Wong A, Liu Y, Ruvkun G The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 1997;11(20):2679-90 - PMID: 9334330 - PMCID: PMC316611 - DOI: 10.1101/gad.11.20.2679

Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature. 1997;389(6654):994-9 - PMID: 9353126 - DOI: 10.1038/40194

Baumeister R, Liu Y, Ruvkun G Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Genes Dev. 1996;10(11):1395-410 - PMID: 8647436 - DOI: 10.1101/gad.10.11.1395

Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. J Neurochem. 1996;67(1):46-57 - PMID: 8667025 - DOI: 10.1046/j.1471-4159.1996.67010046.x

Morris JZ, Tissenbaum HA, Ruvkun G A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 1996;382(6591):536-9 - PMID: 8700226 - DOI: 10.1038/382536a0

Ha I, Wightman B, Ruvkun G A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes Dev. 1996;10(23):3041-50 - PMID: 8957004 - DOI: 10.1101/gad.10.23.3041

Gottlieb S, Ruvkun G daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans. Genetics. 1994;137(1):107-20 - PMID: 8056303 - PMCID: PMC1205929 - DOI: 10.1093/genetics/137.1.107

Greenstein D, Hird S, Plasterk RH, Andachi Y, Kohara Y, Wang B, Finney M, Ruvkun G Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation. Genes Dev. 1994;8(16):1935-48 - PMID: 7958868 - DOI: 10.1101/gad.8.16.1935

Ruvkun G Cell signalling. A molecular growth industry. Nature. 1993;360(6406):711-2 - PMID: 1334532 - DOI: 10.1038/360711a0

Bürglin TR, Ruvkun G The Caenorhabditis elegans homeobox gene cluster. Curr Opin Genet Dev. 1993;3(4):615-20 - PMID: 7902148 - DOI: 10.1016/0959-437x(93)90097-9

Wightman B, Ha I, Ruvkun G Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 1993;75(5):855-62 - PMID: 8252622 - DOI: 10.1016/0092-8674(93)90530-4

Ruvkun G, Wightman B, Bürglin T, Arasu P Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes. Dev Suppl. 1992;1:47-54 - PMID: 1742500

Miller DM, Shen MM, Shamu CE, Bürglin TR, Ruvkun G, Dubois ML, Ghee M, Wilson L C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Nature. 1992;355(6363):841-5 - PMID: 1347150 - DOI: 10.1038/355841a0

Bürglin TR, Ruvkun G New motif in PBX genes. Nat Genet. 1992;1(5):319-20 - PMID: 1363814 - DOI: 10.1038/ng0892-319

Xue D, Finney M, Ruvkun G, Chalfie M Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3. EMBO J. 1992;11(13):4969-79 - PMID: 1361171 - PMCID: PMC556975 - DOI: 10.1002/j.1460-2075.1992.tb05604.x

Ruvkun G, Finney M Regulation of transcription and cell identity by POU domain proteins. Cell. 1991;64(3):475-8 - PMID: 1991317 - DOI: 10.1016/0092-8674(91)90227-p

Bürglin TR, Ruvkun G, Coulson A, Hawkins NC, McGhee JD, Schaller D, Wittmann C, Müller F, Waterston RH Nematode homeobox cluster. Nature. 1991;351(6329):703 - PMID: 1676487 - DOI: 10.1038/351703a0

Wightman B, Bürglin TR, Gatto J, Arasu P, Ruvkun G Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development. Genes Dev. 1991;5(10):1813-24 - PMID: 1916264 - DOI: 10.1101/gad.5.10.1813

Arasu P, Wightman B, Ruvkun G Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28. Genes Dev. 1991;5(10):1825-33 - PMID: 1916265 - DOI: 10.1101/gad.5.10.1825

Ruvkun G, Gilbert W, Horvitz HR Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization. Nucleic Acids Res. 1990;18(4):809-15 - PMID: 2315039 - PMCID: PMC330331 - DOI: 10.1093/nar/18.4.809

Finney M, Ruvkun G The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell. 1990;63(5):895-905 - PMID: 2257628 - DOI: 10.1016/0092-8674(90)90493-x

Ruvkun G, Ambros V, Coulson A, Waterston R, Sulston J, Horvitz HR Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. Genetics. 1989;121(3):501-16 - PMID: 2565854 - PMCID: PMC1203636 - DOI: 10.1093/genetics/121.3.501

Ruvkun G, Giusto J The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch. Nature. 1989;338(6213):313-9 - PMID: 2922060 - DOI: 10.1038/338313a0

Bürglin TR, Finney M, Coulson A, Ruvkun G Caenorhabditis elegans has scores of homoeobox-containing genes. Nature. 1989;341(6239):239-43 - PMID: 2571091 - DOI: 10.1038/341239a0

Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev. 1988;2(12A):1513-6 - PMID: 3215510 - DOI: 10.1101/gad.2.12a.1513

Finney M, Ruvkun G, Horvitz HR The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors. Cell. 1988;55(5):757-69 - PMID: 2903797 - DOI: 10.1016/0092-8674(88)90132-8

Ruvkun GB, Long SR, Meade HM, van den Bos RC, Ausubel FM ISRm1: A Rhizobium meliloti insertion sequence that transposes preferentially into nitrogen fixation genes. J Mol Appl Genet. 1983;1(5):405-18 - PMID: 6296251

Meade HM, Long SR, Ruvkun GB, Brown SE, Ausubel FM Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis. J Bacteriol. 1982;149(1):114-22 - PMID: 6274841 - PMCID: PMC216598 - DOI: 10.1128/JB.149.1.114-122.1982

Ruvkun GB, Sundaresan V, Ausubel FM Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes. Cell. 1982;29(2):551-9 - PMID: 6288262 - DOI: 10.1016/0092-8674(82)90171-4

Ruvkun GB, Sundaresan V, Ausubel FM Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts. Gene. 1982;18(3):247-55 - PMID: 6290328 - DOI: 10.1016/0378-1119(82)90162-7

Ruvkun GB, Sundaresan V, Ausubel FM Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes. Cell. 1982;29(2):551-9 - PMID: 6288262 - DOI: 10.1016/0092-8674(82)90171-4

Ruvkun GB, Ausubel FM A general method for site-directed mutagenesis in prokaryotes. Nature. 1981;289(5793):85-8 - PMID: 6256652 - DOI: 10.1038/289085a0

Ruvkun GB, Ausubel FM A general method for site-directed mutagenesis in prokaryotes. Nature. 1981;289(5793):85-8 - PMID: 6256652 - DOI: 10.1038/289085a0

Ruvkun GB, Ausubel FM Interspecies homology of nitrogenase genes. Proc Natl Acad Sci U S A. 1980;77(1):191-5 - PMID: 6987649 - PMCID: PMC348234 - DOI: 10.1073/pnas.77.1.191

Ruvkun GB, Ausubel FM Interspecies homology of nitrogenase genes. Proc Natl Acad Sci U S A. 1980;77(1):191-5 - PMID: 6987649 - PMCID: PMC348234 - DOI: 10.1073/pnas.77.1.191