About UsIn addition to inquiries into the origins of life, atherosclerosis, host-pathogen interactions, and physiological harbingers of advers outcomes, CCIB supports investigators at the hospital and across Boston through our autonomous cores that provide services in DNA sequencing, oligonucleotide synthesis and research laboratory automation.
Program: DNA Core
Date Posted: 2017-05-30
DescriptionThe CCIB DNA Core has opened up a full-time position for a Research Technologist. As a member of the DNA Core, the ResearchTechnologist will provide standard and custom medium- to high-throughput sample processing services for various molecular biology and genomics applications, including maintenance of automated laboratory workstations, and will participate in the development, implementation and execution of automated molecular biology procedures and processes. The Research Technologist reports directly to Core Director, and/or managers of the core laboratory and is expected to work independently on assigned research with minimal guidance from a higher level staff member. The ideal candidate must be able to learn and work in a collaborative and fast-paced team environment, and to interact with all levels of staff and with researchers using our services. He/she will have good organizational and time management skills as well as an ability both to follow directions carefully and to solve common problems independently. We are looking for a team member who can learn quickly and is enthusiastic about laboratory automation instruments and devices and methodologies used to enable, expedite and increase the efficiency and effectiveness of scientific research. Review of applications will begin immediately and continue until the position is filled. Salary will be commensurate with the candidate’s experience and qualifications. The position typically requires a bachelor’s degree or higher plus three years of related experience, or an equivalent combination of education and experience.
ResponsibilitiesDevelops, validates, and applies high-throughput methods for various scientific applications using and programming laboratory automation. Provides standard and custom medium- to high-throughput sample processing services for molecular biology and genomics applications (including but not limited to Custom Automation projects, Mouse Genotyping, 96-well Plasmid Preparation, High-Throughput Library Screening, and Next-Generation Sequencing (NGS) Library Preparation). Working with senior personnel, performs early research and development activity to create new core services that are robust, cost-effective and time efficient. Collaborates with core customers (senior scientists and postdoctoral research fellows) to transfer new assays and methods to automation platforms. Works closely with IT group and instrument vendors to develop and implement integration layers between automation platform and the LIMS systems. Develops project timelines and utilizes time management practices and tools to manage demands and deadlines and to deliver on key project milestones; proactively communicates impending changes in work, project schedules and experimental design. Accurately and consistently records experimental methods, materials and results in laboratory notebooks. Analyzes data, evaluates results, forms conclusions, and determines future experiments. Uses broad knowledge of molecular biology techniques to proactively troubleshoot assays, to resolve technical issues and challenges, and to perform data interpretation. Presents findings or comprehensive project status reviews at internal meetings. Applies advanced technical writing and graphical skills to produce documents and reports. Writes and implements standard operation procedures (SOPs). Determines all chemicals, reagents and supplies needed for a project; develops a strong knowledge of all related third-party vendors and their technologies and products. Maintains and troubleshoots liquid handling platforms, including cleanliness of work areas and instrument scheduling for various core and collaborator activities. Assists Core Director in cost modeling and in the analysis of yearly volumes of automation services for the core budget process. Flexibility in a fast-paced, changing environment; be willing to accept responsibilities outside of the initial job description. Establishes and maintains productive relationship with all core personnel; develops internal and external collaborations. For specific research services, works as a liaison between core laboratory and customers.
RequirementsStrong molecular biology background and good hands-on knowledge of the latest molecular biology methods Experience operating and programming liquid-handling robotics Proficiency in Microsoft Word, Excel, and PowerPoint Excellent general laboratory and organizational skills including the ability to multitask and to work independently and well as part of a team Superior time management skills Excellent communication skills (written and verbal) and orientation toward teamwork and collaboration Critical thinking, excellent data analysis and interpretation skills, good problem solving skills Preferred: Background in automated sample processing Ability to operate LIMS Experience in: Laboratory Automation/Liquid Handling; High-throughput sample processing; cDNA screening; Mouse Genotyping; Next-Generation sequencing methods and library preparation; Real-time PCR; Advanced molecular biology techniques used in Genomics Next-Generation Sequencing using Illumina instruments such as MiSeq Education: The candidate must have a bachelor’s degree or higher in the Life Sciences, with strong training in the theory and practice of molecular biology, plus a minimum of three years experience in a research environment (5 years preferred), or an equivalent combination of education and experience. Specific experience in programming and use of laboratory robotics for high-throughput sample processing is required. LIMS experience and/or familiarity with some of the technologies listed under Responsibilities is a plus. Some related work experience in a fast-paced and multi-tasked environment is preferred.
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Lynelle CortelliniAdministrative Manager, Research
Marc DavignonSystems Manager
Chris KelleherFacilities Manager
Chia-Chia LuProject Coordinator
Tara ThurberAdministrative Director, Research
The Center for Computational and Integrative Biology
The Center for Computational and Integrative Biology
Massachusetts General Hospital
Richard B. Simches Research Center
185 Cambridge Street
Boston, MA 02114