Center for Computational and Integrative Biology
About our Center
Faculty in the Center for Computational and Integrative Biology (CCIB) apply interdisciplinary approaches and new technologies to answer enduring biological questions and provide insights into human disease. Novel chemical, genomics and computational tools are developed to probe signaling pathways, identify mediators of host-microbe interactions, understand and simulate the conditions associated with the emergence of life, and design therapeutic disease interventions. Center investigators also conduct translational research to explore the potential utility of early-stage drug candidates in phase 1 studies carried out in small populations of individuals with the target disease indication.
The CCIB provides support for investigators at Mass General Hospital and across the greater Boston area through a variety of autonomous cores that provide services in DNA sequencing, oligonucleotide synthesis and research laboratory automation.
In the News
Celebrating a historic $100M gift to establish the Gene Lay Institute for Immunology and Inflammation! The gift, from eminent biotechnology entrepreneur Gene Lay, founder and CEO of BioLegend, is the largest in Brigham's history. The Gene Lay Institute will be led by Vijay Kuchroo, an immunologist and principal investigator at the Brigham who will serve as inaugural director, Arlene Sharpe, chair of the Department of Immunology at HMS, and Ramnik Xavier, our Center Director. Areas of research will include basic understanding of immune-mediated diseases, aging, and cancer toward the development of new immunotherapies. The Institute will also provide training opportunities for students and fellows to support immunology innovators of the future.
Congratulations Emanuel Burgos-Robles in the Smillie lab, for receiving the prestigious NSF Graduate Research Fellowship! Ema is a graduate student in the MIT Computational and Systems Biology PhD Program (CSB).
The Cell Press webinar, Multi-omics in drug discovery, is now freely available to view on demand. Omics technologies have emerged as powerful tools that are used to investigate broad scientific questions. This webinar delves into how omics has been used to identify leads in drug discovery. Listen to Deb Hung discuss using omics to identify therapeutic options for bacterial pathogens.
Welcome Chris Smillie, our new faculty member! Chris is an Assistant Professor in the Department of Medicine at Harvard Medical School. His research program in CCIB will focus on mechanistically understanding how microbial perturbations alter host tissues and impact disease. You can learn more about his program in his website: https://www.smillielab.org/
Congratulations to Nitya Jain on receiving the Mass General Center for Faculty Development’s Anne Klibanski Visiting Scholars Award! This award is given to women faculty clinicians, educators, researchers and postdocs at MGH who have shown exceptional promise as leaders in their field and whose careers would specifically benefit from speaking, mentoring and networking opportunities.
Congratulations to Keith Joung on being awarded the Samsung Ho-Am Prize in Medicine! This award is presented each year to individuals of Korean heritage who have furthered the welfare of humanity through distinguished accomplishments in the field of medicine. This year’s award recognizes contributions the Joung laboratory has made in innovating genome editing approaches for basic, clinical and translational science.
Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan. Nat Microbiol. 2023;8(6):1064-1078
Association of distinct microbial signatures with premalignant colorectal adenomas. Cell Host Microbe. 2023;31(5):827-838.e3
Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13. Nat Commun. 2023;14(1):1803
Remodeling of colon plasma cell repertoire within ulcerative colitis patients. J Exp Med. 2023;220(4):ePub
The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon. Immunity. 2023;56(2):444-458.e5
Bacterial droplet-based single-cell RNA-seq reveals antibiotic-associated heterogeneous cellular states. Cell. 2023;186(4):877-891.e14
Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism. Cell. 2022;185(26):4921-4936.e15
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Proc Natl Acad Sci U S A. 2022;119(49):e2215966119
Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension. N Engl J Med. 2022;388(5):395-405
A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning. Cell. 2022;185(23):4280-4297.e12
Folding and Duplex Formation in Sequence-Defined Aniline Benzaldehyde Oligoarylacetylenes. J Am Chem Soc. 2022;144(40):18350-18358
Engineered CRISPR prime editors with compact, untethered reverse transcriptases. Nat Biotechnol. 2022;41(3):337-343
NIN-like protein 7 transcription factor is a plant nitrate sensor. Science. 2022;377(6613):1419-1425
Glucose-driven TOR-FIE-PRC2 signalling controls plant development. Nature. 2022;609(7929):986-993