Center for Computational and Integrative Biology
Our Mission
Faculty in the Center for Computational and Integrative Biology (CCIB) apply interdisciplinary approaches and new technologies to answer enduring biological questions and provide insights into human disease. Novel chemical, genomics and computational tools are developed to probe signaling pathways, identify mediators of host-microbe interactions, and design therapeutic disease interventions. Center investigators also conduct translational research to explore the potential utility of early-stage drug candidates in phase 1 studies carried out in small populations of individuals with the target disease indication.
The CCIB provides support for investigators at Mass General Hospital and across the greater Boston area through a core that provides a wide range of high-quality, cutting-edge services in the areas of molecular biology, genomics and laboratory automation, and access to advanced instrumentation, methodologies and expertise.
News and Events
Congratulations Strecker! for receiving the 2025 NIH Director's New Innovator Award (DP2) to support a project on the discovery and characterization of programmable biological systems. Read more here.
Applying AI To Transform Biomedical Research - January 28, 2026. The AI4ID: Bridging Infection and Artificial Intelligence Symposium, jointly hosted by CISID and the Eric and Wendy Schmidt Center, will bring together leading infectious disease scientists and clinicians with AI experts to think creatively about how AI technologies can solve the most pressing challenges in infection research. More information and registration here.
Gut Check: How the Microbiome Shapes Inflammation and Depression. A recent collaboration between investigators in CCIB and the HMS Blavatnik Institute revealed that the gut bacterium Morganella morganii may contribute to major depressive disorder by incorporating an environmental contaminant into a molecule that triggers inflammation. This contaminant could serve as a biomarker and supports links between depression and autoimmune processes. Read more in the HMS news story.
Publications
Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis. Nat Commun. 2025;16(1):9673
Human immunodeficiency virus and antiretroviral therapies exert distinct influences across diverse gut microbiomes. Nat Microbiol. 2025;10(11):2720-2735
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation. Science. 2025;390(6772):eadr3545
Kmo restricts Salmonella in a whole organism infection model by promoting macrophage lysosomal acidification through kainate receptor antagonism. PLoS Pathog. 2025;21(10):e1013273
Single-cell transcriptomic characterization of microscopic colitis. Nat Commun. 2025;16(1):4618
Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans. PLoS Biol. 2025;23(1):e3002748
Hydrogen sulfide mediates the interaction between C. elegans and Actinobacteria from its natural microbial environment. Cell Rep. 2025;44(1):115170
Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator. Cell Chem Biol. 2025;32(3):498-510.e35
Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen. Cell Chem Biol. 2024;32(2):307-324.e15
ABA-activated low-nanomolar Ca2+-CPK signalling controls root cap cycle plasticity and stress adaptation. Nat Plants. 2024;11(1):90-104
