Center for Computational and Integrative Biology

The Center for Computational and Integrative Biology (CCIB) is an affiliation of faculty drawn together by a common interest in the study of biology through methods engaging a broader scale of inquiry than the existing standard of the era. The faculty collectively has highly diverse interests, ranging from inquiries into the origins of life, the mechanisms of host-pathogen interactions in plants and model organisms, the relationship between atherosclerosis and inflammatory responses in vertebrates, and the collection and analysis of comprehensive measures of physiology in an attempt to understand the harbingers of adverse outcomes (principally sepsis and its sequelae) in individuals treated for trauma.

The Center for Computational and Integrative Biology provides support for investigators at the hospital and across Boston through a variety of autonomous cores that provide services in DNA sequencing, oligonucleotide synthesis and research laboratory automation.

Awards and Honors

Gary Ruvkun: 2016 March of Dimes and Richard B. Johnston, Jr., MD Prize in Developmental Biology

Gary Ruvkun, along with Victor Ambros of the University of Massachusetts Medical School, has been awarded the 2016 March of Dimes and Richard B. Johnston, Jr., MD Prize in Developmental Biology. The Prize recognizes their pioneering co-discovery of microRNAs and the mechanism by which they regulate their targets. Awarded annually, the March of Dimes Prize is given to investigators whose research advances the understanding of birth defects.

J. Keith Joung: 2016 MGH Research Scholar

Keith Joung has been named one of the 2016 MGH Research Scholars for his work entitled “Advancing CRISPR-based Genome and Epigenome Editing Technologies.” Awarded annually, the Massachusetts General Hospital Research Scholars program was established to provide forward-thinking researchers with the funding they need to take their work into new and uncharted territories. These projects are often not readily funded by the NIH or other sources and so this program was developed to provided institutional support for these outstanding researchers.

Ramnik Xavier: Center for Microbiome Informatics and Therapeutics

MGH and MIT have announced a new strategic partnership in microbiome research to be led by Ramnik Xavier, Chief of the Division of Gastroenterology at MGH and a founding member of CCIB, and Eric Alm, an associate professor of biological engineering at MIT. Named the Center for Microbiome Informatics and Therapeutics, the center is designed to advance the science of the human microbiome, and the treatment of conditions and diseases associated with an altered microbiome.

The center’s main functions are to fund cross-disciplinary and innovative research proposals, to provide shared services for researchers studying the microbiome, and to build an interactive academic community of clinicians and academic researchers interested in tackling microbiome-related disease. Initial projects will focus on the role of the microbiome in inflammatory bowel disease, with future plans to explore the role of the microbiome in other systemic autoimmune diseases, including autism, MS, arthritis, diabetes, and allergies.