Center for Computational and Integrative Biology

The Center for Computational and Integrative Biology (CCIB) is an affiliation of faculty drawn together by a common interest in the study of biology through methods engaging a broader scale of inquiry than the existing standard of the era. The faculty collectively has highly diverse interests, ranging from inquiries into the origins of life, the mechanisms of host-pathogen interactions in plants and model organisms, the relationship between atherosclerosis and inflammatory responses in vertebrates, and the collection and analysis of comprehensive measures of physiology in an attempt to understand the harbingers of adverse outcomes (principally sepsis and its sequelae) in individuals treated for trauma.

The Center for Computational and Integrative Biology provides support for investigators at the hospital and across Boston through a variety of autonomous cores that provide services in DNA sequencing, oligonucleotide synthesis and research laboratory automation. 

In the News

 Welcome Chris Smillie, our new principal investigator! Chris’s research program in CCIB will focus on mechanistically understanding how microbial perturbations alter host tissues and impact disease. You can learn more about his program in his website:

 Congratulations to Keith Joung and Ramnik Xavier, who were listed amongst the 2020 Highly Cited Researchers by the Web of Science Group. According to Web of Science Group, the Highly Cited Researchers list identifies scientists and social scientists who have demonstrated significant influence through publication of multiple papers, highly cited by their peers, during the last decade. In 2019, fewer than 6,300, or 0.1%, of the world’s researchers were named across 21 research fields.