Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars.

Pontefract A, Zhu TF, Walker VK, Hepburn H, Lui C, Zuber MT, Ruvkun G, Carr CE
Front Microbiol. 2017;8:1819 - PMID: 29018418 - PMCID: PMC5623196

Nucleic Acid Extraction from Synthetic Mars Analog Soils for in situ Life Detection.

Mojarro A, Ruvkun G, Zuber MT, Carr CE
Astrobiology. 2017;17(8):747-760 - PMID: 28704064 - PMCID: PMC5567878

Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.

Lehrbach NJ, Ruvkun G
Elife. 2016;5:ePub - PMID: 27528192 - PMCID: PMC4987142

A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport.

Dowen RH, Breen PC, Tullius T, Conery AL, Ruvkun G
Genes Dev. 2016;30(13):1515-28 - PMID: 27401555 - PMCID: PMC4949325

Caenorhabditis elegans responses to bacteria from its natural habitats.

Samuel BS, Rowedder H, Braendle C, Félix MA, Ruvkun G
Proc Natl Acad Sci U S A. 2016;113(27):E3941-9 - PMID: 27317746 - PMCID: PMC4941482

Planetary Protection and Mars Special Regions-A Suggestion for Updating the Definition.

Rettberg P, Anesio AM, Baker VR, Baross JA, Cady SL, Detsis E, Foreman CM, Hauber E, Ori GG, Pearce DA, Renno NO, Ruvkun G, Sattler B, Saunders MP, Smith DH, Wagner D, Westall F
Astrobiology. 2016;16(2):119-125 - PMID: 26848950

Dialogue between E. coli free radical pathways and the mitochondria of C. elegans.

Govindan JA, Jayamani E, Zhang X, Mylonakis E, Ruvkun G
Proc Natl Acad Sci U S A. 2015;112(40):12456-61 - PMID: 26392561 - PMCID: PMC4603447

Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans.

Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G
Nat Cell Biol. 2015;17(10):1294-303 - PMID: 26322678 - PMCID: PMC4589496

piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway.

Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA
Dev Cell. 2015;34(4):457-465 - PMID: 26279487 - PMCID: PMC4550515

PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles.

Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y
Nucleic Acids Res. 2015;43(W1):W154-W159 - PMID: 25958392 - PMCID: PMC4489270

Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa.

Kirienko NV, Ausubel FM, Ruvkun G
Proc Natl Acad Sci U S A. 2015;112(6):1821-6 - PMID: 25624506 - PMCID: PMC4330731

Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence.

Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G
PLoS Genet. 2014;10(12):e1004752 - PMID: 25474471 - PMCID: PMC4256158

Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.

O'Rourke EJ, Ruvkun G
Nat Cell Biol. 2014;17(1):104 - PMID: 25534088


Govindan JA, Ruvkun G
Virulence. 2014;5(7):ePub - PMID: 25290904 - PMCID: PMC4189874


Govindan JA, Ruvkun G
Virulence. 2014;5(7):695-696 - PMID: 25513769 - PMCID: PMC4189874

Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.

Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G
Nat Struct Mol Biol. 2014;21(8):712-720 - PMID: 25038802 - PMCID: PMC4125460

Caenorhabditis elegans pathways that surveil and defend mitochondria.

Liu Y, Samuel BS, Breen PC, Ruvkun G
Nature. 2014;508(7496):406-10 - PMID: 24695221 - PMCID: PMC4102179

MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation.

Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA
Curr Biol. 2014;24(8):839-44 - PMID: 24684932 - PMCID: PMC4010136

Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans.

Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G
Genes Dev. 2013;27(24):2678-95 - PMID: 24352423 - PMCID: PMC3877757

High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis.

Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A
Cell. 2013;155(6):1409-21 - PMID: 24269006 - PMCID: PMC3956118

Genetic Regulation of Caenorhabditis elegans Lysosome Related Organelle Function.

Soukas AA, Carr CE, Ruvkun G
PLoS Genet. 2013;9(10):e1003908 - PMID: 24204312 - PMCID: PMC3812091

Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling.

Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G
Mol Syst Biol. 2013;9:692 - PMID: 24084807 - PMCID: PMC3817400

Dual Regulation of the lin-14 Target mRNA by the lin-4 miRNA.

Shi Z, Hayes G, Ruvkun G
PLoS One. 2013;8(9):e75475 - PMID: 24058689 - PMCID: PMC3772890

Radiation Resistance of Sequencing Chips for in situ Life Detection.

Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, Ruvkun G
Astrobiology. 2013;13(6):560-9 - PMID: 23734755

A cytoprotective perspective on longevity regulation.

Shore DE, Ruvkun G
Trends Cell Biol. 2013;23(9):409-20 - PMID: 23726168 - PMCID: PMC4057428

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.

O'Rourke EJ, Ruvkun G
Nat Cell Biol. 2013;15(6):668-676 - PMID: 23604316 - PMCID: PMC3723461

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.

Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G
Nat Cell Biol. 2013;15(5):491-501 - PMID: 23604319 - PMCID: PMC3748955

Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death.

Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM
Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844

Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death.

Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM
Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844

MicroRNAs Visit the ER.

Montgomery TA, Ruvkun G
Cell. 2013;153(3):511-2 - PMID: 23622236

?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.

O'Rourke EJ, Kuballa P, Xavier R, Ruvkun G
Genes Dev. 2013;27(4):429-40 - PMID: 23392608 - PMCID: PMC3589559

High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes.

Shi Z, Montgomery TA, Qi Y, Ruvkun G
Genome Res. 2013;23(3):497-508 - PMID: 23363624 - PMCID: PMC3589538

Radiation resistance of biological reagents for in situ life detection.

Carr CE, Rowedder H, Vafadari C, Lui CS, Cascio E, Zuber MT, Ruvkun G
Astrobiology. 2013;13(1):68-78 - PMID: 23330963

Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence.

Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G
Nature. 2012;493(7434):694-8 - PMID: 23364702 - PMCID: PMC3762460

Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.

Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP
PLoS One. 2012;7(10):e48282 - PMID: 23144747 - PMCID: PMC3483217

New insights into siRNA amplification and RNAi.

Zhang C, Ruvkun G
RNA Biol. 2012;9(8):1045-9 - PMID: 22858672 - PMCID: PMC3551858

Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways.

Shore DE, Carr CE, Ruvkun G
PLoS Genet. 2012;8(7):e1002792 - PMID: 22829775 - PMCID: PMC3400582

MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline.

Phillips CM, Montgomery TA, Breen PC, Ruvkun G
Genes Dev. 2012;26(13):1433-44 - PMID: 22713602 - PMCID: PMC3403012

The Caenorhabditis elegans RDE-10/RDE-11 Complex Regulates RNAi by Promoting Secondary siRNA Amplification.

Zhang C, Montgomery TA, Fischer SE, Garcia SM, Riedel CG, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G
Curr Biol. 2012;22(10):881-90 - PMID: 22542102 - PMCID: PMC3371361

An image analysis toolbox for high-throughput C. elegans assays.

Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE
Nat Methods. 2012;9(7):714-6 - PMID: 22522656 - PMCID: PMC3433711

PIWI Associated siRNAs and piRNAs Specifically Require the Caenorhabditis elegans HEN1 Ortholog henn-1.

Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G
PLoS Genet. 2012;8(4):e1002616 - PMID: 22536158 - PMCID: PMC3334881

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses.

Melo JA, Ruvkun G
Cell. 2012;149(2):452-66 - PMID: 22500807 - PMCID: PMC3613046

Repression of Germline RNAi Pathways in Somatic Cells by Retinoblastoma Pathway Chromatin Complexes.

Wu X, Shi Z, Cui M, Han M, Ruvkun G
PLoS Genet. 2012;8(3):e1002542 - PMID: 22412383 - PMCID: PMC3297578

The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans.

Shi Z, Ruvkun G
Proc Natl Acad Sci U S A. 2012;109(12):4568-73 - PMID: 22396595 - PMCID: PMC3311396

The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status.

Kimura KD, Riddle DL, Ruvkun G
Cold Spring Harb Symp Quant Biol. 2011;76:113-20 - PMID: 22123849

The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.

Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G
PLoS Genet. 2011;7(11):e1002369 - PMID: 22102828 - PMCID: PMC3213143

Regulation of the C. elegans molt by pqn-47.

Russel S, Frand AR, Ruvkun G
Dev Biol. 2011;360(2):297-309 - PMID: 21989027 - PMCID: PMC3618673

The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.

Hayes GD, Riedel CG, Ruvkun G
Genes Dev. 2011;25(19):2079-92 - PMID: 21979920 - PMCID: PMC3197206

mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.

Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G
Proc Natl Acad Sci U S A. 2011;108(4):1201-8 - PMID: 21245313 - PMCID: PMC3029761

RNAi screening for fat regulatory genes with SRS microscopy.

Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS
Nat Methods. 2011;8(2):135-8 - PMID: 21240281 - PMCID: PMC3061290

Cancer. Germ cell genes and cancer.

Wu X, Ruvkun G
Science. 2010;330(6012):1761-2 - PMID: 21205660

MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans.

Meli VS, Osuna B, Ruvkun G, Frand AR
Mol Biol Cell. 2010;21(10):1648-61 - PMID: 20335506 - PMCID: PMC2869372

RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.

Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT
PLoS One. 2009;4(12):e8210 - PMID: 20011587 - PMCID: PMC2788130

C. elegans major fats are stored in vesicles distinct from lysosome-related organelles.

O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G
Cell Metab. 2009;10(5):430-5 - PMID: 19883620 - PMCID: PMC2921818

A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.

Curran SP, Wu X, Riedel CG, Ruvkun G
Nature. 2009;459(7250):1079-84 - PMID: 19506556 - PMCID: PMC2716045

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.

Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G
Genes Dev. 2009;23(4):496-511 - PMID: 19240135 - PMCID: PMC2648650

Biosynthesis of the Caenorhabditis elegans dauer pheromone.

Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY
Proc Natl Acad Sci U S A. 2009;106(6):1875-9 - PMID: 19174521 - PMCID: PMC2631283

Fat metabolism links germline stem cells and longevity in C. elegans.

Wang MC, O'Rourke EJ, Ruvkun G
Science. 2008;322(5903):957-60 - PMID: 18988854 - PMCID: PMC2760269

The most conserved genome segments for life detection on Earth and other planets.

Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G
Orig Life Evol Biosph. 2008;38(6):517-33 - PMID: 18853276

The perfect storm of tiny RNAs.

Ruvkun G
Nat Med. 2008;14(10):1041-5 - PMID: 18841145

Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.

Fischer SE, Butler MD, Pan Q, Ruvkun G
Nature. 2008;455(7212):491-6 - PMID: 18784652 - PMCID: PMC2756026

Tiny RNA: Where do we come from? What are we? Where are we going?

Ruvkun G
Trends Plant Sci. 2008;13(7):313-6 - PMID: 18562240

Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.

Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G
Cold Spring Harb Symp Quant Biol. 2008;72:489-97 - PMID: 18419309

Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.

Patel DS, Fang LL, Svy DK, Ruvkun G, Li W
Development. 2008;135(13):2239-49 - PMID: 18495818

The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.

Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK
Cell. 2008;133(5):903-15 - PMID: 18510933 - PMCID: PMC2553566

The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.

Gabel HW, Ruvkun G
Nat Struct Mol Biol. 2008;15(5):531-3 - PMID: 18438419 - PMCID: PMC2910399

MicroRNA-183 family conservation and ciliated neurosensory organ expression.

Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA
Evol Dev. 2008;10(1):106-13 - PMID: 18184361 - PMCID: PMC2637451

Miniprimer PCR, a new lens for viewing the microbial world.

Isenbarger TA, Finney M, Ríos-Velázquez C, Handelsman J, Ruvkun G
Appl Environ Microbiol. 2007;74(3):840-9 - PMID: 18083877 - PMCID: PMC2227730

A whole-genome RNAi Screen for C. elegans miRNA pathway genes.

Parry DH, Xu J, Ruvkun G
Curr Biol. 2007;17(23):2013-22 - PMID: 18023351 - PMCID: PMC2211719

Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.

Samuelson AV, Carr CE, Ruvkun G
Genes Dev. 2007;21(22):2976-94 - PMID: 18006689 - PMCID: PMC2049198

Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans.

Kim N, Dempsey CM, Kuan CJ, Zoval JV, O'Rourke E, Ruvkun G, Madou MJ, Sze JY
Genetics. 2007;177(2):835-45 - PMID: 17720915 - PMCID: PMC2034647

Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs.

Hayes GD, Ruvkun G
Cold Spring Harb Symp Quant Biol. 2007;71:21-7 - PMID: 17381276

Lifespan regulation by evolutionarily conserved genes essential for viability.

Curran SP, Ruvkun G
PLoS Genet. 2007;3(4):e56 - PMID: 17411345 - PMCID: PMC1847696

The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25.

Hayes GD, Frand AR, Ruvkun G
Development. 2006;133(23):4631-41 - PMID: 17065234

Detection of broadly expressed neuronal genes in C. elegans.

Ruvinsky I, Ohler U, Burge CB, Ruvkun G
Dev Biol. 2006;302(2):617-26 - PMID: 17046742

Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.

Hu PJ, Xu J, Ruvkun G
PLoS Genet. 2006;2(7):e99 - PMID: 16839187 - PMCID: PMC1487177

A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans.

Sandoval GM, Duerr JS, Hodgkin J, Rand JB, Ruvkun G
Nat Neurosci. 2006;9(5):599-601 - PMID: 16604067

Polygenic control of Caenorhabditis elegans fat storage.

Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G
Nat Genet. 2006;38(3):363-8 - PMID: 16462744

Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.

Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC
Cell. 2006;124(2):343-54 - PMID: 16439208

Clarifications on miRNA and cancer.

Ruvkun G
Science. 2006;311(5757):36-7 - PMID: 16400132

Functional genomic analysis of C. elegans molting.

Frand AR, Russel S, Ruvkun G
PLoS Biol. 2005;3(10):e312 - PMID: 16122351 - PMCID: PMC1233573

Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway.

Wang D, Ruvkun G
Cold Spring Harb Symp Quant Biol. 2005;69:429-31 - PMID: 16117677

Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.

Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G
Nature. 2005;436(7050):593-7 - PMID: 16049496

Systematic analysis of genes required for synapse structure and function.

Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM
Nature. 2005;436(7050):510-7 - PMID: 16049479

A systematic RNAi screen for longevity genes in C. elegans.

Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS
Genes Dev. 2005;19(13):1544-55 - PMID: 15998808 - PMCID: PMC1172061

The tiny RNA world.

Ruvkun GB
Harvey Lect. 2005;99:1-21 - PMID: 15984549

Analysis of xbx genes in C. elegans.

Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P
Development. 2005;132(8):1923-34 - PMID: 15790967

Functional genomic analysis of RNA interference in C. elegans.

Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G
Science. 2005;308(5725):1164-7 - PMID: 15790806

MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression.

Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT
Nat Genet. 2004;36(10):1079-83 - PMID: 15361871

Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450.

Mak HY, Ruvkun G
Development. 2004;131(8):1777-86 - PMID: 15084462

Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network.

Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M
Mol Cell. 2004;13(4):469-82 - PMID: 14992718

A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.

Kennedy S, Wang D, Ruvkun G
Nature. 2004;427(6975):645-9 - PMID: 14961122

The 20 years it took to recognize the importance of tiny RNAs.

Ruvkun G, Wightman B, Ha I
Cell. 2004;116(2 Suppl):S93-6, 2 p following S96 - PMID: 15055593

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons.

Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G
Proc Natl Acad Sci U S A. 2003;101(1):360-5 - PMID: 14691248 - PMCID: PMC314190

Unraveling the secrets of the cell.

Komaroff AL, Ruvkun G
Newsweek. 2003;142(23):96 - PMID: 14712576

Functional tests of enhancer conservation between distantly related species.

Ruvinsky I, Ruvkun G
Development. 2003;130(21):5133-42 - PMID: 12944426

The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function.

Aspöck G, Ruvkun G, Bürglin TR
Development. 2003;130(15):3369-78 - PMID: 12810585

Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity.

Sze JY, Ruvkun G
Proc Natl Acad Sci U S A. 2003;100(16):9560-5 - PMID: 12883006 - PMCID: PMC170957

Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis.

Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS
Dev Biol. 2003;259(1):1-8 - PMID: 12812783

Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?

Pasquinelli AE, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J
Evol Dev. 2003;5(4):372-8 - PMID: 12823453

Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.

Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM
Science. 2003;300(5627):1921 - PMID: 12817143

Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.

Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM
Science. 2003;300(5627):1921 - PMID: 12817143

Computational and experimental identification of C. elegans microRNAs.

Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J
Mol Cell. 2003;11(5):1253-63 - PMID: 12769849

DAF-16 target genes that control C. elegans life-span and metabolism.

Lee SS, Kennedy S, Tolonen AC, Ruvkun G
Science. 2003;300(5619):644-7 - PMID: 12690206

daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway.

Li W, Kennedy SG, Ruvkun G
Genes Dev. 2003;17(7):844-58 - PMID: 12654727 - PMCID: PMC196030

A uniform system for microRNA annotation.

Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T
RNA. 2003;9(3):277-9 - PMID: 12592000 - PMCID: PMC1370393

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes.

Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G
Nature. 2003;421(6920):268-72 - PMID: 12529643

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.

Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G
Nat Genet. 2002;33(1):40-8 - PMID: 12447374

Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway.

Wolkow CA, Muñoz MJ, Riddle DL, Ruvkun G
J Biol Chem. 2002;277(51):49591-7 - PMID: 12393910

The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons.

Sze JY, Zhang S, Li J, Ruvkun G
Development. 2002;129(16):3901-11 - PMID: 12135927

Longevity: don't hold your breath.

Lee SS, Ruvkun G
Nature. 2002;418(6895):287-8 - PMID: 12124610

Control of developmental timing by micrornas and their targets.

Pasquinelli AE, Ruvkun G
Annu Rev Cell Dev Biol. 2002;18:495-513 - PMID: 12142272

Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway.

Lee RY, Hench J, Ruvkun G
Curr Biol. 2001;11(24):1950-7 - PMID: 11747821

The genetics of aging.

Finch CE, Ruvkun G
Annu Rev Genomics Hum Genet. 2001;2:435-62 - PMID: 11701657

Molecular biology. Glimpses of a tiny RNA world.

Ruvkun G
Science. 2001;294(5543):797-9 - PMID: 11679654

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.

Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC
Cell. 2001;106(1):23-34 - PMID: 11461699

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.

Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G
Genes Dev. 2001;15(6):672-86 - PMID: 11274053 - PMCID: PMC312654

Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6.

Bürglin TR, Ruvkun G
Development. 2001;128(5):779-90 - PMID: 11171402

Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning.

Reinhart BJ, Ruvkun G
Genetics. 2001;157(1):199-209 - PMID: 11139502 - PMCID: PMC1461488

Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways.

Cahill CM, Tzivion G, Nasrin N, Ogg S, Dore J, Ruvkun G, Alexander-Bridges M
J Biol Chem. 2000;276(16):13402-10 - PMID: 11124266

Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal.

Kagoshima H, Sommer R, Reinhart BJ, Cassata G, Ruvkun G, Bürglin TR
Dev Genes Evol. 2000;210(11):564-9 - PMID: 11180807

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.

Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G
Nature. 2000;408(6808):86-9 - PMID: 11081512

Regulation of C. elegans life-span by insulinlike signaling in the nervous system.

Wolkow CA, Kimura KD, Lee MS, Ruvkun G
Science. 2000;290(5489):147-50 - PMID: 11021802

DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.

Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC
Proc Natl Acad Sci U S A. 2000;97(19):10412-7 - PMID: 10973497 - PMCID: PMC27038

The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.

Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G
Mol Cell. 2000;5(4):659-69 - PMID: 10882102

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.

Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G
Nature. 2000;403(6772):901-6 - PMID: 10706289

Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant.

Sze JY, Victor M, Loer C, Shi Y, Ruvkun G
Nature. 2000;403(6769):560-4 - PMID: 10676966

A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum.

Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G
Proc Natl Acad Sci U S A. 2000;97(1):460-5 - PMID: 10618440 - PMCID: PMC26685

Themes from a NASA workshop on gene regulatory processes in development and evolution.

Davidson EH, Ruvkun G
J Exp Zool. 1999;285(2):104-15 - PMID: 10440721

Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4.

Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI
Genes Dev. 1999;13(14):1794-806 - PMID: 10421632 - PMCID: PMC316880

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.

Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G
Genes Dev. 1999;13(11):1438-52 - PMID: 10364160 - PMCID: PMC316759

Pax genes in Caenorhabditis elegans: a new twist.

Hobert O, Ruvkun G
Trends Genet. 1999;15(6):214-6 - PMID: 10354580

The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons.

Hobert O, Tessmar K, Ruvkun G
Development. 1999;126(7):1547-62 - PMID: 10068647

A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans.

Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G
J Cell Biol. 1999;144(1):45-57 - PMID: 9885243 - PMCID: PMC2148118

A common theme for LIM homeobox gene function across phylogeny?

Hobert O, Ruvkun G
Biol Bull. 1998;195(3):377-80 - PMID: 9924780

Heterochronic genes in development and evolution.

Slack F, Ruvkun G
Biol Bull. 1998;195(3):375-6 - PMID: 9924779

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.

Ogg S, Ruvkun G
Mol Cell. 1998;2(6):887-93 - PMID: 9885576

A novel repeat domain that is often associated with RING finger and B-box motifs.

Slack FJ, Ruvkun G
Trends Biochem Sci. 1998;23(12):474-5 - PMID: 9868369

The taxonomy of developmental control in Caenorhabditis elegans.

Ruvkun G, Hobert O
Science. 1998;282(5396):2033-41 - PMID: 9851920

Aging, life span, and senescence.

Guarente L, Ruvkun G, Amasino R
Proc Natl Acad Sci U S A. 1998;95(19):11034-6 - PMID: 9736682 - PMCID: PMC33892

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.

Paradis S, Ruvkun G
Genes Dev. 1998;12(16):2488-98 - PMID: 9716402 - PMCID: PMC317081

Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11.

Hobert O, D'Alberti T, Liu Y, Ruvkun G
J Neurosci. 1998;18(6):2084-96 - PMID: 9482795

Temporal pattern formation by heterochronic genes.

Slack F, Ruvkun G
Annu Rev Genet. 1998;31:611-34 - PMID: 9442909

An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.

Tissenbaum HA, Ruvkun G
Genetics. 1998;148(2):703-17 - PMID: 9504918 - PMCID: PMC1459840

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.

Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G
Nature. 1997;389(6654):994-9 - PMID: 9353126

The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway.

Patterson GI, Koweek A, Wong A, Liu Y, Ruvkun G
Genes Dev. 1997;11(20):2679-90 - PMID: 9334330 - PMCID: PMC316611

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.

Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G
Science. 1997;277(5328):942-6 - PMID: 9252323

Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene.

Hobert O, Mori I, Yamashita Y, Honda H, Ohshima Y, Liu Y, Ruvkun G
Neuron. 1997;19(2):345-57 - PMID: 9292724

The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development.

Sluder AE, Lindblom T, Ruvkun G
Dev Biol. 1997;184(2):303-19 - PMID: 9133437

VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth.

Sze JY, Liu Y, Ruvkun G
Development. 1997;124(6):1159-68 - PMID: 9102303

A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.

Ha I, Wightman B, Ruvkun G
Genes Dev. 1996;10(23):3041-50 - PMID: 8957004

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.

Morris JZ, Tissenbaum HA, Ruvkun G
Nature. 1996;382(6591):536-9 - PMID: 8700226

The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein.

Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S
J Neurochem. 1996;67(1):46-57 - PMID: 8667025

Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis.

Baumeister R, Liu Y, Ruvkun G
Genes Dev. 1996;10(11):1395-410 - PMID: 8647436

Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation.

Greenstein D, Hird S, Plasterk RH, Andachi Y, Kohara Y, Wang B, Finney M, Ruvkun G
Genes Dev. 1994;8(16):1935-48 - PMID: 7958868

daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.

Gottlieb S, Ruvkun G
Genetics. 1994;137(1):107-20 - PMID: 8056303 - PMCID: PMC1205929

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.

Wightman B, Ha I, Ruvkun G
Cell. 1993;75(5):855-62 - PMID: 8252622

The Caenorhabditis elegans homeobox gene cluster.

Bürglin TR, Ruvkun G
Curr Opin Genet Dev. 1993;3(4):615-20 - PMID: 7902148

Cell signalling. A molecular growth industry.

Ruvkun G
Nature. 1993;360(6406):711-2 - PMID: 1334532

Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3.

Xue D, Finney M, Ruvkun G, Chalfie M
EMBO J. 1992;11(13):4969-79 - PMID: 1361171 - PMCID: PMC556975

New motif in PBX genes.

Bürglin TR, Ruvkun G
Nat Genet. 1992;1(5):319-20 - PMID: 1363814

C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons.

Miller DM, Shen MM, Shamu CE, Bürglin TR, Ruvkun G, Dubois ML, Ghee M, Wilson L
Nature. 1992;355(6363):841-5 - PMID: 1347150

Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes.

Ruvkun G, Wightman B, Bürglin T, Arasu P
Dev Suppl. 1992;1:47-54 - PMID: 1742500

Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.

Arasu P, Wightman B, Ruvkun G
Genes Dev. 1991;5(10):1825-33 - PMID: 1916265

Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.

Wightman B, Bürglin TR, Gatto J, Arasu P, Ruvkun G
Genes Dev. 1991;5(10):1813-24 - PMID: 1916264

Nematode homeobox cluster.

Bürglin TR, Ruvkun G, Coulson A, Hawkins NC, McGhee JD, Schaller D, Wittmann C, Müller F, Waterston RH
Nature. 1991;351(6329):703 - PMID: 1676487

Regulation of transcription and cell identity by POU domain proteins.

Ruvkun G, Finney M
Cell. 1991;64(3):475-8 - PMID: 1991317

The unc-86 gene product couples cell lineage and cell identity in C. elegans.

Finney M, Ruvkun G
Cell. 1990;63(5):895-905 - PMID: 2257628

Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization.

Ruvkun G, Gilbert W, Horvitz HR
Nucleic Acids Res. 1990;18(4):809-15 - PMID: 2315039 - PMCID: PMC330331

Caenorhabditis elegans has scores of homoeobox-containing genes.

Bürglin TR, Finney M, Coulson A, Ruvkun G
Nature. 1989;341(6239):239-43 - PMID: 2571091

The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch.

Ruvkun G, Giusto J
Nature. 1989;338(6213):313-9 - PMID: 2922060

Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14.

Ruvkun G, Ambros V, Coulson A, Waterston R, Sulston J, Horvitz HR
Genetics. 1989;121(3):501-16 - PMID: 2565854 - PMCID: PMC1203636

The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors.

Finney M, Ruvkun G, Horvitz HR
Cell. 1988;55(5):757-69 - PMID: 2903797

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G
Genes Dev. 1988;2(12A):1513-6 - PMID: 3215510

ISRm1: A Rhizobium meliloti insertion sequence that transposes preferentially into nitrogen fixation genes.

Ruvkun GB, Long SR, Meade HM, van den Bos RC, Ausubel FM
J Mol Appl Genet. 1983;1(5):405-18 - PMID: 6296251

Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes.

Ruvkun GB, Sundaresan V, Ausubel FM
Cell. 1982;29(2):551-9 - PMID: 6288262

Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts.

Ruvkun GB, Sundaresan V, Ausubel FM
Gene. 1982;18(3):247-55 - PMID: 6290328

Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes.

Ruvkun GB, Sundaresan V, Ausubel FM
Cell. 1982;29(2):551-9 - PMID: 6288262

Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis.

Meade HM, Long SR, Ruvkun GB, Brown SE, Ausubel FM
J Bacteriol. 1982;149(1):114-22 - PMID: 6274841 - PMCID: PMC216598

A general method for site-directed mutagenesis in prokaryotes.

Ruvkun GB, Ausubel FM
Nature. 1981;289(5793):85-8 - PMID: 6256652

A general method for site-directed mutagenesis in prokaryotes.

Ruvkun GB, Ausubel FM
Nature. 1981;289(5793):85-8 - PMID: 6256652

Interspecies homology of nitrogenase genes.

Ruvkun GB, Ausubel FM
Proc Natl Acad Sci U S A. 1980;77(1):191-5 - PMID: 6987649 - PMCID: PMC348234

Interspecies homology of nitrogenase genes.

Ruvkun GB, Ausubel FM
Proc Natl Acad Sci U S A. 1980;77(1):191-5 - PMID: 6987649 - PMCID: PMC348234