• Warnhoff K, Hercher TW, Mendel RR, Ruvkun G Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans. Genes Dev. 2021;35(3-4):212-217 - PMID: 33446569 - PMCID: PMC7849362 - DOI: 10.1101/gad.345579.120

  • Mao K, Breen P, Ruvkun G Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response. PLoS Biol. 2020;18(12):e3000996 - PMID: 33264285 - PMCID: PMC7735679 - DOI: 10.1371/journal.pbio.3000996

  • Wei W, Ruvkun G Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism. Proc Natl Acad Sci U S A. 2020;117(33):19970-19981 - PMID: 32737159 - PMCID: PMC7443905 - DOI: 10.1073/pnas.2008021117

  • Fischer SEJ, Ruvkun G Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons. Proc Natl Acad Sci U S A. 2020;117(11):5987-5996 - PMID: 32123111 - PMCID: PMC7084138 - DOI: 10.1073/pnas.1919028117

  • Govindan JA, Jayamani E, Ruvkun G ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants. Proc Natl Acad Sci U S A. 2019;116(43):21651-21658 - PMID: 31591219 - PMCID: PMC6815122 - DOI: 10.1073/pnas.1912628116

  • Mojarro A, Hachey J, Bailey R, Brown M, Doebler R, Ruvkun G, Zuber MT, Carr CE Nucleic Acid Extraction and Sequencing from Low-Biomass Synthetic Mars Analog Soils for In Situ Life Detection. Astrobiology. 2019;19(9):1139-1152 - PMID: 31204862 - PMCID: PMC6708270 - DOI: 10.1089/ast.2018.1929

  • Armakola M, Ruvkun G Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes. Proc Natl Acad Sci U S A. 2019;116(25):12327-12336 - PMID: 31164416 - PMCID: PMC6589651 - DOI: 10.1073/pnas.1820928116

  • Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019;177(6):1507-1521.e16 - PMID: 31031004 - PMCID: PMC6911770 - DOI: 10.1016/j.cell.2019.03.045

  • Lehrbach NJ, Ruvkun G Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity. Elife. 2019;8:ePub - PMID: 30973820 - PMCID: PMC6459674 - DOI: 10.7554/eLife.44425

  • Lehrbach NJ, Breen PC, Ruvkun G Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression. Cell. 2019;177(3):737-750.e15 - PMID: 31002798 - PMCID: PMC6574124 - DOI: 10.1016/j.cell.2019.03.035

  • Warnhoff K, Ruvkun G Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification. Nat Chem Biol. 2019;15(5):480-488 - PMID: 30911177 - PMCID: PMC6470025 - DOI: 10.1038/s41589-019-0249-y

  • Mao K, Ji F, Breen P, Sewell A, Han M, Sadreyev R, Ruvkun G Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes. Cell Metab. 2019;29(5):1182-1191.e4 - PMID: 30799287 - PMCID: PMC6506380 - DOI: 10.1016/j.cmet.2019.01.022

  • Kniazeva M, Ruvkun G Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells. Proc Natl Acad Sci U S A. 2019;116(9):3784-3792 - PMID: 30808764 - PMCID: PMC6397575 - DOI: 10.1073/pnas.1815656116

  • Lin XX, Sen I, Janssens GE, Zhou X, Fonslow BR, Edgar D, Stroustrup N, Swoboda P, Yates JR, Ruvkun G, Riedel CG DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Nat Commun. 2018;9(1):4400 - PMID: 30353013 - PMCID: PMC6199276 - DOI: 10.1038/s41467-018-06624-0

  • Tillman EJ, Richardson CE, Cattie DJ, Reddy KC, Lehrbach NJ, Droste R, Ruvkun G, Kim DH Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans. Genetics. 2018;210(4):1329-1337 - PMID: 30287474 - PMCID: PMC6283152 - DOI: 10.1534/genetics.118.301450

  • Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT Acceleration profiles and processing methods for parabolic flight. NPJ Microgravity. 2018;4:14 - PMID: 30109261 - PMCID: PMC6081456 - DOI: 10.1038/s41526-018-0050-3

  • Ambros V, Ruvkun G Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs. Genetics. 2018;209(3):651-673 - PMID: 29967059 - PMCID: PMC6028246 - DOI: 10.1534/genetics.118.300291

  • Pontefract A, Hachey J, Zuber MT, Ruvkun G, Carr CE Sequencing nothing: Exploring failure modes of nanopore sensing and implications for life detection. Life Sci Space Res (Amst). 2018;18:80-86 - PMID: 30100151 - DOI: 10.1016/j.lssr.2018.05.004

  • Newman MA, Ji F, Fischer SEJ, Anselmo A, Sadreyev RI, Ruvkun G The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes. Genes Dev. 2018;32(9-10):670-681 - PMID: 29739806 - PMCID: PMC6004069 - DOI: 10.1101/gad.311514.118

  • Mojarro A, Hachey J, Ruvkun G, Zuber MT, Carr CE CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing. BMC Bioinformatics. 2018;19(1):108 - PMID: 29587645 - PMCID: PMC5872496 - DOI: 10.1186/s12859-018-2124-3

  • Pontefract A, Zhu TF, Walker VK, Hepburn H, Lui C, Zuber MT, Ruvkun G, Carr CE Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars. Front Microbiol. 2017;8:1819 - PMID: 29018418 - PMCID: PMC5623196 - DOI: 10.3389/fmicb.2017.01819

  • Mojarro A, Ruvkun G, Zuber MT, Carr CE Nucleic Acid Extraction from Synthetic Mars Analog Soils for in situ Life Detection. Astrobiology. 2017;17(8):747-760 - PMID: 28704064 - PMCID: PMC5567878 - DOI: 10.1089/ast.2016.1535

  • Lehrbach NJ, Ruvkun G Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1. Elife. 2016;5:ePub - PMID: 27528192 - PMCID: PMC4987142 - DOI: 10.7554/eLife.17721

  • Dowen RH, Breen PC, Tullius T, Conery AL, Ruvkun G A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport. Genes Dev. 2016;30(13):1515-28 - PMID: 27401555 - PMCID: PMC4949325 - DOI: 10.1101/gad.283895.116

  • Samuel BS, Rowedder H, Braendle C, Félix MA, Ruvkun G Caenorhabditis elegans responses to bacteria from its natural habitats. Proc Natl Acad Sci U S A. 2016;113(27):E3941-9 - PMID: 27317746 - PMCID: PMC4941482 - DOI: 10.1073/pnas.1607183113

  • Rettberg P, Anesio AM, Baker VR, Baross JA, Cady SL, Detsis E, Foreman CM, Hauber E, Ori GG, Pearce DA, Renno NO, Ruvkun G, Sattler B, Saunders MP, Smith DH, Wagner D, Westall F Planetary Protection and Mars Special Regions-A Suggestion for Updating the Definition. Astrobiology. 2016;16(2):119-25 - PMID: 26848950 - DOI: 10.1089/ast.2016.1472

  • Govindan JA, Jayamani E, Zhang X, Mylonakis E, Ruvkun G Dialogue between E. coli free radical pathways and the mitochondria of C. elegans. Proc Natl Acad Sci U S A. 2015;112(40):12456-61 - PMID: 26392561 - PMCID: PMC4603447 - DOI: 10.1073/pnas.1517448112

  • Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans. Nat Cell Biol. 2015;17(10):1294-303 - PMID: 26322678 - PMCID: PMC4589496 - DOI: 10.1038/ncb3229

  • Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway. Dev Cell. 2015;34(4):457-465 - PMID: 26279487 - PMCID: PMC4550515 - DOI: 10.1016/j.devcel.2015.07.009

  • Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles. Nucleic Acids Res. 2015;43(W1):W154-W159 - PMID: 25958392 - PMCID: PMC4489270 - DOI: 10.1093/nar/gkv452

  • Kirienko NV, Ausubel FM, Ruvkun G Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2015;112(6):1821-6 - PMID: 25624506 - PMCID: PMC4330731 - DOI: 10.1073/pnas.1424954112

  • Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence. PLoS Genet. 2014;10(12):e1004752 - PMID: 25474471 - PMCID: PMC4256158 - DOI: 10.1371/journal.pgen.1004752

  • O'Rourke EJ, Ruvkun G Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2014;17(1):104 - PMID: 25534088

  • Govindan JA, Ruvkun G Pathogens. Virulence. 2014;5(7):ePub - PMID: 25290904 - PMCID: PMC4189874

  • Govindan JA, Ruvkun G Pathogens. Virulence. 2014;5(7):695-696 - PMID: 25513769 - PMCID: PMC4189874 - DOI: 10.4161/viru.36667

  • Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans. Nat Struct Mol Biol. 2014;21(8):712-720 - PMID: 25038802 - PMCID: PMC4125460 - DOI: 10.1038/nsmb.2858

  • Liu Y, Samuel BS, Breen PC, Ruvkun G Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature. 2014;508(7496):406-10 - PMID: 24695221 - PMCID: PMC4102179 - DOI: 10.1038/nature13204

  • Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation. Curr Biol. 2014;24(8):839-44 - PMID: 24684932 - PMCID: PMC4010136 - DOI: 10.1016/j.cub.2014.02.060

  • Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev. 2013;27(24):2678-95 - PMID: 24352423 - PMCID: PMC3877757 - DOI: 10.1101/gad.233254.113

  • Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis. Cell. 2013;155(6):1409-21 - PMID: 24269006 - PMCID: PMC3956118 - DOI: 10.1016/j.cell.2013.10.047

  • Soukas AA, Carr CE, Ruvkun G Genetic Regulation of Caenorhabditis elegans Lysosome Related Organelle Function. PLoS Genet. 2013;9(10):e1003908 - PMID: 24204312 - PMCID: PMC3812091 - DOI: 10.1371/journal.pgen.1003908

  • Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Mol Syst Biol. 2013;9:692 - PMID: 24084807 - PMCID: PMC3817400 - DOI: 10.1038/msb.2013.50

  • Shi Z, Hayes G, Ruvkun G Dual Regulation of the lin-14 Target mRNA by the lin-4 miRNA. PLoS One. 2013;8(9):e75475 - PMID: 24058689 - PMCID: PMC3772890 - DOI: 10.1371/journal.pone.0075475

  • Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, Ruvkun G Radiation Resistance of Sequencing Chips for in situ Life Detection. Astrobiology. 2013;13(6):560-9 - PMID: 23734755 - DOI: 10.1089/ast.2012.0923

  • Shore DE, Ruvkun G A cytoprotective perspective on longevity regulation. Trends Cell Biol. 2013;23(9):409-20 - PMID: 23726168 - PMCID: PMC4057428 - DOI: 10.1016/j.tcb.2013.04.007

  • O'Rourke EJ, Ruvkun G MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2013;15(6):668-676 - PMID: 23604316 - PMCID: PMC3723461 - DOI: 10.1038/ncb2741

  • Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol. 2013;15(5):491-501 - PMID: 23604319 - PMCID: PMC3748955 - DOI: 10.1038/ncb2720

  • Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death. Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003

  • Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death. Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003

  • Montgomery TA, Ruvkun G MicroRNAs Visit the ER. Cell. 2013;153(3):511-2 - PMID: 23622236 - DOI: 10.1016/j.cell.2013.04.014

  • O'Rourke EJ, Kuballa P, Xavier R, Ruvkun G ?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev. 2013;27(4):429-40 - PMID: 23392608 - PMCID: PMC3589559 - DOI: 10.1101/gad.205294.112

  • Shi Z, Montgomery TA, Qi Y, Ruvkun G High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes. Genome Res. 2013;23(3):497-508 - PMID: 23363624 - PMCID: PMC3589538 - DOI: 10.1101/gr.149112.112

  • Carr CE, Rowedder H, Vafadari C, Lui CS, Cascio E, Zuber MT, Ruvkun G Radiation resistance of biological reagents for in situ life detection. Astrobiology. 2013;13(1):68-78 - PMID: 23330963 - DOI: 10.1089/ast.2012.0869

  • Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature. 2013;493(7434):694-8 - PMID: 23364702 - PMCID: PMC3762460 - DOI: 10.1038/nature11779

  • Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks. PLoS One. 2012;7(10):e48282 - PMID: 23144747 - PMCID: PMC3483217 - DOI: 10.1371/journal.pone.0048282

  • Zhang C, Ruvkun G New insights into siRNA amplification and RNAi. RNA Biol. 2012;9(8):1045-9 - PMID: 22858672 - PMCID: PMC3551858 - DOI: 10.4161/rna.21246

  • Shore DE, Carr CE, Ruvkun G Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet. 2012;8(7):e1002792 - PMID: 22829775 - PMCID: PMC3400582 - DOI: 10.1371/journal.pgen.1002792

  • Phillips CM, Montgomery TA, Breen PC, Ruvkun G MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline. Genes Dev. 2012;26(13):1433-44 - PMID: 22713602 - PMCID: PMC3403012 - DOI: 10.1101/gad.193904.112

  • Zhang C, Montgomery TA, Fischer SE, Garcia SM, Riedel CG, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G The Caenorhabditis elegans RDE-10/RDE-11 Complex Regulates RNAi by Promoting Secondary siRNA Amplification. Curr Biol. 2012;22(10):881-90 - PMID: 22542102 - PMCID: PMC3371361 - DOI: 10.1016/j.cub.2012.04.011

  • Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE An image analysis toolbox for high-throughput C. elegans assays. Nat Methods. 2012;9(7):714-6 - PMID: 22522656 - PMCID: PMC3433711 - DOI: 10.1038/nmeth.1984

  • Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G PIWI Associated siRNAs and piRNAs Specifically Require the Caenorhabditis elegans HEN1 Ortholog henn-1. PLoS Genet. 2012;8(4):e1002616 - PMID: 22536158 - PMCID: PMC3334881 - DOI: 10.1371/journal.pgen.1002616

  • Melo JA, Ruvkun G Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses. Cell. 2012;149(2):452-66 - PMID: 22500807 - PMCID: PMC3613046 - DOI: 10.1016/j.cell.2012.02.050

  • Wu X, Shi Z, Cui M, Han M, Ruvkun G Repression of Germline RNAi Pathways in Somatic Cells by Retinoblastoma Pathway Chromatin Complexes. PLoS Genet. 2012;8(3):e1002542 - PMID: 22412383 - PMCID: PMC3297578 - DOI: 10.1371/journal.pgen.1002542

  • Shi Z, Ruvkun G The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2012;109(12):4568-73 - PMID: 22396595 - PMCID: PMC3311396 - DOI: 10.1073/pnas.1202421109

  • Kimura KD, Riddle DL, Ruvkun G The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status. Cold Spring Harb Symp Quant Biol. 2011;76:113-20 - PMID: 22123849 - DOI: 10.1101/sqb.2011.76.010660

  • Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet. 2011;7(11):e1002369 - PMID: 22102828 - PMCID: PMC3213143 - DOI: 10.1371/journal.pgen.1002369

  • Russel S, Frand AR, Ruvkun G Regulation of the C. elegans molt by pqn-47. Dev Biol. 2011;360(2):297-309 - PMID: 21989027 - PMCID: PMC3618673 - DOI: 10.1016/j.ydbio.2011.09.025

  • Hayes GD, Riedel CG, Ruvkun G The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev. 2011;25(19):2079-92 - PMID: 21979920 - PMCID: PMC3197206 - DOI: 10.1101/gad.17153811

  • Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2011;108(4):1201-8 - PMID: 21245313 - PMCID: PMC3029761 - DOI: 10.1073/pnas.1018695108

  • Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods. 2011;8(2):135-8 - PMID: 21240281 - PMCID: PMC3061290 - DOI: 10.1038/nmeth.1556

  • Wu X, Ruvkun G Cancer. Germ cell genes and cancer. Science. 2010;330(6012):1761-2 - PMID: 21205660 - DOI: 10.1126/science.1200772

  • Meli VS, Osuna B, Ruvkun G, Frand AR MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Mol Biol Cell. 2010;21(10):1648-61 - PMID: 20335506 - PMCID: PMC2869372 - DOI: 10.1091/mbc.E08-07-0708

  • Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One. 2009;4(12):e8210 - PMID: 20011587 - PMCID: PMC2788130 - DOI: 10.1371/journal.pone.0008210

  • O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 2009;10(5):430-5 - PMID: 19883620 - PMCID: PMC2921818 - DOI: 10.1016/j.cmet.2009.10.002

  • Curran SP, Wu X, Riedel CG, Ruvkun G A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009;459(7250):1079-84 - PMID: 19506556 - PMCID: PMC2716045 - DOI: 10.1038/nature08106

  • Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009;23(4):496-511 - PMID: 19240135 - PMCID: PMC2648650 - DOI: 10.1101/gad.1775409

  • Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A. 2009;106(6):1875-9 - PMID: 19174521 - PMCID: PMC2631283 - DOI: 10.1073/pnas.0810338106

  • Wang MC, O'Rourke EJ, Ruvkun G Fat metabolism links germline stem cells and longevity in C. elegans. Science. 2008;322(5903):957-60 - PMID: 18988854 - PMCID: PMC2760269 - DOI: 10.1126/science.1162011

  • Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G The most conserved genome segments for life detection on Earth and other planets. Orig Life Evol Biosph. 2008;38(6):517-33 - PMID: 18853276 - DOI: 10.1007/s11084-008-9148-z

  • Ruvkun G The perfect storm of tiny RNAs. Nat Med. 2008;14(10):1041-5 - PMID: 18841145 - DOI: 10.1038/nm1008-1041

  • Fischer SE, Butler MD, Pan Q, Ruvkun G Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature. 2008;455(7212):491-6 - PMID: 18784652 - PMCID: PMC2756026 - DOI: 10.1038/nature07274

  • Ruvkun G Tiny RNA: Where do we come from? What are we? Where are we going?. Trends Plant Sci. 2008;13(7):313-6 - PMID: 18562240 - DOI: 10.1016/j.tplants.2008.05.005

  • Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Cold Spring Harb Symp Quant Biol. 2008;72:489-97 - PMID: 18419309 - DOI: 10.1101/sqb.2007.72.068

  • Patel DS, Fang LL, Svy DK, Ruvkun G, Li W Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans. Development. 2008;135(13):2239-49 - PMID: 18495818 - DOI: 10.1242/dev.016972

  • Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell. 2008;133(5):903-15 - PMID: 18510933 - PMCID: PMC2553566 - DOI: 10.1016/j.cell.2008.04.035

  • Gabel HW, Ruvkun G The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol. 2008;15(5):531-3 - PMID: 18438419 - PMCID: PMC2910399 - DOI: 10.1038/nsmb.1411

  • Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol Dev. 2008;10(1):106-13 - PMID: 18184361 - PMCID: PMC2637451 - DOI: 10.1111/j.1525-142X.2007.00217.x

  • Parry DH, Xu J, Ruvkun G A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol. 2007;17(23):2013-22 - PMID: 18023351 - PMCID: PMC2211719 - DOI: 10.1016/j.cub.2007.10.058

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  • Ruvkun G, Giusto J The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch. Nature. 1989;338(6213):313-9 - PMID: 2922060 - DOI: 10.1038/338313a0

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  • Ruvkun GB, Long SR, Meade HM, van den Bos RC, Ausubel FM ISRm1: A Rhizobium meliloti insertion sequence that transposes preferentially into nitrogen fixation genes. J Mol Appl Genet. 1983;1(5):405-18 - PMID: 6296251

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  • Ruvkun GB, Sundaresan V, Ausubel FM Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts. Gene. 1982;18(3):247-55 - PMID: 6290328 - DOI: 10.1016/0378-1119(82)90162-7

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