Publications - Ruvkun

  • Kniazeva M, Ruvkun G

    A spurious fln-2 mutation in a wide variety of commonly used C. elegans strains. MicroPubl Biol. 2025;2025:ePub - PMID: 40708994 - PMCID: PMC12287765 - DOI: 10.17912/micropub.biology.001684

  • Kniazeva M, Ruvkun G

    Translation elongation defects activate the Caenorhabditis elegans ZIP-2 bZIP transcription factor-mediated toxin defense. Proc Natl Acad Sci U S A. 2025;122(6):e2423578122 - PMID: 39899724 - PMCID: PMC11831180 - DOI: 10.1073/pnas.2423578122

  • Seetharaman A, Galagali H, Linarte E, Liu MHX, Cohen JD, Chetal K, Sadreyev R, Tate AJ, Montgomery TA, Ruvkun G

    Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans. PLoS Biol. 2025;23(1):e3002748 - PMID: 39879188 - PMCID: PMC11778786 - DOI: 10.1371/journal.pbio.3002748

  • Patange O, Breen P, Arsuffi G, Ruvkun G

    Hydrogen sulfide mediates the interaction between C. elegans and Actinobacteria from its natural microbial environment. Cell Rep. 2025;44(1):115170 - PMID: 39786993 - DOI: 10.1016/j.celrep.2024.115170

  • Seetharaman A, Galagali H, Linarte E, Liu MHX, Cohen JD, Chetal K, Sadreyev R, Tate AJ, Montgomery TA, Ruvkun G

    Caenorhabditis elegans SynMuv B gene activity is down-regulated during a viral infection to enhance RNA interference. bioRxiv. 2024;:ePub - PMID: 39071373 - PMCID: PMC11275910 - DOI: 10.1101/2024.07.12.603258

  • Yanagi KS, Jochim B, Kunjo SO, Breen P, Ruvkun G, Lehrbach N

    Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans. PLoS Biol. 2024;22(7):e3002720 - PMID: 38991033 - PMCID: PMC11265709 - DOI: 10.1371/journal.pbio.3002720

  • Meisel JD, Wiesenthal PP, Mootha VK, Ruvkun G

    CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene. Curr Biol. 2024;34(12):2728-2738.e6 - PMID: 38810637 - PMCID: PMC11265314 - DOI: 10.1016/j.cub.2024.04.079

  • Warnhoff K, Bhattacharya S, Snoozy J, Breen PC, Ruvkun G

    Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans. Elife. 2024;12:ePub - PMID: 38349720 - PMCID: PMC10942545 - DOI: 10.7554/eLife.89173

  • Meisel JD, Miranda M, Skinner OS, Wiesenthal PP, Wellner SM, Jourdain AA, Ruvkun G, Mootha VK

    Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism. Cell. 2024;187(3):659-675.e18 - PMID: 38215760 - PMCID: PMC10919891 - DOI: 10.1016/j.cell.2023.12.010

  • Warnhoff K, Snoozy J, Breen PC, Ruvkun G

    Hypoxia-inducible factor promotes cysteine homeostasis in Caenorhabditis elegans. bioRxiv. 2023;:ePub - PMID: 37205365 - PMCID: PMC10187278 - DOI: 10.1101/2023.05.04.538701

  • Mao K, Breen P, Ruvkun G

    The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Proc Natl Acad Sci U S A. 2022;119(49):e2215966119 - PMID: 36445965 - PMCID: PMC9894117 - DOI: 10.1073/pnas.2215966119

  • Ruvkun G, Lehrbach N

    Regulation and Functions of the ER-Associated Nrf1 Transcription Factor. Cold Spring Harb Perspect Biol. 2022;15(1):ePub - PMID: 35940907 - PMCID: PMC9808582 - DOI: 10.1101/cshperspect.a041266

  • Snoozy J, Breen PC, Ruvkun G, Warnhoff K

    moc-6/MOCS2A is necessary for molybdenum cofactor synthesis in C. elegans. MicroPubl Biol. 2022;2022:ePub - PMID: 35224462 - PMCID: PMC8864482 - DOI: 10.17912/micropub.biology.000531

  • Charlesworth AG, Seroussi U, Lehrbach NJ, Renaud MS, Sundby AE, Molnar RI, Lao RX, Willis AR, Woock JR, Aber MJ, Diao AJ, Reinke AW, Ruvkun G, Claycomb JM

    Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility. Nucleic Acids Res. 2021;49(15):8836-8865 - PMID: 34329465 - PMCID: PMC8421154 - DOI: 10.1093/nar/gkab619

  • Warnhoff K, Hercher TW, Mendel RR, Ruvkun G

    Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans. Genes Dev. 2021;35(3-4):212-217 - PMID: 33446569 - PMCID: PMC7849362 - DOI: 10.1101/gad.345579.120

  • Mao K, Breen P, Ruvkun G

    Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response. PLoS Biol. 2020;18(12):e3000996 - PMID: 33264285 - PMCID: PMC7735679 - DOI: 10.1371/journal.pbio.3000996

  • Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT

    Nanopore sequencing at Mars, Europa, and microgravity conditions. NPJ Microgravity. 2020;6(1):24 - PMID: 34489469 - DOI: 10.1038/s41526-020-00113-9

  • Wei W, Ruvkun G

    Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism. Proc Natl Acad Sci U S A. 2020;117(33):19970-19981 - PMID: 32737159 - PMCID: PMC7443905 - DOI: 10.1073/pnas.2008021117

  • Fischer SEJ, Ruvkun G

    Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons. Proc Natl Acad Sci U S A. 2020;117(11):5987-5996 - PMID: 32123111 - PMCID: PMC7084138 - DOI: 10.1073/pnas.1919028117

  • Govindan JA, Jayamani E, Ruvkun G

    ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants. Proc Natl Acad Sci U S A. 2019;116(43):21651-21658 - PMID: 31591219 - PMCID: PMC6815122 - DOI: 10.1073/pnas.1912628116

  • Mojarro A, Hachey J, Bailey R, Brown M, Doebler R, Ruvkun G, Zuber MT, Carr CE

    Nucleic Acid Extraction and Sequencing from Low-Biomass Synthetic Mars Analog Soils for In Situ Life Detection. Astrobiology. 2019;19(9):1139-1152 - PMID: 31204862 - PMCID: PMC6708270 - DOI: 10.1089/ast.2018.1929

  • Armakola M, Ruvkun G

    Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes. Proc Natl Acad Sci U S A. 2019;116(25):12327-12336 - PMID: 31164416 - PMCID: PMC6589651 - DOI: 10.1073/pnas.1820928116

  • Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK

    Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019;177(6):1507-1521.e16 - PMID: 31031004 - PMCID: PMC6911770 - DOI: 10.1016/j.cell.2019.03.045

  • Lehrbach NJ, Ruvkun G

    Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity. Elife. 2019;8:ePub - PMID: 30973820 - PMCID: PMC6459674 - DOI: 10.7554/eLife.44425

  • Lehrbach NJ, Breen PC, Ruvkun G

    Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression. Cell. 2019;177(3):737-750.e15 - PMID: 31002798 - PMCID: PMC6574124 - DOI: 10.1016/j.cell.2019.03.035

  • Warnhoff K, Ruvkun G

    Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification. Nat Chem Biol. 2019;15(5):480-488 - PMID: 30911177 - PMCID: PMC6470025 - DOI: 10.1038/s41589-019-0249-y

  • Mao K, Ji F, Breen P, Sewell A, Han M, Sadreyev R, Ruvkun G

    Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes. Cell Metab. 2019;29(5):1182-1191.e4 - PMID: 30799287 - PMCID: PMC6506380 - DOI: 10.1016/j.cmet.2019.01.022

  • Kniazeva M, Ruvkun G

    Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells. Proc Natl Acad Sci U S A. 2019;116(9):3784-3792 - PMID: 30808764 - PMCID: PMC6397575 - DOI: 10.1073/pnas.1815656116

  • Lin XX, Sen I, Janssens GE, Zhou X, Fonslow BR, Edgar D, Stroustrup N, Swoboda P, Yates JR, Ruvkun G, Riedel CG

    DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Nat Commun. 2018;9(1):4400 - PMID: 30353013 - PMCID: PMC6199276 - DOI: 10.1038/s41467-018-06624-0

  • Tillman EJ, Richardson CE, Cattie DJ, Reddy KC, Lehrbach NJ, Droste R, Ruvkun G, Kim DH

    Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans. Genetics. 2018;210(4):1329-1337 - PMID: 30287474 - PMCID: PMC6283152 - DOI: 10.1534/genetics.118.301450

  • Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT

    Acceleration profiles and processing methods for parabolic flight. NPJ Microgravity. 2018;4:14 - PMID: 30109261 - PMCID: PMC6081456 - DOI: 10.1038/s41526-018-0050-3

  • Ambros V, Ruvkun G

    Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs. Genetics. 2018;209(3):651-673 - PMID: 29967059 - PMCID: PMC6028246 - DOI: 10.1534/genetics.118.300291

  • Pontefract A, Hachey J, Zuber MT, Ruvkun G, Carr CE

    Sequencing nothing: Exploring failure modes of nanopore sensing and implications for life detection. Life Sci Space Res (Amst). 2018;18:80-86 - PMID: 30100151 - DOI: 10.1016/j.lssr.2018.05.004

  • Newman MA, Ji F, Fischer SEJ, Anselmo A, Sadreyev RI, Ruvkun G

    The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes. Genes Dev. 2018;32(9-10):670-681 - PMID: 29739806 - PMCID: PMC6004069 - DOI: 10.1101/gad.311514.118

  • Mojarro A, Hachey J, Ruvkun G, Zuber MT, Carr CE

    CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing. BMC Bioinformatics. 2018;19(1):108 - PMID: 29587645 - PMCID: PMC5872496 - DOI: 10.1186/s12859-018-2124-3

  • Pontefract A, Zhu TF, Walker VK, Hepburn H, Lui C, Zuber MT, Ruvkun G, Carr CE

    Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars. Front Microbiol. 2017;8:1819 - PMID: 29018418 - PMCID: PMC5623196 - DOI: 10.3389/fmicb.2017.01819

  • Mojarro A, Ruvkun G, Zuber MT, Carr CE

    Nucleic Acid Extraction from Synthetic Mars Analog Soils for in situ Life Detection. Astrobiology. 2017;17(8):747-760 - PMID: 28704064 - PMCID: PMC5567878 - DOI: 10.1089/ast.2016.1535

  • Lehrbach NJ, Ruvkun G

    Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1. Elife. 2016;5:ePub - PMID: 27528192 - PMCID: PMC4987142 - DOI: 10.7554/eLife.17721

  • Dowen RH, Breen PC, Tullius T, Conery AL, Ruvkun G

    A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport. Genes Dev. 2016;30(13):1515-28 - PMID: 27401555 - PMCID: PMC4949325 - DOI: 10.1101/gad.283895.116

  • Samuel BS, Rowedder H, Braendle C, Félix MA, Ruvkun G

    Caenorhabditis elegans responses to bacteria from its natural habitats. Proc Natl Acad Sci U S A. 2016;113(27):E3941-9 - PMID: 27317746 - PMCID: PMC4941482 - DOI: 10.1073/pnas.1607183113

  • Rettberg P, Anesio AM, Baker VR, Baross JA, Cady SL, Detsis E, Foreman CM, Hauber E, Ori GG, Pearce DA, Renno NO, Ruvkun G, Sattler B, Saunders MP, Smith DH, Wagner D, Westall F

    Planetary Protection and Mars Special Regions-A Suggestion for Updating the Definition. Astrobiology. 2016;16(2):119-25 - PMID: 26848950 - DOI: 10.1089/ast.2016.1472

  • Govindan JA, Jayamani E, Zhang X, Mylonakis E, Ruvkun G

    Dialogue between E. coli free radical pathways and the mitochondria of C. elegans. Proc Natl Acad Sci U S A. 2015;112(40):12456-61 - PMID: 26392561 - PMCID: PMC4603447 - DOI: 10.1073/pnas.1517448112

  • Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G

    Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans. Nat Cell Biol. 2015;17(10):1294-303 - PMID: 26322678 - PMCID: PMC4589496 - DOI: 10.1038/ncb3229

  • Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA

    piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway. Dev Cell. 2015;34(4):457-465 - PMID: 26279487 - PMCID: PMC4550515 - DOI: 10.1016/j.devcel.2015.07.009

  • Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y

    PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles. Nucleic Acids Res. 2015;43(W1):W154-W159 - PMID: 25958392 - PMCID: PMC4489270 - DOI: 10.1093/nar/gkv452

  • Kirienko NV, Ausubel FM, Ruvkun G

    Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2015;112(6):1821-6 - PMID: 25624506 - PMCID: PMC4330731 - DOI: 10.1073/pnas.1424954112

  • Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G

    Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence. PLoS Genet. 2014;10(12):e1004752 - PMID: 25474471 - PMCID: PMC4256158 - DOI: 10.1371/journal.pgen.1004752

  • O'Rourke EJ, Ruvkun G

    Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2014;17(1):104 - PMID: 25534088

  • Govindan JA, Ruvkun G

    Pathogens. Virulence. 2014;5(7):ePub - PMID: 25290904 - PMCID: PMC4189874

  • Govindan JA, Ruvkun G

    Pathogens. Virulence. 2014;5(7):695-696 - PMID: 25513769 - PMCID: PMC4189874 - DOI: 10.4161/viru.36667

  • Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G

    Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans. Nat Struct Mol Biol. 2014;21(8):712-720 - PMID: 25038802 - PMCID: PMC4125460 - DOI: 10.1038/nsmb.2858

  • Liu Y, Samuel BS, Breen PC, Ruvkun G

    Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature. 2014;508(7496):406-10 - PMID: 24695221 - PMCID: PMC4102179 - DOI: 10.1038/nature13204

  • Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA

    MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation. Curr Biol. 2014;24(8):839-44 - PMID: 24684932 - PMCID: PMC4010136 - DOI: 10.1016/j.cub.2014.02.060

  • Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G

    Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev. 2013;27(24):2678-95 - PMID: 24352423 - PMCID: PMC3877757 - DOI: 10.1101/gad.233254.113

  • Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A

    High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis. Cell. 2013;155(6):1409-21 - PMID: 24269006 - PMCID: PMC3956118 - DOI: 10.1016/j.cell.2013.10.047

  • Soukas AA, Carr CE, Ruvkun G

    Genetic Regulation of Caenorhabditis elegans Lysosome Related Organelle Function. PLoS Genet. 2013;9(10):e1003908 - PMID: 24204312 - PMCID: PMC3812091 - DOI: 10.1371/journal.pgen.1003908

  • Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G

    Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Mol Syst Biol. 2013;9:692 - PMID: 24084807 - PMCID: PMC3817400 - DOI: 10.1038/msb.2013.50

  • Shi Z, Hayes G, Ruvkun G

    Dual Regulation of the lin-14 Target mRNA by the lin-4 miRNA. PLoS One. 2013;8(9):e75475 - PMID: 24058689 - PMCID: PMC3772890 - DOI: 10.1371/journal.pone.0075475

  • Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, Ruvkun G

    Radiation Resistance of Sequencing Chips for in situ Life Detection. Astrobiology. 2013;13(6):560-9 - PMID: 23734755 - DOI: 10.1089/ast.2012.0923

  • Shore DE, Ruvkun G

    A cytoprotective perspective on longevity regulation. Trends Cell Biol. 2013;23(9):409-20 - PMID: 23726168 - PMCID: PMC4057428 - DOI: 10.1016/j.tcb.2013.04.007

  • O'Rourke EJ, Ruvkun G

    MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2013;15(6):668-676 - PMID: 23604316 - PMCID: PMC3723461 - DOI: 10.1038/ncb2741

  • Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G

    DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol. 2013;15(5):491-501 - PMID: 23604319 - PMCID: PMC3748955 - DOI: 10.1038/ncb2720

  • Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM

    Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death. Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003

  • Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM

    Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death. Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003

  • Montgomery TA, Ruvkun G

    MicroRNAs Visit the ER. Cell. 2013;153(3):511-2 - PMID: 23622236 - DOI: 10.1016/j.cell.2013.04.014

  • O'Rourke EJ, Kuballa P, Xavier R, Ruvkun G

    ?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev. 2013;27(4):429-40 - PMID: 23392608 - PMCID: PMC3589559 - DOI: 10.1101/gad.205294.112

  • Shi Z, Montgomery TA, Qi Y, Ruvkun G

    High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes. Genome Res. 2013;23(3):497-508 - PMID: 23363624 - PMCID: PMC3589538 - DOI: 10.1101/gr.149112.112

  • Carr CE, Rowedder H, Vafadari C, Lui CS, Cascio E, Zuber MT, Ruvkun G

    Radiation resistance of biological reagents for in situ life detection. Astrobiology. 2013;13(1):68-78 - PMID: 23330963 - DOI: 10.1089/ast.2012.0869

  • Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G

    Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature. 2013;493(7434):694-8 - PMID: 23364702 - PMCID: PMC3762460 - DOI: 10.1038/nature11779

  • Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP

    Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks. PLoS One. 2012;7(10):e48282 - PMID: 23144747 - PMCID: PMC3483217 - DOI: 10.1371/journal.pone.0048282

  • Zhang C, Ruvkun G

    New insights into siRNA amplification and RNAi. RNA Biol. 2012;9(8):1045-9 - PMID: 22858672 - PMCID: PMC3551858 - DOI: 10.4161/rna.21246

  • Shore DE, Carr CE, Ruvkun G

    Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet. 2012;8(7):e1002792 - PMID: 22829775 - PMCID: PMC3400582 - DOI: 10.1371/journal.pgen.1002792

  • Phillips CM, Montgomery TA, Breen PC, Ruvkun G

    MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline. Genes Dev. 2012;26(13):1433-44 - PMID: 22713602 - PMCID: PMC3403012 - DOI: 10.1101/gad.193904.112

  • Zhang C, Montgomery TA, Fischer SE, Garcia SM, Riedel CG, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G

    The Caenorhabditis elegans RDE-10/RDE-11 Complex Regulates RNAi by Promoting Secondary siRNA Amplification. Curr Biol. 2012;22(10):881-90 - PMID: 22542102 - PMCID: PMC3371361 - DOI: 10.1016/j.cub.2012.04.011

  • Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE

    An image analysis toolbox for high-throughput C. elegans assays. Nat Methods. 2012;9(7):714-6 - PMID: 22522656 - PMCID: PMC3433711 - DOI: 10.1038/nmeth.1984

  • Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G

    PIWI Associated siRNAs and piRNAs Specifically Require the Caenorhabditis elegans HEN1 Ortholog henn-1. PLoS Genet. 2012;8(4):e1002616 - PMID: 22536158 - PMCID: PMC3334881 - DOI: 10.1371/journal.pgen.1002616

  • Melo JA, Ruvkun G

    Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses. Cell. 2012;149(2):452-66 - PMID: 22500807 - PMCID: PMC3613046 - DOI: 10.1016/j.cell.2012.02.050

  • Wu X, Shi Z, Cui M, Han M, Ruvkun G

    Repression of Germline RNAi Pathways in Somatic Cells by Retinoblastoma Pathway Chromatin Complexes. PLoS Genet. 2012;8(3):e1002542 - PMID: 22412383 - PMCID: PMC3297578 - DOI: 10.1371/journal.pgen.1002542

  • Shi Z, Ruvkun G

    The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2012;109(12):4568-73 - PMID: 22396595 - PMCID: PMC3311396 - DOI: 10.1073/pnas.1202421109

  • Kimura KD, Riddle DL, Ruvkun G

    The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status. Cold Spring Harb Symp Quant Biol. 2011;76:113-20 - PMID: 22123849 - DOI: 10.1101/sqb.2011.76.010660

  • Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G

    The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet. 2011;7(11):e1002369 - PMID: 22102828 - PMCID: PMC3213143 - DOI: 10.1371/journal.pgen.1002369

  • Russel S, Frand AR, Ruvkun G

    Regulation of the C. elegans molt by pqn-47. Dev Biol. 2011;360(2):297-309 - PMID: 21989027 - PMCID: PMC3618673 - DOI: 10.1016/j.ydbio.2011.09.025

  • Hayes GD, Riedel CG, Ruvkun G

    The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev. 2011;25(19):2079-92 - PMID: 21979920 - PMCID: PMC3197206 - DOI: 10.1101/gad.17153811

  • Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G

    mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2011;108(4):1201-8 - PMID: 21245313 - PMCID: PMC3029761 - DOI: 10.1073/pnas.1018695108

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    RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods. 2011;8(2):135-8 - PMID: 21240281 - PMCID: PMC3061290 - DOI: 10.1038/nmeth.1556

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    Cancer. Germ cell genes and cancer. Science. 2010;330(6012):1761-2 - PMID: 21205660 - DOI: 10.1126/science.1200772

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    MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Mol Biol Cell. 2010;21(10):1648-61 - PMID: 20335506 - PMCID: PMC2869372 - DOI: 10.1091/mbc.E08-07-0708

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    RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One. 2009;4(12):e8210 - PMID: 20011587 - PMCID: PMC2788130 - DOI: 10.1371/journal.pone.0008210

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    C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 2009;10(5):430-5 - PMID: 19883620 - PMCID: PMC2921818 - DOI: 10.1016/j.cmet.2009.10.002

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    A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009;459(7250):1079-84 - PMID: 19506556 - PMCID: PMC2716045 - DOI: 10.1038/nature08106

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    Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009;23(4):496-511 - PMID: 19240135 - PMCID: PMC2648650 - DOI: 10.1101/gad.1775409

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    Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A. 2009;106(6):1875-9 - PMID: 19174521 - PMCID: PMC2631283 - DOI: 10.1073/pnas.0810338106

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    Fat metabolism links germline stem cells and longevity in C. elegans. Science. 2008;322(5903):957-60 - PMID: 18988854 - PMCID: PMC2760269 - DOI: 10.1126/science.1162011

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    The most conserved genome segments for life detection on Earth and other planets. Orig Life Evol Biosph. 2008;38(6):517-33 - PMID: 18853276 - DOI: 10.1007/s11084-008-9148-z

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    The perfect storm of tiny RNAs. Nat Med. 2008;14(10):1041-5 - PMID: 18841145 - DOI: 10.1038/nm1008-1041

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    Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature. 2008;455(7212):491-6 - PMID: 18784652 - PMCID: PMC2756026 - DOI: 10.1038/nature07274

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    Tiny RNA: Where do we come from? What are we? Where are we going?. Trends Plant Sci. 2008;13(7):313-6 - PMID: 18562240 - DOI: 10.1016/j.tplants.2008.05.005

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    Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Cold Spring Harb Symp Quant Biol. 2008;72:489-97 - PMID: 18419309 - DOI: 10.1101/sqb.2007.72.068

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    Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans. Development. 2008;135(13):2239-49 - PMID: 18495818 - DOI: 10.1242/dev.016972

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    The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell. 2008;133(5):903-15 - PMID: 18510933 - PMCID: PMC2553566 - DOI: 10.1016/j.cell.2008.04.035

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    The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol. 2008;15(5):531-3 - PMID: 18438419 - PMCID: PMC2910399 - DOI: 10.1038/nsmb.1411

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    MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol Dev. 2008;10(1):106-13 - PMID: 18184361 - PMCID: PMC2637451 - DOI: 10.1111/j.1525-142X.2007.00217.x

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    A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol. 2007;17(23):2013-22 - PMID: 18023351 - PMCID: PMC2211719 - DOI: 10.1016/j.cub.2007.10.058

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    Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev. 2007;21(22):2976-94 - PMID: 18006689 - PMCID: PMC2049198 - DOI: 10.1101/gad.1588907

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    Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Genetics. 2007;177(2):835-45 - PMID: 17720915 - PMCID: PMC2034647 - DOI: 10.1534/genetics.107.076901

  • Hayes GD, Ruvkun G

    Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Cold Spring Harb Symp Quant Biol. 2007;71:21-7 - PMID: 17381276 - DOI: 10.1101/sqb.2006.71.018

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    Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 2007;3(4):e56 - PMID: 17411345 - PMCID: PMC1847696 - DOI: 10.1371/journal.pgen.0030056

  • Hayes GD, Frand AR, Ruvkun G

    The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development. 2006;133(23):4631-41 - PMID: 17065234 - DOI: 10.1242/dev.02655

  • Hu PJ, Xu J, Ruvkun G

    Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006;2(7):e99 - PMID: 16839187 - PMCID: PMC1487177 - DOI: 10.1371/journal.pgen.0020099

  • Sandoval GM, Duerr JS, Hodgkin J, Rand JB, Ruvkun G

    A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nat Neurosci. 2006;9(5):599-601 - PMID: 16604067 - DOI: 10.1038/nn1685

  • Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G

    Polygenic control of Caenorhabditis elegans fat storage. Nat Genet. 2006;38(3):363-8 - PMID: 16462744 - DOI: 10.1038/ng1739

  • Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC

    Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 2006;124(2):343-54 - PMID: 16439208 - DOI: 10.1016/j.cell.2005.11.036

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    Clarifications on miRNA and cancer. Science. 2006;311(5757):36-7 - PMID: 16400132 - DOI: 10.1126/science.311.5757.36d

  • Frand AR, Russel S, Ruvkun G

    Functional genomic analysis of C. elegans molting. PLoS Biol. 2005;3(10):e312 - PMID: 16122351 - PMCID: PMC1233573 - DOI: 10.1371/journal.pbio.0030312

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    Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway. Cold Spring Harb Symp Quant Biol. 2005;69:429-31 - PMID: 16117677 - DOI: 10.1101/sqb.2004.69.429

  • Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G

    Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 2005;436(7050):593-7 - PMID: 16049496 - DOI: 10.1038/nature04010

  • Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM

    Systematic analysis of genes required for synapse structure and function. Nature. 2005;436(7050):510-7 - PMID: 16049479 - DOI: 10.1038/nature03809

  • Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS

    A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 2005;19(13):1544-55 - PMID: 15998808 - PMCID: PMC1172061 - DOI: 10.1101/gad.1308205

  • Ruvkun GB

    The tiny RNA world. Harvey Lect. 2005;99:1-21 - PMID: 15984549

  • Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P

    Analysis of xbx genes in C. elegans. Development. 2005;132(8):1923-34 - PMID: 15790967 - DOI: 10.1242/dev.01775

  • Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G

    Functional genomic analysis of RNA interference in C. elegans. Science. 2005;308(5725):1164-7 - PMID: 15790806 - DOI: 10.1126/science.1109267

  • Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT

    MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004;36(10):1079-83 - PMID: 15361871 - DOI: 10.1038/ng1421

  • Mak HY, Ruvkun G

    Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Development. 2004;131(8):1777-86 - PMID: 15084462 - DOI: 10.1242/dev.01069

  • Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M

    Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Mol Cell. 2004;13(4):469-82 - PMID: 14992718 - DOI: 10.1016/s1097-2765(04)00033-4

  • Kennedy S, Wang D, Ruvkun G

    A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 2004;427(6975):645-9 - PMID: 14961122 - DOI: 10.1038/nature02302

  • Ruvkun G, Wightman B, Ha I

    The 20 years it took to recognize the importance of tiny RNAs. Cell. 2004;116(2 Suppl):S93-6, 2 p following S96 - PMID: 15055593 - DOI: 10.1016/s0092-8674(04)00034-0

  • Komaroff AL, Ruvkun G

    Unraveling the secrets of the cell. Newsweek. 2003;142(23):96 - PMID: 14712576

  • Ruvinsky I, Ruvkun G

    Functional tests of enhancer conservation between distantly related species. Development. 2003;130(21):5133-42 - PMID: 12944426 - DOI: 10.1242/dev.00711

  • Aspöck G, Ruvkun G, Bürglin TR

    The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development. 2003;130(15):3369-78 - PMID: 12810585 - DOI: 10.1242/dev.00551

  • Sze JY, Ruvkun G

    Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity. Proc Natl Acad Sci U S A. 2003;100(16):9560-5 - PMID: 12883006 - PMCID: PMC170957 - DOI: 10.1073/pnas.1530752100

  • Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS

    Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol. 2003;259(1):1-8 - PMID: 12812783 - DOI: 10.1016/s0012-1606(03)00063-0

  • Pasquinelli AE, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J

    Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?. Evol Dev. 2003;5(4):372-8 - PMID: 12823453 - DOI: 10.1046/j.1525-142x.2003.03044.x

  • Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM

    Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 2003;300(5627):1921 - PMID: 12817143 - DOI: 10.1126/science.1080147

  • Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM

    Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 2003;300(5627):1921 - PMID: 12817143 - DOI: 10.1126/science.1080147

  • Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J

    Computational and experimental identification of C. elegans microRNAs. Mol Cell. 2003;11(5):1253-63 - PMID: 12769849 - DOI: 10.1016/s1097-2765(03)00153-9

  • Lee SS, Kennedy S, Tolonen AC, Ruvkun G

    DAF-16 target genes that control C. elegans life-span and metabolism. Science. 2003;300(5619):644-7 - PMID: 12690206 - DOI: 10.1126/science.1083614

  • Li W, Kennedy SG, Ruvkun G

    daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev. 2003;17(7):844-58 - PMID: 12654727 - PMCID: PMC196030 - DOI: 10.1101/gad.1066503

  • Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T

    A uniform system for microRNA annotation. RNA. 2003;9(3):277-9 - PMID: 12592000 - PMCID: PMC1370393 - DOI: 10.1261/rna.2183803

  • Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G

    Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 2003;421(6920):268-72 - PMID: 12529643 - DOI: 10.1038/nature01279

  • Wolkow CA, Muñoz MJ, Riddle DL, Ruvkun G

    Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem. 2002;277(51):49591-7 - PMID: 12393910 - DOI: 10.1074/jbc.M207866200

  • Sze JY, Zhang S, Li J, Ruvkun G

    The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development. 2002;129(16):3901-11 - PMID: 12135927 - DOI: 10.1242/dev.129.16.3901

  • Lee SS, Ruvkun G

    Longevity: don't hold your breath. Nature. 2002;418(6895):287-8 - PMID: 12124610 - DOI: 10.1038/418287a

  • Pasquinelli AE, Ruvkun G

    Control of developmental timing by micrornas and their targets. Annu Rev Cell Dev Biol. 2002;18:495-513 - PMID: 12142272 - DOI: 10.1146/annurev.cellbio.18.012502.105832

  • Lee RY, Hench J, Ruvkun G

    Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol. 2001;11(24):1950-7 - PMID: 11747821 - DOI: 10.1016/s0960-9822(01)00595-4

  • Finch CE, Ruvkun G

    The genetics of aging. Annu Rev Genomics Hum Genet. 2001;2:435-62 - PMID: 11701657 - DOI: 10.1146/annurev.genom.2.1.435

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    Molecular biology. Glimpses of a tiny RNA world. Science. 2001;294(5543):797-9 - PMID: 11679654 - DOI: 10.1126/science.1066315

  • Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC

    Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001;106(1):23-34 - PMID: 11461699 - DOI: 10.1016/s0092-8674(01)00431-7

  • Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G

    Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 2001;15(6):672-86 - PMID: 11274053 - PMCID: PMC312654 - DOI: 10.1101/gad.867301

  • Bürglin TR, Ruvkun G

    Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6. Development. 2001;128(5):779-90 - PMID: 11171402 - DOI: 10.1242/dev.128.5.779

  • Reinhart BJ, Ruvkun G

    Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics. 2001;157(1):199-209 - PMID: 11139502 - PMCID: PMC1461488 - DOI: 10.1093/genetics/157.1.199

  • Kagoshima H, Sommer R, Reinhart BJ, Cassata G, Ruvkun G, Bürglin TR

    Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal. Dev Genes Evol. 2000;210(11):564-9 - PMID: 11180807 - DOI: 10.1007/s004270000099

  • Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G

    Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000;408(6808):86-9 - PMID: 11081512 - DOI: 10.1038/35040556

  • Wolkow CA, Kimura KD, Lee MS, Ruvkun G

    Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science. 2000;290(5489):147-50 - PMID: 11021802 - DOI: 10.1126/science.290.5489.147

  • Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC

    DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc Natl Acad Sci U S A. 2000;97(19):10412-7 - PMID: 10973497 - PMCID: PMC27038 - DOI: 10.1073/pnas.190326997

  • Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G

    The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell. 2000;5(4):659-69 - PMID: 10882102 - DOI: 10.1016/s1097-2765(00)80245-2

  • Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G

    The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000;403(6772):901-6 - PMID: 10706289 - DOI: 10.1038/35002607

  • Sze JY, Victor M, Loer C, Shi Y, Ruvkun G

    Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature. 2000;403(6769):560-4 - PMID: 10676966 - DOI: 10.1038/35000609

  • Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G

    A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc Natl Acad Sci U S A. 2000;97(1):460-5 - PMID: 10618440 - PMCID: PMC26685 - DOI: 10.1073/pnas.97.1.460

  • Davidson EH, Ruvkun G

    Themes from a NASA workshop on gene regulatory processes in development and evolution. J Exp Zool. 1999;285(2):104-15 - PMID: 10440721 - DOI: 10.1002/(sici)1097-010x(19990815)285:2<104::aid-jez2>3.0.co;2-z

  • Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI

    Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes Dev. 1999;13(14):1794-806 - PMID: 10421632 - PMCID: PMC316880 - DOI: 10.1101/gad.13.14.1794

  • Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G

    A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 1999;13(11):1438-52 - PMID: 10364160 - PMCID: PMC316759 - DOI: 10.1101/gad.13.11.1438

  • Hobert O, Ruvkun G

    Pax genes in Caenorhabditis elegans: a new twist. Trends Genet. 1999;15(6):214-6 - PMID: 10354580 - DOI: 10.1016/s0168-9525(99)01731-x

  • Hobert O, Tessmar K, Ruvkun G

    The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development. 1999;126(7):1547-62 - PMID: 10068647 - DOI: 10.1242/dev.126.7.1547

  • Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G

    A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol. 1999;144(1):45-57 - PMID: 9885243 - PMCID: PMC2148118 - DOI: 10.1083/jcb.144.1.45

  • Hobert O, Ruvkun G

    A common theme for LIM homeobox gene function across phylogeny?. Biol Bull. 1998;195(3):377-80 - PMID: 9924780 - DOI: 10.2307/1543153

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    Heterochronic genes in development and evolution. Biol Bull. 1998;195(3):375-6 - PMID: 9924779 - DOI: 10.2307/1543152

  • Ogg S, Ruvkun G

    The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell. 1998;2(6):887-93 - PMID: 9885576 - DOI: 10.1016/s1097-2765(00)80303-2

  • Slack FJ, Ruvkun G

    A novel repeat domain that is often associated with RING finger and B-box motifs. Trends Biochem Sci. 1998;23(12):474-5 - PMID: 9868369 - DOI: 10.1016/s0968-0004(98)01299-7

  • Ruvkun G, Hobert O

    The taxonomy of developmental control in Caenorhabditis elegans. Science. 1998;282(5396):2033-41 - PMID: 9851920 - DOI: 10.1126/science.282.5396.2033

  • Guarente L, Ruvkun G, Amasino R

    Aging, life span, and senescence. Proc Natl Acad Sci U S A. 1998;95(19):11034-6 - PMID: 9736682 - PMCID: PMC33892 - DOI: 10.1073/pnas.95.19.11034

  • Paradis S, Ruvkun G

    Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 1998;12(16):2488-98 - PMID: 9716402 - PMCID: PMC317081 - DOI: 10.1101/gad.12.16.2488

  • Hobert O, D'Alberti T, Liu Y, Ruvkun G

    Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11. J Neurosci. 1998;18(6):2084-96 - PMID: 9482795 - PMCID: PMC6792926 - DOI: 10.1523/JNEUROSCI.18-06-02084.1998

  • Slack F, Ruvkun G

    Temporal pattern formation by heterochronic genes. Annu Rev Genet. 1998;31:611-34 - PMID: 9442909 - DOI: 10.1146/annurev.genet.31.1.611

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    An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics. 1998;148(2):703-17 - PMID: 9504918 - PMCID: PMC1459840 - DOI: 10.1093/genetics/148.2.703

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    The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. J Neurochem. 1996;67(1):46-57 - PMID: 8667025 - DOI: 10.1046/j.1471-4159.1996.67010046.x

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    Cell signalling. A molecular growth industry. Nature. 1993;360(6406):711-2 - PMID: 1334532 - DOI: 10.1038/360711a0

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    New motif in PBX genes. Nat Genet. 1992;1(5):319-20 - PMID: 1363814 - DOI: 10.1038/ng0892-319

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    C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Nature. 1992;355(6363):841-5 - PMID: 1347150 - DOI: 10.1038/355841a0

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    Nematode homeobox cluster. Nature. 1991;351(6329):703 - PMID: 1676487 - DOI: 10.1038/351703a0

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    Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization. Nucleic Acids Res. 1990;18(4):809-15 - PMID: 2315039 - PMCID: PMC330331 - DOI: 10.1093/nar/18.4.809

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    ISRm1: A Rhizobium meliloti insertion sequence that transposes preferentially into nitrogen fixation genes. J Mol Appl Genet. 1983;1(5):405-18 - PMID: 6296251

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    Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts. Gene. 1982;18(3):247-55 - PMID: 6290328 - DOI: 10.1016/0378-1119(82)90162-7

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    Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis. J Bacteriol. 1982;149(1):114-22 - PMID: 6274841 - PMCID: PMC216598 - DOI: 10.1128/JB.149.1.114-122.1982

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    A general method for site-directed mutagenesis in prokaryotes. Nature. 1981;289(5793):85-8 - PMID: 6256652 - DOI: 10.1038/289085a0

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    A general method for site-directed mutagenesis in prokaryotes. Nature. 1981;289(5793):85-8 - PMID: 6256652 - DOI: 10.1038/289085a0

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