Whole-organism phenotypic screening for anti-infectives promoting host health.

Clatworthy AE, Romano KP, Hung DT
Nat Chem Biol. 2018;14(4):331-341 - PMID: 29556098 - DOI: 10.1038/s41589-018-0018-3

The expanding diversity of Mycobacterium tuberculosis drug targets.

Wellington S, Hung DT
ACS Infect Dis. 2018;4(5):696-714 - PMID: 29412643 - DOI: 10.1021/acsinfecdis.7b00255

scDual-Seq: mapping the gene regulatory program of Salmonella infection by host and pathogen single-cell RNA-sequencing.

Avital G, Avraham R, Fan A, Hashimshony T, Hung DT, Yanai I
Genome Biol. 2017;18(1):200 - PMID: 29073931 - PMCID: PMC5658913 - DOI: 10.1186/s13059-017-1340-x

A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.

Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, Hung DT
Nat Chem Biol. 2017;13(9):943-950 - PMID: 28671682 - DOI: 10.1038/nchembio.2420

Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence.

Barczak AK, Avraham R, Singh S, Luo SS, Zhang WR, Bray MA, Hinman AE, Thompson M, Nietupski RM, Golas A, Montgomery P, Fitzgerald M, Smith RS, White DW, Tischler AD, Carpenter AE, Hung DT
PLoS Pathog. 2017;13(5):e1006363 - PMID: 28505176 - PMCID: PMC5444860 - DOI: 10.1371/journal.ppat.1006363

Nucleic acid detection with CRISPR-Cas13a/C2c2.

Gootenberg JS, Abudayyeh OO, Lee JW, Essletzbichler P, Dy AJ, Joung J, Verdine V, Donghia N, Daringer NM, Freije CA, Myhrvold C, Bhattacharyya RP, Livny J, Regev A, Koonin EV, Hung DT, Sabeti PC, Collins JJ, Zhang F
Science. 2017;356(6336):438-442 - PMID: 28408723 - PMCID: PMC5526198 - DOI: 10.1126/science.aam9321

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment.

Gomez JE, Kaufmann-Malaga BB, Wivagg CN, Kim PB, Silvis MR, Renedo N, Ioerger TR, Ahmad R, Livny J, Fishbein S, Sacchettini JC, Carr SA, Hung DT
Elife. 2017;6:ePub - PMID: 28220755 - PMCID: PMC5319836 - DOI: 10.7554/eLife.20420

Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks.

Cerqueira GC, Earl AM, Ernst CM, Grad YH, Dekker JP, Feldgarden M, Chapman SB, Reis-Cunha JL, Shea TP, Young S, Zeng Q, Delaney ML, Kim D, Peterson EM, O'Brien TF, Ferraro MJ, Hooper DC, Huang SS, Kirby JE, Onderdonk AB, Birren BW, Hung DT, Cosimi LA, Wortman JR, Murphy CI, Hanage WP
Proc Natl Acad Sci U S A. 2017;114(5):1135-1140 - PMID: 28096418 - PMCID: PMC5293017 - DOI: 10.1073/pnas.1616248114

A perspective on single cell behavior during infection.

Avraham R, Hung DT
Gut Microbes. 2016;7(6):0 - PMID: 27658058 - PMCID: PMC5153611 - DOI: 10.1080/19490976.2016.1239001

Genomic analysis of the evolution of fluoroquinolone resistance in Mycobacterium tuberculosis prior to tuberculosis diagnosis.

Zhang D, Gomez JE, Chien JY, Haseley N, Desjardins CA, Earl AM, Hsueh PR, Hung DT
Antimicrob Agents Chemother. 2016;60(11):6600-6608 - PMID: 27572408 - PMCID: PMC5075065 - DOI: 10.1128/AAC.00664-16

Accelerating global innovation to address antibacterial resistance: introducing CARB-X.

Outterson K, Rex JH, Jinks T, Jackson P, Hallinan J, Karp S, Hung DT, Franceschi F, Merkeley T, Houchens C, Dixon DM, Kurilla MG, Aurigemma R, Larsen J
Nat Rev Drug Discov. 2016;15(9):589-90 - PMID: 27469032 - DOI: 10.1038/nrd.2016.155

A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes.

Avraham R, Haseley N, Fan A, Bloom-Ackermann Z, Livny J, Hung DT
Nat Protoc. 2016;11(8):1477-1491 - PMID: 27442864 - DOI: 10.1038/nprot.2016.090

Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors.

Grant SS, Wellington S, Kawate T, Desjardins CA, Silvis MR, Wivagg C, Thompson M, Gordon K, Kazyanskaya E, Nietupski R, Haseley N, Iwase N, Earl AM, Fitzgerald M, Hung DT
Cell Chem Biol. 2016;23(6):666-77 - PMID: 27321573 - PMCID: PMC4920728 - DOI: 10.1016/j.chembiol.2016.05.011

Loss of a Class A Penicillin-Binding Protein Alters ?-Lactam Susceptibilities in Mycobacterium tuberculosis.

Wivagg CN, Wellington S, Gomez JE, Hung DT
ACS Infect Dis. 2015;2(2):104-10 - PMID: 27624961 - DOI: 10.1021/acsinfecdis.5b00119

Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.

Avraham R, Haseley N, Brown D, Penaranda C, Jijon HB, Trombetta JJ, Satija R, Shalek AK, Xavier RJ, Regev A, Hung DT
Cell. 2015;162(6):1309-21 - PMID: 26343579 - PMCID: PMC4578813 - DOI: 10.1016/j.cell.2015.08.027

Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.

Avraham R, Haseley N, Brown D, Penaranda C, Jijon HB, Trombetta JJ, Satija R, Shalek AK, Xavier RJ, Regev A, Hung DT
Cell. 2015;162(6):1309-21 - PMID: 26343579 - PMCID: PMC4578813 - DOI: 10.1016/j.cell.2015.08.027

Direct detection and drug-resistance profiling of bacteremias using inertial microfluidics.

Hou HW, Bhattacharyya RP, Hung DT, Han J
Lab Chip. 2015;15(10):2297-2307 - PMID: 25882432 - PMCID: PMC4437799 - DOI: 10.1039/c5lc00311c

Simultaneous generation of many RNA-seq libraries in a single reaction.

Shishkin AA, Giannoukos G, Kucukural A, Ciulla D, Busby M, Surka C, Chen J, Bhattacharyya RP, Rudy RF, Patel MM, Novod N, Hung DT, Gnirke A, Garber M, Guttman M, Livny J
Nat Methods. 2015;12(4):323-325 - PMID: 25730492 - PMCID: PMC4712044 - DOI: 10.1038/nmeth.3313

Mechanisms of ?-lactam killing and resistance in the context of Mycobacterium tuberculosis.

Wivagg CN, Bhattacharyya RP, Hung DT
J Antibiot (Tokyo). 2014;67(9):645-654 - PMID: 25052484 - DOI: 10.1038/ja.2014.94

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth.

Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT
PLoS Pathog. 2014;10(2):e1003946 - PMID: 24586159 - PMCID: PMC3930586 - DOI: 10.1371/journal.ppat.1003946

Bacterial toxins and small molecules elucidate endosomal trafficking.

Slater LH, Clatworthy AE, Hung DT
Trends Microbiol. 2013;22(2):53-5 - PMID: 24370463 - DOI: 10.1016/j.tim.2013.12.002

Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32.

Kawate T, Iwase N, Shimizu M, Stanley SA, Wellington S, Kazyanskaya E, Hung DT
Bioorg Med Chem Lett. 2013;23(22):6052-9 - PMID: 24103299 - DOI: 10.1016/j.bmcl.2013.09.035

Identification of novel inhibitors of non-replicating M. tuberculosis using a carbon starvation model.

Grant SS, Kawate T, Nag PP, Silvis MR, Gordon K, Stanley SA, Kazyanskaya E, Nietupski R, Golas A, Fitzgerald M, Cho S, Franzblau SG, Hung DT
ACS Chem Biol. 2013;8(10):2224-34 - PMID: 23898841 - PMCID: PMC3864639 - DOI: 10.1021/cb4004817

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.

Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT
Nat Chem Biol. 2013;9(7):466 - PMID: 23774875

Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32.

Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Schmidt Grant S, Rubin EJ, Hung DT
Proc Natl Acad Sci U S A. 2013;110(28):11565-70 - PMID: 23798446 - PMCID: PMC3710825 - DOI: 10.1073/pnas.1302114110

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.

Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT
Proc Natl Acad Sci U S A. 2013;110(24):9932-7 - PMID: 23716698 - PMCID: PMC3683768 - DOI: 10.1073/pnas.1302257110

How antibiotics kill bacteria: new models needed?

Wright GD, Hung DT, Helmann JD
Nat Med. 2013;19(5):544-5 - PMID: 23652106 - DOI: 10.1038/nm.3198

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.

Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT
Nat Chem Biol. 2013;9(6):398-405 - PMID: 23603659 - DOI: 10.1038/nchembio.1236

Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response.

Grant SS, Hung DT
Virulence. 2013;4(4):273-283 - PMID: 23563389 - PMCID: PMC3710330 - DOI: 10.4161/viru.23987

Identification of Novel Host-Targeted Compounds That Protect From Anthrax Lethal Toxin-Induced Cell Death.

Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT
ACS Chem Biol. 2013;8(4):812-822 - PMID: 23343607 - PMCID: PMC3638717 - DOI: 10.1021/cb300555n

Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany.

Grad YH, Lipsitch M, Griggs AD, Haas BJ, Shea TP, McCowan C, Montmayeur A, FitzGerald M, Wortman JR, Krogfelt KA, Bingen E, Weill FX, Tietze E, Flieger A, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP
Proc Natl Acad Sci U S A. 2012;109(52):E3629-30 - PMID: 23479789 - PMCID: PMC3535640

The Two-Component Sensor KinB Acts as a Phosphatase to Regulate Pseudomonas aeruginosa Virulence.

Chand NS, Clatworthy AE, Hung DT
J Bacteriol. 2012;194(23):6537-47 - PMID: 23024348 - PMCID: PMC3497526 - DOI: 10.1128/JB.01168-12

Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.

Schmidt Grant S, Kaufmann BB, Chand NS, Haseley N, Hung DT
Proc Natl Acad Sci U S A. 2012;109(30):12147-52 - PMID: 22778419 - PMCID: PMC3409745 - DOI: 10.1073/pnas.1203735109

Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.

Stanley SA, Schmidt Grant S, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT
ACS Chem Biol. 2012;7(8):1377-84 - PMID: 22577943 - PMCID: PMC3560293 - DOI: 10.1021/cb300151m

RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities.

Barczak AK, Gomez JE, Kaufmann BB, Hinson ER, Cosimi L, Borowsky ML, Onderdonk AB, Stanley SA, Kaur D, Bryant KF, Knipe DM, Sloutsky A, Hung DT
Proc Natl Acad Sci U S A. 2012;109(16):6217-22 - PMID: 22474362 - PMCID: PMC3341018 - DOI: 10.1073/pnas.1119540109

Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011.

Grad YH, Lipsitch M, Feldgarden M, Arachchi HM, Cerqueira GC, Fitzgerald M, Godfrey P, Haas BJ, Murphy CI, Russ C, Sykes S, Walker BJ, Wortman JR, Young S, Zeng Q, Abouelleil A, Bochicchio J, Chauvin S, Desmet T, Gujja S, McCowan C, Montmayeur A, Steelman S, Frimodt-Møller J, Petersen AM, Struve C, Krogfelt KA, Bingen E, Weill FX, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP
Proc Natl Acad Sci U S A. 2012;109(8):3065-70 - PMID: 22315421 - PMCID: PMC3286951 - DOI: 10.1073/pnas.1121491109

Resuscitation-promoting factors are required for ?-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis.

Wivagg CN, Hung DT
Antimicrob Agents Chemother. 2011;56(3):1591-4 - PMID: 22155826 - PMCID: PMC3294900 - DOI: 10.1128/AAC.06027-11

Systematics-guided bioprospecting for bioactive microbial natural products.

Liu X, Bolla K, Ashforth EJ, Zhuo Y, Gao H, Huang P, Stanley SA, Hung DT, Zhang L
Antonie Van Leeuwenhoek. 2011;101(1):55-66 - PMID: 22086462 - DOI: 10.1007/s10482-011-9671-1

The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection.

Chand NS, Hung DT
Virulence. 2011;2(6):553-8 - PMID: 21971182 - DOI: 10.4161/viru.2.6.17987

GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro.

Tamayo AG, Slater L, Taylor-Parker J, Bharti A, Harrison R, Hung DT, Murphy JR
Mol Microbiol. 2011;81(5):1390-401 - PMID: 21797942 - PMCID: PMC4041151 - DOI: 10.1111/j.1365-2958.2011.07770.x

The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection.

Chand NS, Lee JS, Clatworthy AE, Golas AJ, Smith RS, Hung DT
J Bacteriol. 2011;193(12):2989-99 - PMID: 21515773 - PMCID: PMC3133189 - DOI: 10.1128/JB.01546-10

Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.

Gomez JE, Clatworthy A, Hung DT
Crit Rev Biochem Mol Biol. 2011;46(1):41-66 - PMID: 21250782 - DOI: 10.3109/10409238.2010.538663

The fast track to multidrug resistance.

Kaufmann BB, Hung DT
Mol Cell. 2010;37(3):297-8 - PMID: 20159549 - DOI: 10.1016/j.molcel.2010.01.027

Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells.

Stanley SA, Hung DT
Sci Transl Med. 2009;1(11):11ps13 - PMID: 20371455 - DOI: 10.1126/scitranslmed.3000550

Targeting multiple biofilm pathways.

Hett EC, Hung DT
Chem Biol. 2009;16(12):1216-8 - PMID: 20064430 - DOI: 10.1016/j.chembiol.2009.12.003

Chemical tools for dissecting bacterial physiology and virulence.

Stanley SA, Hung DT
Biochemistry. 2009;48(37):8776-86 - PMID: 19653697 - DOI: 10.1021/bi9009083

Productive steps toward an antimicrobial targeting virulence.

Barczak AK, Hung DT
Curr Opin Microbiol. 2009;12(5):490-6 - PMID: 19631578 - PMCID: PMC2763366 - DOI: 10.1016/j.mib.2009.06.012

Development of a second-generation antiandrogen for treatment of advanced prostate cancer.

Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL
Science. 2009;324(5928):787-90 - PMID: 19359544 - PMCID: PMC2981508 - DOI: 10.1126/science.1168175

Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants.

Clatworthy AE, Lee JS, Leibman M, Kostun Z, Davidson AJ, Hung DT
Infect Immun. 2009;77(4):1293-303 - PMID: 19168742 - PMCID: PMC2663173 - DOI: 10.1128/IAI.01181-08

Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing.

Nusbaum C, Ohsumi TK, Gomez J, Aquadro J, Victor TC, Warren RM, Hung DT, Birren BW, Lander ES, Jaffe DB
Nat Methods. 2008;6(1):67-9 - PMID: 19079253 - PMCID: PMC2613166 - DOI: 10.1038/nmeth.1286

Targeting virulence: a new paradigm for antimicrobial therapy.

Clatworthy AE, Pierson E, Hung DT
Nat Chem Biol. 2007;3(9):541-8 - PMID: 17710100 - DOI: 10.1038/nchembio.2007.24

Virstatin inhibits dimerization of the transcriptional activator ToxT.

Shakhnovich EA, Hung DT, Pierson E, Lee K, Mekalanos JJ
Proc Natl Acad Sci U S A. 2007;104(7):2372-7 - PMID: 17283330 - PMCID: PMC1892951 - DOI: 10.1073/pnas.0611643104

Chemical biology and bacteria: not simply a matter of life or death.

Hung DT, Rubin EJ
Curr Opin Chem Biol. 2006;10(4):321-6 - PMID: 16814591 - DOI: 10.1016/j.cbpa.2006.06.016

Bile acids stimulate biofilm formation in Vibrio cholerae.

Hung DT, Zhu J, Sturtevant D, Mekalanos JJ
Mol Microbiol. 2006;59(1):193-201 - PMID: 16359328 - DOI: 10.1111/j.1365-2958.2005.04846.x

Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization.

Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ
Science. 2005;310(5748):670-4 - PMID: 16223984 - DOI: 10.1126/science.1116739

Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner.

Hung DT, Mekalanos JJ
Proc Natl Acad Sci U S A. 2005;102(8):3028-33 - PMID: 15699331 - PMCID: PMC549475 - DOI: 10.1073/pnas.0409559102

Ductal lavage and the clinical management of women at high risk for breast carcinoma: a commentary.

O'Shaughnessy JA, Ljung BM, Dooley WC, Chang J, Kuerer HM, Hung DT, Grant MD, Khan SA, Phillips RF, Duvall K, Euhus DM, King BL, Anderson BO, Troyan SL, Kim J, Veronesi U, Cazzaniga M
Cancer. 2002;94(2):292-8 - PMID: 11900214 - DOI: 10.1002/cncr.10238

Ductal lavage for detection of cellular atypia in women at high risk for breast cancer.

Dooley WC, Ljung BM, Veronesi U, Cazzaniga M, Elledge RM, O'Shaughnessy JA, Kuerer HM, Hung DT, Khan SA, Phillips RF, Ganz PA, Euhus DM, Esserman LJ, Haffty BG, King BL, Kelley MC, Anderson MM, Schmit PJ, Clark RR, Kass FC, Anderson BO, Troyan SL, Arias RD, Quiring JN, Love SM, Page DL, King EB
J Natl Cancer Inst. 2001;93(21):1624-32 - PMID: 11698566

Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR.

Evron E, Dooley WC, Umbricht CB, Rosenthal D, Sacchi N, Gabrielson E, Soito AB, Hung DT, Ljung B, Davidson NE, Sukumar S
Lancet. 2001;357(9265):1335-6 - PMID: 11343741

Understanding and controlling the cell cycle with natural products.

Hung DT, Jamison TF, Schreiber SL
Chem Biol. 1996;3(8):623-39 - PMID: 8807895

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest.

Hung DT, Chen J, Schreiber SL
Chem Biol. 1996;3(4):287-93 - PMID: 8807856

Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides.

Hung DT, Nerenberg JB, Schreiber SL
Chem Biol. 1994;1(1):67-71 - PMID: 9383372

Thrombin receptor structure and function.

Coughlin SR, Scarborough RM, Vu TK, Hung DT
Cold Spring Harb Symp Quant Biol. 1993;57:149-54 - PMID: 1339654

Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location.

Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR
Mol Cell Biol. 1993;13(8):4760-9 - PMID: 7687744 - PMCID: PMC360102

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.

Hung DT, Wong YH, Vu TK, Coughlin SR
J Biol Chem. 1992;267(29):20831-4 - PMID: 1328213

Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.

Coughlin SR, Vu TK, Hung DT, Wheaton VI
Semin Thromb Hemost. 1992;18(2):161-6 - PMID: 1321504 - DOI: 10.1055/s-2007-1002422

Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function.

Scarborough RM, Naughton MA, Teng W, Hung DT, Rose J, Vu TK, Wheaton VI, Turck CW, Coughlin SR
J Biol Chem. 1992;267(19):13146-9 - PMID: 1320011

cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein.

Hung DT, Schreiber SL
Biochem Biophys Res Commun. 1992;184(2):733-8 - PMID: 1374240

HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides.

Garboczi DN, Hung DT, Wiley DC
Proc Natl Acad Sci U S A. 1992;89(8):3429-33 - PMID: 1565634 - PMCID: PMC48881

Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation.

Hung DT, Vu TK, Wheaton VI, Ishii K, Coughlin SR
J Clin Invest. 1992;89(4):1350-3 - PMID: 1313452 - PMCID: PMC442997 - DOI: 10.1172/JCI115721

"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure.

Hung DT, Vu TK, Wheaton VI, Charo IF, Nelken NA, Esmon N, Esmon CT, Coughlin SR
J Clin Invest. 1992;89(2):444-50 - PMID: 1310695 - PMCID: PMC442871 - DOI: 10.1172/JCI115604

Characterization of a functional thrombin receptor. Issues and opportunities.

Coughlin SR, Vu TK, Hung DT, Wheaton VI
J Clin Invest. 1992;89(2):351-5 - PMID: 1310691 - PMCID: PMC442859 - DOI: 10.1172/JCI115592

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor.

Hung DT, Vu TH, Nelken NA, Coughlin SR
J Cell Biol. 1992;116(3):827-32 - PMID: 1309820 - PMCID: PMC2289317

Domains specifying thrombin-receptor interaction.

Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR
Nature. 1991;353(6345):674-7 - PMID: 1717851 - DOI: 10.1038/353674a0

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.

Vu TK, Hung DT, Wheaton VI, Coughlin SR
Cell. 1991;64(6):1057-68 - PMID: 1672265

Decreased cell kill of vincristine and methotrexate against 9L rat brain tumor cells in vitro caused by alpha-difluoromethylornithine-induced polyamine depletion.

Alhonen-Hongisto L, Hung DT, Deen DF, Marton LJ
Cancer Res. 1984;44(10):4440-2 - PMID: 6432313

Potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L rat brain tumor cells by methylglyoxal-bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase.

Hung DT, Oredsson SM, Pegg AE, Deen DF, Marton LJ
Eur J Cancer Clin Oncol. 1984;20(3):417-20 - PMID: 6538500

Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells.

Hung DT, Marton LJ, Deen DF, Shafer RH
Science. 1983;221(4608):368-70 - PMID: 6408733

Sensitization of 9L rat brain gliosarcoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.

Hung DT, Deen DF, Seidenfeld J, Marton LJ
Cancer Res. 1981;41(7):2783-5 - PMID: 6788362

Preparation of an ecdysone immunogen for radioimmunoassay work.

Hung DT, Benner SA, Williams CM
J Biol Chem. 1980;255(13):6047-8 - PMID: 7190146