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Ma P, Amemiya HM, He LL, Gandhi SJ, Nicol R, Bhattacharyya RP, Smillie CS, Hung DT Bacterial droplet-based single-cell RNA-seq reveals antibiotic-associated heterogeneous cellular states. Cell. 2023;186(4):877-891.e14 - PMID: 36708705 - PMCID: PMC10014032 - DOI: 10.1016/j.cell.2023.01.002

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Penaranda C, Hung DT Single-Cell RNA Sequencing to Understand Host-Pathogen Interactions. ACS Infect Dis. 2019;5(3):336-344 - PMID: 30702856 - DOI: 10.1021/acsinfecdis.8b00369

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Chand NS, Lee JS, Clatworthy AE, Golas AJ, Smith RS, Hung DT The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection. J Bacteriol. 2011;193(12):2989-99 - PMID: 21515773 - PMCID: PMC3133189 - DOI: 10.1128/JB.01546-10

Gomez JE, Clatworthy A, Hung DT Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches. Crit Rev Biochem Mol Biol. 2011;46(1):41-66 - PMID: 21250782 - DOI: 10.3109/10409238.2010.538663

Kaufmann BB, Hung DT The fast track to multidrug resistance. Mol Cell. 2010;37(3):297-8 - PMID: 20159549 - DOI: 10.1016/j.molcel.2010.01.027

Stanley SA, Hung DT Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells. Sci Transl Med. 2009;1(11):11ps13 - PMID: 20371455 - DOI: 10.1126/scitranslmed.3000550

Hett EC, Hung DT Targeting multiple biofilm pathways. Chem Biol. 2009;16(12):1216-8 - PMID: 20064430 - DOI: 10.1016/j.chembiol.2009.12.003

Stanley SA, Hung DT Chemical tools for dissecting bacterial physiology and virulence. Biochemistry. 2009;48(37):8776-86 - PMID: 19653697 - DOI: 10.1021/bi9009083

Barczak AK, Hung DT Productive steps toward an antimicrobial targeting virulence. Curr Opin Microbiol. 2009;12(5):490-6 - PMID: 19631578 - PMCID: PMC2763366 - DOI: 10.1016/j.mib.2009.06.012

Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science. 2009;324(5928):787-90 - PMID: 19359544 - PMCID: PMC2981508 - DOI: 10.1126/science.1168175

Clatworthy AE, Lee JS, Leibman M, Kostun Z, Davidson AJ, Hung DT Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants. Infect Immun. 2009;77(4):1293-303 - PMID: 19168742 - PMCID: PMC2663173 - DOI: 10.1128/IAI.01181-08

Clatworthy AE, Pierson E, Hung DT Targeting virulence: a new paradigm for antimicrobial therapy. Nat Chem Biol. 2007;3(9):541-8 - PMID: 17710100 - DOI: 10.1038/nchembio.2007.24

Shakhnovich EA, Hung DT, Pierson E, Lee K, Mekalanos JJ Virstatin inhibits dimerization of the transcriptional activator ToxT. Proc Natl Acad Sci U S A. 2007;104(7):2372-7 - PMID: 17283330 - PMCID: PMC1892951 - DOI: 10.1073/pnas.0611643104

Hung DT, Rubin EJ Chemical biology and bacteria: not simply a matter of life or death. Curr Opin Chem Biol. 2006;10(4):321-6 - PMID: 16814591 - DOI: 10.1016/j.cbpa.2006.06.016

Hung DT, Zhu J, Sturtevant D, Mekalanos JJ Bile acids stimulate biofilm formation in Vibrio cholerae. Mol Microbiol. 2006;59(1):193-201 - PMID: 16359328 - DOI: 10.1111/j.1365-2958.2005.04846.x

Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science. 2005;310(5748):670-4 - PMID: 16223984 - DOI: 10.1126/science.1116739

Hung DT, Mekalanos JJ Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner. Proc Natl Acad Sci U S A. 2005;102(8):3028-33 - PMID: 15699331 - PMCID: PMC549475 - DOI: 10.1073/pnas.0409559102

O'Shaughnessy JA, Ljung BM, Dooley WC, Chang J, Kuerer HM, Hung DT, Grant MD, Khan SA, Phillips RF, Duvall K, Euhus DM, King BL, Anderson BO, Troyan SL, Kim J, Veronesi U, Cazzaniga M Ductal lavage and the clinical management of women at high risk for breast carcinoma: a commentary. Cancer. 2002;94(2):292-8 - PMID: 11900214 - DOI: 10.1002/cncr.10238

Dooley WC, Ljung BM, Veronesi U, Cazzaniga M, Elledge RM, O'Shaughnessy JA, Kuerer HM, Hung DT, Khan SA, Phillips RF, Ganz PA, Euhus DM, Esserman LJ, Haffty BG, King BL, Kelley MC, Anderson MM, Schmit PJ, Clark RR, Kass FC, Anderson BO, Troyan SL, Arias RD, Quiring JN, Love SM, Page DL, King EB Ductal lavage for detection of cellular atypia in women at high risk for breast cancer. J Natl Cancer Inst. 2001;93(21):1624-32 - PMID: 11698566 - DOI: 10.1093/jnci/93.21.1624

Evron E, Dooley WC, Umbricht CB, Rosenthal D, Sacchi N, Gabrielson E, Soito AB, Hung DT, Ljung B, Davidson NE, Sukumar S Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR. Lancet. 2001;357(9265):1335-6 - PMID: 11343741 - DOI: 10.1016/s0140-6736(00)04501-3

Hung DT, Jamison TF, Schreiber SL Understanding and controlling the cell cycle with natural products. Chem Biol. 1996;3(8):623-39 - PMID: 8807895 - DOI: 10.1016/s1074-5521(96)90129-5

Hung DT, Chen J, Schreiber SL (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chem Biol. 1996;3(4):287-93 - PMID: 8807856 - DOI: 10.1016/s1074-5521(96)90108-8

Hung DT, Nerenberg JB, Schreiber SL Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides. Chem Biol. 1994;1(1):67-71 - PMID: 9383372 - DOI: 10.1016/1074-5521(94)90042-6

Coughlin SR, Scarborough RM, Vu TK, Hung DT Thrombin receptor structure and function. Cold Spring Harb Symp Quant Biol. 1993;57:149-54 - PMID: 1339654 - DOI: 10.1101/sqb.1992.057.01.019

Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol Cell Biol. 1993;13(8):4760-9 - PMID: 7687744 - PMCID: PMC360102 - DOI: 10.1128/mcb.13.8.4760

Hung DT, Wong YH, Vu TK, Coughlin SR The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. J Biol Chem. 1992;267(29):20831-4 - PMID: 1328213

Coughlin SR, Vu TK, Hung DT, Wheaton VI Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Semin Thromb Hemost. 1992;18(2):161-6 - PMID: 1321504 - DOI: 10.1055/s-2007-1002422

Scarborough RM, Naughton MA, Teng W, Hung DT, Rose J, Vu TK, Wheaton VI, Turck CW, Coughlin SR Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function. J Biol Chem. 1992;267(19):13146-9 - PMID: 1320011

Hung DT, Schreiber SL cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. Biochem Biophys Res Commun. 1992;184(2):733-8 - PMID: 1374240 - DOI: 10.1016/0006-291x(92)90651-z

Garboczi DN, Hung DT, Wiley DC HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. Proc Natl Acad Sci U S A. 1992;89(8):3429-33 - PMID: 1565634 - PMCID: PMC48881 - DOI: 10.1073/pnas.89.8.3429

Hung DT, Vu TK, Wheaton VI, Ishii K, Coughlin SR Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation. J Clin Invest. 1992;89(4):1350-3 - PMID: 1313452 - PMCID: PMC442997 - DOI: 10.1172/JCI115721

Hung DT, Vu TK, Wheaton VI, Charo IF, Nelken NA, Esmon N, Esmon CT, Coughlin SR "Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure. J Clin Invest. 1992;89(2):444-50 - PMID: 1310695 - PMCID: PMC442871 - DOI: 10.1172/JCI115604

Coughlin SR, Vu TK, Hung DT, Wheaton VI Characterization of a functional thrombin receptor. Issues and opportunities. J Clin Invest. 1992;89(2):351-5 - PMID: 1310691 - PMCID: PMC442859 - DOI: 10.1172/JCI115592

Hung DT, Vu TH, Nelken NA, Coughlin SR Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. J Cell Biol. 1992;116(3):827-32 - PMID: 1309820 - PMCID: PMC2289317 - DOI: 10.1083/jcb.116.3.827

Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR Domains specifying thrombin-receptor interaction. Nature. 1991;353(6345):674-7 - PMID: 1717851 - DOI: 10.1038/353674a0

Vu TK, Hung DT, Wheaton VI, Coughlin SR Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991;64(6):1057-68 - PMID: 1672265 - DOI: 10.1016/0092-8674(91)90261-v

Alhonen-Hongisto L, Hung DT, Deen DF, Marton LJ Decreased cell kill of vincristine and methotrexate against 9L rat brain tumor cells in vitro caused by alpha-difluoromethylornithine-induced polyamine depletion. Cancer Res. 1984;44(10):4440-2 - PMID: 6432313

Hung DT, Oredsson SM, Pegg AE, Deen DF, Marton LJ Potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L rat brain tumor cells by methylglyoxal-bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase. Eur J Cancer Clin Oncol. 1984;20(3):417-20 - PMID: 6538500 - DOI: 10.1016/0277-5379(84)90090-7

Hung DT, Marton LJ, Deen DF, Shafer RH Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells. Science. 1983;221(4608):368-70 - PMID: 6408733 - DOI: 10.1126/science.6408733

Hung DT, Deen DF, Seidenfeld J, Marton LJ Sensitization of 9L rat brain gliosarcoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor. Cancer Res. 1981;41(7):2783-5 - PMID: 6788362

Hung DT, Benner SA, Williams CM Preparation of an ecdysone immunogen for radioimmunoassay work. J Biol Chem. 1980;255(13):6047-8 - PMID: 7190146