Publications - Hung
Mutations in pmrB confer cross-resistance between the LptD inhibitor POL7080 and colistin in Pseudomonas aeruginosa.
Antimicrob Agents Chemother. 2019;63(9):ePub - PMID: 31235628 - PMCID: PMC6709506 - DOI: 10.1128/AAC.00511-19
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.
Nature. 2019;571(7763):72-78 - PMID: 31217586 - DOI: 10.1038/s41586-019-1315-z
Conservation of the structure and function of bacterial tryptophan synthases.
Publisher Correction: Definitions and guidelines for research on antibiotic persistence.
Nat Rev Microbiol. 2019;17(7):460 - PMID: 31036919 - DOI: 10.1038/s41579-019-0207-4
Defining the core essential genome of Pseudomonas aeruginosa.
Proc Natl Acad Sci U S A. 2019;116(20):10072-10080 - PMID: 31036669 - PMCID: PMC6525520 - DOI: 10.1073/pnas.1900570116
Rapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA.
Single-Cell RNA Sequencing to Understand Host-Pathogen Interactions.
ACS Infect Dis. 2019;5(3):336-344 - PMID: 30702856 - DOI: 10.1021/acsinfecdis.8b00369
Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors.
Bioorg Med Chem Lett. 2018;28(22):3529-3533 - PMID: 30316633 - PMCID: PMC6233306 - DOI: 10.1016/j.bmcl.2018.09.037
Carbapenem resistance caused by high-level expression of OXA-663 β-lactamase in an OmpK36-deficient Klebsiella pneumoniae clinical isolate.
Antimicrob Agents Chemother. 2018;62(11):ePub - PMID: 30126962 - PMCID: PMC6201135 - DOI: 10.1128/AAC.01281-18
Harnessing CRISPR Effectors for Infectious Disease Diagnostics.
ACS Infect Dis. 2018;4(9):1278-1282 - PMID: 30113801 - DOI: 10.1021/acsinfecdis.8b00170
Whole-organism phenotypic screening for anti-infectives promoting host health.
Nat Chem Biol. 2018;14(4):331-341 - PMID: 29556098 - DOI: 10.1038/s41589-018-0018-3
The expanding diversity of Mycobacterium tuberculosis drug targets.
ACS Infect Dis. 2018;4(5):696-714 - PMID: 29412643 - DOI: 10.1021/acsinfecdis.7b00255
scDual-Seq: mapping the gene regulatory program of Salmonella infection by host and pathogen single-cell RNA-sequencing.
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Nat Chem Biol. 2017;13(9):943-950 - PMID: 28671682 - DOI: 10.1038/nchembio.2420
Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence.
PLoS Pathog. 2017;13(5):e1006363 - PMID: 28505176 - PMCID: PMC5444860 - DOI: 10.1371/journal.ppat.1006363
Nucleic acid detection with CRISPR-Cas13a/C2c2.
Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment.
Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks.
Proc Natl Acad Sci U S A. 2017;114(5):1135-1140 - PMID: 28096418 - PMCID: PMC5293017 - DOI: 10.1073/pnas.1616248114
A perspective on single cell behavior during infection.
Genomic analysis of the evolution of fluoroquinolone resistance in Mycobacterium tuberculosis prior to tuberculosis diagnosis.
Antimicrob Agents Chemother. 2016;60(11):6600-6608 - PMID: 27572408 - PMCID: PMC5075065 - DOI: 10.1128/AAC.00664-16
Accelerating global innovation to address antibacterial resistance: introducing CARB-X.
Nat Rev Drug Discov. 2016;15(9):589-590 - PMID: 27469032 - DOI: 10.1038/nrd.2016.155
A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes.
Nat Protoc. 2016;11(8):1477-91 - PMID: 27442864 - DOI: 10.1038/nprot.2016.090
Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors.
Cell Chem Biol. 2016;23(6):666-77 - PMID: 27321573 - PMCID: PMC4920728 - DOI: 10.1016/j.chembiol.2016.05.011
Loss of a Class A Penicillin-Binding Protein Alters ?-Lactam Susceptibilities in Mycobacterium tuberculosis.
ACS Infect Dis. 2015;2(2):104-10 - PMID: 27624961 - DOI: 10.1021/acsinfecdis.5b00119
Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.
Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.
Direct detection and drug-resistance profiling of bacteremias using inertial microfluidics.
Simultaneous generation of many RNA-seq libraries in a single reaction.
Mechanisms of ?-lactam killing and resistance in the context of Mycobacterium tuberculosis.
J Antibiot (Tokyo). 2014;67(9):645-54 - PMID: 25052484 - DOI: 10.1038/ja.2014.94
Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth.
PLoS Pathog. 2014;10(2):e1003946 - PMID: 24586159 - PMCID: PMC3930586 - DOI: 10.1371/journal.ppat.1003946
Bacterial toxins and small molecules elucidate endosomal trafficking.
Trends Microbiol. 2013;22(2):53-5 - PMID: 24370463 - DOI: 10.1016/j.tim.2013.12.002
Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32.
Bioorg Med Chem Lett. 2013;23(22):6052-9 - PMID: 24103299 - DOI: 10.1016/j.bmcl.2013.09.035
Identification of novel inhibitors of non-replicating M. tuberculosis using a carbon starvation model.
Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.
Nat Chem Biol. 2013;9(7):466 - PMID: 23774875
Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32.
Proc Natl Acad Sci U S A. 2013;110(28):11565-70 - PMID: 23798446 - PMCID: PMC3710825 - DOI: 10.1073/pnas.1302114110
CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.
Proc Natl Acad Sci U S A. 2013;110(24):9932-7 - PMID: 23716698 - PMCID: PMC3683768 - DOI: 10.1073/pnas.1302257110
How antibiotics kill bacteria: new models needed?
Nat Med. 2013;19(5):544-5 - PMID: 23652106 - DOI: 10.1038/nm.3198
Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.
Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response.
Identification of Novel Host-Targeted Compounds That Protect From Anthrax Lethal Toxin-Induced Cell Death.
Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany.
Proc Natl Acad Sci U S A. 2012;109(52):E3629-30 - PMID: 23479789 - PMCID: PMC3535640 - DOI: 10.1073/pnas.1209419110
The Two-Component Sensor KinB Acts as a Phosphatase to Regulate Pseudomonas aeruginosa Virulence.
Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.
Proc Natl Acad Sci U S A. 2012;109(30):12147-52 - PMID: 22778419 - PMCID: PMC3409745 - DOI: 10.1073/pnas.1203735109
Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.
RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities.
Proc Natl Acad Sci U S A. 2012;109(16):6217-22 - PMID: 22474362 - PMCID: PMC3341018 - DOI: 10.1073/pnas.1119540109
Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011.
Proc Natl Acad Sci U S A. 2012;109(8):3065-70 - PMID: 22315421 - PMCID: PMC3286951 - DOI: 10.1073/pnas.1121491109
Resuscitation-promoting factors are required for ?-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis.
Antimicrob Agents Chemother. 2011;56(3):1591-4 - PMID: 22155826 - PMCID: PMC3294900 - DOI: 10.1128/AAC.06027-11
Systematics-guided bioprospecting for bioactive microbial natural products.
Antonie Van Leeuwenhoek. 2011;101(1):55-66 - PMID: 22086462 - DOI: 10.1007/s10482-011-9671-1
The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection.
Virulence. 2011;2(6):553-8 - PMID: 21971182 - DOI: 10.4161/viru.2.6.17987
GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro.
Mol Microbiol. 2011;81(5):1390-401 - PMID: 21797942 - PMCID: PMC4041151 - DOI: 10.1111/j.1365-2958.2011.07770.x
The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection.
Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.
Crit Rev Biochem Mol Biol. 2011;46(1):41-66 - PMID: 21250782 - DOI: 10.3109/10409238.2010.538663
The fast track to multidrug resistance.
Mol Cell. 2010;37(3):297-8 - PMID: 20159549 - DOI: 10.1016/j.molcel.2010.01.027
Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells.
Sci Transl Med. 2009;1(11):11ps13 - PMID: 20371455 - DOI: 10.1126/scitranslmed.3000550
Targeting multiple biofilm pathways.
Chem Biol. 2009;16(12):1216-8 - PMID: 20064430 - DOI: 10.1016/j.chembiol.2009.12.003
Chemical tools for dissecting bacterial physiology and virulence.
Biochemistry. 2009;48(37):8776-86 - PMID: 19653697 - DOI: 10.1021/bi9009083
Productive steps toward an antimicrobial targeting virulence.
Curr Opin Microbiol. 2009;12(5):490-6 - PMID: 19631578 - PMCID: PMC2763366 - DOI: 10.1016/j.mib.2009.06.012
Development of a second-generation antiandrogen for treatment of advanced prostate cancer.
Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants.
Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing.
Targeting virulence: a new paradigm for antimicrobial therapy.
Nat Chem Biol. 2007;3(9):541-8 - PMID: 17710100 - DOI: 10.1038/nchembio.2007.24
Virstatin inhibits dimerization of the transcriptional activator ToxT.
Proc Natl Acad Sci U S A. 2007;104(7):2372-7 - PMID: 17283330 - PMCID: PMC1892951 - DOI: 10.1073/pnas.0611643104
Chemical biology and bacteria: not simply a matter of life or death.
Curr Opin Chem Biol. 2006;10(4):321-6 - PMID: 16814591 - DOI: 10.1016/j.cbpa.2006.06.016
Bile acids stimulate biofilm formation in Vibrio cholerae.
Mol Microbiol. 2006;59(1):193-201 - PMID: 16359328 - DOI: 10.1111/j.1365-2958.2005.04846.x
Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization.
Science. 2005;310(5748):670-4 - PMID: 16223984 - DOI: 10.1126/science.1116739
Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner.
Proc Natl Acad Sci U S A. 2005;102(8):3028-33 - PMID: 15699331 - PMCID: PMC549475 - DOI: 10.1073/pnas.0409559102
Ductal lavage and the clinical management of women at high risk for breast carcinoma: a commentary.
Cancer. 2002;94(2):292-8 - PMID: 11900214 - DOI: 10.1002/cncr.10238
Ductal lavage for detection of cellular atypia in women at high risk for breast cancer.
J Natl Cancer Inst. 2001;93(21):1624-32 - PMID: 11698566 - DOI: 10.1093/jnci/93.21.1624
Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR.
Lancet. 2001;357(9265):1335-6 - PMID: 11343741 - DOI: 10.1016/s0140-6736(00)04501-3
Understanding and controlling the cell cycle with natural products.
Chem Biol. 1996;3(8):623-39 - PMID: 8807895 - DOI: 10.1016/s1074-5521(96)90129-5
(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest.
Chem Biol. 1996;3(4):287-93 - PMID: 8807856 - DOI: 10.1016/s1074-5521(96)90108-8
Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides.
Chem Biol. 1994;1(1):67-71 - PMID: 9383372 - DOI: 10.1016/1074-5521(94)90042-6
Thrombin receptor structure and function.
Cold Spring Harb Symp Quant Biol. 1993;57:149-54 - PMID: 1339654 - DOI: 10.1101/sqb.1992.057.01.019
Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location.
The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.
J Biol Chem. 1992;267(29):20831-4 - PMID: 1328213
Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
Semin Thromb Hemost. 1992;18(2):161-6 - PMID: 1321504 - DOI: 10.1055/s-2007-1002422
Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function.
J Biol Chem. 1992;267(19):13146-9 - PMID: 1320011
cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein.
Biochem Biophys Res Commun. 1992;184(2):733-8 - PMID: 1374240 - DOI: 10.1016/0006-291x(92)90651-z
HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides.
Proc Natl Acad Sci U S A. 1992;89(8):3429-33 - PMID: 1565634 - PMCID: PMC48881 - DOI: 10.1073/pnas.89.8.3429
Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation.
"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure.
Characterization of a functional thrombin receptor. Issues and opportunities.
Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor.
Domains specifying thrombin-receptor interaction.
Nature. 1991;353(6345):674-7 - PMID: 1717851 - DOI: 10.1038/353674a0
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
Cell. 1991;64(6):1057-68 - PMID: 1672265 - DOI: 10.1016/0092-8674(91)90261-v
Decreased cell kill of vincristine and methotrexate against 9L rat brain tumor cells in vitro caused by alpha-difluoromethylornithine-induced polyamine depletion.
Cancer Res. 1984;44(10):4440-2 - PMID: 6432313
Potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L rat brain tumor cells by methylglyoxal-bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase.
Eur J Cancer Clin Oncol. 1984;20(3):417-20 - PMID: 6538500 - DOI: 10.1016/0277-5379(84)90090-7
Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells.
Science. 1983;221(4608):368-70 - PMID: 6408733 - DOI: 10.1126/science.6408733
Sensitization of 9L rat brain gliosarcoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.
Cancer Res. 1981;41(7):2783-5 - PMID: 6788362
Preparation of an ecdysone immunogen for radioimmunoassay work.
J Biol Chem. 1980;255(13):6047-8 - PMID: 7190146