Publications - Hung - 2024
Poulsen BE, Warrier T, Barkho S, Bagnall J, Romano KP, White T, Yu X, Kawate T, Nguyen PH, Raines K, Ferrara K, Golas AL, FitzGerald M, Boeszoermenyi A, Kaushik V, Serrano-Wu M, Shoresh N, Hung DT
Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen. Cell Chem Biol. 2024;32(2):307-324.e15 - PMID: 39732052 - PMCID: PMC12117999 - DOI: 10.1016/j.chembiol.2024.12.001Romano KP, Bagnall J, Warrier T, Sullivan J, Ferrara K, Orzechowski M, Nguyen PH, Raines K, Livny J, Shoresh N, Hung DT
Perturbation-specific transcriptional mapping for unbiased target elucidation of antibiotics. Proc Natl Acad Sci U S A. 2024;121(45):e2409747121 - PMID: 39467118 - PMCID: PMC11551328 - DOI: 10.1073/pnas.2409747121Parada-Kusz M, Clatworthy AE, Goering ER, Blackwood SM, Shigeta JY, Mashin E, Salm EJ, Choi C, Combs S, Lee JSW, Rodriguez-Osorio C, Clish C, Tomita S, Hung DT
3-Hydroxykynurenine targets kainate receptors to promote defense against infection. Nat Chem Biol. 2024;20(12):1586-1596 - PMID: 38898166 - PMCID: PMC12204212 - DOI: 10.1038/s41589-024-01635-zRomano KP, Bagnall J, Warrier T, Sullivan J, Ferrara K, Orzechowski M, Nguyen PH, Raines K, Livny J, Shoresh N, Hung DT
Perturbation-Specific Transcriptional Mapping facilitates unbiased target elucidation of antibiotics. bioRxiv. 2024;:ePub - PMID: 38712067 - PMCID: PMC11071498 - DOI: 10.1101/2024.04.25.590978Poulsen BE, Warrier T, Barkho S, Bagnall J, Romano KP, White T, Yu X, Kawate T, Nguyen PH, Raines K, Ferrara K, Golas A, Fitzgerald M, Boeszoermenyi A, Kaushik V, Serrano-Wu M, Shoresh N, Hung DT
"Multiplexed screen identifies a Pseudomonas aeruginosa -specific small molecule targeting the outer membrane protein OprH and its interaction with LPS". bioRxiv. 2024;:ePub - PMID: 38559044 - PMCID: PMC10980007 - DOI: 10.1101/2024.03.16.585348Neo DM, Clatworthy AE, Hung DT
A dual-plasmid CRISPR/Cas9-based method for rapid and efficient genetic disruption in Mycobacterium abscessus. J Bacteriol. 2024;206(3):e0033523 - PMID: 38319218 - PMCID: PMC10955840 - DOI: 10.1128/jb.00335-23Sturm A, Sun P, Avila-Pacheco J, Clatworthy AE, Bloom-Ackermann Z, Wuo MG, Gomez JE, Jin S, Clish CB, Kiessling LL, Hung DT
Genetic factors affecting storage and utilization of lipids during dormancy in Mycobacterium tuberculosis. MBio. 2024;15(2):e0320823 - PMID: 38236034 - PMCID: PMC10865790 - DOI: 10.1128/mbio.03208-23
