Role of dietary fiber in the recovery of the human gut microbiome and its metabolome.

QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.

Sorting nexin 5 mediates virus-induced autophagy and immunity.

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41.

A missense variant in SLC39A8 confers risk for Crohn's disease by disrupting manganese homeostasis and intestinal barrier integrity.

USP15 Deubiquitinates CARD9 to Downregulate C-Type Lectin Receptor-Mediated Signaling.

Multi-"-Omics" Profiling in Patients With Quiescent Inflammatory Bowel Disease Identifies Biomarkers Predicting Relapse.

The Human and Mouse Enteric Nervous System at Single-Cell Resolution.

Linking strain engraftment in fecal microbiota transplantation with maintenance of remission in Crohn's disease.

Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.

Beth Cindy Levine (1960-2020).

Growth and the Microbiome - Integrating Global Health with Basic Science.

Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level.

Cell Type- and Stimulation-Dependent Transcriptional Programs Regulated by Atg16L1 and Its Crohn's Disease Risk Variant T300A.

Alterations in Fecal Microbiomes and Serum Metabolomes of Fatigued Patients With Quiescent Inflammatory Bowel Diseases.

Defining trained immunity and its role in health and disease.

Pathway paradigms revealed from the genetics of inflammatory bowel disease.

Global chemical effects of the microbiome include new bile-acid conjugations.

Growth effects of N-acylethanolamines on gut bacteria reflect altered bacterial abundances in inflammatory bowel disease.

Comprehensive analysis of chromosomal mobile genetic elements in the gut microbiome reveals phylum-level niche-adaptive gene pools.

Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses.

Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1.

Use of narrative concepts in the EHR to validate genetic determinants of treatment response in a virtual inflammatory bowel disease cohort.

Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease.

Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships.

Predictive metabolomic profiling of microbial communities using amplicon or metagenomic sequences.

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis.

Microbial genes and pathways in inflammatory bowel disease.

Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide.

Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis.

Correction: Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases.

Induction of the metal transporter ZIP8 by interferon gamma in intestinal epithelial cells: Potential role of metal dyshomeostasis in Crohn's disease.

Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.

Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis.

Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans.

Adaptive Evolution within Gut Microbiomes of Healthy People.

Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk: A Cross-Sectional Study.

Author Correction: Gut microbiome structure and metabolic activity in inflammatory bowel disease.

Gut Microbiota Regulation of T Cells During Inflammation and Autoimmunity.

Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study.

Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential: (Trends Endocrinol. Metab. 29, 723-735, 2018).

Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity.

SLC39A8 missense variant is associated with Crohn's disease but does not have a major impact on gut microbiome composition in healthy subjects.

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity.

The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response.

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response.

Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome.

An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread.

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study.

Temporal development of the gut microbiome in early childhood from the TEDDY study.

Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes.

Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course.

Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential.

TMEM41B is a novel regulator of autophagy and lipid mobilization.

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome.

Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.

The causes and consequences of variation in human cytokine production in health.

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses.

Genetic Markers Predict Primary Nonresponse and Durable Response to Anti-Tumor Necrosis Factor Therapy in Ulcerative Colitis.

Without Adaptive Immunity, There's a Cost to Responding STAT.

A common mechanism links activities of butyrate in the colon.

C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.

Strain Tracking Reveals the Determinants of Bacterial Engraftment in the Human Gut Following Fecal Microbiota Transplantation.

Host genetic variation and its microbiome interactions within the Human Microbiome Project.

Loss of Response to Anti-Tumor Necrosis Factor Alpha Therapy in Crohn's Disease Is Not Associated with Emergence of Novel Inflammatory Pathways.

Genomic and expression analyses identify a disease modifying variant for fibrostenotic Crohn's disease.

Dynamics of metatranscription in the inflammatory bowel disease gut microbiome.

A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients.

A single-cell survey of the small intestinal epithelium.

A role for bacterial urease in gut dysbiosis and Crohn's disease.

Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo.

p40 (phox) -Deficient Mice Exhibit Impaired Bacterial Clearance and Enhanced Pro-inflammatory Responses during Salmonella enterica serovar Typhimurium Infection.

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease.

SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCε-dependent Pathway.

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation.

Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.

The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.

SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCε-dependent Pathway.

Human genetic variation and the gut microbiome in disease.

Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine.

Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children.

Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.

Fine-mapping inflammatory bowel disease loci to single-variant resolution.

E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.

Dissecting the human microbiome with single-cell genomics.

Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota.

Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies.

Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases.

Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.

Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140.

A Microbiome Foundation for the Study of Crohn's Disease.

Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study.

The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.

The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD).

The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.

TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.

Visceral Adiposity, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.

Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits.

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

Host and Environmental Factors Influencing Individual Human Cytokine Responses.

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.

RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy.

Vedolizumab Therapy Is Associated with an Improvement in Sleep Quality and Mood in Inflammatory Bowel Diseases.

SIKs control osteocyte responses to parathyroid hormone.

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease.

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.

Increased Intestinal Microbial Diversity Following Fecal Microbiota Transplant for Active Crohn's Disease.

Characterization of candidate genes in inflammatory bowel disease-associated risk loci.

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Understanding human immune function using the resources from the Human Functional Genomics Project.

A pleiotropic missense variant in SLC39A8 is associated with Crohn's disease and human gut microbiome composition.

Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease.

Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62.

Microbiota as Therapeutic Targets.

Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks.

The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1.

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.

Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability.

Metagenomic Characterization of Microbial Communities In Situ Within the Deeper Layers of the Ileum in Crohn's Disease.

Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function In Vivo.

Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing.

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.

Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn's Disease Phenotypes.

Mechanisms of Pediatric Inflammatory Bowel Disease.

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.

Trained immunity: A program of innate immune memory in health and disease.

Timothy C. Wang, MD: Our next AGA President.

?v Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells.

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.

New Regulatory Roles of Galectin-3 in the High-affinity IgE Receptor Signaling.

Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Proton pump inhibitors affect the gut microbiome.

Flow Cytometric Analysis of Mononuclear Phagocytes in Non-diseased Human Lung and Lung-draining Lymph Nodes.

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids.

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-?-Activated Human Cells.

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-?-Activated Human Cells.

ConStrains identifies microbial strains in metagenomic datasets.

Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.

Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.

Common Genetic Variants Influence Circulating Vitamin D Levels in Inflammatory Bowel Diseases.

Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples.

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.

Body Mass Index, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.

Role of Autophagy in the Maintenance of Intestinal Homeostasis.

Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.

Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease.

CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation.

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.

An Integrative View of Microbiome-Host Interactions in Inflammatory Bowel Diseases.

Discovery of a Small-Molecule Probe for V-ATPase Function.

Associations between host gene expression, the mucosal microbiome, and clinical outcome in the pelvic pouch of patients with inflammatory bowel disease.

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.

A novel role for KLF14 in T regulatory cell differentiation.

The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes.

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease.

Pyruvate Kinase M2 Regulates Hif-1? Activity and IL-1? Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.

Early life environment and natural history of inflammatory bowel diseases.

Complex host genetics influence the microbiome in inflammatory bowel disease.

Autophagy and checkpoints for intracellular pathogen defense.

Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer.

BCG-induced trained immunity in NK cells: Role for non-specific protection to infection.

Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism.

An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse.

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.

Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.

Small-molecule control of cytokine function: new opportunities for treating immune disorders.

Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.

mTOR- and HIF-1?-mediated aerobic glycolysis as metabolic basis for trained immunity.

Multivariate inference of pathway activity in host immunity and response to therapeutics.

An alteration in ATG16L1 stability in Crohn disease.

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.

SLCO3A1, a Novel Crohn's Disease-Associated Gene, Regulates NF-?B Activity and Associates with Intestinal Perforation.

Inflammatory Bowel Disease as a Model for Translating the Microbiome.

Dectin-1 dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages.

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

Genetic Polymorphisms in Metabolizing Enzymes Modifying the Association Between Smoking and Inflammatory Bowel Diseases.

The treatment-naive microbiome in new-onset Crohn's disease.

Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response.

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans.

The Microbiome in Inflammatory Bowel Diseases: Current Status and the Future Ahead.

SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.

Differential Effect of Genetic Burden on Disease Phenotypes in Crohn's Disease and Ulcerative Colitis: Analysis of a North American Cohort.

Autophagy is essential for cardiac morphogenesis during vertebrate development.

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.

Autophagy is redundant for the host defense against systemic Candida albicans infections.

Autophagy at the crossroads of metabolism and cellular defense.

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity.

Selective Modulation of Autophagy, Innate Immunity, and Adaptive Immunity by Small Molecules.

Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL.

Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome.

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis.

Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice from Salmonella Infection.

Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism.

Functional profiling of the gut microbiome in disease-associated inflammation.

Genetic risk factors for Clostridium difficile infection in ulcerative colitis.

Skin Microbiome Imbalance in Patients with STAT1/STAT3 Defects Impairs Innate Host Defense Responses.

Card9 Mediates Intestinal Epithelial Cell Restitution, T-helper 17 Responses, and Control of Bacterial Infection in Mice.

Conformational stability, vibrational spectra, HOMO-LUMO and NBO analysis of 1,3,4-thiadiazolidine-2,5-dithione with experimental (FT-IR and FT-Raman) techniques and scaled quantum mechanical calculations.

How Does Genotype Influence Disease Phenotype in Inflammatory Bowel Disease?

Concomitant BRAF and PI3K/mTOR Blockade Is Required for Effective Treatment of BRAFV600E Colorectal Cancer.

From genetics of inflammatory bowel disease towards mechanistic insights.

Genome-wide Analysis of Immune System Genes by Expressed Sequence Tag Profiling.

Succinate is an inflammatory signal that induces IL-1? through HIF-1?.

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.

Polarity gene discs large homolog 1 regulates the generation of memory T cells.

Cutting Edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells.

Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation.

Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing.

?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.

Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1? (IL-1?).

Identification of a candidate therapeutic autophagy-inducing peptide.

ATG5 regulates plasma cell differentiation.

Angiotensin II Drives the Production of Tumor-Promoting Macrophages.

Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans.

The LRR and RING Domain Protein LRSAM1 Is an E3 Ligase Crucial for Ubiquitin-Dependent Autophagy of Intracellular Salmonella Typhimurium.

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Common alleles that influence autophagy and the risk for inflammatory bowel disease.

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment.

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes.

Essential cell autonomous role for interferon regulatory factor 1 in interferon-?-mediated inhibition of norovirus replication in macrophages.

p40phox Expression Regulates Neutrophil Recruitment and Function during the Resolution Phase of Intestinal Inflammation.

Enhanced Tim3 Activity Improves Survival after Influenza Infection.

Enhanced Tim3 activity improves survival after influenza infection.

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes.

Case 23-2012.

Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease.

Helminth Infection Impairs Autophagy-Mediated Killing of Bacterial Enteropathogens by Macrophages.

Establishment and characterization of a novel chordoma cell line: CH22.

Regulation of monocyte functional heterogeneity by miR-146a and Relb.

Autophagy and the immune system.

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma.

Guidelines for the use and interpretation of assays for monitoring autophagy.

ONCOGENIC KRAS REGULATES BMP4 EXPRESSION IN COLON CANCER CELL LINES.

Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling.

Genome-wide siRNA screen for mediators of NF-?B activation.

Image-based genome-wide siRNA screen identifies selective autophagy factors.

CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.

Caspase 8 inhibits programmed necrosis by processing CYLD.

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.

HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.

Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.

Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.

Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging.

Genetics and pathogenesis of inflammatory bowel disease.

A Francisella tularensis locus required for spermine responsiveness is necessary for virulence.

MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.

Recurrent chromosomal copy number alterations in sporadic chordomas.

Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.

Crohn disease: a current perspective on genetics, autophagy and immunity.

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.

Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions.

Failure and exploitation of autophagy in human pathologies-cellular integrity between inflammation, infection, and cell survival.

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.

LRRK2 is involved in the IFN-gamma response and host response to pathogens.

Human IRGM gene "to be or not to be".

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.

Wnt signaling regulates mitochondrial physiology and insulin sensitivity.

A systems biology viewpoint on autophagy in health and disease.

A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.

Characterization and analysis of human chordoma cell lines.

Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.

Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression.

Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor.

Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.

Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases.

The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.

Common variants at five new loci associated with early-onset inflammatory bowel disease.

Autophagy, immunity and human disease.

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.

A genome-wide genetic screen for host factors required for hepatitis C virus propagation.

Building complex biological networks based upon model organisms: mapping the human autophagy interactome via a hybrid yeast-human protein interaction network.

Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes.

Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.

The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.

A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.

Selective activation of nuclear factor kappa B in the cochlea by sensory and inflammatory stress.

Selective activation of nuclear factor kappa B in the cochlea by sensory and inflammatory stress.

A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.

Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.

HIF-1alpha and HIF-2alpha have divergent roles in colon cancer.

On the level: IRGM gene function is all about expression.

Differential requirement for CARMA1 in agonist-selected T-cell development.

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.

Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

RNA interference screen for human genes associated with West Nile virus infection.

Genome-wide association studies: a new window into immune-mediated diseases.

Genome-wide association studies: a new window into immune-mediated diseases.

MAST3: a novel IBD risk factor that modulates TLR4 signaling.

Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth.

Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling.

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.

Neither hide nor hair: the difficulty of identifying useful disease biomarkers.

Spinophilin and the immune synapse.

Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.

Improvement of bone disease by imiglucerase (Cerezyme) therapy in patients with skeletal manifestations of type 1 Gaucher disease: results of a 48-month longitudinal cohort study.

Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.

Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis.

Defective signal transduction in B lymphocytes lacking presenilin proteins.

Identification of host proteins required for HIV infection through a functional genomic screen.

SNPping away at the pathogenesis of Crohn's disease.

AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling.

Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.

DLGH1 is a negative regulator of T-lymphocyte proliferation.

Unravelling the pathogenesis of inflammatory bowel disease.

Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine.

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter.

Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation.

Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation.

A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands.

Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation.

Isolation and analysis of lipid rafts in cell-cell interactions.

Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes.

CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma.

Nore1B regulates TCR signaling via Ras and Carma1.

Large-scale screens for cDNAs with in vivo activity.

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition.

PDZ domains and the politics of polarity in lymphocytes.

Commensal flora: wolf in sheep's clothing.

GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells.

Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells.

Wave2 activates serum response element via its VCA region and functions downstream of Rac.

Discs large (Dlg1) complexes in lymphocyte activation.

The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.

Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor.

Paradoxical roles of different nitric oxide synthase isoforms in colonic injury.

Colonic epithelial functional phenotype varies with type and phase of experimental colitis.

Essential role for Vav1 in activation, but not development, of gammadelta T cells.

Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells.

Decreased bone density in splenectomized Gaucher patients receiving enzyme replacement therapy.

Identification of a novel Ras-regulated proapoptotic pathway.

Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice.

L-histidine decarboxylase decreases its own transcription through downregulation of ERK activity.

Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system.

Gaucher disease. New approaches to an ancient disease.

TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome.

Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice.

Microbiology. How to get along--friendly microbes in a hostile world.

Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa.

A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells.

Membrane compartmentation and the response to antigen.

Health information in the developing world.

Tumor induction of VEGF promoter activity in stromal cells.

Membrane compartmentation is required for efficient T cell activation.

SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development.

Paracoccidioidomycosis of bones and joints. A clinical, radiologic, and pathologic study of 9 cases.

Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.

Clustered syk tyrosine kinase domains trigger phagocytosis.

Atheroembolic renal failure after invasive procedures. Natural history based on 52 histologically proven cases.

Enzyme replacement therapy for Gaucher disease: skeletal responses to macrophage-targeted glucocerebrosidase.

Malignant epithelioid hemangioendothelioma of the tibia associated with a bone infarct in a patient who had Gaucher disease. A case report.

Nonreceptor tyrosine kinases in aggregation-mediated cell activation.

Peroxynitrite-induced rat colitis--a new model of colonic inflammation.

Value of the history and stool occult blood test in selection of patients for upper endoscopy in Zimbabwe.