Characterization of Five Novel Anti-MRSA Compounds Identified Using a Whole-Animal Caenorhabditis elegans/Galleria mellonella Sequential-Screening Approach.

Khader R, Tharmalingam N, Mishra B, Felix L, Ausubel FM, Kelso MJ, Mylonakis E
Antibiotics (Basel). 2020;9(8):ePub - PMID: 32726955 - PMCID: PMC7459823 - DOI: 10.3390/antibiotics9080449

The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus.

Kim W, Zou G, Pan W, Fricke N, Faizi HA, Kim SM, Khader R, Li S, Lee K, Escorba I, Vlahovska PM, Gao H, Ausubel FM, Mylonakis E
MBio. 2020;11(3):ePub - PMID: 32605985 - PMCID: PMC7327171 - DOI: 10.1128/mBio.01140-20

The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans.

Vasquez-Rifo A, Veksler-Lublinsky I, Cheng Z, Ausubel FM, Ambros V
Genome Biol. 2019;20(1):270 - PMID: 31823826 - PMCID: PMC6902481 - DOI: 10.1186/s13059-019-1890-1

A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus.

Kim W, Zou G, Hari TPA, Wilt IK, Zhu W, Galle N, Faizi HA, Hendricks GL, Tori K, Pan W, Huang X, Steele AD, Csatary EE, Dekarske MM, Rosen JL, Ribeiro NQ, Lee K, Port J, Fuchs BB, Vlahovska PM, Wuest WM, Gao H, Ausubel FM, Mylonakis E
Proc Natl Acad Sci U S A. 2019;116(33):16529-16534 - PMID: 31358625 - PMCID: PMC6697817 - DOI: 10.1073/pnas.1904700116

Tracing My Roots: How I Became a Plant Biologist.

Ausubel FM
Annu Rev Genet. 2018;52:1-20 - PMID: 30192637 - DOI: 10.1146/annurev-genet-120417-031722

Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters.

Kim W, Steele AD, Zhu W, Csatary EE, Fricke N, Dekarske MM, Jayamani E, Pan W, Kwon B, Sinitsa IF, Rosen JL, Conery AL, Fuchs BB, Vlahovska PM, Ausubel FM, Gao H, Wuest WM, Mylonakis E
ACS Infect Dis. 2018;4(11):1540-1545 - PMID: 30132650 - PMCID: PMC6468991 - DOI: 10.1021/acsinfecdis.8b00161

A new class of synthetic retinoid antibiotics effective against bacterial persisters.

Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N, Conery AL, Shen S, Pan W, Lee K, Rajamuthiah R, Fuchs BB, Vlahovska PM, Wuest WM, Gilmore MS, Gao H, Ausubel FM, Mylonakis E
Nature. 2018;556(7699):103-107 - PMID: 29590091 - PMCID: PMC6462414 - DOI: 10.1038/nature26157

Quorum-sensing regulator RhlR but not its autoinducer RhlI enablesPseudomonasto evade opsonization.

Haller S, Franchet A, Hakkim A, Chen J, Drenkard E, Yu S, Schirmeier S, Li Z, Martins N, Ausubel FM, Liégeois S, Ferrandon D
EMBO Rep. 2018;19(5):ePub - PMID: 29523648 - PMCID: PMC5934776 - DOI: 10.15252/embr.201744880

Both live and dead Enterococci activate Caenorhabditis elegans host defense via immune and stress pathways.

Yuen GJ, Ausubel FM
Virulence. 2018;9(1):0 - PMID: 29436902 - PMCID: PMC5955442 - DOI: 10.1080/21505594.2018.1438025

An Anti-Persister Strategy for the Treatment of Chronic Pseudomonas aeruginosa Infections.

Koeva M, Gutu AD, Hebert W, Wager JD, Yonker LM, O'Toole GA, Ausubel FM, Moskowitz SM, Joseph-McCarthy D
Antimicrob Agents Chemother. 2017;61(12):ePub - PMID: 28923873 - PMCID: PMC5700368 - DOI: 10.1128/AAC.00987-17

Investment in secreted enzymes during nutrient-limited growth is utility dependent.

Cezairliyan B, Ausubel FM
Proc Natl Acad Sci U S A. 2017;114(37):E7796-E7802 - PMID: 28847943 - PMCID: PMC5604031 - DOI: 10.1073/pnas.1708580114

Characterization of a Francisella tularensis-Caenorhabditis elegans pathosystem for the evaluation of therapeutic compounds.

Jayamani E, Tharmalingam N, Rajamuthiah R, Coleman JJ, Kim W, Okoli I, Hernandez AM, Lee K, Nau GJ, Ausubel FM, Mylonakis E
Antimicrob Agents Chemother. 2017;61(9):ePub - PMID: 28652232 - PMCID: PMC5571314 - DOI: 10.1128/AAC.00310-17

The NBS-LRR architectures of plant R-proteins and metazoan NLRs evolved in independent events.

Urbach JM, Ausubel FM
Proc Natl Acad Sci U S A. 2017;114(5):1063-1068 - PMID: 28096345 - PMCID: PMC5293065 - DOI: 10.1073/pnas.1619730114

Influence of maternal breast milk ingestion on acquisition of the intestinal microbiome in preterm infants.

Gregory KE, Samuel BS, Houghteling P, Shan G, Ausubel FM, Sadreyev RI, Walker WA
Microbiome. 2016;4(1):68 - PMID: 28034306 - PMCID: PMC5200970 - DOI: 10.1186/s40168-016-0214-x

Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway.

McEwan DL, Feinbaum RL, Stroustrup N, Haas W, Conery AL, Anselmo A, Sadreyev R, Ausubel FM
BMC Biol. 2016;14(1):105 - PMID: 27927200 - PMCID: PMC5143455 - DOI: 10.1186/s12915-016-0334-6

Introduction to Gene Editing and Manipulation Using CRISPR/Cas9 Technology.

Newman M, Ausubel FM
Curr Protoc Mol Biol. 2016;115:31.4.1-6 - PMID: 27366890 - PMCID: PMC4963815 - DOI: 10.1002/cpmb.14

Mutation of the Glucosinolate Biosynthesis Enzyme Cytochrome P450 83A1 Monooxygenase Increases Camalexin Accumulation and Powdery Mildew Resistance.

Liu S, Bartnikas LM, Volko SM, Ausubel FM, Tang D
Front Plant Sci. 2016;7:227 - PMID: 26973671 - PMCID: PMC4774424 - DOI: 10.3389/fpls.2016.00227

NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption.

Kim W, Fricke N, Conery AL, Fuchs BB, Rajamuthiah R, Jayamani E, Vlahovska PM, Ausubel FM, Mylonakis E
Future Med Chem. 2016;8(3):257-69 - PMID: 26910612 - PMCID: PMC4976882 - DOI: 10.4155/fmc.15.189

On the Mechanism of Berberine-INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials.

Dolla NK, Chen C, Larkins-Ford J, Rajamuthiah R, Jagadeesan S, Conery AL, Ausubel FM, Mylonakis E, Bremner JB, Lewis K, Kelso MJ
Aust J Chem. 2016;67:1471-1480 - PMID: 26806960 - PMCID: PMC4720975 - DOI: 10.1071/CH14426

Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile.

Rajamuthiah R, Jayamani E, Majed H, Conery AL, Kim W, Kwon B, Fuchs BB, Kelso MJ, Ausubel FM, Mylonakis E
Bioorg Med Chem Lett. 2015;25(22):5203-7 - PMID: 26459212 - PMCID: PMC4718707 - DOI: 10.1016/j.bmcl.2015.09.066

Enhancing immunity by engineering DAMPs.

Cervone F, Ausubel FM, Lorenzo G
Oncotarget. 2015;6(30):28523-4 - PMID: 26387132 - PMCID: PMC4745668 - DOI: 10.18632/oncotarget.5251

MICROBIOME. Plant microbiome blueprints.

Haney CH, Ausubel FM
Science. 2015;349(6250):788-9 - PMID: 26293938 - DOI: 10.1126/science.aad0092

Pseudomonas syringae enhances herbivory by suppressing the reactive oxygen burst in Arabidopsis.

Groen SC, Humphrey PT, Chevasco D, Ausubel FM, Pierce NE, Whiteman NK
J Insect Physiol. 2016;84:90-102 - PMID: 26205072 - PMCID: PMC4721946 - DOI: 10.1016/j.jinsphys.2015.07.011

A Defensin from the Model Beetle Tribolium castaneum Acts Synergistically with Telavancin and Daptomycin against Multidrug Resistant Staphylococcus aureus.

Rajamuthiah R, Jayamani E, Conery AL, Fuchs BB, Kim W, Johnston T, Vilcinskas A, Ausubel FM, Mylonakis E
PLoS One. 2015;10(6):e0128576 - PMID: 26062137 - PMCID: PMC4465704 - DOI: 10.1371/journal.pone.0128576

Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy.

Kim W, Conery AL, Rajamuthiah R, Fuchs BB, Ausubel FM, Mylonakis E
PLoS One. 2015;10(6):e0127640 - PMID: 26039584 - PMCID: PMC4454602 - DOI: 10.1371/journal.pone.0127640

Associations with rhizosphere bacteria can confer an adaptive advantage to plants.

Haney CH, Samuel BS, Bush J, Ausubel FM
Nat Plants. 2015;1(6):ePub - PMID: 27019743 - PMCID: PMC4806546 - DOI: 10.1038/nplants.2015.51

Associations with rhizosphere bacteria can confer an adaptive advantage to plants.

Haney CH, Samuel BS, Bush J, Ausubel FM
Nat Plants. 2015;1:15051 - PMID: 27250003

Jasmonate signalling in Arabidopsis involves SGT1b-HSP70-HSP90 chaperone complexes.

Zhang XC, Millet YA, Cheng Z, Bush J, Ausubel FM
Nat Plants. 2015;1:ePub - PMID: 27054042 - PMCID: PMC4819967 - DOI: 10.1038/nplants.2015.49

Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus.

Rajamuthiah R, Fuchs BB, Conery AL, Kim W, Jayamani E, Kwon B, Ausubel FM, Mylonakis E
PLoS One. 2015;10(4):e0124595 - PMID: 25897961 - PMCID: PMC4405337 - DOI: 10.1371/journal.pone.0124595

Plant immunity triggered by engineered in vivo release of oligogalacturonides, damage-associated molecular patterns.

Benedetti M, Pontiggia D, Raggi S, Cheng Z, Scaloni F, Ferrari S, Ausubel FM, Cervone F, De Lorenzo G
Proc Natl Acad Sci U S A. 2015;112(17):5533-8 - PMID: 25870275 - PMCID: PMC4418913 - DOI: 10.1073/pnas.1504154112

Pathogen-secreted proteases activate a novel plant immune pathway.

Cheng Z, Li JF, Niu Y, Zhang XC, Woody OZ, Xiong Y, Djonovi? S, Millet Y, Bush J, McConkey BJ, Sheen J, Ausubel FM
Nature. 2015;521(7551):213-6 - PMID: 25731164 - PMCID: PMC4433409 - DOI: 10.1038/nature14243

A new antibiotic with potent activity targets MscL.

Iscla I, Wray R, Blount P, Larkins-Ford J, Conery AL, Ausubel FM, Ramu S, Kavanagh A, Huang JX, Blaskovich MA, Cooper MA, Obregon-Henao A, Orme I, Tjandra ES, Stroeher UH, Brown MH, Macardle C, van Holst N, Ling Tong C, Slattery AD, Gibson CT, Raston CL, Boulos RA
J Antibiot (Tokyo). 2015;68(7):453-62 - PMID: 25649856 - PMCID: PMC4430313 - DOI: 10.1038/ja.2015.4

Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa.

Kirienko NV, Ausubel FM, Ruvkun G
Proc Natl Acad Sci U S A. 2015;112(6):1821-6 - PMID: 25624506 - PMCID: PMC4330731 - DOI: 10.1073/pnas.1424954112

Insect-derived Cecropins Display Activity Against Acinetobacter baumannii in a Whole-Animal High-Throughput Caenorhabditis elegans Model.

Jayamani E, Rajamuthiah R, Larkins-Ford J, Fuchs BB, Conery AL, Vilcinskas A, Ausubel FM, Mylonakis E
Antimicrob Agents Chemother. 2015;59(3):1728-37 - PMID: 25583713 - PMCID: PMC4325797 - DOI: 10.1128/AAC.04198-14

Next-Gen Sequencing-Based Mapping and Identification of Ethyl Methanesulfonate-Induced Mutations in Arabidopsis thaliana.

Zhang XC, Millet Y, Ausubel FM, Borowsky M
Curr Protoc Mol Biol. 2014;108:7.18.1-16 - PMID: 25271717 - DOI: 10.1002/0471142727.mb0718s108

Twists and turns: my career path and concerns about the future.

Ausubel FM
Genetics. 2014;198(2):431-4 - PMID: 25316778 - PMCID: PMC4196596 - DOI: 10.1534/genetics.114.169102

Apoplastic peroxidases are required for salicylic acid-mediated defense against Pseudomonas syringae.

Mammarella ND, Cheng Z, Fu ZQ, Daudi A, Bolwell GP, Dong X, Ausubel FM
Phytochemistry. 2015;112:110-121 - PMID: 25096754 - PMCID: PMC4314520 - DOI: 10.1016/j.phytochem.2014.07.010

The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification.

Pukkila-Worley R, Feinbaum RL, McEwan DL, Conery AL, Ausubel FM
PLoS Pathog. 2014;10(5):e1004143 - PMID: 24875643 - PMCID: PMC4038581 - DOI: 10.1371/journal.ppat.1004143

Pseudomonas aeruginosa PA14 Pathogenesis in Caenorhabditis elegans.

Kirienko NV, Cezairliyan BO, Ausubel FM, Powell JR
Methods Mol Biol. 2014;1149:653-69 - PMID: 24818940 - DOI: 10.1007/978-1-4939-0473-0_50

High-Throughput Screening for Novel Anti-Infectives Using a C. elegans Pathogenesis Model.

Conery AL, Larkins-Ford J, Ausubel FM, Kirienko NV
Curr Protoc Chem Biol. 2014;6(1):25-37 - PMID: 24652621 - PMCID: PMC4021578 - DOI: 10.1002/9780470559277.ch130160

Enterococcus infection biology: Lessons from invertebrate host models.

Yuen GJ, Ausubel FM
J Microbiol. 2014;52(3):200-10 - PMID: 24585051 - PMCID: PMC4556283 - DOI: 10.1007/s12275-014-4011-6

Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus.

Rajamuthiah R, Fuchs BB, Jayamani E, Kim Y, Larkins-Ford J, Conery A, Ausubel FM, Mylonakis E
PLoS One. 2014;9(2):e89189 - PMID: 24586584 - PMCID: PMC3929655 - DOI: 10.1371/journal.pone.0089189

Pathogen-Triggered Ethylene Signaling Mediates Systemic-Induced Susceptibility to Herbivory in Arabidopsis.

Groen SC, Whiteman NK, Bahrami AK, Wilczek AM, Cui J, Russell JA, Cibrian-Jaramillo A, Butler IA, Rana JD, Huang GH, Bush J, Ausubel FM, Pierce NE
Plant Cell. 2013;25(11):4755-66 - PMID: 24285796 - PMCID: PMC3875748 - DOI: 10.1105/tpc.113.113415

Virulence profile: Frederick M Ausubel.

Ausubel FM
Virulence. 2013;4(8):730-3 - PMID: 24481134 - PMCID: PMC3925705 - DOI: 10.4161/viru.26579

Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death.

Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM
Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003

Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death.

Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM
Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003

Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants.

Djonovi? S, Urbach JM, Drenkard E, Bush J, Feinbaum R, Ausubel JL, Traficante D, Risech M, Kocks C, Fischbach MA, Priebe GP, Ausubel FM
PLoS Pathog. 2013;9(3):e1003217 - PMID: 23505373 - PMCID: PMC3591346 - DOI: 10.1371/journal.ppat.1003217

Identification of Pseudomonas aeruginosa Phenazines that Kill Caenorhabditis elegans.

Cezairliyan B, Vinayavekhin N, Grenfell-Lee D, Yuen GJ, Saghatelian A, Ausubel FM
PLoS Pathog. 2013;9(1):e1003101 - PMID: 23300454 - PMCID: PMC3536714 - DOI: 10.1371/journal.ppat.1003101

FLS2-Mediated Responses to Ax21-Derived Peptides: Response to the Mueller et al. Commentary.

Danna CH, Zhang XC, Khatri A, Bent AF, Ronald PC, Ausubel FM
Plant Cell. 2012;24(8):3174-6 - PMID: 22923675 - PMCID: PMC3462622 - DOI: 10.1105/tpc.112.099275

Genome-Wide Identification of Pseudomonas aeruginosa Virulence-Related Genes Using a Caenorhabditis elegans Infection Model.

Feinbaum RL, Urbach JM, Liberati NT, Djonovic S, Adonizio A, Carvunis AR, Ausubel FM
PLoS Pathog. 2012;8(7):e1002813 - PMID: 22911607 - PMCID: PMC3406104 - DOI: 10.1371/journal.ppat.1002813

Genes Involved in the Evolution of Herbivory By A Leaf-Mining, Drosophilid Fly.

Whiteman NK, Gloss AD, Sackton TB, Groen SC, Humphrey PT, Lapoint RT, Sønderby IE, Halkier BA, Kocks C, Ausubel FM, Pierce NE
Genome Biol Evol. 2012;4(9):900-16 - PMID: 22813779 - PMCID: PMC3516228 - DOI: 10.1093/gbe/evs063

Perception of volatiles produced by UVC-irradiated plants alters the response to viral infection in naïve neighboring plants.

Yao Y, Danna CH, Ausubel FM, Kovalchuk I
Plant Signal Behav. 2012;7(7):741-5 - PMID: 22751319 - PMCID: PMC3583953 - DOI: 10.4161/psb.20406

Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection.

Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL, Ausubel FM
PLoS Genet. 2012;8(6):e1002733 - PMID: 22719261 - PMCID: PMC3375230 - DOI: 10.1371/journal.pgen.1002733

An image analysis toolbox for high-throughput C. elegans assays.

Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE
Nat Methods. 2012;9(7):714-6 - PMID: 22522656 - PMCID: PMC3433711 - DOI: 10.1038/nmeth.1984

Host Translational Inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an Immune Response in Caenorhabditis elegans.

McEwan DL, Kirienko NV, Ausubel FM
Cell Host Microbe. 2012;11(4):364-74 - PMID: 22520464 - PMCID: PMC3334877 - DOI: 10.1016/j.chom.2012.02.007

A Peroxidase-Dependent Apoplastic Oxidative Burst in Cultured Arabidopsis Cells Functions in MAMP-Elicited Defense.

O'Brien JA, Daudi A, Finch P, Butt VS, Whitelegge JP, Souda P, Ausubel FM, Bolwell GP
Plant Physiol. 2012;158(4):2013-27 - PMID: 22319074 - PMCID: PMC3320203 - DOI: 10.1104/pp.111.190140

The apoplastic oxidative burst peroxidase in Arabidopsis is a major component of pattern-triggered immunity.

Daudi A, Cheng Z, O'Brien JA, Mammarella N, Khan S, Ausubel FM, Bolwell GP
Plant Cell. 2012;24(1):275-87 - PMID: 22247251 - PMCID: PMC3289579 - DOI: 10.1105/tpc.111.093039

Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium.

Pukkila-Worley R, Ausubel FM
Curr Opin Immunol. 2012;24(1):3-9 - PMID: 22236697 - PMCID: PMC3660727 - DOI: 10.1016/j.coi.2011.10.004

UV-C-irradiated Arabidopsis and tobacco emit volatiles that trigger genomic instability in neighboring plants.

Yao Y, Danna CH, Zemp FJ, Titov V, Ciftci ON, Przybylski R, Ausubel FM, Kovalchuk I
Plant Cell. 2011;23(10):3842-52 - PMID: 22028460 - PMCID: PMC3229153 - DOI: 10.1105/tpc.111.089003

Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model.

Limmer S, Haller S, Drenkard E, Lee J, Yu S, Kocks C, Ausubel FM, Ferrandon D
Proc Natl Acad Sci U S A. 2011;108(42):17378-83 - PMID: 21987808 - PMCID: PMC3198323 - DOI: 10.1073/pnas.1114907108

automated DNA sequencing technology.

Slatko BE, Kieleczawa J, Ju J, Gardner AF, Hendrickson CL, Ausubel FM
Curr Protoc Mol Biol. 2011;Chapter 7:Unit7.2 - PMID: 21987057 - DOI: 10.1002/0471142727.mb0702s96

Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses.

Pukkila-Worley R, Ausubel FM, Mylonakis E
PLoS Pathog. 2011;7(6):e1002074 - PMID: 21731485 - PMCID: PMC3121877 - DOI: 10.1371/journal.ppat.1002074

The Arabidopsis flagellin receptor FLS2 mediates the perception of Xanthomonas Ax21 secreted peptides.

Danna CH, Millet YA, Koller T, Han SW, Bent AF, Ronald PC, Ausubel FM
Proc Natl Acad Sci U S A. 2011;108(22):9286-91 - PMID: 21576467 - PMCID: PMC3107323 - DOI: 10.1073/pnas.1106366108

A high throughput amenable Arabidopsis-P. aeruginosa system reveals a rewired regulatory module and the utility to identify potent anti-infectives.

Gopalan S, Ausubel FM
PLoS One. 2011;6(1):e16381 - PMID: 21283656 - PMCID: PMC3025032 - DOI: 10.1371/journal.pone.0016381

Morphology-guided graph search for untangling objects: C. elegans analysis.

Raviv TR, Ljosa V, Conery AL, Ausubel FM, Carpenter AE, Golland P, Wählby C
Med Image Comput Comput Assist Interv. 2010;13(Pt 3):634-41 - PMID: 20879454 - PMCID: PMC3050593 - DOI: 10.1007/978-3-642-15711-0_79

Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus.

Irazoqui JE, Troemel ER, Feinbaum RL, Luhachack LG, Cezairliyan BO, Ausubel FM
PLoS Pathog. 2010;6:e1000982 - PMID: 20617181 - PMCID: PMC2895663 - DOI: 10.1371/journal.ppat.1000982

RESOLVING CLUSTERED WORMS VIA PROBABILISTIC SHAPE MODELS.

Wählby C, Riklin-Raviv T, Ljosa V, Conery AL, Golland P, Ausubel FM, Carpenter AE
Proc IEEE Int Symp Biomed Imaging. 2010;2010(14-17 April 2010):552-555 - PMID: 21383863 - PMCID: PMC3048333 - DOI: 10.1109/ISBI.2010.5490286

Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components.

Tomkiewicz D, Casadei G, Larkins-Ford J, Moy TI, Garner J, Bremner JB, Ausubel FM, Lewis K, Kelso MJ
Antimicrob Agents Chemother. 2010;54(8):3219-24 - PMID: 20498327 - PMCID: PMC2916310 - DOI: 10.1128/AAC.01715-09

99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Caenorhabditis elegans as a model to study tissues involved in host immunity and microbial pathogenesis.

Irazoqui JE, Ausubel FM
Clin Exp Immunol. 2010;160(1):48-57 - PMID: 20415851 - PMCID: PMC2841835 - DOI: 10.1111/j.1365-2249.2010.04122.x

Innate immune responses activated in Arabidopsis roots by microbe-associated molecular patterns.

Millet YA, Danna CH, Clay NK, Songnuan W, Simon MD, Werck-Reichhart D, Ausubel FM
Plant Cell. 2010;22(3):973-90 - PMID: 20348432 - PMCID: PMC2861455 - DOI: 10.1105/tpc.109.069658

bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans.

Estes KA, Dunbar TL, Powell JR, Ausubel FM, Troemel ER
Proc Natl Acad Sci U S A. 2010;107(5):2153-8 - PMID: 20133860 - PMCID: PMC2836710 - DOI: 10.1073/pnas.0914643107

Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates.

Irazoqui JE, Urbach JM, Ausubel FM
Nat Rev Immunol. 2010;10(1):47-58 - PMID: 20029447 - PMCID: PMC2965059 - DOI: 10.1038/nri2689

Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.

Okoli I, Coleman JJ, Tampakakis E, Tempakakis E, An WF, Holson E, Wagner F, Conery AL, Larkins-Ford J, Wu G, Stern A, Ausubel FM, Mylonakis E
PLoS One. 2009;4(9):e7025 - PMID: 19750012 - PMCID: PMC2737148 - DOI: 10.1371/journal.pone.0007025

High-throughput screen for novel antimicrobials using a whole animal infection model.

Moy TI, Conery AL, Larkins-Ford J, Wu G, Mazitschek R, Casadei G, Lewis K, Carpenter AE, Ausubel FM
ACS Chem Biol. 2009;4(7):527-33 - PMID: 19572548 - PMCID: PMC2745594 - DOI: 10.1021/cb900084v

Using PATIMDB to create bacterial transposon insertion mutant libraries.

Urbach JM, Wei T, Liberati N, Grenfell-Lee D, Villanueva J, Wu G, Ausubel FM
Curr Protoc Mol Biol. 2009;Chapter 19:Unit 19.7 - PMID: 19343706 - PMCID: PMC4492697 - DOI: 10.1002/0471142727.mb1907s86

The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response.

Powell JR, Kim DH, Ausubel FM
Proc Natl Acad Sci U S A. 2009;106(8):2782-7 - PMID: 19196974 - PMCID: PMC2650343 - DOI: 10.1073/pnas.0813048106

Temporal global expression data reveal known and novel salicylate-impacted processes and regulators mediating powdery mildew growth and reproduction on Arabidopsis.

Chandran D, Tai YC, Hather G, Dewdney J, Denoux C, Burgess DG, Ausubel FM, Speed TP, Wildermuth MC
Plant Physiol. 2009;149(3):1435-51 - PMID: 19176722 - PMCID: PMC2649394 - DOI: 10.1104/pp.108.132985

A metasystem of framework model organisms to study emergence of new host-microbe adaptations.

Gopalan S, Ausubel FM
PLoS One. 2008;3(12):e3891 - PMID: 19066631 - PMCID: PMC2588659 - DOI: 10.1371/journal.pone.0003891

Microsporidia are natural intracellular parasites of the nematode Caenorhabditis elegans.

Troemel ER, Félix MA, Whiteman NK, Barrière A, Ausubel FM
PLoS Biol. 2008;6(12):2736-52 - PMID: 19071962 - PMCID: PMC2596862 - DOI: 10.1371/journal.pbio.0060309

Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.

Irazoqui JE, Ng A, Xavier RJ, Ausubel FM
Proc Natl Acad Sci U S A. 2008;105(45):17469-74 - PMID: 18981407 - PMCID: PMC2582251 - DOI: 10.1073/pnas.0809527105

The AtrbohD-mediated oxidative burst elicited by oligogalacturonides in Arabidopsis is dispensable for the activation of defense responses effective against Botrytis cinerea.

Galletti R, Denoux C, Gambetta S, Dewdney J, Ausubel FM, De Lorenzo G, Ferrari S
Plant Physiol. 2008;148(3):1695-706 - PMID: 18790995 - PMCID: PMC2577270 - DOI: 10.1104/pp.108.127845

Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system.

Adonizio A, Leal SM, Ausubel FM, Mathee K
J Med Microbiol. 2008;57(Pt 7):809-813 - PMID: 18566137 - DOI: 10.1099/jmm.0.47802-0

Animal models for host-pathogen interactions.

Lemaitre B, Ausubel FM
Curr Opin Microbiol. 2008;11(3):249-50 - PMID: 18539076 - DOI: 10.1016/j.mib.2008.05.002

Activation of defense response pathways by OGs and Flg22 elicitors in Arabidopsis seedlings.

Denoux C, Galletti R, Mammarella N, Gopalan S, Werck D, De Lorenzo G, Ferrari S, Ausubel FM, Dewdney J
Mol Plant. 2008;1(3):423-45 - PMID: 19825551 - PMCID: PMC2954645 - DOI: 10.1093/mp/ssn019

Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality.

Liberati NT, Urbach JM, Thurber TK, Wu G, Ausubel FM
Methods Mol Biol. 2008;416:153-69 - PMID: 18392966 - DOI: 10.1007/978-1-59745-321-9_10

Models of Caenorhabditis elegans infection by bacterial and fungal pathogens.

Powell JR, Ausubel FM
Methods Mol Biol. 2008;415:403-27 - PMID: 18370168 - DOI: 10.1007/978-1-59745-570-1_24

DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans.

Miyata S, Begun J, Troemel ER, Ausubel FM
Genetics. 2008;178(2):903-18 - PMID: 18245330 - PMCID: PMC2248360 - DOI: 10.1534/genetics.107.083923

Exploiting amoeboid and non-vertebrate animal model systems to study the virulence of human pathogenic fungi.

Mylonakis E, Casadevall A, Ausubel FM
PLoS Pathog. 2007;3(7):e101 - PMID: 17676994 - PMCID: PMC1933451 - DOI: 10.1371/journal.ppat.0030101

BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14.

Kuchma SL, Brothers KM, Merritt JH, Liberati NT, Ausubel FM, O'Toole GA
J Bacteriol. 2007;189(22):8165-78 - PMID: 17586641 - PMCID: PMC2168662 - DOI: 10.1128/JB.00586-07

Characterization of the integrated filamentous phage Pf5 and its involvement in small-colony formation.

Mooij MJ, Drenkard E, Llamas MA, Vandenbroucke-Grauls CM, Savelkoul PH, Ausubel FM, Bitter W
Microbiology. 2007;153(Pt 6):1790-8 - PMID: 17526836 - PMCID: PMC3820363 - DOI: 10.1099/mic.0.2006/003533-0

Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses.

Begun J, Gaiani JM, Rohde H, Mack D, Calderwood SB, Ausubel FM, Sifri CD
PLoS Pathog. 2007;3(4):e57 - PMID: 17447841 - PMCID: PMC1853117 - DOI: 10.1371/journal.ppat.0030057

Resistance to Botrytis cinerea induced in Arabidopsis by elicitors is independent of salicylic acid, ethylene, or jasmonate signaling but requires PHYTOALEXIN DEFICIENT3.

Ferrari S, Galletti R, Denoux C, De Lorenzo G, Ausubel FM, Dewdney J
Plant Physiol. 2007;144(1):367-79 - PMID: 17384165 - PMCID: PMC1913806 - DOI: 10.1104/pp.107.095596

Antifungal chemical compounds identified using a C. elegans pathogenicity assay.

Breger J, Fuchs BB, Aperis G, Moy TI, Ausubel FM, Mylonakis E
PLoS Pathog. 2007;3(2):e18 - PMID: 17274686 - PMCID: PMC1790726 - DOI: 10.1371/journal.ppat.0030018

Prospects for plant-derived antibacterials.

Lewis K, Ausubel FM
Nat Biotechnol. 2006;24(12):1504-7 - PMID: 17160050 - DOI: 10.1038/nbt1206-1504

Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial.

Lee DG, Urbach JM, Wu G, Liberati NT, Feinbaum RL, Miyata S, Diggins LT, He J, Saucier M, Déziel E, Friedman L, Li L, Grills G, Montgomery K, Kucherlapati R, Rahme LG, Ausubel FM
Genome Biol. 2006;7(10):R90 - PMID: 17038190 - PMCID: PMC1794565 - DOI: 10.1186/gb-2006-7-10-r90

Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial.

Ball AR, Casadei G, Samosorn S, Bremner JB, Ausubel FM, Moy TI, Lewis K
ACS Chem Biol. 2006;1(9):594-600 - PMID: 17168555 - DOI: 10.1021/cb600238x

p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.

Troemel ER, Chu SW, Reinke V, Lee SS, Ausubel FM, Kim DH
PLoS Genet. 2006;2(11):e183 - PMID: 17096597 - PMCID: PMC1635533 - DOI: 10.1371/journal.pgen.0020183

Peroxidase-dependent apoplastic oxidative burst in Arabidopsis required for pathogen resistance.

Bindschedler LV, Dewdney J, Blee KA, Stone JM, Asai T, Plotnikov J, Denoux C, Hayes T, Gerrish C, Davies DR, Ausubel FM, Bolwell GP
Plant J. 2006;47(6):851-63 - PMID: 16889645 - PMCID: PMC3233234 - DOI: 10.1111/j.1365-313X.2006.02837.x

Identification of novel antimicrobials using a live-animal infection model.

Moy TI, Ball AR, Anklesaria Z, Casadei G, Lewis K, Ausubel FM
Proc Natl Acad Sci U S A. 2006;103(27):10414-9 - PMID: 16801562 - PMCID: PMC1482800 - DOI: 10.1073/pnas.0604055103

Prevention and control of pests and diseases.

Bush J, Jander G, Ausubel FM
Methods Mol Biol. 2006;323:13-25 - PMID: 16739564 - DOI: 10.1385/1-59745-003-0:13

Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence.

Kulasakara H, Lee V, Brencic A, Liberati N, Urbach J, Miyata S, Lee DG, Neely AN, Hyodo M, Hayakawa Y, Ausubel FM, Lory S
Proc Natl Acad Sci U S A. 2006;103(8):2839-44 - PMID: 16477007 - PMCID: PMC1413825 - DOI: 10.1073/pnas.0511090103

An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants.

Liberati NT, Urbach JM, Miyata S, Lee DG, Drenkard E, Wu G, Villanueva J, Wei T, Ausubel FM
Proc Natl Acad Sci U S A. 2006;103(8):2833-8 - PMID: 16477005 - PMCID: PMC1413827 - DOI: 10.1073/pnas.0511100103

Are innate immune signaling pathways in plants and animals conserved?

Ausubel FM
Nat Immunol. 2005;6(10):973-9 - PMID: 16177805 - DOI: 10.1038/ni1253

Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis.

Mylonakis E, Moreno R, El Khoury JB, Idnurm A, Heitman J, Calderwood SB, Ausubel FM, Diener A
Infect Immun. 2005;73(7):3842-50 - PMID: 15972469 - PMCID: PMC1168598 - DOI: 10.1128/IAI.73.7.3842-3850.2005

RESISTANCE TO FUSARIUM OXYSPORUM 1, a dominant Arabidopsis disease-resistance gene, is not race specific.

Diener AC, Ausubel FM
Genetics. 2005;171(1):305-21 - PMID: 15965251 - PMCID: PMC1456520 - DOI: 10.1534/genetics.105.042218

Mediation of pathogen resistance by exudation of antimicrobials from roots.

Bais HP, Prithiviraj B, Jha AK, Ausubel FM, Vivanco JM
Nature. 2005;434(7030):217-21 - PMID: 15759001 - DOI: 10.1038/nature03356

The worm has turned--microbial virulence modeled in Caenorhabditis elegans.

Sifri CD, Begun J, Ausubel FM
Trends Microbiol. 2005;13(3):119-27 - PMID: 15737730 - DOI: 10.1016/j.tim.2005.01.003

A high-throughput, near-saturating screen for type III effector genes from Pseudomonas syringae.

Chang JH, Urbach JM, Law TF, Arnold LW, Hu A, Gombar S, Grant SR, Ausubel FM, Dangl JL
Proc Natl Acad Sci U S A. 2005;102(7):2549-54 - PMID: 15701698 - PMCID: PMC549004 - DOI: 10.1073/pnas.0409660102

Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing model.

Begun J, Sifri CD, Goldman S, Calderwood SB, Ausubel FM
Infect Immun. 2005;73(2):872-7 - PMID: 15664928 - PMCID: PMC547013 - DOI: 10.1128/IAI.73.2.872-877.2005

Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans.

Kim DH, Ausubel FM
Curr Opin Immunol. 2005;17(1):4-10 - PMID: 15653303 - DOI: 10.1016/j.coi.2004.11.007

Pseudomonas syringae manipulates systemic plant defenses against pathogens and herbivores.

Cui J, Bahrami AK, Pringle EG, Hernandez-Guzman G, Bender CL, Pierce NE, Ausubel FM
Proc Natl Acad Sci U S A. 2005;102(5):1791-6 - PMID: 15657122 - PMCID: PMC547856 - DOI: 10.1073/pnas.0409450102

Construction of an Enterococcus faecalis Tn917-mediated-gene-disruption library offers insight into Tn917 insertion patterns.

Garsin DA, Urbach J, Huguet-Tapia JC, Peters JE, Ausubel FM
J Bacteriol. 2004;186(21):7280-9 - PMID: 15489440 - PMCID: PMC523214 - DOI: 10.1128/JB.186.21.7280-7289.2004

VPEgamma exhibits a caspase-like activity that contributes to defense against pathogens.

Rojo E, Martín R, Carter C, Zouhar J, Pan S, Plotnikova J, Jin H, Paneque M, Sánchez-Serrano JJ, Baker B, Ausubel FM, Raikhel NV
Curr Biol. 2004;14(21):1897-906 - PMID: 15530390 - DOI: 10.1016/j.cub.2004.09.056

Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals.

Mylonakis E, Idnurm A, Moreno R, El Khoury J, Rottman JB, Ausubel FM, Heitman J, Calderwood SB
Mol Microbiol. 2004;54(2):407-19 - PMID: 15469513 - DOI: 10.1111/j.1365-2958.2004.04310.x

Cytotoxicity of hydrogen peroxide produced by Enterococcus faecium.

Moy TI, Mylonakis E, Calderwood SB, Ausubel FM
Infect Immun. 2004;72(8):4512-20 - PMID: 15271910 - PMCID: PMC470665 - DOI: 10.1128/IAI.72.8.4512-4520.2004

Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase.

Kim DH, Liberati NT, Mizuno T, Inoue H, Hisamoto N, Matsumoto K, Ausubel FM
Proc Natl Acad Sci U S A. 2004;101(30):10990-4 - PMID: 15256594 - PMCID: PMC503731 - DOI: 10.1073/pnas.0403546101

Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions.

Tenor JL, McCormick BA, Ausubel FM, Aballay A
Curr Biol. 2004;14(11):1018-24 - PMID: 15182677 - DOI: 10.1016/j.cub.2004.05.050

Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis.

Engelbert M, Mylonakis E, Ausubel FM, Calderwood SB, Gilmore MS
Infect Immun. 2004;72(6):3628-33 - PMID: 15155673 - PMCID: PMC415677 - DOI: 10.1128/IAI.72.6.3628-3633.2004

The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response.

Mizuno T, Hisamoto N, Terada T, Kondo T, Adachi M, Nishida E, Kim DH, Ausubel FM, Matsumoto K
EMBO J. 2004;23(11):2226-34 - PMID: 15116070 - PMCID: PMC419906 - DOI: 10.1038/sj.emboj.7600226

Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.

Liberati NT, Fitzgerald KA, Kim DH, Feinbaum R, Golenbock DT, Ausubel FM
Proc Natl Acad Sci U S A. 2004;101(17):6593-8 - PMID: 15123841 - PMCID: PMC404090 - DOI: 10.1073/pnas.0308625101

Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response.

Apidianakis Y, Rahme LG, Heitman J, Ausubel FM, Calderwood SB, Mylonakis E
Eukaryot Cell. 2004;3(2):413-9 - PMID: 15075271 - PMCID: PMC387633 - DOI: 10.1128/ec.3.2.413-419.2004

Arabidopsis local resistance to Botrytis cinerea involves salicylic acid and camalexin and requires EDS4 and PAD2, but not SID2, EDS5 or PAD4.

Ferrari S, Plotnikova JM, De Lorenzo G, Ausubel FM
Plant J. 2003;35(2):193-205 - PMID: 12848825 - DOI: 10.1046/j.1365-313x.2003.01794.x

Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.

Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM
Science. 2003;300(5627):1921 - PMID: 12817143 - DOI: 10.1126/science.1080147

Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.

Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM
Science. 2003;300(5627):1921 - PMID: 12817143 - DOI: 10.1126/science.1080147

The art of serendipity: killing of Caenorhabditis elegans by human pathogens as a model of bacterial and fungal pathogenesis.

Mylonakis E, Ausubel FM, Tang RJ, Calderwood SB
Expert Rev Anti Infect Ther. 2003;1(1):167-73 - PMID: 15482109 - DOI: 10.1586/14787210.1.1.167

Use of the Galleria mellonella caterpillar as a model host to study the role of the type III secretion system in Pseudomonas aeruginosa pathogenesis.

Miyata S, Casey M, Frank DW, Ausubel FM, Drenkard E
Infect Immun. 2003;71(5):2404-13 - PMID: 12704110 - PMCID: PMC153283 - DOI: 10.1128/iai.71.5.2404-2413.2003

Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis.

Sifri CD, Begun J, Ausubel FM, Calderwood SB
Infect Immun. 2003;71(4):2208-17 - PMID: 12654843 - PMCID: PMC152095 - DOI: 10.1128/iai.71.4.2208-2217.2003

Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis.

Alonso JM, Stepanova AN, Solano R, Wisman E, Ferrari S, Ausubel FM, Ecker JR
Proc Natl Acad Sci U S A. 2003;100(5):2992-7 - PMID: 12606727 - PMCID: PMC151454 - DOI: 10.1073/pnas.0438070100

Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection.

Coleman FT, Mueschenborn S, Meluleni G, Ray C, Carey VJ, Vargas SO, Cannon CL, Ausubel FM, Pier GB
Proc Natl Acad Sci U S A. 2003;100(4):1949-54 - PMID: 12578988 - PMCID: PMC149939 - DOI: 10.1073/pnas.0437901100

Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway.

Aballay A, Drenkard E, Hilbun LR, Ausubel FM
Curr Biol. 2003;13(1):47-52 - PMID: 12526744 - DOI: 10.1016/s0960-9822(02)01396-9

Tandemly duplicated Arabidopsis genes that encode polygalacturonase-inhibiting proteins are regulated coordinately by different signal transduction pathways in response to fungal infection.

Ferrari S, Vairo D, Ausubel FM, Cervone F, De Lorenzo G
Plant Cell. 2003;15(1):93-106 - PMID: 12509524 - PMCID: PMC143454 - DOI: 10.1105/tpc.005165

Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis.

Mylonakis E, Ausubel FM, Perfect JR, Heitman J, Calderwood SB
Proc Natl Acad Sci U S A. 2002;99(24):15675-80 - PMID: 12438649 - PMCID: PMC137775 - DOI: 10.1073/pnas.232568599

Virulence effect of Enterococcus faecalis protease genes and the quorum-sensing locus fsr in Caenorhabditis elegans and mice.

Sifri CD, Mylonakis E, Singh KV, Qin X, Garsin DA, Murray BE, Ausubel FM, Calderwood SB
Infect Immun. 2002;70(10):5647-50 - PMID: 12228293 - PMCID: PMC128331 - DOI: 10.1128/iai.70.10.5647-5650.2002

The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model.

Mylonakis E, Engelbert M, Qin X, Sifri CD, Murray BE, Ausubel FM, Gilmore MS, Calderwood SB
Infect Immun. 2002;70(8):4678-81 - PMID: 12117982 - PMCID: PMC128160 - DOI: 10.1128/iai.70.8.4678-4681.2002

A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.

Kim DH, Feinbaum R, Alloing G, Emerson FE, Garsin DA, Inoue H, Tanaka-Hino M, Hisamoto N, Matsumoto K, Tan MW, Ausubel FM
Science. 2002;297(5581):623-6 - PMID: 12142542 - DOI: 10.1126/science.1073759

Signals involved in Arabidopsis resistance to Trichoplusia ni caterpillars induced by virulent and avirulent strains of the phytopathogen Pseudomonas syringae.

Cui J, Jander G, Racki LR, Kim PD, Pierce NE, Ausubel FM
Plant Physiol. 2002;129(2):551-64 - PMID: 12068100 - PMCID: PMC161673 - DOI: 10.1104/pp.010815

Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation.

Drenkard E, Ausubel FM
Nature. 2002;416(6882):740-3 - PMID: 11961556 - DOI: 10.1038/416740a

Polymorphic amplified typing sequences provide a novel approach to Escherichia coli O157:H7 strain typing.

Kudva IT, Evans PS, Perna NT, Barrett TJ, DeCastro GJ, Ausubel FM, Blattner FR, Calderwood SB
J Clin Microbiol. 2002;40(4):1152-9 - PMID: 11923324 - PMCID: PMC140341 - DOI: 10.1128/jcm.40.4.1152-1159.2002

Strains of Escherichia coli O157:H7 differ primarily by insertions or deletions, not single-nucleotide polymorphisms.

Kudva IT, Evans PS, Perna NT, Barrett TJ, Ausubel FM, Blattner FR, Calderwood SB
J Bacteriol. 2002;184(7):1873-9 - PMID: 11889093 - PMCID: PMC134921 - DOI: 10.1128/jb.184.7.1873-1879.2002

MAP kinase signalling cascade in Arabidopsis innate immunity.

Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J
Nature. 2002;415(6875):977-83 - PMID: 11875555 - DOI: 10.1038/415977a

Caenorhabditis elegans as a host for the study of host-pathogen interactions.

Aballay A, Ausubel FM
Curr Opin Microbiol. 2002;5(1):97-101 - PMID: 11834377 - DOI: 10.1016/s1369-5274(02)00293-x

Identification of virulence genes in a pathogenic strain of Pseudomonas aeruginosa by representational difference analysis.

Choi JY, Sifri CD, Goumnerov BC, Rahme LG, Ausubel FM, Calderwood SB
J Bacteriol. 2002;184(4):952-61 - PMID: 11807055 - PMCID: PMC134824 - DOI: 10.1128/jb.184.4.952-961.2002

Differential roles of the Pseudomonas aeruginosa PA14 rpoN gene in pathogenicity in plants, nematodes, insects, and mice.

Hendrickson EL, Plotnikova J, Mahajan-Miklos S, Rahme LG, Ausubel FM
J Bacteriol. 2001;183(24):7126-34 - PMID: 11717271 - PMCID: PMC95561 - DOI: 10.1128/JB.183.24.7126-7134.2001

Isochorismate synthase is required to synthesize salicylic acid for plant defence.

Wildermuth MC, Dewdney J, Wu G, Ausubel FM
Nature. 2001;414(6863):562-5 - PMID: 11734859 - DOI: 10.1038/35107108

A simple model host for identifying Gram-positive virulence factors.

Garsin DA, Sifri CD, Mylonakis E, Qin X, Singh KV, Murray BE, Calderwood SB, Ausubel FM
Proc Natl Acad Sci U S A. 2001;98(19):10892-7 - PMID: 11535834 - PMCID: PMC58570 - DOI: 10.1073/pnas.191378698

The roles of mucD and alginate in the virulence of Pseudomonas aeruginosa in plants, nematodes and mice.

Yorgey P, Rahme LG, Tan MW, Ausubel FM
Mol Microbiol. 2001;41(5):1063-76 - PMID: 11555287 - DOI: 10.1046/j.1365-2958.2001.02580.x

The TASTY locus on chromosome 1 of Arabidopsis affects feeding of the insect herbivore Trichoplusia ni.

Jander G, Cui J, Nhan B, Pierce NE, Ausubel FM
Plant Physiol. 2001;126(2):890-8 - PMID: 11402216 - PMCID: PMC111178 - DOI: 10.1104/pp.126.2.890

Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing.

Aballay A, Ausubel FM
Proc Natl Acad Sci U S A. 2001;98(5):2735-9 - PMID: 11226309 - PMCID: PMC30208 - DOI: 10.1073/pnas.041613098

Arabidopsis genome. A milestone in plant biology.

Ausubel FM
Plant Physiol. 2000;124(4):1451-4 - PMID: 11115856 - PMCID: PMC1539293 - DOI: 10.1104/pp.124.4.1451

Pathogenesis of the human opportunistic pathogen Pseudomonas aeruginosa PA14 in Arabidopsis.

Plotnikova JM, Rahme LG, Ausubel FM
Plant Physiol. 2000;124(4):1766-74 - PMID: 11115892 - PMCID: PMC59873 - DOI: 10.1104/pp.124.4.1766

A simple procedure for the analysis of single nucleotide polymorphisms facilitates map-based cloning in Arabidopsis.

Drenkard E, Richter BG, Rozen S, Stutius LM, Angell NA, Mindrinos M, Cho RJ, Oefner PJ, Davis RW, Ausubel FM
Plant Physiol. 2000;124(4):1483-92 - PMID: 11115864 - PMCID: PMC1539302 - DOI: 10.1104/pp.124.4.1483

Mutational analysis of the Arabidopsis nucleotide binding site-leucine-rich repeat resistance gene RPS2.

Tao Y, Yuan F, Leister RT, Ausubel FM, Katagiri F
Plant Cell. 2000;12(12):2541-2554 - PMID: 11148296 - PMCID: PMC102236 - DOI: 10.1105/tpc.12.12.2541

Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegans.

Aballay A, Yorgey P, Ausubel FM
Curr Biol. 2000;10(23):1539-42 - PMID: 11114525 - DOI: 10.1016/s0960-9822(00)00830-7

Roles of salicylic acid, jasmonic acid, and ethylene in cpr-induced resistance in arabidopsis.

Clarke JD, Volko SM, Ledford H, Ausubel FM, Dong X
Plant Cell. 2000;12(11):2175-90 - PMID: 11090217 - PMCID: PMC150166 - DOI: 10.1105/tpc.12.11.2175

Fumonisin B1-induced cell death in arabidopsis protoplasts requires jasmonate-, ethylene-, and salicylate-dependent signaling pathways.

Asai T, Stone JM, Heard JE, Kovtun Y, Yorgey P, Sheen J, Ausubel FM
Plant Cell. 2000;12(10):1823-36 - PMID: 11041879 - PMCID: PMC149122 - DOI: 10.1105/tpc.12.10.1823

Simulation of fungal-mediated cell death by fumonisin B1 and selection of fumonisin B1-resistant (fbr) Arabidopsis mutants.

Stone JM, Heard JE, Asai T, Ausubel FM
Plant Cell. 2000;12(10):1811-22 - PMID: 11041878 - PMCID: PMC149121 - DOI: 10.1105/tpc.12.10.1811

Three unique mutants of Arabidopsis identify eds loci required for limiting growth of a biotrophic fungal pathogen.

Dewdney J, Reuber TL, Wildermuth MC, Devoto A, Cui J, Stutius LM, Drummond EP, Ausubel FM
Plant J. 2000;24(2):205-18 - PMID: 11069695 - DOI: 10.1046/j.1365-313x.2000.00870.x

Isolation and characterization of disease resistance gene homologues from rice cultivar IR64.

Ilag LL, Yadav RC, Huang N, Ronald PC, Ausubel FM
Gene. 2000;255(2):245-55 - PMID: 11024284 - DOI: 10.1016/s0378-1119(00)00333-4

Elucidating the molecular mechanisms of bacterial virulence using non-mammalian hosts.

Mahajan-Miklos S, Rahme LG, Ausubel FM
Mol Microbiol. 2000;37(5):981-8 - PMID: 10972817 - DOI: 10.1046/j.1365-2958.2000.02056.x

Plants and animals share functionally common bacterial virulence factors.

Rahme LG, Ausubel FM, Cao H, Drenkard E, Goumnerov BC, Lau GW, Mahajan-Miklos S, Plotnikova J, Tan MW, Tsongalis J, Walendziewicz CL, Tompkins RG
Proc Natl Acad Sci U S A. 2000;97(16):8815-21 - PMID: 10922040 - PMCID: PMC34017 - DOI: 10.1073/pnas.97.16.8815

Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects.

Jander G, Rahme LG, Ausubel FM
J Bacteriol. 2000;182(13):3843-5 - PMID: 10851003 - PMCID: PMC94559 - DOI: 10.1128/jb.182.13.3843-3845.2000

Virulence of the phytopathogen Pseudomonas syringae pv. maculicola is rpoN dependent.

Hendrickson EL, Guevera P, Peñaloza-Vàzquez A, Shao J, Bender C, Ausubel FM
J Bacteriol. 2000;182(12):3498-507 - PMID: 10852883 - PMCID: PMC101941 - DOI: 10.1128/jb.182.12.3498-3507.2000

The alternative sigma factor RpoN is required for hrp activity in Pseudomonas syringae pv. maculicola and acts at the level of hrpL transcription.

Hendrickson EL, Guevera P, Ausubel FM
J Bacteriol. 2000;182(12):3508-16 - PMID: 10852884 - PMCID: PMC101944 - DOI: 10.1128/jb.182.12.3508-3516.2000

Caenorhabditis elegans: a model genetic host to study Pseudomonas aeruginosa pathogenesis.

Tan MW, Ausubel FM
Curr Opin Microbiol. 2000;3(1):29-34 - PMID: 10679415 - DOI: 10.1016/s1369-5274(99)00047-8

Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling.

Jirage D, Tootle TL, Reuber TL, Frost LN, Feys BJ, Parker JE, Ausubel FM, Glazebrook J
Proc Natl Acad Sci U S A. 1999;96(23):13583-8 - PMID: 10557364 - PMCID: PMC23991 - DOI: 10.1073/pnas.96.23.13583

Genome-wide mapping with biallelic markers in Arabidopsis thaliana.

Cho RJ, Mindrinos M, Richards DR, Sapolsky RJ, Anderson M, Drenkard E, Dewdney J, Reuber TL, Stammers M, Federspiel N, Theologis A, Yang WH, Hubbell E, Au M, Chung EY, Lashkari D, Lemieux B, Dean C, Lipshutz RJ, Ausubel FM, Davis RW, Oefner PJ
Nat Genet. 1999;23(2):203-7 - PMID: 10508518 - DOI: 10.1038/13833

Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors.

Tan MW, Rahme LG, Sternberg JA, Tompkins RG, Ausubel FM
Proc Natl Acad Sci U S A. 1999;96(5):2408-13 - PMID: 10051655 - PMCID: PMC26797 - DOI: 10.1073/pnas.96.5.2408

Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis.

Tan MW, Mahajan-Miklos S, Ausubel FM
Proc Natl Acad Sci U S A. 1999;96(2):715-20 - PMID: 9892699 - PMCID: PMC15202 - DOI: 10.1073/pnas.96.2.715

Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model.

Mahajan-Miklos S, Tan MW, Rahme LG, Ausubel FM
Cell. 1999;96(1):47-56 - PMID: 9989496 - DOI: 10.1016/s0092-8674(00)80958-7

Modulation of expression of the ToxR regulon in Vibrio cholerae by a member of the two-component family of response regulators.

Wong SM, Carroll PA, Rahme LG, Ausubel FM, Calderwood SB
Infect Immun. 1998;66(12):5854-61 - PMID: 9826365 - PMCID: PMC108741 - DOI: 10.1128/IAI.66.12.5854-5861.1998

Correlation of defense gene induction defects with powdery mildew susceptibility in Arabidopsis enhanced disease susceptibility mutants.

Reuber TL, Plotnikova JM, Dewdney J, Rogers EE, Wood W, Ausubel FM
Plant J. 1998;16(4):473-85 - PMID: 9881167 - DOI: 10.1046/j.1365-313x.1998.00319.x

Use of cleaved amplified polymorphic sequences (CAPS) as genetic markers in Arabidopsis thaliana.

Glazebrook J, Drenkard E, Preuss D, Ausubel FM
Methods Mol Biol. 1998;82:173-82 - PMID: 9664424 - DOI: 10.1385/0-89603-391-0:173

Isolation of new Arabidopsis mutants with enhanced disease susceptibility to Pseudomonas syringae by direct screening.

Volko SM, Boller T, Ausubel FM
Genetics. 1998;149(2):537-48 - PMID: 9611172 - PMCID: PMC1460196

A light-independent developmental mechanism potentiates flavonoid gene expression in Arabidopsis seedlings.

Kubasek WL, Ausubel FM, Shirley BW
Plant Mol Biol. 1998;37(2):217-23 - PMID: 9617795 - DOI: 10.1023/a:1005977103116

Use of Arabidopsis for genetic dissection of plant defense responses.

Glazebrook J, Rogers EE, Ausubel FM
Annu Rev Genet. 1998;31:547-69 - PMID: 9442907 - DOI: 10.1146/annurev.genet.31.1.547

The epidemiology of resistance to ofloxacin and oxacillin among clinical coagulase-negative staphylococcal isolates: analysis of risk factors and strain types.

Pegues DA, Colby C, Hibberd PL, Cohen LG, Ausubel FM, Calderwood SB, Hooper DC
Clin Infect Dis. 1998;26(1):72-9 - PMID: 9455512 - DOI: 10.1086/516270

Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors.

Rahme LG, Tan MW, Le L, Wong SM, Tompkins RG, Calderwood SB, Ausubel FM
Proc Natl Acad Sci U S A. 1997;94(24):13245-50 - PMID: 9371831 - PMCID: PMC24294 - DOI: 10.1073/pnas.94.24.13245

Inactivation of the alpha C protein antigen gene, bca, by a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus.

Li J, Kasper DL, Ausubel FM, Rosner B, Michel JL
Proc Natl Acad Sci U S A. 1997;94(24):13251-6 - PMID: 9371832 - PMCID: PMC24295 - DOI: 10.1073/pnas.94.24.13251

Phytoalexin-deficient mutants of Arabidopsis reveal that PAD4 encodes a regulatory factor and that four PAD genes contribute to downy mildew resistance.

Glazebrook J, Zook M, Mert F, Kagan I, Rogers EE, Crute IR, Holub EB, Hammerschmidt R, Ausubel FM
Genetics. 1997;146(1):381-92 - PMID: 9136026 - PMCID: PMC1207952

Arabidopsis enhanced disease susceptibility mutants exhibit enhanced susceptibility to several bacterial pathogens and alterations in PR-1 gene expression.

Rogers EE, Ausubel FM
Plant Cell. 1997;9(3):305-16 - PMID: 9090877 - PMCID: PMC156920 - DOI: 10.1105/tpc.9.3.305

Molecular recognition of pathogen attack occurs inside of plant cells in plant disease resistance specified by the Arabidopsis genes RPS2 and RPM1.

Leister RT, Ausubel FM, Katagiri F
Proc Natl Acad Sci U S A. 1996;93(26):15497-502 - PMID: 8986840 - PMCID: PMC26433 - DOI: 10.1073/pnas.93.26.15497

Use of cleaved amplified polymorphic sequences to distinguish strains of Staphylococcus epidermidis.

Calderwood SB, Baker MA, Carroll PA, Michel JL, Arbeit RD, Ausubel FM
J Clin Microbiol. 1996;34(11):2860-5 - PMID: 8897202 - PMCID: PMC229423 - DOI: 10.1128/JCM.34.11.2860-2865.1996

Mode of action of the Arabidopsis thaliana phytoalexin camalexin and its role in Arabidopsis-pathogen interactions.

Rogers EE, Glazebrook J, Ausubel FM
Mol Plant Microbe Interact. 1996;9(8):748-57 - PMID: 8870273 - DOI: 10.1094/mpmi-9-0748

Isolation of Arabidopsis mutants with enhanced disease susceptibility by direct screening.

Glazebrook J, Rogers EE, Ausubel FM
Genetics. 1996;143(2):973-82 - PMID: 8725243 - PMCID: PMC1207353

Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes.

Reuber TL, Ausubel FM
Plant Cell. 1996;8(2):241-9 - PMID: 8742710 - PMCID: PMC161094 - DOI: 10.1105/tpc.8.2.241

Differential mRNA display.

Reuber TL, Ausubel FM
Methods Cell Biol. 1996;49:431-40 - PMID: 8531774

Analysis of Arabidopsis mutants deficient in flavonoid biosynthesis.

Shirley BW, Kubasek WL, Storz G, Bruggemann E, Koornneef M, Ausubel FM, Goodman HM
Plant J. 1995;8(5):659-71 - PMID: 8528278 - DOI: 10.1046/j.1365-313x.1995.08050659.x

Common virulence factors for bacterial pathogenicity in plants and animals.

Rahme LG, Stevens EJ, Wolfort SF, Shao J, Tompkins RG, Ausubel FM
Science. 1995;268(5219):1899-902 - PMID: 7604262 - DOI: 10.1126/science.7604262

Use of Arabidopsis thaliana defense-related mutants to dissect the plant response to pathogens.

Ausubel FM, Katagiri F, Mindrinos M, Glazebrook J
Proc Natl Acad Sci U S A. 1995;92(10):4189-96 - PMID: 7753782 - PMCID: PMC41909 - DOI: 10.1073/pnas.92.10.4189

Molecular genetics of plant disease resistance.

Staskawicz BJ, Ausubel FM, Baker BJ, Ellis JG, Jones JD
Science. 1995;268(5211):661-7 - PMID: 7732374 - DOI: 10.1126/science.7732374

Haplotypic divergence coupled with lack of diversity at the Arabidopsis thaliana alcohol dehydrogenase locus: roles for both balancing and directional selection?

Hanfstingl U, Berry A, Kellogg EA, Costa JT, Rüdiger W, Ausubel FM
Genetics. 1994;138(3):811-28 - PMID: 7851777 - PMCID: PMC1206230

The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site and leucine-rich repeats.

Mindrinos M, Katagiri F, Yu GL, Ausubel FM
Cell. 1994;78(6):1089-99 - PMID: 7923358 - DOI: 10.1016/0092-8674(94)90282-8

Isolation of phytoalexin-deficient mutants of Arabidopsis thaliana and characterization of their interactions with bacterial pathogens.

Glazebrook J, Ausubel FM
Proc Natl Acad Sci U S A. 1994;91(19):8955-9 - PMID: 8090752 - PMCID: PMC44725 - DOI: 10.1073/pnas.91.19.8955

Programmed cell death in plants: a pathogen-triggered response activated coordinately with multiple defense functions.

Greenberg JT, Guo A, Klessig DF, Ausubel FM
Cell. 1994;77(4):551-63 - PMID: 8187175 - DOI: 10.1016/0092-8674(94)90217-8

Arabidopsis mutations at the RPS2 locus result in loss of resistance to Pseudomonas syringae strains expressing the avirulence gene avrRpt2.

Yu GL, Katagiri F, Ausubel FM
Mol Plant Microbe Interact. 1993;6(4):434-43 - PMID: 8400373 - DOI: 10.1094/mpmi-6-434

Signal transduction mutants of Arabidopsis uncouple nuclear CAB and RBCS gene expression from chloroplast development.

Susek RE, Ausubel FM, Chory J
Cell. 1993;74(5):787-99 - PMID: 7690685 - DOI: 10.1016/0092-8674(93)90459-4

A procedure for mapping Arabidopsis mutations using co-dominant ecotype-specific PCR-based markers.

Konieczny A, Ausubel FM
Plant J. 1993;4(2):403-10 - PMID: 8106085 - DOI: 10.1046/j.1365-313x.1993.04020403.x

Arabidopsis mutants compromised for the control of cellular damage during pathogenesis and aging.

Greenberg JT, Ausubel FM
Plant J. 1993;4(2):327-41 - PMID: 8220484 - DOI: 10.1046/j.1365-313x.1993.04020327.x

An Arabidopsis thaliana lipoxygenase gene can be induced by pathogens, abscisic acid, and methyl jasmonate.

Melan MA, Dong X, Endara ME, Davis KR, Ausubel FM, Peterman TK
Plant Physiol. 1993;101(2):441-50 - PMID: 7506426 - PMCID: PMC160590 - DOI: 10.1104/pp.101.2.441

Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci.

Michel JL, Madoff LC, Olson K, Kling DE, Kasper DL, Ausubel FM
Proc Natl Acad Sci U S A. 1992;89(21):10060-4 - PMID: 1438195 - PMCID: PMC50277 - DOI: 10.1073/pnas.89.21.10060

Regulation of Flavonoid Biosynthetic Genes in Germinating Arabidopsis Seedlings.

Kubasek WL, Shirley BW, McKillop A, Goodman HM, Briggs W, Ausubel FM
Plant Cell. 1992;4(10):1229-1236 - PMID: 12297632 - PMCID: PMC160210 - DOI: 10.1105/tpc.4.10.1229

copia-like retrotransposons are ubiquitous among plants.

Voytas DF, Cummings MP, Koniczny A, Ausubel FM, Rodermel SR
Proc Natl Acad Sci U S A. 1992;89(15):7124-8 - PMID: 1379734 - PMCID: PMC49658 - DOI: 10.1073/pnas.89.15.7124

Cloning the Arabidopsis GA1 Locus by Genomic Subtraction.

Sun T, Goodman HM, Ausubel FM
Plant Cell. 1992;4(2):119-128 - PMID: 12297643 - PMCID: PMC160113 - DOI: 10.1105/tpc.4.2.119

The central domain of Rhizobium leguminosarum DctD functions independently to activate transcription.

Huala E, Stigter J, Ausubel FM
J Bacteriol. 1992;174(4):1428-31 - PMID: 1735730 - PMCID: PMC206444 - DOI: 10.1128/jb.174.4.1428-1431.1992

Nodules elicited by Rhizobium meliloti heme mutants are arrested at an early stage of development.

Dickstein R, Scheirer DC, Fowle WH, Ausubel FM
Mol Gen Genet. 1991;230(3):423-32 - PMID: 1766439 - DOI: 10.1007/BF00280299

Differential induction of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase genes in Arabidopsis thaliana by wounding and pathogenic attack.

Keith B, Dong XN, Ausubel FM, Fink GR
Proc Natl Acad Sci U S A. 1991;88(19):8821-5 - PMID: 1681544 - PMCID: PMC52602 - DOI: 10.1073/pnas.88.19.8821

Cloned alpha and beta C-protein antigens of group B streptococci elicit protective immunity.

Michel JL, Madoff LC, Kling DE, Kasper DL, Ausubel FM
Infect Immun. 1991;59(6):2023-8 - PMID: 1674738 - PMCID: PMC257960 - DOI: 10.1128/IAI.59.6.2023-2028.1991

The centromere region of Arabidopsis thaliana chromosome 1 contains telomere-similar sequences.

Richards EJ, Goodman HM, Ausubel FM
Nucleic Acids Res. 1991;19(12):3351-7 - PMID: 1648204 - PMCID: PMC328334 - DOI: 10.1093/nar/19.12.3351

High intensity and blue light regulated expression of chimeric chalcone synthase genes in transgenic Arabidopsis thaliana plants.

Feinbaum RL, Storz G, Ausubel FM
Mol Gen Genet. 1991;226(3):449-56 - PMID: 2038307 - DOI: 10.1007/BF00260658

A superfamily of Arabidopsis thaliana retrotransposons.

Konieczny A, Voytas DF, Cummings MP, Ausubel FM
Genetics. 1991;127(4):801-9 - PMID: 1709409 - PMCID: PMC1204407

Induction of Arabidopsis defense genes by virulent and avirulent Pseudomonas syringae strains and by a cloned avirulence gene.

Dong X, Mindrinos M, Davis KR, Ausubel FM
Plant Cell. 1991;3(1):61-72 - PMID: 1824335 - PMCID: PMC159979 - DOI: 10.1105/tpc.3.1.61

Aerobic inactivation of Rhizobium meliloti NifA in Escherichia coli is mediated by lon and two newly identified genes, snoB and snoC.

Huala E, Moon AL, Ausubel FM
J Bacteriol. 1991;173(1):382-90 - PMID: 1846139 - PMCID: PMC207197 - DOI: 10.1128/jb.173.1.382-390.1991

The structure, distribution and evolution of the Ta1 retrotransposable element family of Arabidopsis thaliana.

Voytas DF, Konieczny A, Cummings MP, Ausubel FM
Genetics. 1990;126(3):713-21 - PMID: 2174394 - PMCID: PMC1204225

Prokaryotic signal transduction mediated by sensor and regulator protein pairs.

Albright LM, Huala E, Ausubel FM
Annu Rev Genet. 1990;23:311-36 - PMID: 2694934 - DOI: 10.1146/annurev.ge.23.120189.001523

Genomic subtraction for cloning DNA corresponding to deletion mutations.

Straus D, Ausubel FM
Proc Natl Acad Sci U S A. 1990;87(5):1889-93 - PMID: 2408039 - PMCID: PMC53589 - DOI: 10.1073/pnas.87.5.1889

Rhizobium meliloti nodD genes mediate host-specific activation of nodABC.

Honma MA, Asomaning M, Ausubel FM
J Bacteriol. 1990;172(2):901-11 - PMID: 2298703 - PMCID: PMC208518 - DOI: 10.1128/jb.172.2.901-911.1990

Arabidopsis thaliana mutant that develops as a light-grown plant in the absence of light.

Chory J, Peto C, Feinbaum R, Pratt L, Ausubel F
Cell. 1989;58(5):991-9 - PMID: 2776216 - DOI: 10.1016/0092-8674(89)90950-1

General method for site-directed mutagenesis in Escherichia coli O18ac:K1:H7: deletion of the inducible superoxide dismutase gene, sodA, does not diminish bacteremia in neonatal rats.

Bloch CA, Thorne GM, Ausubel FM
Infect Immun. 1989;57(7):2141-8 - PMID: 2543632 - PMCID: PMC313853 - DOI: 10.1128/IAI.57.7.2141-2148.1989

The central domain of Rhizobium meliloti NifA is sufficient to activate transcription from the R. meliloti nifH promoter.

Huala E, Ausubel FM
J Bacteriol. 1989;171(6):3354-65 - PMID: 2722751 - PMCID: PMC210058 - DOI: 10.1128/jb.171.6.3354-3365.1989

Identification of a gene linked to Rhizobium meliloti ntrA whose product is homologous to a family to ATP-binding proteins.

Albright LM, Ronson CW, Nixon BT, Ausubel FM
J Bacteriol. 1989;171(4):1932-41 - PMID: 2703463 - PMCID: PMC209842 - DOI: 10.1128/jb.171.4.1932-1941.1989

A dual-labeling method for identifying differentially expressed genes: use in the identification of cDNA clones that hybridize to RNAs whose abundance in tomato flowers is potentially regulated by gibberellins.

Olszewski NE, Gast RT, Ausubel FM
Gene. 1989;77(1):155-62 - PMID: 2663653 - DOI: 10.1016/0378-1119(89)90369-7

Rhizobium meliloti 1021 has three differentially regulated loci involved in glutamine biosynthesis, none of which is essential for symbiotic nitrogen fixation.

de Bruijn FJ, Rossbach S, Schneider M, Ratet P, Messmer S, Szeto WW, Ausubel FM, Schell J
J Bacteriol. 1989;171(3):1673-82 - PMID: 2563998 - PMCID: PMC209797 - DOI: 10.1128/jb.171.3.1673-1682.1989

Interference between Rhizobium meliloti and Rhizobium trifolii nodulation genes: genetic basis of R. meliloti dominance.

Debellé F, Maillet F, Vasse J, Rosenberg C, de Billy F, Truchet G, Dénarié J, Ausubel FM
J Bacteriol. 1988;170(12):5718-27 - PMID: 2848012 - PMCID: PMC211674 - DOI: 10.1128/jb.170.12.5718-5727.1988

A copia-like transposable element family in Arabidopsis thaliana.

Voytas DF, Ausubel FM
Nature. 1988;336(6196):242-4 - PMID: 2904123 - DOI: 10.1038/336242a0

Specialized binary vector for plant transformation: expression of the Arabidopsis thaliana AHAS gene in Nicotiana tabacum.

Olszewski NE, Martin FB, Ausubel FM
Nucleic Acids Res. 1988;16(22):10765-82 - PMID: 3060849 - PMCID: PMC338938 - DOI: 10.1093/nar/16.22.10765

Expression of nodule-specific genes in alfalfa root nodules blocked at an early stage of development.

Dickstein R, Bisseling T, Reinhold VN, Ausubel FM
Genes Dev. 1988;2(6):677-87 - PMID: 3417147 - DOI: 10.1101/gad.2.6.677

Transcriptional regulation of the Arabidopsis thaliana chalcone synthase gene.

Feinbaum RL, Ausubel FM
Mol Cell Biol. 1988;8(5):1985-92 - PMID: 3386631 - PMCID: PMC363377 - DOI: 10.1128/mcb.8.5.1985

Isolation of a higher eukaryotic telomere from Arabidopsis thaliana.

Richards EJ, Ausubel FM
Cell. 1988;53(1):127-36 - PMID: 3349525 - DOI: 10.1016/0092-8674(88)90494-1

Developmental regulation of nodule-specific genes in alfalfa root nodules.

Dunn K, Dickstein R, Feinbaum R, Burnett BK, Peterman TK, Thoidis G, Goodman HM, Ausubel FM
Mol Plant Microbe Interact. 1988;1(2):66-74 - PMID: 2908768 - DOI: 10.1094/mpmi-1-066

Rhizobium meliloti has three functional copies of the nodD symbiotic regulatory gene.

Honma MA, Ausubel FM
Proc Natl Acad Sci U S A. 1987;84(23):8558-62 - PMID: 3479806 - PMCID: PMC299584 - DOI: 10.1073/pnas.84.23.8558

Deduced products of C4-dicarboxylate transport regulatory genes of Rhizobium leguminosarum are homologous to nitrogen regulatory gene products.

Ronson CW, Astwood PM, Nixon BT, Ausubel FM
Nucleic Acids Res. 1987;15(19):7921-34 - PMID: 3671068 - PMCID: PMC306317 - DOI: 10.1093/nar/15.19.7921

Conserved domains in bacterial regulatory proteins that respond to environmental stimuli.

Ronson CW, Nixon BT, Ausubel FM
Cell. 1987;49(5):579-81 - PMID: 3555840 - DOI: 10.1016/0092-8674(87)90530-7

Rhizobium meliloti ntrA (rpoN) gene is required for diverse metabolic functions.

Ronson CW, Nixon BT, Albright LM, Ausubel FM
J Bacteriol. 1987;169(6):2424-31 - PMID: 3034856 - PMCID: PMC212082 - DOI: 10.1128/jb.169.6.2424-2431.1987

Isolation and characterization of symbiotic mutants of bradyrhizobium sp. (Arachis) strain NC92: mutants with host-specific defects in nodulation and nitrogen fixation.

Wilson KJ, Anjaiah V, Nambiar PT, Ausubel FM
J Bacteriol. 1987;169(5):2177-86 - PMID: 3032910 - PMCID: PMC212124 - DOI: 10.1128/jb.169.5.2177-2186.1987

Identification and characterization of the Rhizobium meliloti ntrC gene: R. meliloti has separate regulatory pathways for activation of nitrogen fixation genes in free-living and symbiotic cells.

Szeto WW, Nixon BT, Ronson CW, Ausubel FM
J Bacteriol. 1987;169(4):1423-32 - PMID: 2881918 - PMCID: PMC211963 - DOI: 10.1128/jb.169.4.1423-1432.1987

Rhizobium symbiotic genes required for nodulation of legume and nonlegume hosts.

Marvel DJ, Torrey JG, Ausubel FM
Proc Natl Acad Sci U S A. 1987;84(5):1319-23 - PMID: 16593814 - PMCID: PMC304419 - DOI: 10.1073/pnas.84.5.1319

Genetic and structural analysis of the Rhizobium meliloti fixA, fixB, fixC, and fixX genes.

Earl CD, Ronson CW, Ausubel FM
J Bacteriol. 1987;169(3):1127-36 - PMID: 3029021 - PMCID: PMC211910 - DOI: 10.1128/jb.169.3.1127-1136.1987

Conservation of structure and location of Rhizobium meliloti and Klebsiella pneumoniae nifB genes.

Buikema WJ, Klingensmith JA, Gibbons SL, Ausubel FM
J Bacteriol. 1987;169(3):1120-6 - PMID: 3029020 - PMCID: PMC211909 - DOI: 10.1128/jb.169.3.1120-1126.1987

Regulation of nitrogen fixation genes.

Gussin GN, Ronson CW, Ausubel FM
Annu Rev Genet. 1987;20:567-91 - PMID: 3545064 - DOI: 10.1146/annurev.ge.20.120186.003031

Gibberellin-Induced Changes in the Populations of Translatable mRNAs and Accumulated Polypeptides in Dwarfs of Maize and Pea.

Chory J, Voytas DF, Olszewski NE, Ausubel FM
Plant Physiol. 1987;83(1):15-23 - PMID: 16665192 - PMCID: PMC1056291 - DOI: 10.1104/pp.83.1.15

Paraquat-mediated selection for mutations in the manganese-superoxide dismutase gene sodA.

Bloch CA, Ausubel FM
J Bacteriol. 1986;168(2):795-8 - PMID: 3023287 - PMCID: PMC213554 - DOI: 10.1128/jb.168.2.795-798.1986

Two-component regulatory systems responsive to environmental stimuli share strongly conserved domains with the nitrogen assimilation regulatory genes ntrB and ntrC.

Nixon BT, Ronson CW, Ausubel FM
Proc Natl Acad Sci U S A. 1986;83(20):7850-4 - PMID: 3020561 - PMCID: PMC386820 - DOI: 10.1073/pnas.83.20.7850

Symbiotic nitrogen fixation: developmental genetics of nodule formation.

Lang-Unnasch N, Dunn K, Ausubel FM
Cold Spring Harb Symp Quant Biol. 1986;50:555-63 - PMID: 3868494 - DOI: 10.1101/sqb.1985.050.01.068

Biological nitrogen fixation: recent advances and future prospects.

Ausubel FM
Regul Toxicol Pharmacol. 1986;6(1):1-10 - PMID: 3704206 - DOI: 10.1016/0273-2300(86)90035-8

Conservation of nodulation genes between Rhizobium meliloti and a slow-growing Rhizobium strain that nodulates a nonlegume host.

Marvel DJ, Kuldau G, Hirsch A, Richards E, Torrey JG, Ausubel FM
Proc Natl Acad Sci U S A. 1985;82(17):5841-5 - PMID: 16593600 - PMCID: PMC390649 - DOI: 10.1073/pnas.82.17.5841

Nitrogen fixation specific regulatory genes of Klebsiella pneumoniae and Rhizobium meliloti share homology with the general nitrogen regulatory gene ntrC of K. pneumoniae.

Buikema WJ, Szeto WW, Lemley PV, Orme-Johnson WH, Ausubel FM
Nucleic Acids Res. 1985;13(12):4539-55 - PMID: 2989799 - PMCID: PMC321805 - DOI: 10.1093/nar/13.12.4539

Nodule-specific polypeptides from effective alfalfa root nodules and from ineffective nodules lacking nitrogenase.

Lang-Unnasch N, Ausubel FM
Plant Physiol. 1985;77(4):833-9 - PMID: 16664146 - PMCID: PMC1064615 - DOI: 10.1104/pp.77.4.833

Rhizobium meliloti nodulation genes allow Agrobacterium tumefaciens and Escherichia coli to form pseudonodules on alfalfa.

Hirsch AM, Wilson KJ, Jones JD, Bang M, Walker VV, Ausubel FM
J Bacteriol. 1984;158(3):1133-43 - PMID: 6327629 - PMCID: PMC215561 - DOI: 10.1128/JB.158.3.1133-1143.1984

Regulation of nitrogen fixation genes.

Ausubel FM
Cell. 1984;37(1):5-6 - PMID: 6373013 - DOI: 10.1016/0092-8674(84)90294-0

A Rhizobium meliloti symbiotic regulatory gene.

Szeto WW, Zimmerman JL, Sundaresan V, Ausubel FM
Cell. 1984;36(4):1035-43 - PMID: 6423287 - DOI: 10.1016/0092-8674(84)90053-9

Physical and genetic characterization of Rhizobium meliloti symbiotic mutants.

Buikema WJ, Long SR, Brown SE, van den Bos RC, Earl C, Ausubel FM
J Mol Appl Genet. 1984;2(3):249-60 - PMID: 6363587

Construction of a correlated physical and genetic map of the Klebsiella pneumoniae hisDGO region using transposon Tn5 mutagenesis.

de Bruijn FJ, Stroke IL, Marvel DJ, Ausubel FM
EMBO J. 1984;2(10):1831-8 - PMID: 6315405 - PMCID: PMC555367

Mutations affecting regulation of the Klebsiella pneumoniae nifH (nitrogenase reductase) promotor.

Brown SE, Ausubel FM
J Bacteriol. 1984;157(1):143-7 - PMID: 6360993 - PMCID: PMC215143 - DOI: 10.1128/JB.157.1.143-147.1984

Molecular characterization of Tn5-induced symbiotic (Fix-) mutants of Rhizobium meliloti.

Zimmerman JL, Szeto WW, Ausubel FM
J Bacteriol. 1983;156(3):1025-34 - PMID: 6196347 - PMCID: PMC217946 - DOI: 10.1128/JB.156.3.1025-1034.1983

Conditionally replicating plasmid vectors that can integrate into the Klebsiella pneumoniae chromosome via bacteriophage P4 site-specific recombination.

Ow DW, Ausubel FM
J Bacteriol. 1983;155(2):704-13 - PMID: 6307977 - PMCID: PMC217740 - DOI: 10.1128/JB.155.2.704-713.1983

Activation of Klebsiella pneumoniae and Rhizobium meliloti nitrogenase promoters by gln (ntr) regulatory proteins.

Sundaresan V, Ow DW, Ausubel FM
Proc Natl Acad Sci U S A. 1983;80(13):4030-4 - PMID: 6306658 - PMCID: PMC394194 - DOI: 10.1073/pnas.80.13.4030

Ultrastructural analysis of ineffective alfalfa nodules formed by nif::Tn5 mutants of Rhizobium meliloti.

Hirsch AM, Bang M, Ausubel FM
J Bacteriol. 1983;155(1):367-80 - PMID: 6575011 - PMCID: PMC217689 - DOI: 10.1128/JB.155.1.367-380.1983

Promoters regulated by the glnG (ntrC) and nifA gene products share a heptameric consensus sequence in the -15 region.

Ow DW, Sundaresan V, Rothstein DM, Brown SE, Ausubel FM
Proc Natl Acad Sci U S A. 1983;80(9):2524-8 - PMID: 6133280 - PMCID: PMC393858 - DOI: 10.1073/pnas.80.9.2524

ISRm1: A Rhizobium meliloti insertion sequence that transposes preferentially into nitrogen fixation genes.

Ruvkun GB, Long SR, Meade HM, van den Bos RC, Ausubel FM
J Mol Appl Genet. 1983;1(5):405-18 - PMID: 6296251

Klebsiella pneumoniae nifA product activates the Rhizobium meliloti nitrogenase promoter.

Sundaresan V, Jones JD, Ow DW, Ausubel FM
Nature. 1983;301(5902):728-32 - PMID: 6338395 - DOI: 10.1038/301728a0

Regulation of nitrogen metabolism genes by nifA gene product in Klebsiella pneumoniae.

Ow DW, Ausubel FM
Nature. 1983;301(5898):307-13 - PMID: 6337346 - DOI: 10.1038/301307a0

The genetic engineering of nitrogen fixation.

Earl CD, Ausubel FM
Nutr Rev. 1983;41(1):1-6 - PMID: 6302610 - DOI: 10.1111/j.1753-4887.1983.tb07114.x

Nitrogen fixation by Klebsiella pneumoniae is inhibited by certain multicopy hybrid nif plasmids.

Riedel GE, Brown SE, Ausubel FM
J Bacteriol. 1983;153(1):45-56 - PMID: 6336738 - PMCID: PMC217340 - DOI: 10.1128/JB.153.1.45-56.1983

Structural studies of alfalfa roots infected with nodulation mutants of Rhizobium meliloti.

Hirsch AM, Long SR, Bang M, Haskins N, Ausubel FM
J Bacteriol. 1982;151(1):411-9 - PMID: 7085566 - PMCID: PMC220253 - DOI: 10.1128/JB.151.1.411-419.1982

Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes.

Ruvkun GB, Sundaresan V, Ausubel FM
Cell. 1982;29(2):551-9 - PMID: 6288262 - DOI: 10.1016/0092-8674(82)90171-4

Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts.

Ruvkun GB, Sundaresan V, Ausubel FM
Gene. 1982;18(3):247-55 - PMID: 6290328 - DOI: 10.1016/0378-1119(82)90162-7

Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes.

Ruvkun GB, Sundaresan V, Ausubel FM
Cell. 1982;29(2):551-9 - PMID: 6288262 - DOI: 10.1016/0092-8674(82)90171-4

Construction of a broad host range cosmid cloning vector and its use in the genetic analysis of Rhizobium mutants.

Friedman AM, Long SR, Brown SE, Buikema WJ, Ausubel FM
Gene. 1982;18(3):289-96 - PMID: 6290332 - DOI: 10.1016/0378-1119(82)90167-6

Molecular genetics of symbiotic nitrogen fixation.

Ausubel FM
Cell. 1982;29(1):1-2 - PMID: 6286135 - DOI: 10.1016/0092-8674(82)90082-4

The cloning and transposon Tn5 mutagenesis of the glnA region of Klebsiella pneumoniae: identification of glnR, a gene involved in the regulation of the nif and hut operons.

de Bruijn FJ, Ausubel FM
Mol Gen Genet. 1982;183(2):289-97 - PMID: 6120440 - DOI: 10.1007/BF00270631

Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis.

Meade HM, Long SR, Ruvkun GB, Brown SE, Ausubel FM
J Bacteriol. 1982;149(1):114-22 - PMID: 6274841 - PMCID: PMC216598 - DOI: 10.1128/JB.149.1.114-122.1982

Molecular genetic analysis of Klebsiella pneumoniae nitrogen-fixation (nif) genes.

Ausubel FM, Cannon FC
Cold Spring Harb Symp Quant Biol. 1981;45 Pt 2:487-99 - PMID: 6266743 - DOI: 10.1101/sqb.1981.045.01.064

Nucleotide sequence of the gene coding for the nitrogenase iron protein from Klebsiella pneumoniae.

Sundaresan V, Ausubel FM
J Biol Chem. 1981;256(6):2808-12 - PMID: 6259144

Recombinant P4 bacteriophages propagate as viable lytic phages or as autonomous plasmids in Klebsiella pneumoniae.

Ow DW, Ausubel FM
Mol Gen Genet. 1981;180(1):165-75 - PMID: 6255293 - DOI: 10.1007/BF00267366

A general method for site-directed mutagenesis in prokaryotes.

Ruvkun GB, Ausubel FM
Nature. 1981;289(5793):85-8 - PMID: 6256652 - DOI: 10.1038/289085a0

A general method for site-directed mutagenesis in prokaryotes.

Ruvkun GB, Ausubel FM
Nature. 1981;289(5793):85-8 - PMID: 6256652 - DOI: 10.1038/289085a0

Interspecies homology of nitrogenase genes.

Ruvkun GB, Ausubel FM
Proc Natl Acad Sci U S A. 1980;77(1):191-5 - PMID: 6987649 - PMCID: PMC348234 - DOI: 10.1073/pnas.77.1.191

Interspecies homology of nitrogenase genes.

Ruvkun GB, Ausubel FM
Proc Natl Acad Sci U S A. 1980;77(1):191-5 - PMID: 6987649 - PMCID: PMC348234 - DOI: 10.1073/pnas.77.1.191

Glutamine synthetase mutations which affect expression of nitrogen fixation genes in Klebsiella pneumoniae.

Ausubel FM, Bird SC, Durbin KJ, Janssen KA, Margolskee RF, Peskin AP
J Bacteriol. 1979;140(2):597-606 - PMID: 40960 - PMCID: PMC216687 - DOI: 10.1128/JB.140.2.597-606.1979

Directive segregation in the basis of colE1 plasmid incompatibility.

Bedbrook JR, Lehrach H, Ausubel FM
Nature. 1979;281(5731):447-52 - PMID: 386132 - DOI: 10.1038/281447a0

Cyanobacterial ribonucleic acid polymerases recognize lambda promoters.

Miller SS, Ausubel FM, Bogorad L
J Bacteriol. 1979;140(1):246-50 - PMID: 159286 - PMCID: PMC216802 - DOI: 10.1128/JB.140.1.246-250.1979

Overlapping sequences of Klebsiella pneumoniae nifDNA cloned and characterized.

Cannon FC, Riedel GE, Ausubel FM
Mol Gen Genet. 1979;174(1):59-66 - PMID: 384162 - DOI: 10.1007/BF00433306

Physical map of chromosomal nitrogen fixation (nif) genes of Klebsiella pneumoniae.

Riedel GE, Ausubel FM, Cannon FC
Proc Natl Acad Sci U S A. 1979;76(6):2866-70 - PMID: 379866 - PMCID: PMC383710 - DOI: 10.1073/pnas.76.6.2866

Radiochemical identification of the kil gene product of bacteriophage lambda.

Greer H, Ausubel FM
Virology. 1979;95(2):577-80 - PMID: 462802 - DOI: 10.1016/0042-6822(79)90511-7

Recombinant plasmid that carries part of the nitrogen fixation (nif) gene cluster of Klebsiella pneumoniae.

Cannon FC, Riedel GE, Ausubel FM
Proc Natl Acad Sci U S A. 1977;74(7):2963-7 - PMID: 331321 - PMCID: PMC431364 - DOI: 10.1073/pnas.74.7.2963

Recombination between bacterial plasmids leading to the formation of plasmid multimers.

Bedbrook JR, Ausubel FM
Cell. 1976;9(4 PT 2):707-16 - PMID: 797459 - DOI: 10.1016/0092-8674(76)90134-3

Radiochemical purification of bacteriophage lambda integrase.

Ausubel FM
Nature. 1974;247(5437):152-4 - PMID: 4589454 - DOI: 10.1038/247152a0