Publications - Freeman
Freeman MW, Halvorsen YD, Bond M, Murphy B, Isaacsohn J
Results from a Phase 1 Study Assessing the Pharmacokinetics of the Aldosterone Synthase Inhibitor Baxdrostat in Participants with Varying Degrees of Renal Function. Clin Pharmacol Drug Dev. 2024;13(4):410-418 - PMID: 38311833 - DOI: 10.1002/cpdd.1371McMurray JJV, Solomon SD, Lock JP, Massaro JM, Zhu F, Zhou W, Skali H, Lewis EF, Freeman MW, Halvorsen YC
Meta-analysis of risk of major adverse cardiovascular events in adults with type 2 diabetes treated with bexagliflozin. Diabetes Obes Metab. 2023;26(3):971-979 - PMID: 38151752 - DOI: 10.1111/dom.15394Halvorsen YD, Conery AL, Lock JP, Zhou W, Freeman MW
Bexagliflozin as an adjunct to metformin for the treatment of type 2 diabetes in adults: A 24-week, randomized, double-blind, placebo-controlled trial. Diabetes Obes Metab. 2023;25(10):2954-2962 - PMID: 37409573 - DOI: 10.1111/dom.15192Freeman MW, Bond M, Murphy B, Hui J, Isaacsohn J
Results From a Randomized, Open-Label, Crossover Study Evaluating the Effect of the Aldosterone Synthase Inhibitor Baxdrostat on the Pharmacokinetics of Metformin in Healthy Human Subjects. Am J Cardiovasc Drugs. 2023;23(3):277-286 - PMID: 36790596 - PMCID: PMC9930700 - DOI: 10.1007/s40256-023-00572-xFreeman MW, Halvorsen YD, Marshall W, Pater M, Isaacsohn J, Pearce C, Murphy B, Alp N, Srivastava A, Bhatt DL, Brown MJ, BrigHTN Investigators
Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension. N Engl J Med. 2022;388(5):395-405 - PMID: 36342143 - DOI: 10.1056/NEJMoa2213169Freeman MW, Bond M, Murphy B, Hui J, Isaacsohn J
Results from a phase 1, randomized, double-blind, multiple ascending dose study characterizing the pharmacokinetics and demonstrating the safety and selectivity of the aldosterone synthase inhibitor baxdrostat in healthy volunteers. Hypertens Res. 2022;46(1):108-118 - PMID: 36266539 - PMCID: PMC9747611 - DOI: 10.1038/s41440-022-01070-4Halvorsen YD, Lock JP, Frias JP, Tinahones FJ, Dahl D, Conery AL, Freeman MW
A 96-Week, Double-Blind, Randomized, Controlled Trial Comparing Bexagliflozin to Glimepiride as an Adjunct to Metformin for the Treatment of Type 2 Diabetes in Adults. Diabetes Obes Metab. 2022;25(1):293-301 - PMID: 36178197 - DOI: 10.1111/dom.14875Zabaleta N, Dai W, Bhatt U, Chichester JA, Estelien R, Sanmiguel J, Michalson KT, Diop C, Maciorowski D, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Vandenberghe LH
Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates. bioRxiv. 2021;:ePub - PMID: 33442684 - PMCID: PMC7805441 - DOI: 10.1101/2021.01.05.422952Halvorsen YD, Walford GA, Massaro J, Aftring RP, Freeman MW
A 96-Week Multinational Randomized Double-Blind Parallel-Group Clinical Trial Evaluating the Safety and Effectiveness of Bexagliflozin as a Monotherapy for Adults with Type 2 Diabetes. Diabetes Obes Metab. 2019;21(11):2496-2504 - PMID: 31297965 - DOI: 10.1111/dom.13833Freeman MW, Singh AK, Guidon AC, Arvikar SL, Goldstein RH, Clement NF
Case 22-2019: A 65-Year-Old Woman with Weakness, Dark Urine, and Dysphagia. N Engl J Med. 2019;381(3):275-283 - PMID: 31314973 - DOI: 10.1056/NEJMcpc1900589Halvorsen YD, Lock JP, Zhou W, Zhu F, Freeman MW
A 24-week, randomized, double-blind, active-controlled clinical trial comparing bexagliflozin to sitagliptin as an adjunct to metformin for the treatment of type 2 diabetes in adults. Diabetes Obes Metab. 2019;21(10):2248-2256 - PMID: 31161692 - DOI: 10.1111/dom.13801Allegretti AS, Zhang W, Zhou W, Thurber TK, Rigby SP, Bowman-Stroud C, Trescoli C, Serusclat P, Freeman MW, Halvorsen YC
Safety and Effectiveness of Bexagliflozin in Patients With Type 2 Diabetes Mellitus and Stage 3a/3b CKD. Am J Kidney Dis. 2019;74(3):328-337 - PMID: 31101403 - PMCID: PMC10077840 - DOI: 10.1053/j.ajkd.2019.03.417Pitt B, Bakris GL, Weir MR, Freeman MW, Lainscak M, Mayo MR, Garza D, Zawadzki R, Berman L, Bushinsky DA
Long-term effects of patiromer for hyperkalaemia treatment in patients with mild heart failure and diabetic nephropathy on angiotensin-converting enzymes/angiotensin receptor blockers: results from AMETHYST-DN. ESC Heart Fail. 2018;5(4):592-602 - PMID: 29767459 - PMCID: PMC6073017 - DOI: 10.1002/ehf2.12292Antman EM, Di Corleto PE, Freeman MW, Ganz T, Golan DE, Kitterman R, Loscalzo J, Low M, McKenna E, O'Connor AC, Palazzolo M, Parrish J, Reizes O, Ross RS, Vaughan C, Vince DG, Watts L, NIH Centers for Accelerated Innovations
NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges. Nat Rev Drug Discov. 2017;16(10):663-664 - PMID: 28775338 - PMCID: PMC5963257 - DOI: 10.1038/nrd.2017.131Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, Bermingham N, Bloch S, Blum RI, Bolno PB, Bonney MW, Booth B, Bradbury DM, Brauer SK, Byers B, Cagnoni PJ, Cali BM, Ciechanover I, Clark C, Clayman MD, Cleland JL, Cobb P, Cooper R, Currie MG, Diekman J, Dobmeier EL, Doerfler D, Donley EL, Dunsire D, During M, Eckstein JW, Elenko E, Exter NA, Fleming JJ, Flesher GJ, Formela JF, Forrester R, Francois C, Franklin H, Freeman MW, Furst H, Gage LP, Galakatos N, Gallagher BM, Geraghty JA, Gill S, Goeddel DV, Goldsmith MA, Gowen M, Goyal V, Graney T, Grayzel D, Greene B, Grint P, Gutierrez-Ramos JC, Haney B, Ha-Ngoc T, Harris T, Hasnain F, Hata YS, Hecht P, Henshaw L, Heyman R, Hoppenot H, Horvitz HR, Hughes TE, Hutton WS, Isaacs ST, Jenkins A, Jonker J, Kaplan J, Karsen P, Keiper J, Kim J, Kindler J, King R, King V, Kjellson N, Koenig S, Koenig G, Kolchinsky P, Laikind P, Langer RB, Lee JJ, Leff JS, Leicher BA, Leschly N, Levin A, Levin M, Levine AJ, Levy A, Liu DR, Lodish HF, Lopatin U, Love TW, Macdonald G, Maderis GJ, Mahadevia A, Mahanthappa NK, Martin JF, Martin A, Martucci WE, McArthur JG, McCann CM, McCarthy SA, McDonough CG, Mendlein J, Miller L, Miralles D, Moch KI, More B, Myers AG, Narachi MA, Nashat A, Nelson W, Newell WJ, Olle B, Osborn JE, Owens JC, Pande A, Papadopoulos S, Parker HS, Parmar KM, Patterson MR, Paul SM, Perez R, Perry M, Pfeffer CG, Powell M, Pruzanski M, Purcell DJ, Rakhit A, Ramamoorthi K, Rastetter W, Rawcliffe AA, Reid LE, Renaud RC, Rhodes JP, Rieflin WJ, Robins C, Rocklage SM, Rosenblatt M, Rosin JG, Rutter WJ, Saha S, Samuels C, Sato VL, Scangos G, Scarlett JA, Schenkein D, Schreiber SL, Schwab A, Sekhri P, Shah R, Shenk T, Siegall CB, Simon NJ, Simonian N, Stein J, Su M, Szela MT, Taglietti M, Tandon N, Termeer H, Thornberry NA, Tolar M, Ulevitch R, Vaishnaw AK, VanLent A, Varsavsky M, Vlasuk GP, Vounatsos M, Waksal SG, Warma N, Watts RJ, Werber Y, Westphal C, Wierenga W, Williams DE, Williams LR, Xanthopoulos KG, Zohar D, Zweifach SS
US immigration order strikes against biotech. Nat Biotechnol. 2017;35(3):204-206 - PMID: 28267733 - DOI: 10.1038/nbt.3824Bushinsky DA, Williams GH, Pitt B, Weir MR, Freeman MW, Garza D, Stasiv Y, Li E, Berman L, Bakris GL
Patiromer induces rapid and sustained potassium lowering in patients with chronic kidney disease and hyperkalemia. Kidney Int. 2015;88(6):1427-1433 - PMID: 26376130 - PMCID: PMC4678168 - DOI: 10.1038/ki.2015.270Bakris GL, Pitt B, Weir MR, Freeman MW, Mayo MR, Garza D, Stasiv Y, Zawadzki R, Berman L, Bushinsky DA,
Effect of Patiromer on Serum Potassium Level in Patients With Hyperkalemia and Diabetic Kidney Disease: The AMETHYST-DN Randomized Clinical Trial. JAMA. 2015;314(2):151-61 - PMID: 26172895 - DOI: 10.1001/jama.2015.7446Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, Freeman MW, Johnson JA, Lanfear DE, Liggett SB, Lusis AJ, Loscalzo J, MacRae CA, Musunuru K, Newby LK, O'Donnell CJ, Rich SS, Terzic A
Future Translational Applications From the Contemporary Genomics Era: A Scientific Statement From the American Heart Association. Circulation. 2015;131(19):1715-36 - PMID: 25882488 - PMCID: PMC4825323 - DOI: 10.1161/CIR.0000000000000211Stitziel NO, Peloso GM, Abifadel M, Cefalù AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, , Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S
Exome Sequencing in Suspected Monogenic Dyslipidemias. Circ Cardiovasc Genet. 2015;8(2):343-50 - PMID: 25632026 - PMCID: PMC4406825 - DOI: 10.1161/CIRCGENETICS.114.000776Lo J, Rosenberg ES, Fitzgerald ML, Bazner SB, Ihenachor EJ, Hawxhurst V, Borkowska AH, Wei J, Zimmerman CO, Burdo TH, Williams KC, Freeman MW, Grinspoon SK
High-density lipoprotein-mediated cholesterol efflux capacity is improved by treatment with antiretroviral therapy in acute human immunodeficiency virus infection. Open Forum Infect Dis. 2014;1(3):ofu108 - PMID: 25734176 - PMCID: PMC4324225 - DOI: 10.1093/ofid/ofu108Haller JF, Cavallaro P, Hernandez NJ, Dolat L, Soscia SJ, Welti R, Grabowski GA, Fitzgerald ML, Freeman MW
Endogenous ?-glucocerebrosidase activity in Abca12-/-epidermis elevates ceramide levels after topical lipid application but does not restore barrier function. J Lipid Res. 2014;55(3):493-503 - PMID: 24293640 - PMCID: PMC3934733 - DOI: 10.1194/jlr.M044941Best SR, Friedman AD, Landau-Zemer T, Barbu AM, Burns JA, Freeman MW, Halvorsen YD, Hillman RE, Zeitels SM
Safety and dosing of bevacizumab (avastin) for the treatment of recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol. 2012;121(9):587-93 - PMID: 23012897 - DOI: 10.1177/000348941212100905Kim WS, Hill AF, Fitzgerald ML, Freeman MW, Evin G, Garner B
Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-? production independent of cholesterol efflux activity. J Alzheimers Dis. 2011;27(2):441-52 - PMID: 21860089 - DOI: 10.3233/JAD-2011-110521Zeitels SM, Barbu AM, Landau-Zemer T, Lopez-Guerra G, Burns JA, Friedman AD, Freeman MW, Halvorsen YD, Hillman RE
Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study. Ann Otol Rhinol Laryngol. 2011;120(10):627-34 - PMID: 22097147 - DOI: 10.1177/000348941112001001MW Freeman
Lipoprotein Metabolism and the Treatment of Lipid Disorders, Chapter 42. In: DeGroot LJ and JL Jameson, eds. Endocrinology, 6th edition. 2010;:ePubMoore KJ, Freeman MW
Targeting Innate Immunity for CV Benefit. Drug Discov Today Ther Strateg. 2011;5(1):15-23 - PMID: 19430537 - PMCID: PMC2678718 - DOI: 10.1016/j.ddstr.2008.05.007Freeman MW, Dervan AP
The path from bench to bedside: considerations before starting the journey. J Investig Med. 2011;59(5):746-51 - PMID: 21441830 - PMCID: PMC4255460 - DOI: 10.2310/JIM.0b013e3182160d70Moore KJ, Freeman MW
Embryonal Stem (ES) Cell-Derived Macrophages : A Cellular System that Facilitates the Genetic Dissection of Macrophage Function. Methods Mol Med. 2011;30:343-55 - PMID: 21341038 - DOI: 10.1385/1-59259-247-3:343M Freeman, Consultant editor, 4th edition. Buckley, Rita
What to do about high cholesterol. President and Fellows of Harvard College. Harvard Health Publications. 2009;:ePubMW Freeman
Approach to the patient with hypercholesterolemia. In: Goroll A, May L, Mulley A, eds. Primary Care Medicine, 6th Edition. 2009;:ePubHaydock GS and MW Freeman
Screening for hyperlipidemia. In: Goroll A and Mulley A, eds. . Primary Care Medicine, 6th Edition. 2009;:ePubZuo Y, Zhuang DZ, Han R, Isaac G, Tobin JJ, McKee M, Welti R, Brissette JL, Fitzgerald ML, Freeman MW
ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. J Biol Chem. 2008;283(52):36624-35 - PMID: 18957418 - PMCID: PMC2605993 - DOI: 10.1074/jbc.M807377200KJ Moore and MW Freeman
Targeting innate immunity for CV benefit. Drug Discovery Today: Therapeutic Strategies. 2008;5:15-23Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML
SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter. Biochemistry. 2008;47(23):6138-47 - PMID: 18484747 - PMCID: PMC2504083 - DOI: 10.1021/bi800182tKiss RS, Kavaslar N, Okuhira K, Freeman MW, Walter S, Milne RW, McPherson R, Marcel YL
Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects. Arterioscler Thromb Vasc Biol. 2007;27(5):1139-45 - PMID: 17303779 - DOI: 10.1161/ATVBAHA.106.137646MW Freeman
Lipid Disorders and Coronary Heart Disease. In: Runge, MS and Patterson, W Eds. . Molecular Medicine. 2006;:ePubMW Freeman
Statins, cholesterol, and the prevention of coronary heart disease. FASEB J. 2006;20(2):200-201Kuo WP, Liu F, Trimarchi J, Punzo C, Lombardi M, Sarang J, Whipple ME, Maysuria M, Serikawa K, Lee SY, McCrann D, Kang J, Shearstone JR, Burke J, Park DJ, Wang X, Rector TL, Ricciardi-Castagnoli P, Perrin S, Choi S, Bumgarner R, Kim JH, Short GF, Freeman MW, Seed B, Jensen R, Church GM, Hovig E, Cepko CL, Park P, Ohno-Machado L, Jenssen TK
A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Nat Biotechnol. 2006;24(7):832-40 - PMID: 16823376 - DOI: 10.1038/nbt1217Moore KJ, Freeman MW
Scavenger receptors in atherosclerosis: beyond lipid uptake. Arterioscler Thromb Vasc Biol. 2006;26(8):1702-11 - PMID: 16728653 - DOI: 10.1161/01.ATV.0000229218.97976.43Freeman MW
Statins, cholesterol, and the prevention of coronary heart disease. FASEB J. 2006;20(2):200-1 - PMID: 16449790 - DOI: 10.1096/fj.06-0202ufmOkuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW
Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. J Biol Chem. 2005;280(47):39653-64 - PMID: 16192269 - DOI: 10.1074/jbc.M510187200MW Freeman and Christine Junge
Harvard Medical School Guide to Lowering your Cholesterol. 2005;:ePubM Freeman, Consultant editor 3rd edition Junge C, Skerret PJ, and Emond, SD.
What to do about high cholesterol. President and Fellows of Harvard College. Harvard Health Publications. 2005;:ePubMW Freeman
Approach to the patient with hypercholesterolemia. In: Goroll A, May L, Mulley A, eds. Primary Care Medicine, 5th Edition. 2005;:ePubGilmore O’Neill and MW Freeman
Tangier Disease and Neuropathy. In: Dyck, PJ and Thomas, PK, Eds. Peripheral Neuropathy 4th edition. 2005;:ePubLaberge MA, Moore KJ, and MW Freeman.
Atherosclerosis and innate immunity signaling. Annals of Medicine. 2005;37:130-140Lee ML, Whitmore GA, Björkbacka H, Freeman MW
Nonparametric methods for microarray data based on exchangeability and borrowed power. J Biopharm Stat. 2005;15(5):783-97 - PMID: 16078385 - DOI: 10.1081/BIP-200067778Moore KJ, Kunjathoor VV, Koehn SL, Manning JJ, Tseng AA, Silver JM, McKee M, Freeman MW
Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J Clin Invest. 2005;115(8):2192-201 - PMID: 16075060 - PMCID: PMC1180534 - DOI: 10.1172/JCI24061Laberge MA, Moore KJ, Freeman MW
Atherosclerosis and innate immune signaling. Ann Med. 2005;37(2):130-40 - PMID: 16026120 - DOI: 10.1080/07853890510007304Heller EA, Liu E, Tager AM, Sinha S, Roberts JD, Koehn SL, Libby P, Aikawa ER, Chen JQ, Huang P, Freeman MW, Moore KJ, Luster AD, Gerszten RE
Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation. 2005;112(4):578-86 - PMID: 16043658 - DOI: 10.1161/CIRCULATIONAHA.105.545616Farnier M, Freeman MW, Macdonell G, Perevozskaya I, Davies MJ, Mitchel YB, Gumbiner B,
Efficacy and safety of the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidaemia. Eur Heart J. 2005;26(9):897-905 - PMID: 15781429 - DOI: 10.1093/eurheartj/ehi231Jeyaseelan S, Chu HW, Young SK, Freeman MW, Worthen GS
Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun. 2005;73(3):1754-63 - PMID: 15731076 - PMCID: PMC1064978 - DOI: 10.1128/IAI.73.3.1754-1763.2005Lee ML, Gray RJ, Björkbacka H, Freeman MW
Generalized rank tests for replicated microarray data. Stat Appl Genet Mol Biol. 2005;4:Article3 - PMID: 16646848 - DOI: 10.2202/1544-6115.1093Ricci R, Sumara G, Sumara I, Rozenberg I, Kurrer M, Akhmedov A, Hersberger M, Eriksson U, Eberli FR, Becher B, Borén J, Chen M, Cybulsky MI, Moore KJ, Freeman MW, Wagner EF, Matter CM, Lüscher TF
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science. 2004;306(5701):1558-61 - PMID: 15567863 - DOI: 10.1126/science.1101909Björkbacka H, Fitzgerald KA, Huet F, Li X, Gregory JA, Lee MA, Ordija CM, Dowley NE, Golenbock DT, Freeman MW
The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades. Physiol Genomics. 2004;19(3):319-30 - PMID: 15367722 - DOI: 10.1152/physiolgenomics.00128.2004Fitzgerald ML, Okuhira K, Short GF, Manning JJ, Bell SA, Freeman MW
ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities. J Biol Chem. 2004;279(46):48477-85 - PMID: 15347662 - DOI: 10.1074/jbc.M409848200Björkbacka H, Kunjathoor VV, Moore KJ, Koehn S, Ordija CM, Lee MA, Means T, Halmen K, Luster AD, Golenbock DT, Freeman MW
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med. 2004;10(4):416-21 - PMID: 15034566 - DOI: 10.1038/nm1008Chroni A, Liu T, Fitzgerald ML, Freeman MW, Zannis VI
Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1. Biochemistry. 2004;43(7):2126-39 - PMID: 14967052 - DOI: 10.1021/bi035813pKim WS, Ordija CM, Freeman MW
Activation of signaling pathways by putative scavenger receptor class A (SR-A) ligands requires CD14 but not SR-A. Biochem Biophys Res Commun. 2003;310(2):542-9 - PMID: 14521944 - DOI: 10.1016/j.bbrc.2003.09.049El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD
CD36 mediates the innate host response to beta-amyloid. J Exp Med. 2003;197(12):1657-66 - PMID: 12796468 - PMCID: PMC2193948 - DOI: 10.1084/jem.20021546Freeman MW, Moore KJ
eLiXiRs for restraining inflammation. Nat Med. 2003;9(2):168-9 - PMID: 12563335 - DOI: 10.1038/nm0203-168Kunjathoor VV, Febbraio M, Podrez EA, Moore KJ, Andersson L, Koehn S, Rhee JS, Silverstein R, Hoff HF, Freeman MW
Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem. 2002;277(51):49982-8 - PMID: 12376530 - DOI: 10.1074/jbc.M209649200Yang KK, Dorner BG, Merkel U, Ryffel B, Schütt C, Golenbock D, Freeman MW, Jack RS
Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice. J Immunol. 2002;169(8):4475-80 - PMID: 12370383 - DOI: 10.4049/jimmunol.169.8.4475Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT
Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol. 2002;169(7):3970-7 - PMID: 12244198 - DOI: 10.4049/jimmunol.169.7.3970Moore KJ, El Khoury J, Medeiros LA, Terada K, Geula C, Luster AD, Freeman MW
A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem. 2002;277(49):47373-9 - PMID: 12239221 - DOI: 10.1074/jbc.M208788200MW Freeman
The Treatment of Dyslipidemia: LDL Reduction and Beyond. In Endocrinology Rounds. 2002;1, Issue 8:ePubFitzgerald ML, Morris AL, Rhee JS, Andersson LP, Mendez AJ, Freeman MW
Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J Biol Chem. 2002;277(36):33178-87 - PMID: 12084722 - DOI: 10.1074/jbc.M204996200Fitzgerald ML, Moore KJ, Freeman MW
Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home. J Mol Med (Berl). 2002;80(5):271-81 - PMID: 12021839 - DOI: 10.1007/s00109-001-0318-yRosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev. 2002;16(1):22-6 - PMID: 11782441 - PMCID: PMC155311 - DOI: 10.1101/gad.948702Bernheiden M, Heinrich JM, Minigo G, Schütt C, Stelter F, Freeman M, Golenbock D, Jack RS
LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection. J Endotoxin Res. 2001;7(6):447-50 - PMID: 11753215Moore KJ, Fitzgerald ML, Freeman MW
Peroxisome proliferator-activated receptors in macrophage biology: friend or foe?. Curr Opin Lipidol. 2001;12(5):519-27 - PMID: 11561171 - DOI: 10.1097/00041433-200110000-00007Bobryshev YV, Taksir T, Lord RS, Freeman MW
Evidence that dendritic cells infiltrate atherosclerotic lesions in apolipoprotein E-deficient mice. Histol Histopathol. 2001;16(3):801-8 - PMID: 11510970 - DOI: 10.14670/HH-16.801Fitzgerald ML, Mendez AJ, Moore KJ, Andersson LP, Panjeton HA, Freeman MW
ATP-binding cassette transporter A1 contains an NH2-terminal signal anchor sequence that translocates the protein's first hydrophilic domain to the exoplasmic space. J Biol Chem. 2001;276(18):15137-45 - PMID: 11328826 - DOI: 10.1074/jbc.m100474200Rigotti A, Freeman MW
Manipulating intestinal cholesterol absorption and hepatic cholesterol and bile acid metabolism by activation of deorphanized nuclear receptors. Gastroenterology. 2001;120(4):1054-5 - PMID: 11231965 - DOI: 10.1016/s0016-5085(01)83919-6Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW
The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. Nat Med. 2001;7(1):41-7 - PMID: 11135614 - DOI: 10.1038/83328Li Z, Kako Y, Pang L, Freeman MW, Glick JM, Wang X, Goldberg IJ
Effects of overexpression of the amino-terminal fragment of apolipoprotein B on apolipoprotein B and lipoprotein production. J Lipid Res. 2000;41(12):1912-20 - PMID: 11108724Wang X, Zeng W, Murakawa M, Freeman MW, Seed B
Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression. J Virol. 2000;74(23):11296-303 - PMID: 11070029 - PMCID: PMC113234 - DOI: 10.1128/jvi.74.23.11296-11303.2000Wang X, Zeng W, Murakawa M, Freeman MW, Seed B
Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression. J Virol. 2000;74(23):11296-303 - PMID: 11070029 - PMCID: PMC113234 - DOI: 10.1128/jvi.74.23.11296-11303.2000Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, Finberg RW
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol. 2000;1(5):398-401 - PMID: 11062499 - DOI: 10.1038/80833Moore KJ, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, Golenbock DT, Freeman MW
Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol. 2000;165(8):4272-80 - PMID: 11035061 - DOI: 10.4049/jimmunol.165.8.4272M Freeman, Consultant editor 2nd edition. PJ Skerret and SD Emond
What to do about high cholesterol. President and Fellows of Harvard College. Harvard Health Publications. 2000;:ePubBrousseau ME, Eberhart GP, Dupuis J, Asztalos BF, Goldkamp AL, Schaefer EJ, Freeman MW
Cellular cholesterol efflux in heterozygotes for tangier disease is markedly reduced and correlates with high density lipoprotein cholesterol concentration and particle size. J Lipid Res. 2000;41(7):1125-35 - PMID: 10884295Brousseau ME, Schaefer EJ, Dupuis J, Eustace B, Van Eerdewegh P, Goldkamp AL, Thurston LM, FitzGerald MG, Yasek-McKenna D, O'Neill G, Eberhart GP, Weiffenbach B, Ordovas JM, Freeman MW, Brown RH, Gu JZ
Novel mutations in the gene encoding ATP-binding cassette 1 in four tangier disease kindreds. J Lipid Res. 2000;41(3):433-41 - PMID: 10706591Fitzgerald ML, Moore KJ, Freeman MW, Reed GL
Lipopolysaccharide induces scavenger receptor A expression in mouse macrophages: a divergent response relative to human THP-1 monocyte/macrophages. J Immunol. 2000;164(5):2692-700 - PMID: 10679110 - DOI: 10.4049/jimmunol.164.5.2692Fabunmi RP, Moore KJ, Libby P, Freeman MW
Stromelysin-1 (MMP-3) expression driven by a macrophage-specific promoter results in reduced viability in transgenic mice. Atherosclerosis. 2000;148(2):375-86 - PMID: 10657574 - DOI: 10.1016/s0021-9150(99)00405-0Freeman MW
Effluxed lipids: Tangier Island's latest export. Proc Natl Acad Sci U S A. 1999;96(20):10950-2 - PMID: 10500104 - PMCID: PMC34222 - DOI: 10.1073/pnas.96.20.10950Chiang N, Gronert K, Clish CB, O'Brien JA, Freeman MW, Serhan CN
Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. J Clin Invest. 1999;104(3):309-16 - PMID: 10430612 - PMCID: PMC408424 - DOI: 10.1172/JCI7016Moore KJ, Fabunmi RP, Andersson LP, Freeman MW
In vitro-differentiated embryonic stem cell macrophages: a model system for studying atherosclerosis-associated macrophage functions. Arterioscler Thromb Vasc Biol. 1998;18(10):1647-54 - PMID: 9763539 - DOI: 10.1161/01.atv.18.10.1647Andersson L, Freeman MW
Functional changes in scavenger receptor binding conformation are induced by charge mutants spanning the entire collagen domain. J Biol Chem. 1998;273(31):19592-601 - PMID: 9677385 - DOI: 10.1074/jbc.273.31.19592Eberhart GP, Mendez AJ, Freeman MW
Decreased cholesterol efflux from fibroblasts of a patient without Tangier disease, but with markedly reduced high density lipoprotein cholesterol levels. J Clin Endocrinol Metab. 1998;83(3):836-46 - PMID: 9506737 - DOI: 10.1210/jcem.83.3.4642Freeman MW
Scavenger receptors in atherosclerosis. Curr Opin Hematol. 1997;4(1):41-7 - PMID: 9050378 - DOI: 10.1097/00062752-199704010-00007Christie RH, Freeman M, Hyman BT
Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease. Am J Pathol. 1996;148(2):399-403 - PMID: 8579103 - PMCID: PMC1861668Haydock GS and MW Freeman
Screening for hyperlipidemia. In: Goroll A, May L, Mulley A, eds. 1995. 1995;Primary Care Medicine, 3rd Edit:72-75Aftring RP, Freeman MW
Structure of the murine macrophage scavenger receptor gene and evaluation of sequences that regulate expression in the macrophage cell line, P388D. J Lipid Res. 1995;36(6):1305-14 - PMID: 7666008Li H, Freeman MW, Libby P
Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines. J Clin Invest. 1995;95(1):122-33 - PMID: 7814605 - PMCID: PMC295387 - DOI: 10.1172/JCI117628MW Freeman
Macrophage scavenger receptors. Current Opinions in Lipidology . 1994;5:143-148Aftring RP and MW Freeman
Of mice, men and cholesterol. Hepatology. 1994;19:1054-1056Aftring RP, Freeman MW
Of mice, men and cholesterol. Hepatology. 1994;19(4):1054-6 - PMID: 8138246 - DOI: 10.1002/hep.1840190436Freeman MW
Macrophage scavenger receptors. Curr Opin Lipidol. 1994;5(2):143-8 - PMID: 8044417 - DOI: 10.1097/00041433-199404000-00011Golenbock DT, Liu Y, Millham FH, Freeman MW, Zoeller RA
Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin. J Biol Chem. 1993;268(29):22055-9 - PMID: 7691822Martin KA, and Freeman MW
Postmenopausal hormone-replacement therapy . New Engl J Med. 1993;328:1115-1117M Freeman, Consultant editor. PJ Skerret and SD Emond
What to do about high cholesterol. President and Fellows of Harvard College. Harvard Health Publications. 1993;:ePubAshkenas J, Penman M, Vasile E, Acton S, Freeman M, Krieger M
Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors. J Lipid Res. 1993;34(6):983-1000 - PMID: 8394868Segre GV, Abou-Samra AB, Jüppner H, Schipani E, Force T, Urena P, Freeman M, Kong XF, Kolakowski LF, Hock J
Characterization of cloned PTH/PTHrP receptors. J Endocrinol Invest. 1993;15(9 Suppl 6):11-7 - PMID: 1338633Martin KA, Freeman MW
Postmenopausal hormone-replacement therapy. N Engl J Med. 1993;328(15):1115-7 - PMID: 8455670 - DOI: 10.1056/NEJM199304153281509Retsky KL, Freeman MW, Frei B
Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions. J Biol Chem. 1993;268(2):1304-9 - PMID: 8419332Bickel PE, Freeman MW
Rabbit aortic smooth muscle cells express inducible macrophage scavenger receptor messenger RNA that is absent from endothelial cells. J Clin Invest. 1992;90(4):1450-7 - PMID: 1401078 - PMCID: PMC443191 - DOI: 10.1172/JCI116012Abou-Samra AB, Jüppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT
Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci U S A. 1992;89(7):2732-6 - PMID: 1313566 - PMCID: PMC48736 - DOI: 10.1073/pnas.89.7.2732Jüppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LF, Hock J, Potts JT, Kronenberg HM
A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science. 1991;254(5034):1024-6 - PMID: 1658941 - DOI: 10.1126/science.1658941Freeman M, Ekkel Y, Rohrer L, Penman M, Freedman NJ, Chisolm GM, Krieger M
Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein. Proc Natl Acad Sci U S A. 1991;88(11):4931-5 - PMID: 2052575 - PMCID: PMC51781 - DOI: 10.1073/pnas.88.11.4931Freeman M, Ashkenas J, Rees DJ, Kingsley DM, Copeland NG, Jenkins NA, Krieger M
An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Proc Natl Acad Sci U S A. 1990;87(22):8810-4 - PMID: 1978939 - PMCID: PMC55049 - DOI: 10.1073/pnas.87.22.8810Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M
Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature. 1990;343(6258):531-5 - PMID: 2300204 - DOI: 10.1038/343531a0Rohrer L, Freeman M, Kodama T, Penman M, Krieger M
Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II. Nature. 1990;343(6258):570-2 - PMID: 2300208 - DOI: 10.1038/343570a0Atkinson MJ, Freeman MW, Kronenberg HM
Thymosin beta 4 is expressed in ROS 17/2.8 osteosarcoma cells in a regulated manner. Mol Endocrinol. 1990;4(1):69-74 - PMID: 2325669 - DOI: 10.1210/mend-4-1-69Freeman MW, Rigotti NA, and T. Force
Risk factors in coronary artery disease and cardiac rehabilitation. In: Haber E, Eagle KA, Austen WG, eds. The Practice of Cardiology. 1989;:563-614Wiren KM, Ivashkiv L, Ma P, Freeman MW, Potts JT, Kronenberg HM
Mutations in signal sequence cleavage domain of preproparathyroid hormone alter protein translocation, signal sequence cleavage, and membrane-binding properties. Mol Endocrinol. 1989;3(2):240-50 - PMID: 2710131 - DOI: 10.1210/mend-3-2-240Powers TA, Partain CL, Kessler RM, Freeman MW, Robertson RH, Wyatt SH, Whelan HT
Central nervous system lesions in pediatric patients: Gd-DTPA-enhanced MR imaging. Radiology. 1988;169(3):723-6 - PMID: 3055036 - DOI: 10.1148/radiology.169.3.3055036Potts, JT Jr, Nussbaum S, Wiren K, Freeman M, Igarashi T, Okazaki T, Zajac J, Abou-Samra AB, Bringhurst FR, Segre G, HM Kronenberg
Chemistry, molecular biology, and mode of action of parathyroid hormone. Proceedings of the First International Conference on New Actions of Parathyroid Hormone. Kobe, Japan. 1987;:ePubFreeman MW, Wiren KM, Rapoport A, Lazar M, Potts JT, Kronenberg HM
Consequences of amino-terminal deletions of preproparathyroid hormone signal sequence. Mol Endocrinol. 1987;1(9):628-38 - PMID: 3153480 - DOI: 10.1210/mend-1-9-628Wiren KM, Freeman MW, Potts JT Jr, HM Kronenberg
Preproparathyroid hormone: a model for analyzing the secretory pathway. Ann NY Acad Sci. 1987;493:43-49Kronenberg HM, Wiren KM, Freeman MW, JT Potts Jr
Preproparathyroid hormone: Use of mutants to study secretion. In: Cohn DV, Martin TJ, Meunier PJ, eds. Calcium Regulation and Bone Metabolism: Basic and Clinical Aspects, Vol. 9. Amsterdam: Excerpta Medica. 1987;9:773-777Wiren KM, Freeman MW, Potts JT, Kronenberg HM
Preproparathyroid hormone. A model for analyzing the secretory pathway. Ann N Y Acad Sci. 1987;493:43-9 - PMID: 3473968 - DOI: 10.1111/j.1749-6632.1987.tb27179.xKronenberg HM, Igarashi T, Freeman MW, Okazaki T, Brand SJ, Wiren KM, Potts JT
Structure and expression of the human parathyroid hormone gene. Recent Prog Horm Res. 1986;42:641-63 - PMID: 3526456Vasicek TJ, McDevitt BE, Freeman MW, Fennick BJ, Hendy GN, Potts JT, Rich A, Kronenberg HM
Nucleotide sequence of the human parathyroid hormone gene. Proc Natl Acad Sci U S A. 1983;80(8):2127-31 - PMID: 6220408 - PMCID: PMC393770 - DOI: 10.1073/pnas.80.8.2127Freeman MW, Spring-Mills E, Jones AL
The effect of oxandrolone on low and high density lipoprotein profiles in retired breeder rats. J Gerontol. 1980;35(1):31-8 - PMID: 7350219 - DOI: 10.1093/geronj/35.1.31
