NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges.

Antman EM, Di Corleto PE, Freeman MW, Ganz T, Golan DE, Kitterman R, Loscalzo J, Low M, McKenna E, O'Connor AC, Palazzolo M, Parrish J, Reizes O, Ross RS, Vaughan C, Vince DG, Watts L, NIH Centers for Accelerated Innovations
Nat Rev Drug Discov. 2017;16(10):663-664 - PMID: 28775338 - PMCID: PMC5963257 - DOI: 10.1038/nrd.2017.131

US immigration order strikes against biotech.

Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, Bermingham N, Bloch S, Blum RI, Bolno PB, Bonney MW, Booth B, Bradbury DM, Brauer SK, Byers B, Cagnoni PJ, Cali BM, Ciechanover I, Clark C, Clayman MD, Cleland JL, Cobb P, Cooper R, Currie MG, Diekman J, Dobmeier EL, Doerfler D, Donley EL, Dunsire D, During M, Eckstein JW, Elenko E, Exter NA, Fleming JJ, Flesher GJ, Formela JF, Forre ...
Nat Biotechnol. 2017;35(3):204-206 - PMID: 28267733 - DOI: 10.1038/nbt.3824

Patiromer induces rapid and sustained potassium lowering in patients with chronic kidney disease and hyperkalemia.

Bushinsky DA, Williams GH, Pitt B, Weir MR, Freeman MW, Garza D, Stasiv Y, Li E, Berman L, Bakris GL
Kidney Int. 2015;88(6):1427-1433 - PMID: 26376130 - PMCID: PMC4678168 - DOI: 10.1038/ki.2015.270

Effect of Patiromer on Serum Potassium Level in Patients With Hyperkalemia and Diabetic Kidney Disease: The AMETHYST-DN Randomized Clinical Trial.

Bakris GL, Pitt B, Weir MR, Freeman MW, Mayo MR, Garza D, Stasiv Y, Zawadzki R, Berman L, Bushinsky DA,
JAMA. 2015;314(2):151-161 - PMID: 26172895 - DOI: 10.1001/jama.2015.7446

Future Translational Applications From the Contemporary Genomics Era: A Scientific Statement From the American Heart Association.

Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, Freeman MW, Johnson JA, Lanfear DE, Liggett SB, Lusis AJ, Loscalzo J, MacRae CA, Musunuru K, Newby LK, O'Donnell CJ, Rich SS, Terzic A
Circulation. 2015;131(19):1715-36 - PMID: 25882488 - PMCID: PMC4825323 - DOI: 10.1161/CIR.0000000000000211

Exome Sequencing in Suspected Monogenic Dyslipidemias.

Stitziel NO, Peloso GM, Abifadel M, Cefalù AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, , Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S
Circ Cardiovasc Genet. 2015;8(2):343-50 - PMID: 25632026 - PMCID: PMC4406825 - DOI: 10.1161/CIRCGENETICS.114.000776

High-density lipoprotein-mediated cholesterol efflux capacity is improved by treatment with antiretroviral therapy in acute human immunodeficiency virus infection.

Lo J, Rosenberg ES, Fitzgerald ML, Bazner SB, Ihenachor EJ, Hawxhurst V, Borkowska AH, Wei J, Zimmerman CO, Burdo TH, Williams KC, Freeman MW, Grinspoon SK
Open Forum Infect Dis. 2014;1(3):ofu108 - PMID: 25734176 - PMCID: PMC4324225 - DOI: 10.1093/ofid/ofu108

Endogenous ?-glucocerebrosidase activity in Abca12-/-epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.

Haller JF, Cavallaro P, Hernandez NJ, Dolat L, Soscia SJ, Welti R, Grabowski GA, Fitzgerald ML, Freeman MW
J Lipid Res. 2013;55(3):493-503 - PMID: 24293640 - PMCID: PMC3934733 - DOI: 10.1194/jlr.M044941

Safety and dosing of bevacizumab (avastin) for the treatment of recurrent respiratory papillomatosis.

Best SR, Friedman AD, Landau-Zemer T, Barbu AM, Burns JA, Freeman MW, Halvorsen YD, Hillman RE, Zeitels SM
Ann Otol Rhinol Laryngol. 2012;121(9):587-93 - PMID: 23012897 - DOI: 10.1177/000348941212100905

The Creating an Optimal Warfarin Nomogram (CROWN) Study.

Perlstein TS, Goldhaber SZ, Nelson K, Joshi V, Morgan TV, Lesko LJ, Lee JY, Gobburu J, Schoenfeld D, Kucherlapati R, Freeman MW, Creager MA
Thromb Haemost. 2011;107(1):59-68 - PMID: 22116191 - PMCID: PMC4133142 - DOI: 10.1160/TH11-08-0568

Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-? production independent of cholesterol efflux activity.

Kim WS, Hill AF, Fitzgerald ML, Freeman MW, Evin G, Garner B
J Alzheimers Dis. 2011;27(2):441-52 - PMID: 21860089 - DOI: 10.3233/JAD-2011-110521

Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study.

Zeitels SM, Barbu AM, Landau-Zemer T, Lopez-Guerra G, Burns JA, Friedman AD, Freeman MW, Halvorsen YD, Hillman RE
Ann Otol Rhinol Laryngol. 2011;120(10):627-34 - PMID: 22097147 - DOI: 10.1177/000348941112001001

Lipoprotein Metabolism and the Treatment of Lipid Disorders, Chapter 42. In: DeGroot LJ and JL Jameson, eds

MW Freeman
Endocrinology, 6th edition. 2010;:ePub

Targeting Innate Immunity for CV Benefit.

Moore KJ, Freeman MW
Drug Discov Today Ther Strateg. 2011;5(1):15-23 - PMID: 19430537 - PMCID: PMC2678718 - DOI: 10.1016/j.ddstr.2008.05.007

The path from bench to bedside: considerations before starting the journey.

Freeman MW, Dervan AP
J Investig Med. 2011;59(5):746-51 - PMID: 21441830 - PMCID: PMC4255460 - DOI: 10.2310/JIM.0b013e3182160d70

Embryonal Stem (ES) Cell-Derived Macrophages : A Cellular System that Facilitates the Genetic Dissection of Macrophage Function.

Moore KJ, Freeman MW
Methods Mol Med. 2011;30:343-55 - PMID: 21341038 - DOI: 10.1385/1-59259-247-3:343

What to do about high cholesterol

M Freeman, Consultant editor, 4th edition. Buckley, Rita
President and Fellows of Harvard College. Harvard Health Publications. 2009;:ePub

Approach to the patient with hypercholesterolemia. In: Goroll A, May L, Mulley A, eds

MW Freeman
Primary Care Medicine, 6th Edition. 2009;:ePub

Screening for hyperlipidemia. In: Goroll A and Mulley A, eds.

Haydock GS and MW Freeman
Primary Care Medicine, 6th Edition. 2009;:ePub

ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters.

Zuo Y, Zhuang DZ, Han R, Isaac G, Tobin JJ, McKee M, Welti R, Brissette JL, Fitzgerald ML, Freeman MW
J Biol Chem. 2008;283(52):36624-35 - PMID: 18957418 - PMCID: PMC2605993 - DOI: 10.1074/jbc.M807377200

Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice.

Manning-Tobin JJ, Moore KJ, Seimon TA, Bell SA, Sharuk M, Alvarez-Leite JI, de Winther MP, Tabas I, Freeman MW
Arterioscler Thromb Vasc Biol. 2008;29(1):19-26 - PMID: 18948635 - PMCID: PMC2666043 - DOI: 10.1161/ATVBAHA.108.176644

Targeting innate immunity for CV benefit

KJ Moore and MW Freeman
Drug Discovery Today: Therapeutic Strategies. 2008;5:15-23

SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.

Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML
Biochemistry. 2008;47(23):6138-47 - PMID: 18484747 - PMCID: PMC2504083 - DOI: 10.1021/bi800182t

Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects.

Kiss RS, Kavaslar N, Okuhira K, Freeman MW, Walter S, Milne RW, McPherson R, Marcel YL
Arterioscler Thromb Vasc Biol. 2007;27(5):1139-45 - PMID: 17303779 - DOI: 10.1161/ATVBAHA.106.137646

ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol.

Fitzgerald ML, Xavier R, Haley KJ, Welti R, Goss JL, Brown CE, Zhuang DZ, Bell SA, Lu N, McKee M, Seed B, Freeman MW
J Lipid Res. 2006;48(3):621-32 - PMID: 17142808 - DOI: 10.1194/jlr.M600449-JLR200

Risk factors for coronary artery disease in patients with elevated high-density lipoprotein cholesterol.

DeFaria Yeh D, Freeman MW, Meigs JB, Grant RW
Am J Cardiol. 2006;99(1):1-4 - PMID: 17196452 - DOI: 10.1016/j.amjcard.2006.07.053

Lipid Disorders and Coronary Heart Disease. In: Runge, MS and Patterson, W Eds.

MW Freeman
Molecular Medicine. 2006;:ePub

Statins, cholesterol, and the prevention of coronary heart disease

MW Freeman
FASEB J. 2006;20(2):200-201

A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies.

Kuo WP, Liu F, Trimarchi J, Punzo C, Lombardi M, Sarang J, Whipple ME, Maysuria M, Serikawa K, Lee SY, McCrann D, Kang J, Shearstone JR, Burke J, Park DJ, Wang X, Rector TL, Ricciardi-Castagnoli P, Perrin S, Choi S, Bumgarner R, Kim JH, Short GF, Freeman MW, Seed B, Jensen R, Church GM, Hovig E, Cepko CL, Park P, Ohno-Machado L, Jenssen TK
Nat Biotechnol. 2006;24(7):832-40 - PMID: 16823376 - DOI: 10.1038/nbt1217

Scavenger receptors in atherosclerosis: beyond lipid uptake.

Moore KJ, Freeman MW
Arterioscler Thromb Vasc Biol. 2006;26(8):1702-11 - PMID: 16728653 - DOI: 10.1161/01.ATV.0000229218.97976.43

Statins, cholesterol, and the prevention of coronary heart disease.

Freeman MW
FASEB J. 2006;20(2):200-1 - PMID: 16449790 - DOI: 10.1096/fj.06-0202ufm

Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux.

Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW
J Biol Chem. 2005;280(47):39653-64 - PMID: 16192269 - DOI: 10.1074/jbc.M510187200

Harvard Medical School Guide to Lowering your Cholesterol

MW Freeman and Christine Junge
2005;:ePub

What to do about high cholesterol

M Freeman, Consultant editor 3rd edition Junge C, Skerret PJ, and Emond, SD.
President and Fellows of Harvard College. Harvard Health Publications. 2005;:ePub

Approach to the patient with hypercholesterolemia. In: Goroll A, May L, Mulley A, eds

MW Freeman
Primary Care Medicine, 5th Edition. 2005;:ePub

Tangier Disease and Neuropathy. In: Dyck, PJ and Thomas, PK, Eds

Gilmore O’Neill and MW Freeman
Peripheral Neuropathy 4th edition. 2005;:ePub

Atherosclerosis and innate immunity signaling

Laberge MA, Moore KJ, and MW Freeman.
Annals of Medicine. 2005;37:130-140

Nonparametric methods for microarray data based on exchangeability and borrowed power.

Lee ML, Whitmore GA, Björkbacka H, Freeman MW
J Biopharm Stat. 2005;15(5):783-97 - PMID: 16078385 - DOI: 10.1081/BIP-200067778

Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice.

Moore KJ, Kunjathoor VV, Koehn SL, Manning JJ, Tseng AA, Silver JM, McKee M, Freeman MW
J Clin Invest. 2005;115(8):2192-201 - PMID: 16075060 - PMCID: PMC1180534 - DOI: 10.1172/JCI24061

Atherosclerosis and innate immune signaling.

Laberge MA, Moore KJ, Freeman MW
Ann Med. 2005;37(2):130-40 - PMID: 16026120

Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment.

Heller EA, Liu E, Tager AM, Sinha S, Roberts JD, Koehn SL, Libby P, Aikawa ER, Chen JQ, Huang P, Freeman MW, Moore KJ, Luster AD, Gerszten RE
Circulation. 2005;112(4):578-86 - PMID: 16043658 - DOI: 10.1161/CIRCULATIONAHA.105.545616

Efficacy and safety of the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidaemia.

Farnier M, Freeman MW, Macdonell G, Perevozskaya I, Davies MJ, Mitchel YB, Gumbiner B,
Eur Heart J. 2005;26(9):897-905 - PMID: 15781429 - DOI: 10.1093/eurheartj/ehi231

Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury.

Jeyaseelan S, Chu HW, Young SK, Freeman MW, Worthen GS
Infect Immun. 2005;73(3):1754-63 - PMID: 15731076 - PMCID: PMC1064978 - DOI: 10.1128/IAI.73.3.1754-1763.2005

Generalized rank tests for replicated microarray data.

Lee ML, Gray RJ, Björkbacka H, Freeman MW
Stat Appl Genet Mol Biol. 2005;4:Article3 - PMID: 16646848 - DOI: 10.2202/1544-6115.1093

Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels.

Kim WS, Fitzgerald ML, Kang K, Okuhira K, Bell SA, Manning JJ, Koehn SL, Lu N, Moore KJ, Freeman MW
J Biol Chem. 2004;280(5):3989-95 - PMID: 15550377 - DOI: 10.1074/jbc.M412602200

Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis.

Ricci R, Sumara G, Sumara I, Rozenberg I, Kurrer M, Akhmedov A, Hersberger M, Eriksson U, Eberli FR, Becher B, Borén J, Chen M, Cybulsky MI, Moore KJ, Freeman MW, Wagner EF, Matter CM, Lüscher TF
Science. 2004;306(5701):1558-61 - PMID: 15567863 - DOI: 10.1126/science.1101909

The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.

Björkbacka H, Fitzgerald KA, Huet F, Li X, Gregory JA, Lee MA, Ordija CM, Dowley NE, Golenbock DT, Freeman MW
Physiol Genomics. 2004;19(3):319-30 - PMID: 15367722 - DOI: 10.1152/physiolgenomics.00128.2004

ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities.

Fitzgerald ML, Okuhira K, Short GF, Manning JJ, Bell SA, Freeman MW
J Biol Chem. 2004;279(46):48477-85 - PMID: 15347662 - DOI: 10.1074/jbc.M409848200

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways.

Björkbacka H, Kunjathoor VV, Moore KJ, Koehn S, Ordija CM, Lee MA, Means T, Halmen K, Luster AD, Golenbock DT, Freeman MW
Nat Med. 2004;10(4):416-21 - PMID: 15034566 - DOI: 10.1038/nm1008

Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1.

Chroni A, Liu T, Fitzgerald ML, Freeman MW, Zannis VI
Biochemistry. 2004;43(7):2126-39 - PMID: 14967052 - DOI: 10.1021/bi035813p

ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux.

Fitzgerald ML, Morris AL, Chroni A, Mendez AJ, Zannis VI, Freeman MW
J Lipid Res. 2003;45(2):287-94 - PMID: 14617740 - DOI: 10.1194/jlr.M300355-JLR200

Activation of signaling pathways by putative scavenger receptor class A (SR-A) ligands requires CD14 but not SR-A.

Kim WS, Ordija CM, Freeman MW
Biochem Biophys Res Commun. 2003;310(2):542-9 - PMID: 14521944

CD36 mediates the innate host response to beta-amyloid.

El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD
J Exp Med. 2003;197(12):1657-66 - PMID: 12796468 - PMCID: PMC2193948 - DOI: 10.1084/jem.20021546

eLiXiRs for restraining inflammation.

Freeman MW, Moore KJ
Nat Med. 2003;9(2):168-9 - PMID: 12563335 - DOI: 10.1038/nm0203-168

Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages.

Kunjathoor VV, Febbraio M, Podrez EA, Moore KJ, Andersson L, Koehn S, Rhee JS, Silverstein R, Hoff HF, Freeman MW
J Biol Chem. 2002;277(51):49982-8 - PMID: 12376530 - DOI: 10.1074/jbc.M209649200

Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice.

Yang KK, Dorner BG, Merkel U, Ryffel B, Schütt C, Golenbock D, Freeman MW, Jack RS
J Immunol. 2002;169(8):4475-80 - PMID: 12370383

Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.

Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT
J Immunol. 2002;169(7):3970-7 - PMID: 12244198

A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid.

Moore KJ, El Khoury J, Medeiros LA, Terada K, Geula C, Luster AD, Freeman MW
J Biol Chem. 2002;277(49):47373-9 - PMID: 12239221 - DOI: 10.1074/jbc.M208788200

The Treatment of Dyslipidemia: LDL Reduction and Beyond

MW Freeman
In Endocrinology Rounds. 2002;1, Issue 8:ePub

Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I.

Fitzgerald ML, Morris AL, Rhee JS, Andersson LP, Mendez AJ, Freeman MW
J Biol Chem. 2002;277(36):33178-87 - PMID: 12084722 - DOI: 10.1074/jbc.M204996200

Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home.

Fitzgerald ML, Moore KJ, Freeman MW
J Mol Med (Berl). 2002;80(5):271-81 - PMID: 12021839 - DOI: 10.1007/s00109-001-0318-y

C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.

Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM
Genes Dev. 2002;16(1):22-6 - PMID: 11782441 - PMCID: PMC155311 - DOI: 10.1101/gad.948702

LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection.

Bernheiden M, Heinrich JM, Minigo G, Schütt C, Stelter F, Freeman M, Golenbock D, Jack RS
J Endotoxin Res. 2001;7(6):447-50 - PMID: 11753215

Peroxisome proliferator-activated receptors in macrophage biology: friend or foe?

Moore KJ, Fitzgerald ML, Freeman MW
Curr Opin Lipidol. 2001;12(5):519-27 - PMID: 11561171

Evidence that dendritic cells infiltrate atherosclerotic lesions in apolipoprotein E-deficient mice.

Bobryshev YV, Taksir T, Lord RS, Freeman MW
Histol Histopathol. 2001;16(3):801-8 - PMID: 11510970 - DOI: 10.14670/HH-16.801

ATP-binding cassette transporter A1 contains an NH2-terminal signal anchor sequence that translocates the protein's first hydrophilic domain to the exoplasmic space.

Fitzgerald ML, Mendez AJ, Moore KJ, Andersson LP, Panjeton HA, Freeman MW
J Biol Chem. 2001;276(18):15137-45 - PMID: 11328826

Manipulating intestinal cholesterol absorption and hepatic cholesterol and bile acid metabolism by activation of deorphanized nuclear receptors.

Rigotti A, Freeman MW
Gastroenterology. 2001;120(4):1054-5 - PMID: 11231965

The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.

Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW
Nat Med. 2001;7(1):41-7 - PMID: 11135614 - DOI: 10.1038/83328

Effects of overexpression of the amino-terminal fragment of apolipoprotein B on apolipoprotein B and lipoprotein production.

Li Z, Kako Y, Pang L, Freeman MW, Glick JM, Wang X, Goldberg IJ
J Lipid Res. 2000;41(12):1912-20 - PMID: 11108724

Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression.

Wang X, Zeng W, Murakawa M, Freeman MW, Seed B
J Virol. 2000;74(23):11296-303 - PMID: 11070029 - PMCID: PMC113234

Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression.

Wang X, Zeng W, Murakawa M, Freeman MW, Seed B
J Virol. 2000;74(23):11296-303 - PMID: 11070029 - PMCID: PMC113234

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.

Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, Finberg RW
Nat Immunol. 2000;1(5):398-401 - PMID: 11062499 - DOI: 10.1038/80833

Divergent response to LPS and bacteria in CD14-deficient murine macrophages.

Moore KJ, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, Golenbock DT, Freeman MW
J Immunol. 2000;165(8):4272-80 - PMID: 11035061

What to do about high cholesterol

M Freeman, Consultant editor 2nd edition. PJ Skerret and SD Emond
President and Fellows of Harvard College. Harvard Health Publications. 2000;:ePub

Cellular cholesterol efflux in heterozygotes for tangier disease is markedly reduced and correlates with high density lipoprotein cholesterol concentration and particle size.

Brousseau ME, Eberhart GP, Dupuis J, Asztalos BF, Goldkamp AL, Schaefer EJ, Freeman MW
J Lipid Res. 2000;41(7):1125-35 - PMID: 10884295

Novel mutations in the gene encoding ATP-binding cassette 1 in four tangier disease kindreds.

Brousseau ME, Schaefer EJ, Dupuis J, Eustace B, Van Eerdewegh P, Goldkamp AL, Thurston LM, FitzGerald MG, Yasek-McKenna D, O'Neill G, Eberhart GP, Weiffenbach B, Ordovas JM, Freeman MW, Brown RH, Gu JZ
J Lipid Res. 2000;41(3):433-41 - PMID: 10706591

Lipopolysaccharide induces scavenger receptor A expression in mouse macrophages: a divergent response relative to human THP-1 monocyte/macrophages.

Fitzgerald ML, Moore KJ, Freeman MW, Reed GL
J Immunol. 2000;164(5):2692-700 - PMID: 10679110

Stromelysin-1 (MMP-3) expression driven by a macrophage-specific promoter results in reduced viability in transgenic mice.

Fabunmi RP, Moore KJ, Libby P, Freeman MW
Atherosclerosis. 2000;148(2):375-86 - PMID: 10657574

Effluxed lipids: Tangier Island's latest export.

Freeman MW
Proc Natl Acad Sci U S A. 1999;96(20):10950-2 - PMID: 10500104 - PMCID: PMC34222

Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion.

Chiang N, Gronert K, Clish CB, O'Brien JA, Freeman MW, Serhan CN
J Clin Invest. 1999;104(3):309-16 - PMID: 10430612 - PMCID: PMC408424 - DOI: 10.1172/JCI7016

In vitro-differentiated embryonic stem cell macrophages: a model system for studying atherosclerosis-associated macrophage functions.

Moore KJ, Fabunmi RP, Andersson LP, Freeman MW
Arterioscler Thromb Vasc Biol. 1998;18(10):1647-54 - PMID: 9763539

Functional changes in scavenger receptor binding conformation are induced by charge mutants spanning the entire collagen domain.

Andersson L, Freeman MW
J Biol Chem. 1998;273(31):19592-601 - PMID: 9677385

Decreased cholesterol efflux from fibroblasts of a patient without Tangier disease, but with markedly reduced high density lipoprotein cholesterol levels.

Eberhart GP, Mendez AJ, Freeman MW
J Clin Endocrinol Metab. 1998;83(3):836-46 - PMID: 9506737 - DOI: 10.1210/jcem.83.3.4642

Scavenger receptors in atherosclerosis.

Freeman MW
Curr Opin Hematol. 1997;4(1):41-7 - PMID: 9050378

Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease.

Christie RH, Freeman M, Hyman BT
Am J Pathol. 1996;148(2):399-403 - PMID: 8579103 - PMCID: PMC1861668

Screening for hyperlipidemia. In: Goroll A, May L, Mulley A, eds

Haydock GS and MW Freeman
1995. 1995;Primary Care Medicine, 3rd Edit:72-75

Structure of the murine macrophage scavenger receptor gene and evaluation of sequences that regulate expression in the macrophage cell line, P388D.

Aftring RP, Freeman MW
J Lipid Res. 1995;36(6):1305-14 - PMID: 7666008

Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines.

Li H, Freeman MW, Libby P
J Clin Invest. 1995;95(1):122-33 - PMID: 7814605 - PMCID: PMC295387 - DOI: 10.1172/JCI117628

Macrophage scavenger receptors

MW Freeman
Current Opinions in Lipidology . 1994;5:143-148

Of mice, men and cholesterol

Aftring RP and MW Freeman
Hepatology. 1994;19:1054-1056

Of mice, men and cholesterol.

Aftring RP, Freeman MW
Hepatology. 1994;19(4):1054-6 - PMID: 8138246

Macrophage scavenger receptors.

Freeman MW
Curr Opin Lipidol. 1994;5(2):143-8 - PMID: 8044417

Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin.

Golenbock DT, Liu Y, Millham FH, Freeman MW, Zoeller RA
J Biol Chem. 1993;268(29):22055-9 - PMID: 7691822

Postmenopausal hormone-replacement therapy

Martin KA, and Freeman MW
New Engl J Med. 1993;328:1115-1117

What to do about high cholesterol

M Freeman, Consultant editor. PJ Skerret and SD Emond
President and Fellows of Harvard College. Harvard Health Publications. 1993;:ePub

Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors.

Ashkenas J, Penman M, Vasile E, Acton S, Freeman M, Krieger M
J Lipid Res. 1993;34(6):983-1000 - PMID: 8394868

Characterization of cloned PTH/PTHrP receptors.

Segre GV, Abou-Samra AB, Jüppner H, Schipani E, Force T, Urena P, Freeman M, Kong XF, Kolakowski LF, Hock J
J Endocrinol Invest. 1993;15(9 Suppl 6):11-7 - PMID: 1338633

Postmenopausal hormone-replacement therapy.

Martin KA, Freeman MW
N Engl J Med. 1993;328(15):1115-7 - PMID: 8455670 - DOI: 10.1056/NEJM199304153281509

Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions.

Retsky KL, Freeman MW, Frei B
J Biol Chem. 1993;268(2):1304-9 - PMID: 8419332

Rabbit aortic smooth muscle cells express inducible macrophage scavenger receptor messenger RNA that is absent from endothelial cells.

Bickel PE, Freeman MW
J Clin Invest. 1992;90(4):1450-7 - PMID: 1401078 - PMCID: PMC443191 - DOI: 10.1172/JCI116012

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

Abou-Samra AB, Jüppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT
Proc Natl Acad Sci U S A. 1992;89(7):2732-6 - PMID: 1313566 - PMCID: PMC48736

A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.

Jüppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LF, Hock J, Potts JT, Kronenberg HM
Science. 1991;254(5034):1024-6 - PMID: 1658941

Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein.

Freeman M, Ekkel Y, Rohrer L, Penman M, Freedman NJ, Chisolm GM, Krieger M
Proc Natl Acad Sci U S A. 1991;88(11):4931-5 - PMID: 2052575 - PMCID: PMC51781

An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors.

Freeman M, Ashkenas J, Rees DJ, Kingsley DM, Copeland NG, Jenkins NA, Krieger M
Proc Natl Acad Sci U S A. 1990;87(22):8810-4 - PMID: 1978939 - PMCID: PMC55049

Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils.

Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M
Nature. 1990;343(6258):531-5 - PMID: 2300204 - DOI: 10.1038/343531a0

Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II.

Rohrer L, Freeman M, Kodama T, Penman M, Krieger M
Nature. 1990;343(6258):570-2 - PMID: 2300208 - DOI: 10.1038/343570a0

Thymosin beta 4 is expressed in ROS 17/2.8 osteosarcoma cells in a regulated manner.

Atkinson MJ, Freeman MW, Kronenberg HM
Mol Endocrinol. 1990;4(1):69-74 - PMID: 2325669 - DOI: 10.1210/mend-4-1-69

Risk factors in coronary artery disease and cardiac rehabilitation. In: Haber E, Eagle KA, Austen WG, eds

Freeman MW, Rigotti NA, and T. Force
The Practice of Cardiology. 1989;:563-614

Mutations in signal sequence cleavage domain of preproparathyroid hormone alter protein translocation, signal sequence cleavage, and membrane-binding properties.

Wiren KM, Ivashkiv L, Ma P, Freeman MW, Potts JT, Kronenberg HM
Mol Endocrinol. 1989;3(2):240-50 - PMID: 2710131 - DOI: 10.1210/mend-3-2-240

Central nervous system lesions in pediatric patients: Gd-DTPA-enhanced MR imaging.

Powers TA, Partain CL, Kessler RM, Freeman MW, Robertson RH, Wyatt SH, Whelan HT
Radiology. 1988;169(3):723-6 - PMID: 3055036 - DOI: 10.1148/radiology.169.3.3055036

Chemistry, molecular biology, and mode of action of parathyroid hormone.

Potts, JT Jr, Nussbaum S, Wiren K, Freeman M, Igarashi T, Okazaki T, Zajac J, Abou-Samra AB, Bringhurst FR, Segre G, HM Kronenberg
Proceedings of the First International Conference on New Actions of Parathyroid Hormone. Kobe, Japan. 1987;:ePub

Consequences of amino-terminal deletions of preproparathyroid hormone signal sequence.

Freeman MW, Wiren KM, Rapoport A, Lazar M, Potts JT, Kronenberg HM
Mol Endocrinol. 1987;1(9):628-38 - PMID: 3153480 - DOI: 10.1210/mend-1-9-628

Preproparathyroid hormone: a model for analyzing the secretory pathway.

Wiren KM, Freeman MW, Potts JT Jr, HM Kronenberg
Ann NY Acad Sci. 1987;493:43-49

Preproparathyroid hormone: Use of mutants to study secretion. In: Cohn DV, Martin TJ, Meunier PJ, eds.

Kronenberg HM, Wiren KM, Freeman MW, JT Potts Jr
Calcium Regulation and Bone Metabolism: Basic and Clinical Aspects, Vol. 9. Amsterdam: Excerpta Medica. 1987;9:773-777

Preproparathyroid hormone. A model for analyzing the secretory pathway.

Wiren KM, Freeman MW, Potts JT, Kronenberg HM
Ann N Y Acad Sci. 1987;493:43-9 - PMID: 3473968

Structure and expression of the human parathyroid hormone gene.

Kronenberg HM, Igarashi T, Freeman MW, Okazaki T, Brand SJ, Wiren KM, Potts JT
Recent Prog Horm Res. 1986;42:641-63 - PMID: 3526456

Nucleotide sequence of the human parathyroid hormone gene.

Vasicek TJ, McDevitt BE, Freeman MW, Fennick BJ, Hendy GN, Potts JT, Rich A, Kronenberg HM
Proc Natl Acad Sci U S A. 1983;80(8):2127-31 - PMID: 6220408 - PMCID: PMC393770

The effect of oxandrolone on low and high density lipoprotein profiles in retired breeder rats.

Freeman MW, Spring-Mills E, Jones AL
J Gerontol. 1980;35(1):31-8 - PMID: 7350219