Freeman MW, Halvorsen YD, Bond M, Murphy B, Isaacsohn J Results from a Phase 1 Study Assessing the Pharmacokinetics of the Aldosterone Synthase Inhibitor Baxdrostat in Participants with Varying Degrees of Renal Function. Clin Pharmacol Drug Dev. 2024;13(4):410-418 - PMID: 38311833 - DOI: 10.1002/cpdd.1371

McMurray JJV, Solomon SD, Lock JP, Massaro JM, Zhu F, Zhou W, Skali H, Lewis EF, Freeman MW, Halvorsen YC Meta-analysis of risk of major adverse cardiovascular events in adults with type 2 diabetes treated with bexagliflozin. Diabetes Obes Metab. 2023;26(3):971-979 - PMID: 38151752 - DOI: 10.1111/dom.15394

Halvorsen YD, Conery AL, Lock JP, Zhou W, Freeman MW Bexagliflozin as an adjunct to metformin for the treatment of type 2 diabetes in adults: A 24-week, randomized, double-blind, placebo-controlled trial. Diabetes Obes Metab. 2023;25(10):2954-2962 - PMID: 37409573 - DOI: 10.1111/dom.15192

Freeman MW, Bond M, Murphy B, Hui J, Isaacsohn J Results From a Randomized, Open-Label, Crossover Study Evaluating the Effect of the Aldosterone Synthase Inhibitor Baxdrostat on the Pharmacokinetics of Metformin in Healthy Human Subjects. Am J Cardiovasc Drugs. 2023;23(3):277-286 - PMID: 36790596 - PMCID: PMC9930700 - DOI: 10.1007/s40256-023-00572-x

Freeman MW, Halvorsen YD, Marshall W, Pater M, Isaacsohn J, Pearce C, Murphy B, Alp N, Srivastava A, Bhatt DL, Brown MJ, BrigHTN Investigators Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension. N Engl J Med. 2022;388(5):395-405 - PMID: 36342143 - DOI: 10.1056/NEJMoa2213169

Freeman MW, Bond M, Murphy B, Hui J, Isaacsohn J Results from a phase 1, randomized, double-blind, multiple ascending dose study characterizing the pharmacokinetics and demonstrating the safety and selectivity of the aldosterone synthase inhibitor baxdrostat in healthy volunteers. Hypertens Res. 2022;46(1):108-118 - PMID: 36266539 - PMCID: PMC9747611 - DOI: 10.1038/s41440-022-01070-4

Halvorsen YD, Lock JP, Frias JP, Tinahones FJ, Dahl D, Conery AL, Freeman MW A 96-Week, Double-Blind, Randomized, Controlled Trial Comparing Bexagliflozin to Glimepiride as an Adjunct to Metformin for the Treatment of Type 2 Diabetes in Adults. Diabetes Obes Metab. 2022;25(1):293-301 - PMID: 36178197 - DOI: 10.1111/dom.14875

Zabaleta N, Dai W, Bhatt U, Chichester JA, Estelien R, Sanmiguel J, Michalson KT, Diop C, Maciorowski D, Qi W, Hudspeth E, Cucalon A, Dyer CD, Pampena MB, Knox JJ, LaRocque RC, Charles RC, Li D, Kim M, Sheridan A, Storm N, Johnson RI, Feldman J, Hauser BM, Ryan A, Kobayashi DT, Chauhan R, McGlynn M, Ryan ET, Schmidt AG, Price B, Honko A, Griffiths A, Yaghmour S, Hodge R, Betts MR, Freeman MW, Wilson JM, Vandenberghe LH Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates. bioRxiv. 2021;:ePub - PMID: 33442684 - PMCID: PMC7805441 - DOI: 10.1101/2021.01.05.422952

Halvorsen YD, Walford GA, Massaro J, Aftring RP, Freeman MW A 96-Week Multinational Randomized Double-Blind Parallel-Group Clinical Trial Evaluating the Safety and Effectiveness of Bexagliflozin as a Monotherapy for Adults with Type 2 Diabetes. Diabetes Obes Metab. 2019;21(11):2496-2504 - PMID: 31297965 - DOI: 10.1111/dom.13833

Freeman MW, Singh AK, Guidon AC, Arvikar SL, Goldstein RH, Clement NF Case 22-2019: A 65-Year-Old Woman with Weakness, Dark Urine, and Dysphagia. N Engl J Med. 2019;381(3):275-283 - PMID: 31314973 - DOI: 10.1056/NEJMcpc1900589

Halvorsen YD, Lock JP, Zhou W, Zhu F, Freeman MW A 24-week, randomized, double-blind, active-controlled clinical trial comparing bexagliflozin to sitagliptin as an adjunct to metformin for the treatment of type 2 diabetes in adults. Diabetes Obes Metab. 2019;21(10):2248-2256 - PMID: 31161692 - DOI: 10.1111/dom.13801

Allegretti AS, Zhang W, Zhou W, Thurber TK, Rigby SP, Bowman-Stroud C, Trescoli C, Serusclat P, Freeman MW, Halvorsen YC Safety and Effectiveness of Bexagliflozin in Patients With Type 2 Diabetes Mellitus and Stage 3a/3b CKD. Am J Kidney Dis. 2019;74(3):328-337 - PMID: 31101403 - PMCID: PMC10077840 - DOI: 10.1053/j.ajkd.2019.03.417

Pitt B, Bakris GL, Weir MR, Freeman MW, Lainscak M, Mayo MR, Garza D, Zawadzki R, Berman L, Bushinsky DA Long-term effects of patiromer for hyperkalaemia treatment in patients with mild heart failure and diabetic nephropathy on angiotensin-converting enzymes/angiotensin receptor blockers: results from AMETHYST-DN. ESC Heart Fail. 2018;5(4):592-602 - PMID: 29767459 - PMCID: PMC6073017 - DOI: 10.1002/ehf2.12292

Antman EM, Di Corleto PE, Freeman MW, Ganz T, Golan DE, Kitterman R, Loscalzo J, Low M, McKenna E, O'Connor AC, Palazzolo M, Parrish J, Reizes O, Ross RS, Vaughan C, Vince DG, Watts L, NIH Centers for Accelerated Innovations NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges. Nat Rev Drug Discov. 2017;16(10):663-664 - PMID: 28775338 - PMCID: PMC5963257 - DOI: 10.1038/nrd.2017.131

Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, Bermingham N, Bloch S, Blum RI, Bolno PB, Bonney MW, Booth B, Bradbury DM, Brauer SK, Byers B, Cagnoni PJ, Cali BM, Ciechanover I, Clark C, Clayman MD, Cleland JL, Cobb P, Cooper R, Currie MG, Diekman J, Dobmeier EL, Doerfler D, Donley EL, Dunsire D, During M, Eckstein JW, Elenko E, Exter NA, Fleming JJ, Flesher GJ, Formela JF, Forrester R, Francois C, Franklin H, Freeman MW, Furst H, Gage LP, Galakatos N, Gallagher BM, Geraghty JA, Gill S, Goeddel DV, Goldsmith MA, Gowen M, Goyal V, Graney T, Grayzel D, Greene B, Grint P, Gutierrez-Ramos JC, Haney B, Ha-Ngoc T, Harris T, Hasnain F, Hata YS, Hecht P, Henshaw L, Heyman R, Hoppenot H, Horvitz HR, Hughes TE, Hutton WS, Isaacs ST, Jenkins A, Jonker J, Kaplan J, Karsen P, Keiper J, Kim J, Kindler J, King R, King V, Kjellson N, Koenig S, Koenig G, Kolchinsky P, Laikind P, Langer RB, Lee JJ, Leff JS, Leicher BA, Leschly N, Levin A, Levin M, Levine AJ, Levy A, Liu DR, Lodish HF, Lopatin U, Love TW, Macdonald G, Maderis GJ, Mahadevia A, Mahanthappa NK, Martin JF, Martin A, Martucci WE, McArthur JG, McCann CM, McCarthy SA, McDonough CG, Mendlein J, Miller L, Miralles D, Moch KI, More B, Myers AG, Narachi MA, Nashat A, Nelson W, Newell WJ, Olle B, Osborn JE, Owens JC, Pande A, Papadopoulos S, Parker HS, Parmar KM, Patterson MR, Paul SM, Perez R, Perry M, Pfeffer CG, Powell M, Pruzanski M, Purcell DJ, Rakhit A, Ramamoorthi K, Rastetter W, Rawcliffe AA, Reid LE, Renaud RC, Rhodes JP, Rieflin WJ, Robins C, Rocklage SM, Rosenblatt M, Rosin JG, Rutter WJ, Saha S, Samuels C, Sato VL, Scangos G, Scarlett JA, Schenkein D, Schreiber SL, Schwab A, Sekhri P, Shah R, Shenk T, Siegall CB, Simon NJ, Simonian N, Stein J, Su M, Szela MT, Taglietti M, Tandon N, Termeer H, Thornberry NA, Tolar M, Ulevitch R, Vaishnaw AK, VanLent A, Varsavsky M, Vlasuk GP, Vounatsos M, Waksal SG, Warma N, Watts RJ, Werber Y, Westphal C, Wierenga W, Williams DE, Williams LR, Xanthopoulos KG, Zohar D, Zweifach SS US immigration order strikes against biotech. Nat Biotechnol. 2017;35(3):204-206 - PMID: 28267733 - DOI: 10.1038/nbt.3824

Bushinsky DA, Williams GH, Pitt B, Weir MR, Freeman MW, Garza D, Stasiv Y, Li E, Berman L, Bakris GL Patiromer induces rapid and sustained potassium lowering in patients with chronic kidney disease and hyperkalemia. Kidney Int. 2015;88(6):1427-1433 - PMID: 26376130 - PMCID: PMC4678168 - DOI: 10.1038/ki.2015.270

Bakris GL, Pitt B, Weir MR, Freeman MW, Mayo MR, Garza D, Stasiv Y, Zawadzki R, Berman L, Bushinsky DA, Effect of Patiromer on Serum Potassium Level in Patients With Hyperkalemia and Diabetic Kidney Disease: The AMETHYST-DN Randomized Clinical Trial. JAMA. 2015;314(2):151-61 - PMID: 26172895 - DOI: 10.1001/jama.2015.7446

Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, Freeman MW, Johnson JA, Lanfear DE, Liggett SB, Lusis AJ, Loscalzo J, MacRae CA, Musunuru K, Newby LK, O'Donnell CJ, Rich SS, Terzic A Future Translational Applications From the Contemporary Genomics Era: A Scientific Statement From the American Heart Association. Circulation. 2015;131(19):1715-36 - PMID: 25882488 - PMCID: PMC4825323 - DOI: 10.1161/CIR.0000000000000211

Stitziel NO, Peloso GM, Abifadel M, Cefalù AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, , Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S Exome Sequencing in Suspected Monogenic Dyslipidemias. Circ Cardiovasc Genet. 2015;8(2):343-50 - PMID: 25632026 - PMCID: PMC4406825 - DOI: 10.1161/CIRCGENETICS.114.000776

Lo J, Rosenberg ES, Fitzgerald ML, Bazner SB, Ihenachor EJ, Hawxhurst V, Borkowska AH, Wei J, Zimmerman CO, Burdo TH, Williams KC, Freeman MW, Grinspoon SK High-density lipoprotein-mediated cholesterol efflux capacity is improved by treatment with antiretroviral therapy in acute human immunodeficiency virus infection. Open Forum Infect Dis. 2014;1(3):ofu108 - PMID: 25734176 - PMCID: PMC4324225 - DOI: 10.1093/ofid/ofu108

Haller JF, Cavallaro P, Hernandez NJ, Dolat L, Soscia SJ, Welti R, Grabowski GA, Fitzgerald ML, Freeman MW Endogenous ?-glucocerebrosidase activity in Abca12-/-epidermis elevates ceramide levels after topical lipid application but does not restore barrier function. J Lipid Res. 2014;55(3):493-503 - PMID: 24293640 - PMCID: PMC3934733 - DOI: 10.1194/jlr.M044941

Best SR, Friedman AD, Landau-Zemer T, Barbu AM, Burns JA, Freeman MW, Halvorsen YD, Hillman RE, Zeitels SM Safety and dosing of bevacizumab (avastin) for the treatment of recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol. 2012;121(9):587-93 - PMID: 23012897 - DOI: 10.1177/000348941212100905

Kim WS, Hill AF, Fitzgerald ML, Freeman MW, Evin G, Garner B Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-? production independent of cholesterol efflux activity. J Alzheimers Dis. 2011;27(2):441-52 - PMID: 21860089 - DOI: 10.3233/JAD-2011-110521

Zeitels SM, Barbu AM, Landau-Zemer T, Lopez-Guerra G, Burns JA, Friedman AD, Freeman MW, Halvorsen YD, Hillman RE Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study. Ann Otol Rhinol Laryngol. 2011;120(10):627-34 - PMID: 22097147 - DOI: 10.1177/000348941112001001

MW Freeman Lipoprotein Metabolism and the Treatment of Lipid Disorders, Chapter 42. In: DeGroot LJ and JL Jameson, eds. Endocrinology, 6th edition. 2010;:ePub

Moore KJ, Freeman MW Targeting Innate Immunity for CV Benefit. Drug Discov Today Ther Strateg. 2011;5(1):15-23 - PMID: 19430537 - PMCID: PMC2678718 - DOI: 10.1016/j.ddstr.2008.05.007

Freeman MW, Dervan AP The path from bench to bedside: considerations before starting the journey. J Investig Med. 2011;59(5):746-51 - PMID: 21441830 - PMCID: PMC4255460 - DOI: 10.2310/JIM.0b013e3182160d70

Moore KJ, Freeman MW Embryonal Stem (ES) Cell-Derived Macrophages : A Cellular System that Facilitates the Genetic Dissection of Macrophage Function. Methods Mol Med. 2011;30:343-55 - PMID: 21341038 - DOI: 10.1385/1-59259-247-3:343

M Freeman, Consultant editor, 4th edition. Buckley, Rita What to do about high cholesterol. President and Fellows of Harvard College. Harvard Health Publications. 2009;:ePub

MW Freeman Approach to the patient with hypercholesterolemia. In: Goroll A, May L, Mulley A, eds. Primary Care Medicine, 6th Edition. 2009;:ePub

Haydock GS and MW Freeman Screening for hyperlipidemia. In: Goroll A and Mulley A, eds. . Primary Care Medicine, 6th Edition. 2009;:ePub

Zuo Y, Zhuang DZ, Han R, Isaac G, Tobin JJ, McKee M, Welti R, Brissette JL, Fitzgerald ML, Freeman MW ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. J Biol Chem. 2008;283(52):36624-35 - PMID: 18957418 - PMCID: PMC2605993 - DOI: 10.1074/jbc.M807377200

KJ Moore and MW Freeman Targeting innate immunity for CV benefit. Drug Discovery Today: Therapeutic Strategies. 2008;5:15-23

Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter. Biochemistry. 2008;47(23):6138-47 - PMID: 18484747 - PMCID: PMC2504083 - DOI: 10.1021/bi800182t

Kiss RS, Kavaslar N, Okuhira K, Freeman MW, Walter S, Milne RW, McPherson R, Marcel YL Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects. Arterioscler Thromb Vasc Biol. 2007;27(5):1139-45 - PMID: 17303779 - DOI: 10.1161/ATVBAHA.106.137646

MW Freeman Lipid Disorders and Coronary Heart Disease. In: Runge, MS and Patterson, W Eds. . Molecular Medicine. 2006;:ePub

MW Freeman Statins, cholesterol, and the prevention of coronary heart disease. FASEB J. 2006;20(2):200-201

Kuo WP, Liu F, Trimarchi J, Punzo C, Lombardi M, Sarang J, Whipple ME, Maysuria M, Serikawa K, Lee SY, McCrann D, Kang J, Shearstone JR, Burke J, Park DJ, Wang X, Rector TL, Ricciardi-Castagnoli P, Perrin S, Choi S, Bumgarner R, Kim JH, Short GF, Freeman MW, Seed B, Jensen R, Church GM, Hovig E, Cepko CL, Park P, Ohno-Machado L, Jenssen TK A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Nat Biotechnol. 2006;24(7):832-40 - PMID: 16823376 - DOI: 10.1038/nbt1217

Moore KJ, Freeman MW Scavenger receptors in atherosclerosis: beyond lipid uptake. Arterioscler Thromb Vasc Biol. 2006;26(8):1702-11 - PMID: 16728653 - DOI: 10.1161/01.ATV.0000229218.97976.43

Freeman MW Statins, cholesterol, and the prevention of coronary heart disease. FASEB J. 2006;20(2):200-1 - PMID: 16449790 - DOI: 10.1096/fj.06-0202ufm

Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. J Biol Chem. 2005;280(47):39653-64 - PMID: 16192269 - DOI: 10.1074/jbc.M510187200

MW Freeman and Christine Junge Harvard Medical School Guide to Lowering your Cholesterol. 2005;:ePub

M Freeman, Consultant editor 3rd edition Junge C, Skerret PJ, and Emond, SD. What to do about high cholesterol. President and Fellows of Harvard College. Harvard Health Publications. 2005;:ePub

MW Freeman Approach to the patient with hypercholesterolemia. In: Goroll A, May L, Mulley A, eds. Primary Care Medicine, 5th Edition. 2005;:ePub

Gilmore O’Neill and MW Freeman Tangier Disease and Neuropathy. In: Dyck, PJ and Thomas, PK, Eds. Peripheral Neuropathy 4th edition. 2005;:ePub

Laberge MA, Moore KJ, and MW Freeman. Atherosclerosis and innate immunity signaling. Annals of Medicine. 2005;37:130-140

Lee ML, Whitmore GA, Björkbacka H, Freeman MW Nonparametric methods for microarray data based on exchangeability and borrowed power. J Biopharm Stat. 2005;15(5):783-97 - PMID: 16078385 - DOI: 10.1081/BIP-200067778

Moore KJ, Kunjathoor VV, Koehn SL, Manning JJ, Tseng AA, Silver JM, McKee M, Freeman MW Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J Clin Invest. 2005;115(8):2192-201 - PMID: 16075060 - PMCID: PMC1180534 - DOI: 10.1172/JCI24061

Laberge MA, Moore KJ, Freeman MW Atherosclerosis and innate immune signaling. Ann Med. 2005;37(2):130-40 - PMID: 16026120 - DOI: 10.1080/07853890510007304

Heller EA, Liu E, Tager AM, Sinha S, Roberts JD, Koehn SL, Libby P, Aikawa ER, Chen JQ, Huang P, Freeman MW, Moore KJ, Luster AD, Gerszten RE Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation. 2005;112(4):578-86 - PMID: 16043658 - DOI: 10.1161/CIRCULATIONAHA.105.545616

Farnier M, Freeman MW, Macdonell G, Perevozskaya I, Davies MJ, Mitchel YB, Gumbiner B, Efficacy and safety of the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidaemia. Eur Heart J. 2005;26(9):897-905 - PMID: 15781429 - DOI: 10.1093/eurheartj/ehi231

Jeyaseelan S, Chu HW, Young SK, Freeman MW, Worthen GS Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun. 2005;73(3):1754-63 - PMID: 15731076 - PMCID: PMC1064978 - DOI: 10.1128/IAI.73.3.1754-1763.2005

Lee ML, Gray RJ, Björkbacka H, Freeman MW Generalized rank tests for replicated microarray data. Stat Appl Genet Mol Biol. 2005;4:Article3 - PMID: 16646848 - DOI: 10.2202/1544-6115.1093

Ricci R, Sumara G, Sumara I, Rozenberg I, Kurrer M, Akhmedov A, Hersberger M, Eriksson U, Eberli FR, Becher B, Borén J, Chen M, Cybulsky MI, Moore KJ, Freeman MW, Wagner EF, Matter CM, Lüscher TF Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science. 2004;306(5701):1558-61 - PMID: 15567863 - DOI: 10.1126/science.1101909

Björkbacka H, Fitzgerald KA, Huet F, Li X, Gregory JA, Lee MA, Ordija CM, Dowley NE, Golenbock DT, Freeman MW The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades. Physiol Genomics. 2004;19(3):319-30 - PMID: 15367722 - DOI: 10.1152/physiolgenomics.00128.2004

Fitzgerald ML, Okuhira K, Short GF, Manning JJ, Bell SA, Freeman MW ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities. J Biol Chem. 2004;279(46):48477-85 - PMID: 15347662 - DOI: 10.1074/jbc.M409848200

Björkbacka H, Kunjathoor VV, Moore KJ, Koehn S, Ordija CM, Lee MA, Means T, Halmen K, Luster AD, Golenbock DT, Freeman MW Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med. 2004;10(4):416-21 - PMID: 15034566 - DOI: 10.1038/nm1008

Chroni A, Liu T, Fitzgerald ML, Freeman MW, Zannis VI Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1. Biochemistry. 2004;43(7):2126-39 - PMID: 14967052 - DOI: 10.1021/bi035813p

Kim WS, Ordija CM, Freeman MW Activation of signaling pathways by putative scavenger receptor class A (SR-A) ligands requires CD14 but not SR-A. Biochem Biophys Res Commun. 2003;310(2):542-9 - PMID: 14521944 - DOI: 10.1016/j.bbrc.2003.09.049

El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD CD36 mediates the innate host response to beta-amyloid. J Exp Med. 2003;197(12):1657-66 - PMID: 12796468 - PMCID: PMC2193948 - DOI: 10.1084/jem.20021546

Freeman MW, Moore KJ eLiXiRs for restraining inflammation. Nat Med. 2003;9(2):168-9 - PMID: 12563335 - DOI: 10.1038/nm0203-168

Kunjathoor VV, Febbraio M, Podrez EA, Moore KJ, Andersson L, Koehn S, Rhee JS, Silverstein R, Hoff HF, Freeman MW Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem. 2002;277(51):49982-8 - PMID: 12376530 - DOI: 10.1074/jbc.M209649200

Yang KK, Dorner BG, Merkel U, Ryffel B, Schütt C, Golenbock D, Freeman MW, Jack RS Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice. J Immunol. 2002;169(8):4475-80 - PMID: 12370383 - DOI: 10.4049/jimmunol.169.8.4475

Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol. 2002;169(7):3970-7 - PMID: 12244198 - DOI: 10.4049/jimmunol.169.7.3970

Moore KJ, El Khoury J, Medeiros LA, Terada K, Geula C, Luster AD, Freeman MW A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem. 2002;277(49):47373-9 - PMID: 12239221 - DOI: 10.1074/jbc.M208788200

MW Freeman The Treatment of Dyslipidemia: LDL Reduction and Beyond. In Endocrinology Rounds. 2002;1, Issue 8:ePub

Fitzgerald ML, Morris AL, Rhee JS, Andersson LP, Mendez AJ, Freeman MW Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J Biol Chem. 2002;277(36):33178-87 - PMID: 12084722 - DOI: 10.1074/jbc.M204996200

Fitzgerald ML, Moore KJ, Freeman MW Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home. J Mol Med (Berl). 2002;80(5):271-81 - PMID: 12021839 - DOI: 10.1007/s00109-001-0318-y

Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev. 2002;16(1):22-6 - PMID: 11782441 - PMCID: PMC155311 - DOI: 10.1101/gad.948702

Bernheiden M, Heinrich JM, Minigo G, Schütt C, Stelter F, Freeman M, Golenbock D, Jack RS LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection. J Endotoxin Res. 2001;7(6):447-50 - PMID: 11753215

Moore KJ, Fitzgerald ML, Freeman MW Peroxisome proliferator-activated receptors in macrophage biology: friend or foe?. Curr Opin Lipidol. 2001;12(5):519-27 - PMID: 11561171 - DOI: 10.1097/00041433-200110000-00007

Bobryshev YV, Taksir T, Lord RS, Freeman MW Evidence that dendritic cells infiltrate atherosclerotic lesions in apolipoprotein E-deficient mice. Histol Histopathol. 2001;16(3):801-8 - PMID: 11510970 - DOI: 10.14670/HH-16.801

Fitzgerald ML, Mendez AJ, Moore KJ, Andersson LP, Panjeton HA, Freeman MW ATP-binding cassette transporter A1 contains an NH2-terminal signal anchor sequence that translocates the protein's first hydrophilic domain to the exoplasmic space. J Biol Chem. 2001;276(18):15137-45 - PMID: 11328826 - DOI: 10.1074/jbc.m100474200

Rigotti A, Freeman MW Manipulating intestinal cholesterol absorption and hepatic cholesterol and bile acid metabolism by activation of deorphanized nuclear receptors. Gastroenterology. 2001;120(4):1054-5 - PMID: 11231965 - DOI: 10.1016/s0016-5085(01)83919-6

Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. Nat Med. 2001;7(1):41-7 - PMID: 11135614 - DOI: 10.1038/83328

Li Z, Kako Y, Pang L, Freeman MW, Glick JM, Wang X, Goldberg IJ Effects of overexpression of the amino-terminal fragment of apolipoprotein B on apolipoprotein B and lipoprotein production. J Lipid Res. 2000;41(12):1912-20 - PMID: 11108724

Wang X, Zeng W, Murakawa M, Freeman MW, Seed B Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression. J Virol. 2000;74(23):11296-303 - PMID: 11070029 - PMCID: PMC113234 - DOI: 10.1128/jvi.74.23.11296-11303.2000

Wang X, Zeng W, Murakawa M, Freeman MW, Seed B Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression. J Virol. 2000;74(23):11296-303 - PMID: 11070029 - PMCID: PMC113234 - DOI: 10.1128/jvi.74.23.11296-11303.2000

Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, Finberg RW Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol. 2000;1(5):398-401 - PMID: 11062499 - DOI: 10.1038/80833

Moore KJ, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, Golenbock DT, Freeman MW Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol. 2000;165(8):4272-80 - PMID: 11035061 - DOI: 10.4049/jimmunol.165.8.4272

M Freeman, Consultant editor 2nd edition. PJ Skerret and SD Emond What to do about high cholesterol. President and Fellows of Harvard College. Harvard Health Publications. 2000;:ePub

Brousseau ME, Eberhart GP, Dupuis J, Asztalos BF, Goldkamp AL, Schaefer EJ, Freeman MW Cellular cholesterol efflux in heterozygotes for tangier disease is markedly reduced and correlates with high density lipoprotein cholesterol concentration and particle size. J Lipid Res. 2000;41(7):1125-35 - PMID: 10884295

Brousseau ME, Schaefer EJ, Dupuis J, Eustace B, Van Eerdewegh P, Goldkamp AL, Thurston LM, FitzGerald MG, Yasek-McKenna D, O'Neill G, Eberhart GP, Weiffenbach B, Ordovas JM, Freeman MW, Brown RH, Gu JZ Novel mutations in the gene encoding ATP-binding cassette 1 in four tangier disease kindreds. J Lipid Res. 2000;41(3):433-41 - PMID: 10706591

Fitzgerald ML, Moore KJ, Freeman MW, Reed GL Lipopolysaccharide induces scavenger receptor A expression in mouse macrophages: a divergent response relative to human THP-1 monocyte/macrophages. J Immunol. 2000;164(5):2692-700 - PMID: 10679110 - DOI: 10.4049/jimmunol.164.5.2692

Fabunmi RP, Moore KJ, Libby P, Freeman MW Stromelysin-1 (MMP-3) expression driven by a macrophage-specific promoter results in reduced viability in transgenic mice. Atherosclerosis. 2000;148(2):375-86 - PMID: 10657574 - DOI: 10.1016/s0021-9150(99)00405-0

Freeman MW Effluxed lipids: Tangier Island's latest export. Proc Natl Acad Sci U S A. 1999;96(20):10950-2 - PMID: 10500104 - PMCID: PMC34222 - DOI: 10.1073/pnas.96.20.10950

Chiang N, Gronert K, Clish CB, O'Brien JA, Freeman MW, Serhan CN Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. J Clin Invest. 1999;104(3):309-16 - PMID: 10430612 - PMCID: PMC408424 - DOI: 10.1172/JCI7016

Moore KJ, Fabunmi RP, Andersson LP, Freeman MW In vitro-differentiated embryonic stem cell macrophages: a model system for studying atherosclerosis-associated macrophage functions. Arterioscler Thromb Vasc Biol. 1998;18(10):1647-54 - PMID: 9763539 - DOI: 10.1161/01.atv.18.10.1647

Andersson L, Freeman MW Functional changes in scavenger receptor binding conformation are induced by charge mutants spanning the entire collagen domain. J Biol Chem. 1998;273(31):19592-601 - PMID: 9677385 - DOI: 10.1074/jbc.273.31.19592

Eberhart GP, Mendez AJ, Freeman MW Decreased cholesterol efflux from fibroblasts of a patient without Tangier disease, but with markedly reduced high density lipoprotein cholesterol levels. J Clin Endocrinol Metab. 1998;83(3):836-46 - PMID: 9506737 - DOI: 10.1210/jcem.83.3.4642

Freeman MW Scavenger receptors in atherosclerosis. Curr Opin Hematol. 1997;4(1):41-7 - PMID: 9050378 - DOI: 10.1097/00062752-199704010-00007

Christie RH, Freeman M, Hyman BT Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease. Am J Pathol. 1996;148(2):399-403 - PMID: 8579103 - PMCID: PMC1861668

Haydock GS and MW Freeman Screening for hyperlipidemia. In: Goroll A, May L, Mulley A, eds. 1995. 1995;Primary Care Medicine, 3rd Edit:72-75

Aftring RP, Freeman MW Structure of the murine macrophage scavenger receptor gene and evaluation of sequences that regulate expression in the macrophage cell line, P388D. J Lipid Res. 1995;36(6):1305-14 - PMID: 7666008

Li H, Freeman MW, Libby P Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines. J Clin Invest. 1995;95(1):122-33 - PMID: 7814605 - PMCID: PMC295387 - DOI: 10.1172/JCI117628

MW Freeman Macrophage scavenger receptors. Current Opinions in Lipidology . 1994;5:143-148

Aftring RP and MW Freeman Of mice, men and cholesterol. Hepatology. 1994;19:1054-1056

Aftring RP, Freeman MW Of mice, men and cholesterol. Hepatology. 1994;19(4):1054-6 - PMID: 8138246 - DOI: 10.1002/hep.1840190436

Freeman MW Macrophage scavenger receptors. Curr Opin Lipidol. 1994;5(2):143-8 - PMID: 8044417 - DOI: 10.1097/00041433-199404000-00011

Golenbock DT, Liu Y, Millham FH, Freeman MW, Zoeller RA Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin. J Biol Chem. 1993;268(29):22055-9 - PMID: 7691822

Martin KA, and Freeman MW Postmenopausal hormone-replacement therapy . New Engl J Med. 1993;328:1115-1117

M Freeman, Consultant editor. PJ Skerret and SD Emond What to do about high cholesterol. President and Fellows of Harvard College. Harvard Health Publications. 1993;:ePub

Ashkenas J, Penman M, Vasile E, Acton S, Freeman M, Krieger M Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors. J Lipid Res. 1993;34(6):983-1000 - PMID: 8394868

Segre GV, Abou-Samra AB, Jüppner H, Schipani E, Force T, Urena P, Freeman M, Kong XF, Kolakowski LF, Hock J Characterization of cloned PTH/PTHrP receptors. J Endocrinol Invest. 1993;15(9 Suppl 6):11-7 - PMID: 1338633

Martin KA, Freeman MW Postmenopausal hormone-replacement therapy. N Engl J Med. 1993;328(15):1115-7 - PMID: 8455670 - DOI: 10.1056/NEJM199304153281509

Retsky KL, Freeman MW, Frei B Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions. J Biol Chem. 1993;268(2):1304-9 - PMID: 8419332

Bickel PE, Freeman MW Rabbit aortic smooth muscle cells express inducible macrophage scavenger receptor messenger RNA that is absent from endothelial cells. J Clin Invest. 1992;90(4):1450-7 - PMID: 1401078 - PMCID: PMC443191 - DOI: 10.1172/JCI116012

Abou-Samra AB, Jüppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci U S A. 1992;89(7):2732-6 - PMID: 1313566 - PMCID: PMC48736 - DOI: 10.1073/pnas.89.7.2732

Jüppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LF, Hock J, Potts JT, Kronenberg HM A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science. 1991;254(5034):1024-6 - PMID: 1658941 - DOI: 10.1126/science.1658941

Freeman M, Ekkel Y, Rohrer L, Penman M, Freedman NJ, Chisolm GM, Krieger M Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein. Proc Natl Acad Sci U S A. 1991;88(11):4931-5 - PMID: 2052575 - PMCID: PMC51781 - DOI: 10.1073/pnas.88.11.4931

Freeman M, Ashkenas J, Rees DJ, Kingsley DM, Copeland NG, Jenkins NA, Krieger M An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Proc Natl Acad Sci U S A. 1990;87(22):8810-4 - PMID: 1978939 - PMCID: PMC55049 - DOI: 10.1073/pnas.87.22.8810

Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature. 1990;343(6258):531-5 - PMID: 2300204 - DOI: 10.1038/343531a0

Rohrer L, Freeman M, Kodama T, Penman M, Krieger M Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II. Nature. 1990;343(6258):570-2 - PMID: 2300208 - DOI: 10.1038/343570a0

Atkinson MJ, Freeman MW, Kronenberg HM Thymosin beta 4 is expressed in ROS 17/2.8 osteosarcoma cells in a regulated manner. Mol Endocrinol. 1990;4(1):69-74 - PMID: 2325669 - DOI: 10.1210/mend-4-1-69

Freeman MW, Rigotti NA, and T. Force Risk factors in coronary artery disease and cardiac rehabilitation. In: Haber E, Eagle KA, Austen WG, eds. The Practice of Cardiology. 1989;:563-614

Wiren KM, Ivashkiv L, Ma P, Freeman MW, Potts JT, Kronenberg HM Mutations in signal sequence cleavage domain of preproparathyroid hormone alter protein translocation, signal sequence cleavage, and membrane-binding properties. Mol Endocrinol. 1989;3(2):240-50 - PMID: 2710131 - DOI: 10.1210/mend-3-2-240

Powers TA, Partain CL, Kessler RM, Freeman MW, Robertson RH, Wyatt SH, Whelan HT Central nervous system lesions in pediatric patients: Gd-DTPA-enhanced MR imaging. Radiology. 1988;169(3):723-6 - PMID: 3055036 - DOI: 10.1148/radiology.169.3.3055036

Potts, JT Jr, Nussbaum S, Wiren K, Freeman M, Igarashi T, Okazaki T, Zajac J, Abou-Samra AB, Bringhurst FR, Segre G, HM Kronenberg Chemistry, molecular biology, and mode of action of parathyroid hormone. Proceedings of the First International Conference on New Actions of Parathyroid Hormone. Kobe, Japan. 1987;:ePub

Freeman MW, Wiren KM, Rapoport A, Lazar M, Potts JT, Kronenberg HM Consequences of amino-terminal deletions of preproparathyroid hormone signal sequence. Mol Endocrinol. 1987;1(9):628-38 - PMID: 3153480 - DOI: 10.1210/mend-1-9-628

Wiren KM, Freeman MW, Potts JT Jr, HM Kronenberg Preproparathyroid hormone: a model for analyzing the secretory pathway. Ann NY Acad Sci. 1987;493:43-49

Kronenberg HM, Wiren KM, Freeman MW, JT Potts Jr Preproparathyroid hormone: Use of mutants to study secretion. In: Cohn DV, Martin TJ, Meunier PJ, eds. Calcium Regulation and Bone Metabolism: Basic and Clinical Aspects, Vol. 9. Amsterdam: Excerpta Medica. 1987;9:773-777

Wiren KM, Freeman MW, Potts JT, Kronenberg HM Preproparathyroid hormone. A model for analyzing the secretory pathway. Ann N Y Acad Sci. 1987;493:43-9 - PMID: 3473968 - DOI: 10.1111/j.1749-6632.1987.tb27179.x

Kronenberg HM, Igarashi T, Freeman MW, Okazaki T, Brand SJ, Wiren KM, Potts JT Structure and expression of the human parathyroid hormone gene. Recent Prog Horm Res. 1986;42:641-63 - PMID: 3526456

Vasicek TJ, McDevitt BE, Freeman MW, Fennick BJ, Hendy GN, Potts JT, Rich A, Kronenberg HM Nucleotide sequence of the human parathyroid hormone gene. Proc Natl Acad Sci U S A. 1983;80(8):2127-31 - PMID: 6220408 - PMCID: PMC393770 - DOI: 10.1073/pnas.80.8.2127

Freeman MW, Spring-Mills E, Jones AL The effect of oxandrolone on low and high density lipoprotein profiles in retired breeder rats. J Gerontol. 1980;35(1):31-8 - PMID: 7350219 - DOI: 10.1093/geronj/35.1.31