Seetharaman A, Galagali H, Linarte E, Liu MHX, Cohen JD, Chetal K, Sadreyev R, Tate AJ, Montgomery TA, Ruvkun G Caenorhabditis elegans SynMuv B gene activity is down-regulated during a viral infection to enhance RNA interference. bioRxiv. 2024;:ePub - PMID: 39071373 - PMCID: PMC11275910 - DOI: 10.1101/2024.07.12.603258

Yanagi KS, Jochim B, Kunjo SO, Breen P, Ruvkun G, Lehrbach N Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans. PLoS Biol. 2024;22(7):e3002720 - PMID: 38991033 - PMCID: PMC11265709 - DOI: 10.1371/journal.pbio.3002720

Meisel JD, Wiesenthal PP, Mootha VK, Ruvkun G CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene. Curr Biol. 2024;34(12):2728-2738.e6 - PMID: 38810637 - PMCID: PMC11265314 - DOI: 10.1016/j.cub.2024.04.079

Warnhoff K, Bhattacharya S, Snoozy J, Breen PC, Ruvkun G Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans. Elife. 2024;12:ePub - PMID: 38349720 - PMCID: PMC10942545 - DOI: 10.7554/eLife.89173

Meisel JD, Miranda M, Skinner OS, Wiesenthal PP, Wellner SM, Jourdain AA, Ruvkun G, Mootha VK Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism. Cell. 2024;187(3):659-675.e18 - PMID: 38215760 - PMCID: PMC10919891 - DOI: 10.1016/j.cell.2023.12.010

Warnhoff K, Snoozy J, Breen PC, Ruvkun G Hypoxia-inducible factor promotes cysteine homeostasis in Caenorhabditis elegans. bioRxiv. 2023;:ePub - PMID: 37205365 - PMCID: PMC10187278 - DOI: 10.1101/2023.05.04.538701

Mao K, Breen P, Ruvkun G The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Proc Natl Acad Sci U S A. 2022;119(49):e2215966119 - PMID: 36445965 - PMCID: PMC9894117 - DOI: 10.1073/pnas.2215966119

Ruvkun G, Lehrbach N Regulation and Functions of the ER-Associated Nrf1 Transcription Factor. Cold Spring Harb Perspect Biol. 2022;15(1):ePub - PMID: 35940907 - PMCID: PMC9808582 - DOI: 10.1101/cshperspect.a041266

Snoozy J, Breen PC, Ruvkun G, Warnhoff K moc-6/MOCS2A is necessary for molybdenum cofactor synthesis in C. elegans. MicroPubl Biol. 2022;2022:ePub - PMID: 35224462 - PMCID: PMC8864482 - DOI: 10.17912/micropub.biology.000531

Charlesworth AG, Seroussi U, Lehrbach NJ, Renaud MS, Sundby AE, Molnar RI, Lao RX, Willis AR, Woock JR, Aber MJ, Diao AJ, Reinke AW, Ruvkun G, Claycomb JM Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility. Nucleic Acids Res. 2021;49(15):8836-8865 - PMID: 34329465 - PMCID: PMC8421154 - DOI: 10.1093/nar/gkab619

Warnhoff K, Hercher TW, Mendel RR, Ruvkun G Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans. Genes Dev. 2021;35(3-4):212-217 - PMID: 33446569 - PMCID: PMC7849362 - DOI: 10.1101/gad.345579.120

Mao K, Breen P, Ruvkun G Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response. PLoS Biol. 2020;18(12):e3000996 - PMID: 33264285 - PMCID: PMC7735679 - DOI: 10.1371/journal.pbio.3000996

Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT Nanopore sequencing at Mars, Europa, and microgravity conditions. NPJ Microgravity. 2020;6(1):24 - PMID: 34489469 - DOI: 10.1038/s41526-020-00113-9

Wei W, Ruvkun G Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism. Proc Natl Acad Sci U S A. 2020;117(33):19970-19981 - PMID: 32737159 - PMCID: PMC7443905 - DOI: 10.1073/pnas.2008021117

Fischer SEJ, Ruvkun G Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons. Proc Natl Acad Sci U S A. 2020;117(11):5987-5996 - PMID: 32123111 - PMCID: PMC7084138 - DOI: 10.1073/pnas.1919028117

Govindan JA, Jayamani E, Ruvkun G ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants. Proc Natl Acad Sci U S A. 2019;116(43):21651-21658 - PMID: 31591219 - PMCID: PMC6815122 - DOI: 10.1073/pnas.1912628116

Mojarro A, Hachey J, Bailey R, Brown M, Doebler R, Ruvkun G, Zuber MT, Carr CE Nucleic Acid Extraction and Sequencing from Low-Biomass Synthetic Mars Analog Soils for In Situ Life Detection. Astrobiology. 2019;19(9):1139-1152 - PMID: 31204862 - PMCID: PMC6708270 - DOI: 10.1089/ast.2018.1929

Armakola M, Ruvkun G Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes. Proc Natl Acad Sci U S A. 2019;116(25):12327-12336 - PMID: 31164416 - PMCID: PMC6589651 - DOI: 10.1073/pnas.1820928116

Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019;177(6):1507-1521.e16 - PMID: 31031004 - PMCID: PMC6911770 - DOI: 10.1016/j.cell.2019.03.045

Lehrbach NJ, Ruvkun G Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity. Elife. 2019;8:ePub - PMID: 30973820 - PMCID: PMC6459674 - DOI: 10.7554/eLife.44425

Lehrbach NJ, Breen PC, Ruvkun G Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression. Cell. 2019;177(3):737-750.e15 - PMID: 31002798 - PMCID: PMC6574124 - DOI: 10.1016/j.cell.2019.03.035

Warnhoff K, Ruvkun G Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification. Nat Chem Biol. 2019;15(5):480-488 - PMID: 30911177 - PMCID: PMC6470025 - DOI: 10.1038/s41589-019-0249-y

Mao K, Ji F, Breen P, Sewell A, Han M, Sadreyev R, Ruvkun G Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes. Cell Metab. 2019;29(5):1182-1191.e4 - PMID: 30799287 - PMCID: PMC6506380 - DOI: 10.1016/j.cmet.2019.01.022

Kniazeva M, Ruvkun G Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells. Proc Natl Acad Sci U S A. 2019;116(9):3784-3792 - PMID: 30808764 - PMCID: PMC6397575 - DOI: 10.1073/pnas.1815656116

Lin XX, Sen I, Janssens GE, Zhou X, Fonslow BR, Edgar D, Stroustrup N, Swoboda P, Yates JR, Ruvkun G, Riedel CG DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity. Nat Commun. 2018;9(1):4400 - PMID: 30353013 - PMCID: PMC6199276 - DOI: 10.1038/s41467-018-06624-0

Tillman EJ, Richardson CE, Cattie DJ, Reddy KC, Lehrbach NJ, Droste R, Ruvkun G, Kim DH Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans. Genetics. 2018;210(4):1329-1337 - PMID: 30287474 - PMCID: PMC6283152 - DOI: 10.1534/genetics.118.301450

Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT Acceleration profiles and processing methods for parabolic flight. NPJ Microgravity. 2018;4:14 - PMID: 30109261 - PMCID: PMC6081456 - DOI: 10.1038/s41526-018-0050-3

Ambros V, Ruvkun G Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs. Genetics. 2018;209(3):651-673 - PMID: 29967059 - PMCID: PMC6028246 - DOI: 10.1534/genetics.118.300291

Pontefract A, Hachey J, Zuber MT, Ruvkun G, Carr CE Sequencing nothing: Exploring failure modes of nanopore sensing and implications for life detection. Life Sci Space Res (Amst). 2018;18:80-86 - PMID: 30100151 - DOI: 10.1016/j.lssr.2018.05.004

Newman MA, Ji F, Fischer SEJ, Anselmo A, Sadreyev RI, Ruvkun G The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes. Genes Dev. 2018;32(9-10):670-681 - PMID: 29739806 - PMCID: PMC6004069 - DOI: 10.1101/gad.311514.118

Mojarro A, Hachey J, Ruvkun G, Zuber MT, Carr CE CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing. BMC Bioinformatics. 2018;19(1):108 - PMID: 29587645 - PMCID: PMC5872496 - DOI: 10.1186/s12859-018-2124-3

Pontefract A, Zhu TF, Walker VK, Hepburn H, Lui C, Zuber MT, Ruvkun G, Carr CE Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars. Front Microbiol. 2017;8:1819 - PMID: 29018418 - PMCID: PMC5623196 - DOI: 10.3389/fmicb.2017.01819

Mojarro A, Ruvkun G, Zuber MT, Carr CE Nucleic Acid Extraction from Synthetic Mars Analog Soils for in situ Life Detection. Astrobiology. 2017;17(8):747-760 - PMID: 28704064 - PMCID: PMC5567878 - DOI: 10.1089/ast.2016.1535

Lehrbach NJ, Ruvkun G Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1. Elife. 2016;5:ePub - PMID: 27528192 - PMCID: PMC4987142 - DOI: 10.7554/eLife.17721

Dowen RH, Breen PC, Tullius T, Conery AL, Ruvkun G A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport. Genes Dev. 2016;30(13):1515-28 - PMID: 27401555 - PMCID: PMC4949325 - DOI: 10.1101/gad.283895.116

Samuel BS, Rowedder H, Braendle C, Félix MA, Ruvkun G Caenorhabditis elegans responses to bacteria from its natural habitats. Proc Natl Acad Sci U S A. 2016;113(27):E3941-9 - PMID: 27317746 - PMCID: PMC4941482 - DOI: 10.1073/pnas.1607183113

Rettberg P, Anesio AM, Baker VR, Baross JA, Cady SL, Detsis E, Foreman CM, Hauber E, Ori GG, Pearce DA, Renno NO, Ruvkun G, Sattler B, Saunders MP, Smith DH, Wagner D, Westall F Planetary Protection and Mars Special Regions-A Suggestion for Updating the Definition. Astrobiology. 2016;16(2):119-25 - PMID: 26848950 - DOI: 10.1089/ast.2016.1472

Govindan JA, Jayamani E, Zhang X, Mylonakis E, Ruvkun G Dialogue between E. coli free radical pathways and the mitochondria of C. elegans. Proc Natl Acad Sci U S A. 2015;112(40):12456-61 - PMID: 26392561 - PMCID: PMC4603447 - DOI: 10.1073/pnas.1517448112

Govindan JA, Jayamani E, Zhang X, Breen P, Larkins-Ford J, Mylonakis E, Ruvkun G Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans. Nat Cell Biol. 2015;17(10):1294-303 - PMID: 26322678 - PMCID: PMC4589496 - DOI: 10.1038/ncb3229

Phillips CM, Brown KC, Montgomery BE, Ruvkun G, Montgomery TA piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway. Dev Cell. 2015;34(4):457-465 - PMID: 26279487 - PMCID: PMC4550515 - DOI: 10.1016/j.devcel.2015.07.009

Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles. Nucleic Acids Res. 2015;43(W1):W154-W159 - PMID: 25958392 - PMCID: PMC4489270 - DOI: 10.1093/nar/gkv452

Kirienko NV, Ausubel FM, Ruvkun G Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2015;112(6):1821-6 - PMID: 25624506 - PMCID: PMC4330731 - DOI: 10.1073/pnas.1424954112

Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence. PLoS Genet. 2014;10(12):e1004752 - PMID: 25474471 - PMCID: PMC4256158 - DOI: 10.1371/journal.pgen.1004752

O'Rourke EJ, Ruvkun G Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2014;17(1):104 - PMID: 25534088

Govindan JA, Ruvkun G Pathogens. Virulence. 2014;5(7):ePub - PMID: 25290904 - PMCID: PMC4189874

Govindan JA, Ruvkun G Pathogens. Virulence. 2014;5(7):695-696 - PMID: 25513769 - PMCID: PMC4189874 - DOI: 10.4161/viru.36667

Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans. Nat Struct Mol Biol. 2014;21(8):712-720 - PMID: 25038802 - PMCID: PMC4125460 - DOI: 10.1038/nsmb.2858

Liu Y, Samuel BS, Breen PC, Ruvkun G Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature. 2014;508(7496):406-10 - PMID: 24695221 - PMCID: PMC4102179 - DOI: 10.1038/nature13204

Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation. Curr Biol. 2014;24(8):839-44 - PMID: 24684932 - PMCID: PMC4010136 - DOI: 10.1016/j.cub.2014.02.060

Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev. 2013;27(24):2678-95 - PMID: 24352423 - PMCID: PMC3877757 - DOI: 10.1101/gad.233254.113

Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis. Cell. 2013;155(6):1409-21 - PMID: 24269006 - PMCID: PMC3956118 - DOI: 10.1016/j.cell.2013.10.047

Soukas AA, Carr CE, Ruvkun G Genetic Regulation of Caenorhabditis elegans Lysosome Related Organelle Function. PLoS Genet. 2013;9(10):e1003908 - PMID: 24204312 - PMCID: PMC3812091 - DOI: 10.1371/journal.pgen.1003908

Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Mol Syst Biol. 2013;9:692 - PMID: 24084807 - PMCID: PMC3817400 - DOI: 10.1038/msb.2013.50

Shi Z, Hayes G, Ruvkun G Dual Regulation of the lin-14 Target mRNA by the lin-4 miRNA. PLoS One. 2013;8(9):e75475 - PMID: 24058689 - PMCID: PMC3772890 - DOI: 10.1371/journal.pone.0075475

Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, Ruvkun G Radiation Resistance of Sequencing Chips for in situ Life Detection. Astrobiology. 2013;13(6):560-9 - PMID: 23734755 - DOI: 10.1089/ast.2012.0923

Shore DE, Ruvkun G A cytoprotective perspective on longevity regulation. Trends Cell Biol. 2013;23(9):409-20 - PMID: 23726168 - PMCID: PMC4057428 - DOI: 10.1016/j.tcb.2013.04.007

O'Rourke EJ, Ruvkun G MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2013;15(6):668-676 - PMID: 23604316 - PMCID: PMC3723461 - DOI: 10.1038/ncb2741

Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol. 2013;15(5):491-501 - PMID: 23604319 - PMCID: PMC3748955 - DOI: 10.1038/ncb2720

Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death. Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003

Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death. Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003

Montgomery TA, Ruvkun G MicroRNAs Visit the ER. Cell. 2013;153(3):511-2 - PMID: 23622236 - DOI: 10.1016/j.cell.2013.04.014

O'Rourke EJ, Kuballa P, Xavier R, Ruvkun G ?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev. 2013;27(4):429-40 - PMID: 23392608 - PMCID: PMC3589559 - DOI: 10.1101/gad.205294.112

Shi Z, Montgomery TA, Qi Y, Ruvkun G High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes. Genome Res. 2013;23(3):497-508 - PMID: 23363624 - PMCID: PMC3589538 - DOI: 10.1101/gr.149112.112

Carr CE, Rowedder H, Vafadari C, Lui CS, Cascio E, Zuber MT, Ruvkun G Radiation resistance of biological reagents for in situ life detection. Astrobiology. 2013;13(1):68-78 - PMID: 23330963 - DOI: 10.1089/ast.2012.0869

Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature. 2013;493(7434):694-8 - PMID: 23364702 - PMCID: PMC3762460 - DOI: 10.1038/nature11779

Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks. PLoS One. 2012;7(10):e48282 - PMID: 23144747 - PMCID: PMC3483217 - DOI: 10.1371/journal.pone.0048282

Zhang C, Ruvkun G New insights into siRNA amplification and RNAi. RNA Biol. 2012;9(8):1045-9 - PMID: 22858672 - PMCID: PMC3551858 - DOI: 10.4161/rna.21246

Shore DE, Carr CE, Ruvkun G Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet. 2012;8(7):e1002792 - PMID: 22829775 - PMCID: PMC3400582 - DOI: 10.1371/journal.pgen.1002792

Phillips CM, Montgomery TA, Breen PC, Ruvkun G MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline. Genes Dev. 2012;26(13):1433-44 - PMID: 22713602 - PMCID: PMC3403012 - DOI: 10.1101/gad.193904.112

Zhang C, Montgomery TA, Fischer SE, Garcia SM, Riedel CG, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G The Caenorhabditis elegans RDE-10/RDE-11 Complex Regulates RNAi by Promoting Secondary siRNA Amplification. Curr Biol. 2012;22(10):881-90 - PMID: 22542102 - PMCID: PMC3371361 - DOI: 10.1016/j.cub.2012.04.011

Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE An image analysis toolbox for high-throughput C. elegans assays. Nat Methods. 2012;9(7):714-6 - PMID: 22522656 - PMCID: PMC3433711 - DOI: 10.1038/nmeth.1984

Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G PIWI Associated siRNAs and piRNAs Specifically Require the Caenorhabditis elegans HEN1 Ortholog henn-1. PLoS Genet. 2012;8(4):e1002616 - PMID: 22536158 - PMCID: PMC3334881 - DOI: 10.1371/journal.pgen.1002616

Melo JA, Ruvkun G Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses. Cell. 2012;149(2):452-66 - PMID: 22500807 - PMCID: PMC3613046 - DOI: 10.1016/j.cell.2012.02.050

Wu X, Shi Z, Cui M, Han M, Ruvkun G Repression of Germline RNAi Pathways in Somatic Cells by Retinoblastoma Pathway Chromatin Complexes. PLoS Genet. 2012;8(3):e1002542 - PMID: 22412383 - PMCID: PMC3297578 - DOI: 10.1371/journal.pgen.1002542

Shi Z, Ruvkun G The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2012;109(12):4568-73 - PMID: 22396595 - PMCID: PMC3311396 - DOI: 10.1073/pnas.1202421109

Kimura KD, Riddle DL, Ruvkun G The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status. Cold Spring Harb Symp Quant Biol. 2011;76:113-20 - PMID: 22123849 - DOI: 10.1101/sqb.2011.76.010660

Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet. 2011;7(11):e1002369 - PMID: 22102828 - PMCID: PMC3213143 - DOI: 10.1371/journal.pgen.1002369

Russel S, Frand AR, Ruvkun G Regulation of the C. elegans molt by pqn-47. Dev Biol. 2011;360(2):297-309 - PMID: 21989027 - PMCID: PMC3618673 - DOI: 10.1016/j.ydbio.2011.09.025

Hayes GD, Riedel CG, Ruvkun G The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev. 2011;25(19):2079-92 - PMID: 21979920 - PMCID: PMC3197206 - DOI: 10.1101/gad.17153811

Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2011;108(4):1201-8 - PMID: 21245313 - PMCID: PMC3029761 - DOI: 10.1073/pnas.1018695108

Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods. 2011;8(2):135-8 - PMID: 21240281 - PMCID: PMC3061290 - DOI: 10.1038/nmeth.1556

Wu X, Ruvkun G Cancer. Germ cell genes and cancer. Science. 2010;330(6012):1761-2 - PMID: 21205660 - DOI: 10.1126/science.1200772

Meli VS, Osuna B, Ruvkun G, Frand AR MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Mol Biol Cell. 2010;21(10):1648-61 - PMID: 20335506 - PMCID: PMC2869372 - DOI: 10.1091/mbc.E08-07-0708

Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One. 2009;4(12):e8210 - PMID: 20011587 - PMCID: PMC2788130 - DOI: 10.1371/journal.pone.0008210

O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 2009;10(5):430-5 - PMID: 19883620 - PMCID: PMC2921818 - DOI: 10.1016/j.cmet.2009.10.002

Curran SP, Wu X, Riedel CG, Ruvkun G A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009;459(7250):1079-84 - PMID: 19506556 - PMCID: PMC2716045 - DOI: 10.1038/nature08106

Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009;23(4):496-511 - PMID: 19240135 - PMCID: PMC2648650 - DOI: 10.1101/gad.1775409

Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HY Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A. 2009;106(6):1875-9 - PMID: 19174521 - PMCID: PMC2631283 - DOI: 10.1073/pnas.0810338106

Wang MC, O'Rourke EJ, Ruvkun G Fat metabolism links germline stem cells and longevity in C. elegans. Science. 2008;322(5903):957-60 - PMID: 18988854 - PMCID: PMC2760269 - DOI: 10.1126/science.1162011

Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G The most conserved genome segments for life detection on Earth and other planets. Orig Life Evol Biosph. 2008;38(6):517-33 - PMID: 18853276 - DOI: 10.1007/s11084-008-9148-z

Ruvkun G The perfect storm of tiny RNAs. Nat Med. 2008;14(10):1041-5 - PMID: 18841145 - DOI: 10.1038/nm1008-1041

Fischer SE, Butler MD, Pan Q, Ruvkun G Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature. 2008;455(7212):491-6 - PMID: 18784652 - PMCID: PMC2756026 - DOI: 10.1038/nature07274

Ruvkun G Tiny RNA: Where do we come from? What are we? Where are we going?. Trends Plant Sci. 2008;13(7):313-6 - PMID: 18562240 - DOI: 10.1016/j.tplants.2008.05.005

Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Cold Spring Harb Symp Quant Biol. 2008;72:489-97 - PMID: 18419309 - DOI: 10.1101/sqb.2007.72.068

Patel DS, Fang LL, Svy DK, Ruvkun G, Li W Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans. Development. 2008;135(13):2239-49 - PMID: 18495818 - DOI: 10.1242/dev.016972

Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell. 2008;133(5):903-15 - PMID: 18510933 - PMCID: PMC2553566 - DOI: 10.1016/j.cell.2008.04.035

Gabel HW, Ruvkun G The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol. 2008;15(5):531-3 - PMID: 18438419 - PMCID: PMC2910399 - DOI: 10.1038/nsmb.1411

Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol Dev. 2008;10(1):106-13 - PMID: 18184361 - PMCID: PMC2637451 - DOI: 10.1111/j.1525-142X.2007.00217.x

Parry DH, Xu J, Ruvkun G A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol. 2007;17(23):2013-22 - PMID: 18023351 - PMCID: PMC2211719 - DOI: 10.1016/j.cub.2007.10.058

Samuelson AV, Carr CE, Ruvkun G Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev. 2007;21(22):2976-94 - PMID: 18006689 - PMCID: PMC2049198 - DOI: 10.1101/gad.1588907

Kim N, Dempsey CM, Kuan CJ, Zoval JV, O'Rourke E, Ruvkun G, Madou MJ, Sze JY Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Genetics. 2007;177(2):835-45 - PMID: 17720915 - PMCID: PMC2034647 - DOI: 10.1534/genetics.107.076901

Hayes GD, Ruvkun G Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs. Cold Spring Harb Symp Quant Biol. 2007;71:21-7 - PMID: 17381276 - DOI: 10.1101/sqb.2006.71.018

Curran SP, Ruvkun G Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 2007;3(4):e56 - PMID: 17411345 - PMCID: PMC1847696 - DOI: 10.1371/journal.pgen.0030056

Hayes GD, Frand AR, Ruvkun G The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development. 2006;133(23):4631-41 - PMID: 17065234 - DOI: 10.1242/dev.02655

Hu PJ, Xu J, Ruvkun G Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006;2(7):e99 - PMID: 16839187 - PMCID: PMC1487177 - DOI: 10.1371/journal.pgen.0020099

Sandoval GM, Duerr JS, Hodgkin J, Rand JB, Ruvkun G A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nat Neurosci. 2006;9(5):599-601 - PMID: 16604067 - DOI: 10.1038/nn1685

Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G Polygenic control of Caenorhabditis elegans fat storage. Nat Genet. 2006;38(3):363-8 - PMID: 16462744 - DOI: 10.1038/ng1739

Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell. 2006;124(2):343-54 - PMID: 16439208 - DOI: 10.1016/j.cell.2005.11.036

Ruvkun G Clarifications on miRNA and cancer. Science. 2006;311(5757):36-7 - PMID: 16400132 - DOI: 10.1126/science.311.5757.36d

Frand AR, Russel S, Ruvkun G Functional genomic analysis of C. elegans molting. PLoS Biol. 2005;3(10):e312 - PMID: 16122351 - PMCID: PMC1233573 - DOI: 10.1371/journal.pbio.0030312

Wang D, Ruvkun G Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway. Cold Spring Harb Symp Quant Biol. 2005;69:429-31 - PMID: 16117677 - DOI: 10.1101/sqb.2004.69.429

Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 2005;436(7050):593-7 - PMID: 16049496 - DOI: 10.1038/nature04010

Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM Systematic analysis of genes required for synapse structure and function. Nature. 2005;436(7050):510-7 - PMID: 16049479 - DOI: 10.1038/nature03809

Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 2005;19(13):1544-55 - PMID: 15998808 - PMCID: PMC1172061 - DOI: 10.1101/gad.1308205

Ruvkun GB The tiny RNA world. Harvey Lect. 2005;99:1-21 - PMID: 15984549

Efimenko E, Bubb K, Mak HY, Holzman T, Leroux MR, Ruvkun G, Thomas JH, Swoboda P Analysis of xbx genes in C. elegans. Development. 2005;132(8):1923-34 - PMID: 15790967 - DOI: 10.1242/dev.01775

Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G Functional genomic analysis of RNA interference in C. elegans. Science. 2005;308(5725):1164-7 - PMID: 15790806 - DOI: 10.1126/science.1109267

Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004;36(10):1079-83 - PMID: 15361871 - DOI: 10.1038/ng1421

Mak HY, Ruvkun G Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Development. 2004;131(8):1777-86 - PMID: 15084462 - DOI: 10.1242/dev.01069

Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Mol Cell. 2004;13(4):469-82 - PMID: 14992718 - DOI: 10.1016/s1097-2765(04)00033-4

Kennedy S, Wang D, Ruvkun G A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 2004;427(6975):645-9 - PMID: 14961122 - DOI: 10.1038/nature02302

Ruvkun G, Wightman B, Ha I The 20 years it took to recognize the importance of tiny RNAs. Cell. 2004;116(2 Suppl):S93-6, 2 p following S96 - PMID: 15055593 - DOI: 10.1016/s0092-8674(04)00034-0

Komaroff AL, Ruvkun G Unraveling the secrets of the cell. Newsweek. 2003;142(23):96 - PMID: 14712576

Ruvinsky I, Ruvkun G Functional tests of enhancer conservation between distantly related species. Development. 2003;130(21):5133-42 - PMID: 12944426 - DOI: 10.1242/dev.00711

Aspöck G, Ruvkun G, Bürglin TR The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development. 2003;130(15):3369-78 - PMID: 12810585 - DOI: 10.1242/dev.00551

Sze JY, Ruvkun G Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity. Proc Natl Acad Sci U S A. 2003;100(16):9560-5 - PMID: 12883006 - PMCID: PMC170957 - DOI: 10.1073/pnas.1530752100

Bashirullah A, Pasquinelli AE, Kiger AA, Perrimon N, Ruvkun G, Thummel CS Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol. 2003;259(1):1-8 - PMID: 12812783 - DOI: 10.1016/s0012-1606(03)00063-0

Pasquinelli AE, McCoy A, Jiménez E, Saló E, Ruvkun G, Martindale MQ, Baguñà J Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?. Evol Dev. 2003;5(4):372-8 - PMID: 12823453 - DOI: 10.1046/j.1525-142x.2003.03044.x

Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 2003;300(5627):1921 - PMID: 12817143 - DOI: 10.1126/science.1080147

Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 2003;300(5627):1921 - PMID: 12817143 - DOI: 10.1126/science.1080147

Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J Computational and experimental identification of C. elegans microRNAs. Mol Cell. 2003;11(5):1253-63 - PMID: 12769849 - DOI: 10.1016/s1097-2765(03)00153-9

Lee SS, Kennedy S, Tolonen AC, Ruvkun G DAF-16 target genes that control C. elegans life-span and metabolism. Science. 2003;300(5619):644-7 - PMID: 12690206 - DOI: 10.1126/science.1083614

Li W, Kennedy SG, Ruvkun G daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev. 2003;17(7):844-58 - PMID: 12654727 - PMCID: PMC196030 - DOI: 10.1101/gad.1066503

Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones S, Marshall M, Matzke M, Ruvkun G, Tuschl T A uniform system for microRNA annotation. RNA. 2003;9(3):277-9 - PMID: 12592000 - PMCID: PMC1370393 - DOI: 10.1261/rna.2183803

Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 2003;421(6920):268-72 - PMID: 12529643 - DOI: 10.1038/nature01279

Wolkow CA, Muñoz MJ, Riddle DL, Ruvkun G Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem. 2002;277(51):49591-7 - PMID: 12393910 - DOI: 10.1074/jbc.M207866200

Sze JY, Zhang S, Li J, Ruvkun G The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development. 2002;129(16):3901-11 - PMID: 12135927 - DOI: 10.1242/dev.129.16.3901

Lee SS, Ruvkun G Longevity: don't hold your breath. Nature. 2002;418(6895):287-8 - PMID: 12124610 - DOI: 10.1038/418287a

Pasquinelli AE, Ruvkun G Control of developmental timing by micrornas and their targets. Annu Rev Cell Dev Biol. 2002;18:495-513 - PMID: 12142272 - DOI: 10.1146/annurev.cellbio.18.012502.105832

Lee RY, Hench J, Ruvkun G Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol. 2001;11(24):1950-7 - PMID: 11747821 - DOI: 10.1016/s0960-9822(01)00595-4

Finch CE, Ruvkun G The genetics of aging. Annu Rev Genomics Hum Genet. 2001;2:435-62 - PMID: 11701657 - DOI: 10.1146/annurev.genom.2.1.435

Ruvkun G Molecular biology. Glimpses of a tiny RNA world. Science. 2001;294(5543):797-9 - PMID: 11679654 - DOI: 10.1126/science.1066315

Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001;106(1):23-34 - PMID: 11461699 - DOI: 10.1016/s0092-8674(01)00431-7

Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 2001;15(6):672-86 - PMID: 11274053 - PMCID: PMC312654 - DOI: 10.1101/gad.867301

Bürglin TR, Ruvkun G Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6. Development. 2001;128(5):779-90 - PMID: 11171402 - DOI: 10.1242/dev.128.5.779

Reinhart BJ, Ruvkun G Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics. 2001;157(1):199-209 - PMID: 11139502 - PMCID: PMC1461488 - DOI: 10.1093/genetics/157.1.199

Kagoshima H, Sommer R, Reinhart BJ, Cassata G, Ruvkun G, Bürglin TR Graded expression of ceh-14 reporters in the hypodermis is induced by a gonadal signal. Dev Genes Evol. 2000;210(11):564-9 - PMID: 11180807 - DOI: 10.1007/s004270000099

Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B, Müller P, Spring J, Srinivasan A, Fishman M, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun G Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000;408(6808):86-9 - PMID: 11081512 - DOI: 10.1038/35040556

Wolkow CA, Kimura KD, Lee MS, Ruvkun G Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science. 2000;290(5489):147-50 - PMID: 11021802 - DOI: 10.1126/science.290.5489.147

Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc Natl Acad Sci U S A. 2000;97(19):10412-7 - PMID: 10973497 - PMCID: PMC27038 - DOI: 10.1073/pnas.190326997

Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell. 2000;5(4):659-69 - PMID: 10882102 - DOI: 10.1016/s1097-2765(00)80245-2

Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000;403(6772):901-6 - PMID: 10706289 - DOI: 10.1038/35002607

Sze JY, Victor M, Loer C, Shi Y, Ruvkun G Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature. 2000;403(6769):560-4 - PMID: 10676966 - DOI: 10.1038/35000609

Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc Natl Acad Sci U S A. 2000;97(1):460-5 - PMID: 10618440 - PMCID: PMC26685 - DOI: 10.1073/pnas.97.1.460

Davidson EH, Ruvkun G Themes from a NASA workshop on gene regulatory processes in development and evolution. J Exp Zool. 1999;285(2):104-15 - PMID: 10440721 - DOI: 10.1002/(sici)1097-010x(19990815)285:2<104::aid-jez2>3.0.co;2-z

Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes Dev. 1999;13(14):1794-806 - PMID: 10421632 - PMCID: PMC316880 - DOI: 10.1101/gad.13.14.1794

Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 1999;13(11):1438-52 - PMID: 10364160 - PMCID: PMC316759 - DOI: 10.1101/gad.13.11.1438

Hobert O, Ruvkun G Pax genes in Caenorhabditis elegans: a new twist. Trends Genet. 1999;15(6):214-6 - PMID: 10354580 - DOI: 10.1016/s0168-9525(99)01731-x

Hobert O, Tessmar K, Ruvkun G The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development. 1999;126(7):1547-62 - PMID: 10068647 - DOI: 10.1242/dev.126.7.1547

Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol. 1999;144(1):45-57 - PMID: 9885243 - PMCID: PMC2148118 - DOI: 10.1083/jcb.144.1.45

Hobert O, Ruvkun G A common theme for LIM homeobox gene function across phylogeny?. Biol Bull. 1998;195(3):377-80 - PMID: 9924780 - DOI: 10.2307/1543153

Slack F, Ruvkun G Heterochronic genes in development and evolution. Biol Bull. 1998;195(3):375-6 - PMID: 9924779 - DOI: 10.2307/1543152

Ogg S, Ruvkun G The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell. 1998;2(6):887-93 - PMID: 9885576 - DOI: 10.1016/s1097-2765(00)80303-2

Slack FJ, Ruvkun G A novel repeat domain that is often associated with RING finger and B-box motifs. Trends Biochem Sci. 1998;23(12):474-5 - PMID: 9868369 - DOI: 10.1016/s0968-0004(98)01299-7

Ruvkun G, Hobert O The taxonomy of developmental control in Caenorhabditis elegans. Science. 1998;282(5396):2033-41 - PMID: 9851920 - DOI: 10.1126/science.282.5396.2033

Guarente L, Ruvkun G, Amasino R Aging, life span, and senescence. Proc Natl Acad Sci U S A. 1998;95(19):11034-6 - PMID: 9736682 - PMCID: PMC33892 - DOI: 10.1073/pnas.95.19.11034

Paradis S, Ruvkun G Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 1998;12(16):2488-98 - PMID: 9716402 - PMCID: PMC317081 - DOI: 10.1101/gad.12.16.2488

Hobert O, D'Alberti T, Liu Y, Ruvkun G Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11. J Neurosci. 1998;18(6):2084-96 - PMID: 9482795 - PMCID: PMC6792926 - DOI: 10.1523/JNEUROSCI.18-06-02084.1998

Slack F, Ruvkun G Temporal pattern formation by heterochronic genes. Annu Rev Genet. 1998;31:611-34 - PMID: 9442909 - DOI: 10.1146/annurev.genet.31.1.611

Tissenbaum HA, Ruvkun G An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics. 1998;148(2):703-17 - PMID: 9504918 - PMCID: PMC1459840 - DOI: 10.1093/genetics/148.2.703

Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature. 1997;389(6654):994-9 - PMID: 9353126 - DOI: 10.1038/40194

Patterson GI, Koweek A, Wong A, Liu Y, Ruvkun G The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 1997;11(20):2679-90 - PMID: 9334330 - PMCID: PMC316611 - DOI: 10.1101/gad.11.20.2679

Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997;277(5328):942-6 - PMID: 9252323 - DOI: 10.1126/science.277.5328.942

Hobert O, Mori I, Yamashita Y, Honda H, Ohshima Y, Liu Y, Ruvkun G Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron. 1997;19(2):345-57 - PMID: 9292724 - DOI: 10.1016/s0896-6273(00)80944-7

Sluder AE, Lindblom T, Ruvkun G The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development. Dev Biol. 1997;184(2):303-19 - PMID: 9133437 - DOI: 10.1006/dbio.1997.8544

Sze JY, Liu Y, Ruvkun G VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth. Development. 1997;124(6):1159-68 - PMID: 9102303 - DOI: 10.1242/dev.124.6.1159

Ha I, Wightman B, Ruvkun G A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes Dev. 1996;10(23):3041-50 - PMID: 8957004 - DOI: 10.1101/gad.10.23.3041

Morris JZ, Tissenbaum HA, Ruvkun G A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 1996;382(6591):536-9 - PMID: 8700226 - DOI: 10.1038/382536a0

Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. J Neurochem. 1996;67(1):46-57 - PMID: 8667025 - DOI: 10.1046/j.1471-4159.1996.67010046.x

Baumeister R, Liu Y, Ruvkun G Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Genes Dev. 1996;10(11):1395-410 - PMID: 8647436 - DOI: 10.1101/gad.10.11.1395

Greenstein D, Hird S, Plasterk RH, Andachi Y, Kohara Y, Wang B, Finney M, Ruvkun G Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation. Genes Dev. 1994;8(16):1935-48 - PMID: 7958868 - DOI: 10.1101/gad.8.16.1935

Gottlieb S, Ruvkun G daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans. Genetics. 1994;137(1):107-20 - PMID: 8056303 - PMCID: PMC1205929 - DOI: 10.1093/genetics/137.1.107

Wightman B, Ha I, Ruvkun G Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 1993;75(5):855-62 - PMID: 8252622 - DOI: 10.1016/0092-8674(93)90530-4

Bürglin TR, Ruvkun G The Caenorhabditis elegans homeobox gene cluster. Curr Opin Genet Dev. 1993;3(4):615-20 - PMID: 7902148 - DOI: 10.1016/0959-437x(93)90097-9

Ruvkun G Cell signalling. A molecular growth industry. Nature. 1993;360(6406):711-2 - PMID: 1334532 - DOI: 10.1038/360711a0

Xue D, Finney M, Ruvkun G, Chalfie M Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3. EMBO J. 1992;11(13):4969-79 - PMID: 1361171 - PMCID: PMC556975 - DOI: 10.1002/j.1460-2075.1992.tb05604.x

Bürglin TR, Ruvkun G New motif in PBX genes. Nat Genet. 1992;1(5):319-20 - PMID: 1363814 - DOI: 10.1038/ng0892-319

Miller DM, Shen MM, Shamu CE, Bürglin TR, Ruvkun G, Dubois ML, Ghee M, Wilson L C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Nature. 1992;355(6363):841-5 - PMID: 1347150 - DOI: 10.1038/355841a0

Ruvkun G, Wightman B, Bürglin T, Arasu P Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes. Dev Suppl. 1992;1:47-54 - PMID: 1742500

Arasu P, Wightman B, Ruvkun G Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28. Genes Dev. 1991;5(10):1825-33 - PMID: 1916265 - DOI: 10.1101/gad.5.10.1825

Wightman B, Bürglin TR, Gatto J, Arasu P, Ruvkun G Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development. Genes Dev. 1991;5(10):1813-24 - PMID: 1916264 - DOI: 10.1101/gad.5.10.1813

Bürglin TR, Ruvkun G, Coulson A, Hawkins NC, McGhee JD, Schaller D, Wittmann C, Müller F, Waterston RH Nematode homeobox cluster. Nature. 1991;351(6329):703 - PMID: 1676487 - DOI: 10.1038/351703a0

Ruvkun G, Finney M Regulation of transcription and cell identity by POU domain proteins. Cell. 1991;64(3):475-8 - PMID: 1991317 - DOI: 10.1016/0092-8674(91)90227-p

Finney M, Ruvkun G The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell. 1990;63(5):895-905 - PMID: 2257628 - DOI: 10.1016/0092-8674(90)90493-x

Ruvkun G, Gilbert W, Horvitz HR Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization. Nucleic Acids Res. 1990;18(4):809-15 - PMID: 2315039 - PMCID: PMC330331 - DOI: 10.1093/nar/18.4.809

Bürglin TR, Finney M, Coulson A, Ruvkun G Caenorhabditis elegans has scores of homoeobox-containing genes. Nature. 1989;341(6239):239-43 - PMID: 2571091 - DOI: 10.1038/341239a0

Ruvkun G, Giusto J The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch. Nature. 1989;338(6213):313-9 - PMID: 2922060 - DOI: 10.1038/338313a0

Ruvkun G, Ambros V, Coulson A, Waterston R, Sulston J, Horvitz HR Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. Genetics. 1989;121(3):501-16 - PMID: 2565854 - PMCID: PMC1203636 - DOI: 10.1093/genetics/121.3.501

Finney M, Ruvkun G, Horvitz HR The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors. Cell. 1988;55(5):757-69 - PMID: 2903797 - DOI: 10.1016/0092-8674(88)90132-8

Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev. 1988;2(12A):1513-6 - PMID: 3215510 - DOI: 10.1101/gad.2.12a.1513

Ruvkun GB, Long SR, Meade HM, van den Bos RC, Ausubel FM ISRm1: A Rhizobium meliloti insertion sequence that transposes preferentially into nitrogen fixation genes. J Mol Appl Genet. 1983;1(5):405-18 - PMID: 6296251

Ruvkun GB, Sundaresan V, Ausubel FM Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes. Cell. 1982;29(2):551-9 - PMID: 6288262 - DOI: 10.1016/0092-8674(82)90171-4

Ruvkun GB, Sundaresan V, Ausubel FM Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts. Gene. 1982;18(3):247-55 - PMID: 6290328 - DOI: 10.1016/0378-1119(82)90162-7

Ruvkun GB, Sundaresan V, Ausubel FM Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes. Cell. 1982;29(2):551-9 - PMID: 6288262 - DOI: 10.1016/0092-8674(82)90171-4

Meade HM, Long SR, Ruvkun GB, Brown SE, Ausubel FM Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis. J Bacteriol. 1982;149(1):114-22 - PMID: 6274841 - PMCID: PMC216598 - DOI: 10.1128/JB.149.1.114-122.1982

Ruvkun GB, Ausubel FM A general method for site-directed mutagenesis in prokaryotes. Nature. 1981;289(5793):85-8 - PMID: 6256652 - DOI: 10.1038/289085a0

Ruvkun GB, Ausubel FM A general method for site-directed mutagenesis in prokaryotes. Nature. 1981;289(5793):85-8 - PMID: 6256652 - DOI: 10.1038/289085a0

Ruvkun GB, Ausubel FM Interspecies homology of nitrogenase genes. Proc Natl Acad Sci U S A. 1980;77(1):191-5 - PMID: 6987649 - PMCID: PMC348234 - DOI: 10.1073/pnas.77.1.191

Ruvkun GB, Ausubel FM Interspecies homology of nitrogenase genes. Proc Natl Acad Sci U S A. 1980;77(1):191-5 - PMID: 6987649 - PMCID: PMC348234 - DOI: 10.1073/pnas.77.1.191