Wivagg CN, Bhattacharyya RP, Hung DT Mechanisms of ?-lactam killing and resistance in the context of Mycobacterium tuberculosis. J Antibiot (Tokyo). 2014;67(9):645-54 - PMID: 25052484 - DOI: 10.1038/ja.2014.94

Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth. PLoS Pathog. 2014;10(2):e1003946 - PMID: 24586159 - PMCID: PMC3930586 - DOI: 10.1371/journal.ppat.1003946

Slater LH, Clatworthy AE, Hung DT Bacterial toxins and small molecules elucidate endosomal trafficking. Trends Microbiol. 2014;22(2):53-5 - PMID: 24370463 - DOI: 10.1016/j.tim.2013.12.002

Wright GD, Hung DT, Helmann JD How antibiotics kill bacteria: new models needed?. Nat Med. 2013;19(5):544-5 - PMID: 23652106 - DOI: 10.1038/nm.3198

Kawate T, Iwase N, Shimizu M, Stanley SA, Wellington S, Kazyanskaya E, Hung DT Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32. Bioorg Med Chem Lett. 2013;23(22):6052-9 - PMID: 24103299 - DOI: 10.1016/j.bmcl.2013.09.035

Grant SS, Kawate T, Nag PP, Silvis MR, Gordon K, Stanley SA, Kazyanskaya E, Nietupski R, Golas A, Fitzgerald M, Cho S, Franzblau SG, Hung DT Identification of novel inhibitors of non-replicating M. tuberculosis using a carbon starvation model. ACS Chem Biol. 2013;8(10):2224-34 - PMID: 23898841 - PMCID: PMC3864639 - DOI: 10.1021/cb4004817

Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Schmidt Grant S, Rubin EJ, Hung DT Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proc Natl Acad Sci U S A. 2013;110(28):11565-70 - PMID: 23798446 - PMCID: PMC3710825 - DOI: 10.1073/pnas.1302114110

Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013;9(7):466 - PMID: 23774875

Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc Natl Acad Sci U S A. 2013;110(24):9932-7 - PMID: 23716698 - PMCID: PMC3683768 - DOI: 10.1073/pnas.1302257110

Grant SS, Hung DT Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response. Virulence. 2013;4(4):273-283 - PMID: 23563389 - PMCID: PMC3710330 - DOI: 10.4161/viru.23987

Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013;9(6):398-405 - PMID: 23603659 - PMCID: PMC6615456 - DOI: 10.1038/nchembio.1236

Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT Identification of Novel Host-Targeted Compounds That Protect From Anthrax Lethal Toxin-Induced Cell Death. ACS Chem Biol. 2013;8(4):812-822 - PMID: 23343607 - PMCID: PMC3638717 - DOI: 10.1021/cb300555n

Grad YH, Lipsitch M, Griggs AD, Haas BJ, Shea TP, McCowan C, Montmayeur A, FitzGerald M, Wortman JR, Krogfelt KA, Bingen E, Weill FX, Tietze E, Flieger A, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany. Proc Natl Acad Sci U S A. 2012;109(52):E3629-30 - PMID: 23479789 - PMCID: PMC3535640 - DOI: 10.1073/pnas.1209419110

Chand NS, Clatworthy AE, Hung DT The Two-Component Sensor KinB Acts as a Phosphatase to Regulate Pseudomonas aeruginosa Virulence. J Bacteriol. 2012;194(23):6537-47 - PMID: 23024348 - PMCID: PMC3497526 - DOI: 10.1128/JB.01168-12

Schmidt Grant S, Kaufmann BB, Chand NS, Haseley N, Hung DT Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals. Proc Natl Acad Sci U S A. 2012;109(30):12147-52 - PMID: 22778419 - PMCID: PMC3409745 - DOI: 10.1073/pnas.1203735109

Stanley SA, Schmidt Grant S, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol. 2012;7(8):1377-84 - PMID: 22577943 - PMCID: PMC3560293 - DOI: 10.1021/cb300151m

Grad YH, Lipsitch M, Feldgarden M, Arachchi HM, Cerqueira GC, Fitzgerald M, Godfrey P, Haas BJ, Murphy CI, Russ C, Sykes S, Walker BJ, Wortman JR, Young S, Zeng Q, Abouelleil A, Bochicchio J, Chauvin S, Desmet T, Gujja S, McCowan C, Montmayeur A, Steelman S, Frimodt-Møller J, Petersen AM, Struve C, Krogfelt KA, Bingen E, Weill FX, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011. Proc Natl Acad Sci U S A. 2012;109(8):3065-70 - PMID: 22315421 - PMCID: PMC3286951 - DOI: 10.1073/pnas.1121491109

Barczak AK, Gomez JE, Kaufmann BB, Hinson ER, Cosimi L, Borowsky ML, Onderdonk AB, Stanley SA, Kaur D, Bryant KF, Knipe DM, Sloutsky A, Hung DT RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities. Proc Natl Acad Sci U S A. 2012;109(16):6217-22 - PMID: 22474362 - PMCID: PMC3341018 - DOI: 10.1073/pnas.1119540109

Gomez JE, Clatworthy A, Hung DT Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches. Crit Rev Biochem Mol Biol. 2011;46(1):41-66 - PMID: 21250782 - DOI: 10.3109/10409238.2010.538663

Chand NS, Lee JS, Clatworthy AE, Golas AJ, Smith RS, Hung DT The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection. J Bacteriol. 2011;193(12):2989-99 - PMID: 21515773 - PMCID: PMC3133189 - DOI: 10.1128/JB.01546-10

Tamayo AG, Slater L, Taylor-Parker J, Bharti A, Harrison R, Hung DT, Murphy JR GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro. Mol Microbiol. 2011;81(5):1390-401 - PMID: 21797942 - PMCID: PMC4041151 - DOI: 10.1111/j.1365-2958.2011.07770.x

Chand NS, Hung DT The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection. Virulence. 2011;2(6):553-8 - PMID: 21971182 - DOI: 10.4161/viru.2.6.17987

Kaufmann BB, Hung DT The fast track to multidrug resistance. Mol Cell. 2010;37(3):297-8 - PMID: 20159549 - DOI: 10.1016/j.molcel.2010.01.027

Clatworthy AE, Lee JS, Leibman M, Kostun Z, Davidson AJ, Hung DT Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants. Infect Immun. 2009;77(4):1293-303 - PMID: 19168742 - PMCID: PMC2663173 - DOI: 10.1128/IAI.01181-08

Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science. 2009;324(5928):787-90 - PMID: 19359544 - PMCID: PMC2981508 - DOI: 10.1126/science.1168175

Barczak AK, Hung DT Productive steps toward an antimicrobial targeting virulence. Curr Opin Microbiol. 2009;12(5):490-6 - PMID: 19631578 - PMCID: PMC2763366 - DOI: 10.1016/j.mib.2009.06.012

Stanley SA, Hung DT Chemical tools for dissecting bacterial physiology and virulence. Biochemistry. 2009;48(37):8776-86 - PMID: 19653697 - DOI: 10.1021/bi9009083

Hett EC, Hung DT Targeting multiple biofilm pathways. Chem Biol. 2009;16(12):1216-8 - PMID: 20064430 - DOI: 10.1016/j.chembiol.2009.12.003

Stanley SA, Hung DT Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells. Sci Transl Med. 2009;1(11):11ps13 - PMID: 20371455 - DOI: 10.1126/scitranslmed.3000550

Shakhnovich EA, Hung DT, Pierson E, Lee K, Mekalanos JJ Virstatin inhibits dimerization of the transcriptional activator ToxT. Proc Natl Acad Sci U S A. 2007;104(7):2372-7 - PMID: 17283330 - PMCID: PMC1892951 - DOI: 10.1073/pnas.0611643104

Clatworthy AE, Pierson E, Hung DT Targeting virulence: a new paradigm for antimicrobial therapy. Nat Chem Biol. 2007;3(9):541-8 - PMID: 17710100 - DOI: 10.1038/nchembio.2007.24

Hung DT, Zhu J, Sturtevant D, Mekalanos JJ Bile acids stimulate biofilm formation in Vibrio cholerae. Mol Microbiol. 2006;59(1):193-201 - PMID: 16359328 - DOI: 10.1111/j.1365-2958.2005.04846.x

Hung DT, Rubin EJ Chemical biology and bacteria: not simply a matter of life or death. Curr Opin Chem Biol. 2006;10(4):321-6 - PMID: 16814591 - DOI: 10.1016/j.cbpa.2006.06.016

Hung DT, Mekalanos JJ Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner. Proc Natl Acad Sci U S A. 2005;102(8):3028-33 - PMID: 15699331 - PMCID: PMC549475 - DOI: 10.1073/pnas.0409559102

Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science. 2005;310(5748):670-4 - PMID: 16223984 - DOI: 10.1126/science.1116739

O'Shaughnessy JA, Ljung BM, Dooley WC, Chang J, Kuerer HM, Hung DT, Grant MD, Khan SA, Phillips RF, Duvall K, Euhus DM, King BL, Anderson BO, Troyan SL, Kim J, Veronesi U, Cazzaniga M Ductal lavage and the clinical management of women at high risk for breast carcinoma: a commentary. Cancer. 2002;94(2):292-8 - PMID: 11900214 - DOI: 10.1002/cncr.10238

Evron E, Dooley WC, Umbricht CB, Rosenthal D, Sacchi N, Gabrielson E, Soito AB, Hung DT, Ljung B, Davidson NE, Sukumar S Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR. Lancet. 2001;357(9265):1335-6 - PMID: 11343741 - DOI: 10.1016/s0140-6736(00)04501-3

Dooley WC, Ljung BM, Veronesi U, Cazzaniga M, Elledge RM, O'Shaughnessy JA, Kuerer HM, Hung DT, Khan SA, Phillips RF, Ganz PA, Euhus DM, Esserman LJ, Haffty BG, King BL, Kelley MC, Anderson MM, Schmit PJ, Clark RR, Kass FC, Anderson BO, Troyan SL, Arias RD, Quiring JN, Love SM, Page DL, King EB Ductal lavage for detection of cellular atypia in women at high risk for breast cancer. J Natl Cancer Inst. 2001;93(21):1624-32 - PMID: 11698566 - DOI: 10.1093/jnci/93.21.1624

Hung DT, Chen J, Schreiber SL (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chem Biol. 1996;3(4):287-93 - PMID: 8807856 - DOI: 10.1016/s1074-5521(96)90108-8

Hung DT, Jamison TF, Schreiber SL Understanding and controlling the cell cycle with natural products. Chem Biol. 1996;3(8):623-39 - PMID: 8807895 - DOI: 10.1016/s1074-5521(96)90129-5

Hung DT, Nerenberg JB, Schreiber SL Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides. Chem Biol. 1994;1(1):67-71 - PMID: 9383372 - DOI: 10.1016/1074-5521(94)90042-6

Coughlin SR, Scarborough RM, Vu TK, Hung DT Thrombin receptor structure and function. Cold Spring Harb Symp Quant Biol. 1993;57:149-54 - PMID: 1339654 - DOI: 10.1101/sqb.1992.057.01.019

Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol Cell Biol. 1993;13(8):4760-9 - PMID: 7687744 - PMCID: PMC360102 - DOI: 10.1128/mcb.13.8.4760

Coughlin SR, Vu TK, Hung DT, Wheaton VI Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Semin Thromb Hemost. 1992;18(2):161-6 - PMID: 1321504 - DOI: 10.1055/s-2007-1002422

Hung DT, Vu TH, Nelken NA, Coughlin SR Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. J Cell Biol. 1992;116(3):827-32 - PMID: 1309820 - PMCID: PMC2289317 - DOI: 10.1083/jcb.116.3.827

Coughlin SR, Vu TK, Hung DT, Wheaton VI Characterization of a functional thrombin receptor. Issues and opportunities. J Clin Invest. 1992;89(2):351-5 - PMID: 1310691 - PMCID: PMC442859 - DOI: 10.1172/JCI115592

Hung DT, Vu TK, Wheaton VI, Charo IF, Nelken NA, Esmon N, Esmon CT, Coughlin SR "Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure. J Clin Invest. 1992;89(2):444-50 - PMID: 1310695 - PMCID: PMC442871 - DOI: 10.1172/JCI115604

Hung DT, Vu TK, Wheaton VI, Ishii K, Coughlin SR Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation. J Clin Invest. 1992;89(4):1350-3 - PMID: 1313452 - PMCID: PMC442997 - DOI: 10.1172/JCI115721

Garboczi DN, Hung DT, Wiley DC HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. Proc Natl Acad Sci U S A. 1992;89(8):3429-33 - PMID: 1565634 - PMCID: PMC48881 - DOI: 10.1073/pnas.89.8.3429

Hung DT, Schreiber SL cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. Biochem Biophys Res Commun. 1992;184(2):733-8 - PMID: 1374240 - DOI: 10.1016/0006-291x(92)90651-z

Scarborough RM, Naughton MA, Teng W, Hung DT, Rose J, Vu TK, Wheaton VI, Turck CW, Coughlin SR Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function. J Biol Chem. 1992;267(19):13146-9 - PMID: 1320011

Hung DT, Wong YH, Vu TK, Coughlin SR The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. J Biol Chem. 1992;267(29):20831-4 - PMID: 1328213

Vu TK, Hung DT, Wheaton VI, Coughlin SR Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991;64(6):1057-68 - PMID: 1672265 - DOI: 10.1016/0092-8674(91)90261-v

Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR Domains specifying thrombin-receptor interaction. Nature. 1991;353(6345):674-7 - PMID: 1717851 - DOI: 10.1038/353674a0

Hung DT, Oredsson SM, Pegg AE, Deen DF, Marton LJ Potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L rat brain tumor cells by methylglyoxal-bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase. Eur J Cancer Clin Oncol. 1984;20(3):417-20 - PMID: 6538500 - DOI: 10.1016/0277-5379(84)90090-7

Alhonen-Hongisto L, Hung DT, Deen DF, Marton LJ Decreased cell kill of vincristine and methotrexate against 9L rat brain tumor cells in vitro caused by alpha-difluoromethylornithine-induced polyamine depletion. Cancer Res. 1984;44(10):4440-2 - PMID: 6432313

Hung DT, Marton LJ, Deen DF, Shafer RH Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells. Science. 1983;221(4608):368-70 - PMID: 6408733 - DOI: 10.1126/science.6408733

Hung DT, Deen DF, Seidenfeld J, Marton LJ Sensitization of 9L rat brain gliosarcoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor. Cancer Res. 1981;41(7):2783-5 - PMID: 6788362

Hung DT, Benner SA, Williams CM Preparation of an ecdysone immunogen for radioimmunoassay work. J Biol Chem. 1980;255(13):6047-8 - PMID: 7190146