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Graham DB, Xavier RJ

Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology.
Immunity. 2026;59(5):1184-1200 - PMID: 42049036 - PMCID: PMC13132028 - DOI: 10.1016/j.immuni.2026.04.002

Steinberg R, Pust MM, Arias-Rojas A, Pishchany G, Ramsey KA, Kieninger E, Moeller A, Casaulta C, Hilty M, Latzin P, SCILD Study Group, BILD Study Group, Korten I, Xavier RJ

An infant nasal microbial gene atlas uncovers intervention-driven microbiome shifts and salt-resistant pathogen expansion.
Cell Host Microbe. 2026;34(5):925-941.e6 - PMID: 42013836 - DOI: 10.1016/j.chom.2026.03.019

Tanoue T, Nagayama M, Roochana AJA, Zimmerman S, Ashenberg O, Jain T, Igarashi R, Sasajima S, Takeshita K, Hetherington N, Okahashi N, Ueda M, Konishi M, Nakayama Y, Minoda A, Skelly AN, Minokoshi Y, Pucci N, Mende DR, Arita M, Yamamoto H, Watanabe S, Miura K, Behie SW, Suda W, Sato T, Atarashi K, Matsushita M, Kajimura S, Plichta DR, Saito M, Xavier RJ, Honda K

Microbiota-mediated induction of beige adipocytes in response to dietary cues.
Nature. 2026;653(8114):499-509 - PMID: 41781619 - PMCID: PMC13051337 - DOI: 10.1038/s41586-026-10205-3

Reeve MP, Kanai M, Graham DB, Karjalainen J, Luo S, Kolosov N, Adams C, Ritari J, Karczewski KJ, Kiiskinen T, Jiang Y, Fuller Z, Mehtonen J, Kurki MI, Khan Z, FinnGen, Partanen J, McCarthy MI, Artomov M, Palotie A, Tuomi T, Pirinen M, Kero J, Xavier RJ, Daly MJ, Ripatti S

Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.
Nat Genet. 2026;58(3):550-559 - PMID: 41748903 - PMCID: PMC12987720 - DOI: 10.1038/s41588-026-02521-1

Fiskin E, Eraslan G, Alora-Palli MB, Jain T, Leyva-Castillo JM, Kim S, Choe H, Lareau CA, Lau H, Finan EP, Teixeira-Soldano I, LaBere B, Chu A, Woods B, Chou J, Slyper M, Waldman J, Islam S, Schneider L, Phipatanakul W, Platt C, Rozenblatt-Rosen O, Delorey TM, Ashenberg O, Deguine J, Smith GP, Geha RS, Regev A, Xavier RJ

Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis.
Nat Commun. 2026;17(1):ePub - PMID: 41741455 - PMCID: PMC13057205 - DOI: 10.1038/s41467-026-69587-7

Thurimella K, Wu E, Li C, Graham DB, Owens RM, Plichta DR, Sokol CL, Xavier RJ, Bacallado S

Identifying microbial protease allergens through protein language model-guided homology.
Cell Syst. 2026;17(3):101510 - PMID: 41722567 - PMCID: PMC13015258 - DOI: 10.1016/j.cels.2025.101510

Jaiswal A, Kooistra T, Pokatayev V, Bastos HN, Santos RF, Sarraf TR, Segerstolpe Å, Lin C, Amir-Zilberstein L, Twardus S, Shannon K, Murphy SP, Knipe R, Ganzleben IK, Black KE, Delorey TM, Graham DB, Hung YP, Hariri LP, Deguine J, Carvalho A, Medoff BD, Xavier RJ

Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases.
Cell Genom. 2026;6(3):101066 - PMID: 41576947 - PMCID: PMC12985369 - DOI: 10.1016/j.xgen.2025.101066

Rush JS, Wertheimer JD, Goldberg SD, Raymond D, Szuchnicki M, Baltus AJ, Branson J, Stratton CF, Patrick AN, Steele R, Adhikary S, Del Rosario A, Liu A, Gomersall NJ, Chung M, Ranaghan MJ, Gu X, Brandt M, Cao Z, Bebenek A, Oliver BA, Hoebe K, Szewczuk LM, Venable JD, Graham DB, Towne J, Xavier RJ

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity.
Cell. 2026;189(5):1356-1370.e26 - PMID: 41547356 - PMCID: PMC12817910 - DOI: 10.1016/j.cell.2025.12.013

Ashenberg O, Xavier RJ

Bridging AI and biology: Foundation models meet human physiology and disease.
Med. 2026;7(1):100971 - PMID: 41519120 - DOI: 10.1016/j.medj.2025.100971

Pokatayev V, Jaiswal A, Shih AR, Segerstolpe Å, Li B, Creasey EA, Zhao Y, Lin C, Murphy S, Chou CH, Graham DB, Xavier RJ

Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit.
Nature. 2026;650(8103):997-1006 - PMID: 41501466 - PMCID: PMC12820784 - DOI: 10.1038/s41586-025-09907-x
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