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Weickert P, Liu Y, Strecker J

Prokaryotic Schlafen proteins cleave tRNAs during type III CRISPR immunity.
Nat Commun. 2026;:ePub - PMID: 42393087 - DOI: 10.1038/s41467-026-74880-6

Werth VP, Rönnblom L, Wenzel J, Moseley MK, Gaiha-Rohrbach J, Reynolds TL, Barbey C, Grogan JL, Colonna M

Plasmacytoid dendritic cells in systemic and cutaneous lupus erythematosus: an evolving understanding.
Front Immunol. 2026;17:1807771 - PMID: 42254019 - PMCID: PMC13234541 - DOI: 10.3389/fimmu.2026.1807771

Antonova AU, Rodrigues PF, Mannie C, Ferrari G, Carvajal H, Bugatti M, Vermi W, Wu T, Cella M, Eghtesady P, Colonna M

Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer.
Immunity. 2026;59(5):1221-1236.e5 - PMID: 42061412 - PMCID: PMC13191660 - DOI: 10.1016/j.immuni.2026.04.003

Fachi JL, Trsan T, Sécca C, de Oliveira S, Rodovalho VR, Rodrigues PF, Beatty WL, Sudan R, Wu S, Bhattarai B, Panda SK, Cella M, Gilfillan S, Colonna M

LINGO4 coordinates ILC3-intrinsic IL-22 production and microbiota-mediated ILC3 homeostasis.
J Exp Med. 2026;223(6):ePub - PMID: 42048289 - PMCID: PMC13138468 - DOI: 10.1084/jem.20252632

Graham DB, Xavier RJ

Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology.
Immunity. 2026;59(5):1184-1200 - PMID: 42049036 - PMCID: PMC13132028 - DOI: 10.1016/j.immuni.2026.04.002

Steinberg R, Pust MM, Arias-Rojas A, Pishchany G, Ramsey KA, Kieninger E, Moeller A, Casaulta C, Hilty M, Latzin P, SCILD Study Group, BILD Study Group, Korten I, Xavier RJ

An infant nasal microbial gene atlas uncovers intervention-driven microbiome shifts and salt-resistant pathogen expansion.
Cell Host Microbe. 2026;34(5):925-941.e6 - PMID: 42013836 - DOI: 10.1016/j.chom.2026.03.019

Chen X, Holtzman DM, Colonna M.

Immunity in Alzheimer's disease: From mechanisms to therapies
mmunity. 2026;59(3):524-541 - PMID: 41759511

Chen Y, Liu Y, Nguyen K, Wu J, Song S, Lin K, Rodrigues PF, Du S, Zhou C, Xiong K, Bosch M, Lin PB, Khantakova D, Wu S, Wu M, Yuede C, Holtzman DM, Colonna M

Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy.
Science. 2026;391(6789):eads3972 - PMID: 41785364 - PMCID: PMC13294515 - DOI: 10.1126/science.ads3972

Tanoue T, Nagayama M, Roochana AJA, Zimmerman S, Ashenberg O, Jain T, Igarashi R, Sasajima S, Takeshita K, Hetherington N, Okahashi N, Ueda M, Konishi M, Nakayama Y, Minoda A, Skelly AN, Minokoshi Y, Pucci N, Mende DR, Arita M, Yamamoto H, Watanabe S, Miura K, Behie SW, Suda W, Sato T, Atarashi K, Matsushita M, Kajimura S, Plichta DR, Saito M, Xavier RJ, Honda K

Microbiota-mediated induction of beige adipocytes in response to dietary cues.
Nature. 2026;653(8114):499-509 - PMID: 41781619 - PMCID: PMC13051337 - DOI: 10.1038/s41586-026-10205-3

Fachi JL, de Oliveira S, Trsan T, Molgora M, Fernandes Rodrigues P, Gilfillan S, Ulezko Antonova A, Chang HW, Penati S, Cao S, Cella M, Colonna M

Divergent ILC3 responses to PDGF-D control mucosal immunity.
Sci Immunol. 2026;11(116):eaea6848 - PMID: 41758927 - DOI: 10.1126/sciimmunol.aea6848

Reeve MP, Kanai M, Graham DB, Karjalainen J, Luo S, Kolosov N, Adams C, Ritari J, Karczewski KJ, Kiiskinen T, Jiang Y, Fuller Z, Mehtonen J, Kurki MI, Khan Z, FinnGen, Partanen J, McCarthy MI, Artomov M, Palotie A, Tuomi T, Pirinen M, Kero J, Xavier RJ, Daly MJ, Ripatti S

Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.
Nat Genet. 2026;58(3):550-559 - PMID: 41748903 - PMCID: PMC12987720 - DOI: 10.1038/s41588-026-02521-1

Fiskin E, Eraslan G, Alora-Palli MB, Jain T, Leyva-Castillo JM, Kim S, Choe H, Lareau CA, Lau H, Finan EP, Teixeira-Soldano I, LaBere B, Chu A, Woods B, Chou J, Slyper M, Waldman J, Islam S, Schneider L, Phipatanakul W, Platt C, Rozenblatt-Rosen O, Delorey TM, Ashenberg O, Deguine J, Smith GP, Geha RS, Regev A, Xavier RJ

Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis.
Nat Commun. 2026;17(1):ePub - PMID: 41741455 - PMCID: PMC13057205 - DOI: 10.1038/s41467-026-69587-7

Thurimella K, Wu E, Li C, Graham DB, Owens RM, Plichta DR, Sokol CL, Xavier RJ, Bacallado S

Identifying microbial protease allergens through protein language model-guided homology.
Cell Syst. 2026;17(3):101510 - PMID: 41722567 - PMCID: PMC13015258 - DOI: 10.1016/j.cels.2025.101510

Rodrigues PF, Wu S, Trsan T, Bhattarai B, Panda SK, Fachi JL, Cella M, Colonna M

RORγt+ dendritic cells are a distinct lymphoid-derived lineage.
Sci Immunol. 2026;11(116):eaed7439 - PMID: 41591258 - PMCID: PMC13236574 - DOI: 10.1126/sciimmunol.aed7439

Jaiswal A, Kooistra T, Pokatayev V, Bastos HN, Santos RF, Sarraf TR, Segerstolpe Å, Lin C, Amir-Zilberstein L, Twardus S, Shannon K, Murphy SP, Knipe R, Ganzleben IK, Black KE, Delorey TM, Graham DB, Hung YP, Hariri LP, Deguine J, Carvalho A, Medoff BD, Xavier RJ

Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases.
Cell Genom. 2026;6(3):101066 - PMID: 41576947 - PMCID: PMC12985369 - DOI: 10.1016/j.xgen.2025.101066

Rush JS, Wertheimer JD, Goldberg SD, Raymond D, Szuchnicki M, Baltus AJ, Branson J, Stratton CF, Patrick AN, Steele R, Adhikary S, Del Rosario A, Liu A, Gomersall NJ, Chung M, Ranaghan MJ, Gu X, Brandt M, Cao Z, Bebenek A, Oliver BA, Hoebe K, Szewczuk LM, Venable JD, Graham DB, Towne J, Xavier RJ

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity.
Cell. 2026;189(5):1356-1370.e26 - PMID: 41547356 - PMCID: PMC12817910 - DOI: 10.1016/j.cell.2025.12.013

Ashenberg O, Xavier RJ

Bridging AI and biology: Foundation models meet human physiology and disease.
Med. 2026;7(1):100971 - PMID: 41519120 - DOI: 10.1016/j.medj.2025.100971

Pokatayev V, Jaiswal A, Shih AR, Segerstolpe Å, Li B, Creasey EA, Zhao Y, Lin C, Murphy S, Chou CH, Graham DB, Xavier RJ

Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit.
Nature. 2026;650(8103):997-1006 - PMID: 41501466 - PMCID: PMC12820784 - DOI: 10.1038/s41586-025-09907-x

Thurimella K, Mohamed AMT, Li C, Vatanen T, Graham DB, Owens RM, La Rosa SL, Plichta DR, Bacallado S, Xavier RJ

Protein language models uncover carbohydrate-active enzyme function in metagenomics.
BMC Bioinformatics. 2025;26(1):285 - PMID: 41299229 - PMCID: PMC12659350 - DOI: 10.1186/s12859-025-06286-y

Bond AN, Orzechowski M, Zhang S, Ben-Zion I, Lemmer A, Garry N, Lee K, Chen M, Delano K, Gath E, Golas AL, Nietupski R, Fitzgerald M, Ehrt S, Rubin EJ, Sassetti CM, Schnappinger D, Shoresh N, Hunt DK, Gomez JE, Hung DT

Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis.
Nat Commun. 2025;16(1):9673 - PMID: 41184262 - PMCID: PMC12583738 - DOI: 10.1038/s41467-025-64662-x

Tan P, Jaiswal A, Murphy SP, Brown EM, Wheeler H, Su CW, Finan EP, Jasso GJ, Shi HN, Graham DB, Delorey TM, Deguine J, Xavier RJ

Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation.
Science. 2025;390(6772):eadr3545 - PMID: 41166460 - DOI: 10.1126/science.adr3545

Jabbar KS, Priya S, Xu J, Das Adhikari U, Pishchany G, Mohamed ATM, Johansen J, Thurimella K, McCabe C, Vlamakis H, Okello S, Delorey TM, Lankowski A, Mosepele M, Siedner MJ, Plichta DR, Kwon DS, Xavier RJ

Human immunodeficiency virus and antiretroviral therapies exert distinct influences across diverse gut microbiomes.
Nat Microbiol. 2025;10(11):2720-2735 - PMID: 41168431 - PMCID: PMC13188066 - DOI: 10.1038/s41564-025-02157-7

Nie X, Sheen J, Ye R

The plant epigenome governed by nutrients and metabolism.
Curr Opin Plant Biol. 2025;88:102820 - PMID: 41167146 - PMCID: PMC13175398 - DOI: 10.1016/j.pbi.2025.102820

Neo DM, Ben-Zion I, Bagnall J, Solomon MY, Bond AN, Gath E, Zhang S, Shoresh N, Gomez J, Hung DT

A Multiplexed, Target-Based Phenotypic Screening Platform Using CRISPR Interference in Mycobacterium abscessus.
ACS Infect Dis. 2025;11(11):3263-3275 - PMID: 41139833 - PMCID: PMC12624723 - DOI: 10.1021/acsinfecdis.5c00623

Goering ER, Clatworthy AE, Parada-Kusz M, Bagnall J, Hung DT

Kmo restricts Salmonella in a whole organism infection model by promoting macrophage lysosomal acidification through kainate receptor antagonism.
PLoS Pathog. 2025;21(10):e1013273 - PMID: 41129589 - PMCID: PMC12571273 - DOI: 10.1371/journal.ppat.1013273
Total: 2513