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Humeidi R, Oshiro-Rapley N, Gu X, An JS, Ananthakrishnan AN, Creasey EA, Daly MJ, Schreiber SL, Graham DB, Seyedsayamdost MR, Xavier RJ

The Ulcerative Colitis-Associated Gene NXPE1 Catalyzes Glycan Modifications on Colonic Mucin.

J Am Chem Soc. 2025;147(12):10618-10628 - PMID: 40067145 - DOI: 10.1021/jacs.5c00769
Kniazeva M, Ruvkun G

Translation elongation defects activate the Caenorhabditis elegans ZIP-2 bZIP transcription factor-mediated toxin defense.

Proc Natl Acad Sci U S A. 2025;122(6):e2423578122 - PMID: 39899724 - PMCID: PMC11831180 - DOI: 10.1073/pnas.2423578122
Seetharaman A, Galagali H, Linarte E, Liu MHX, Cohen JD, Chetal K, Sadreyev R, Tate AJ, Montgomery TA, Ruvkun G

Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans.

PLoS Biol. 2025;23(1):e3002748 - PMID: 39879188 - PMCID: PMC11778786 - DOI: 10.1371/journal.pbio.3002748
Jimena B, Kazimierczyk D, Kazimierczyk S, Moya H, Shin E, Li L, Korgaonkar P, Porter C, Seed B, Cherayil BJ, Jain N

Prenatal maternal infection promotes maternal microchimeric cells to alter infection risk in male offspring.

bioRxiv. 2025;:ePub - PMID: 39896468 - PMCID: PMC11785123 - DOI: 10.1101/2025.01.17.633596
Patange O, Breen P, Arsuffi G, Ruvkun G

Hydrogen sulfide mediates the interaction between C. elegans and Actinobacteria from its natural microbial environment.

Cell Rep. 2025;44(1):115170 - PMID: 39786993 - DOI: 10.1016/j.celrep.2024.115170
Tan ZY, Adade JKA, Gu X, Hecht CJS, Salcius M, Tong B, Liu S, Hwang S, Zécri FJ, Graham DB, Schreiber SL, Xavier RJ

Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator.

Cell Chem Biol. 2025;32(3):498-510.e35 - PMID: 39753134 - PMCID: PMC11928285 - DOI: 10.1016/j.chembiol.2024.12.002
Total: 6