Publications for All Faculty
Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism.
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways.
Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension.
RNA-activated protein cleavage with a CRISPR-associated endopeptidase.
A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning.
Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription.
Results from a phase 1, randomized, double-blind, multiple ascending dose study characterizing the pharmacokinetics and demonstrating the safety and selectivity of the aldosterone synthase inhibitor baxdrostat in healthy volunteers.
A 96-Week, Double-Blind, Randomized, Controlled Trial Comparing Bexagliflozin to Glimepiride as an Adjunct to Metformin for the Treatment of Type 2 Diabetes in Adults.
Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics.
Folding and Duplex Formation in Sequence-Defined Aniline Benzaldehyde Oligoarylacetylenes.
Engineered CRISPR prime editors with compact, untethered reverse transcriptases.
NIN-like protein 7 transcription factor is a plant nitrate sensor.
Inflammation-associated nitrate facilitates ectopic colonization of oral bacterium Veillonella parvula in the intestine.
Glucose-driven TOR-FIE-PRC2 signalling controls plant development.
Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides.
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn's disease.
Identification of trypsin-degrading commensals in the large intestine.
Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling.
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.
Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults.
Prokaryotic innate immunity through pattern recognition of conserved viral proteins.
ARF2-PIF5 interaction controls transcriptional reprogramming in the ABS3-mediated plant senescence pathway.
Regulation and Functions of the ER-Associated Nrf1 Transcription Factor.
Akkermansia muciniphila phospholipid induces homeostatic immune responses.
Template-Free Assembly of Functional RNAs by Loop-Closing Ligation.
TOR kinase, a GPS in the complex nutrient and hormonal signaling networks to guide plant growth and development.
pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells.
ConducTORs of a Signaling Symphony: Metabolic and Hormone Responses Converge on TOR and EIN2 in plants.
Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation.
Freeze-thaw cycles enable a prebiotically plausible and continuous pathway from nucleotide activation to nonenzymatic RNA copying.
Multiplexed detection of bacterial nucleic acids using Cas13 in droplet microarrays.
moc-6/MOCS2A is necessary for molybdenum cofactor synthesis in C. elegans.
Nonenzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides.
Remodeling of human colon plasma cell repertoire in ulcerative colitis
Lyme Disease, Borrelia burgdorferi, and Lipid Immunogens.
Lyme Disease, Borrelia burgdorferi, and Lipid Immunogens.
DNA-free CRISPR-Cas9 gene editing of wild tetraploid tomato Solanum peruvianum using protoplast regeneration.
Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing.
Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing.
Kinetic explanations for the sequence biases observed in the nonenzymatic copying of RNA templates.
The Use of Tn-Seq and the FiTnEss Analysis to Define the Core Essential Genome of Pseudomonas aeruginosa.
