Publications for All Faculty
A Versatile and Efficient Plant Protoplast Platform for Genome Editing by Cas9 RNPs.
Population study of the gut microbiome: associations with diet, lifestyle, and cardiometabolic disease.
GWAS of stool frequency provides insights into gastrointestinal motility and irritable bowel syndrome.
Innate host defense mechanisms SAC bacteria by regulating phosphoinositide kinases and phosphatases.
Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes.
An integrated taxonomy for monogenic inflammatory bowel disease
An integrated taxonomy for monogenic inflammatory bowel disease.
Single-cell profiling of proteins and chromatin accessibility using PHAGE-ATAC.
Single-cell profiling of proteins and chromatin accessibility using PHAGE-ATAC.
Gut bacterial metabolites modulate endoplasmic reticulum stress.
Efficient and Economical Targeted Insertion in Plant Genomes via Protoplast Regeneration.
Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility.
Spatially organized multicellular immune hubs in human colorectal cancer.
Tuning in to inflammation: A path forward for precise and efficacious microbiome medicines?
Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations.
Gut microbiome ADP-ribosyltransferases are widespread phage-encoded fitness factors.
Augmenting and directing long-range CRISPR-mediated activation in human cells.
Dynamic Nutrient Signaling Networks in Plants.
Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians.
SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance
Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease.
Untargeted plasma metabolome and gut microbiome profiling provide novel insights in the regulation of platelet reactivity in healthy individuals.
pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis.
The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4+ T cells via a novel CDK8-GATA3-FOXP3 pathway.
Structure-based protein function prediction using graph convolutional networks.
Translating the human microbiome: a path to improving health.
Longitudinal proteomic analysis of plasma from patients with severe COVID-19 reveal patient survival-associated signatures, tissue-specific cell death, and cell-cell interactions.
Capsular polysaccharide correlates with immune response to the human gut microbe Ruminococcus gnavus.
CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells.
Dual transcriptional analysis reveals adaptation of host and pathogen to intracellular survival of Pseudomonas aeruginosa associated with urinary tract infection.
B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV.
Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics.
Genome-wide enhancer maps link risk variants to disease genes.
Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1.
Single-cell analyses of Crohn's disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions.
Elevated rates of horizontal gene transfer in the industrialized human microbiome.
Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension.
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
γδ T cells regulate the intestinal response to nutrient sensing.
Congruent microbiome signatures in fibrosis-prone autoimmune diseases: IgG4-related disease and systemic sclerosis.
The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis.
A Code of Ethics for Gene Drive Research.
In search of the RNA world on Mars.
A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry.
Shielding from UV Photodamage: Implications for Surficial Origins of Life Chemistry on the Early Earth.
QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.
Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient C. elegans.
Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates.
Role of dietary fiber in the recovery of the human gut microbiome and its metabolome.
Sorting nexin 5 mediates virus-induced autophagy and immunity.
Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization.
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.
The Virtual Circular Genome Model for Primordial RNA Replication.
CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells.
Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.
Alterations in Fecal Microbiomes and Serum Metabolomes of Fatigued Patients With Quiescent Inflammatory Bowel Diseases.
