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Kim SC, O'Flaherty DK, Zhou L, Lelyveld VS, Szostak JW

Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA.
Proc Natl Acad Sci U S A. 2018;115(52):13318-13323 - PMID: 30509978 - PMCID: PMC6310819 - DOI: 10.1073/pnas.1814367115

Vich Vila A, Imhann F, Collij V, Jankipersadsing SA, Gurry T, Mujagic Z, Kurilshikov A, Bonder MJ, Jiang X, Tigchelaar EF, Dekens J, Peters V, Voskuil MD, Visschedijk MC, van Dullemen HM, Keszthelyi D, Swertz MA, Franke L, Alberts R, Festen EAM, Dijkstra G, Masclee AAM, Hofker MH, Xavier RJ, Alm EJ, Fu J, Wijmenga C, Jonkers DMAE, Zhernakova A, Weersma RK

Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome.
Sci Transl Med. 2018;10(472):ePub - PMID: 30567928 - DOI: 10.1126/scitranslmed.aap8914

Hsu JY, Fulco CP, Cole MA, Canver MC, Pellin D, Sher F, Farouni R, Clement K, Guo JA, Biasco L, Orkin SH, Engreitz JM, Lander ES, Joung JK, Bauer DE, Pinello L

CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data.
Nat Methods. 2018;15(12):992-993 - PMID: 30504875 - PMCID: PMC6620603 - DOI: 10.1038/s41592-018-0225-6

Chen GH, Liu MJ, Xiong Y, Sheen J, Wu SH

TOR and RPS6 transmit light signals to enhance protein translation in deetiolating Arabidopsis seedlings.
Proc Natl Acad Sci U S A. 2018;115(50):12823-12828 - PMID: 30482859 - PMCID: PMC6294885 - DOI: 10.1073/pnas.1809526115

Tan JMJ, Mellouk N, Osborne SE, Ammendolia DA, Dyer DN, Li R, Brunen D, van Rijn JM, Huang J, Czuczman MA, Cemma MA, Won AM, Yip CM, Xavier RJ, MacDuff DA, Reggiori F, Debnath J, Yoshimori T, Kim PK, Fairn GD, Coyaud E, Raught B, Muise AM, Higgins DE, Brumell JH

An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread.
Nat Microbiol. 2018;3(12):1472-1485 - PMID: 30478389 - DOI: 10.1038/s41564-018-0293-5

Biton M, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Z, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen O, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.
Cell. 2018;175(5):1307-1320.e22 - PMID: 30392957 - PMCID: PMC6239889 - DOI: 10.1016/j.cell.2018.10.008

Biton M, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Z, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen O, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.
Cell. 2018;175(5):1307-1320.e22 - PMID: 30392957 - PMCID: PMC6239889 - DOI: 10.1016/j.cell.2018.10.008

Vatanen T, Franzosa EA, Schwager R, Tripathi S, Arthur TD, Vehik K, Lernmark Å, Hagopian WA, Rewers MJ, She JX, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Stewart CJ, Ajami NJ, Petrosino JF, Gevers D, Lähdesmäki H, Vlamakis H, Huttenhower C, Xavier RJ

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study.
Nature. 2018;562(7728):589-594 - PMID: 30356183 - PMCID: PMC6296767 - DOI: 10.1038/s41586-018-0620-2

Stewart CJ, Ajami NJ, O'Brien JL, Hutchinson DS, Smith DP, Wong MC, Ross MC, Lloyd RE, Doddapaneni H, Metcalf GA, Muzny D, Gibbs RA, Vatanen T, Huttenhower C, Xavier RJ, Rewers M, Hagopian W, Toppari J, Ziegler AG, She JX, Akolkar B, Lernmark A, Hyoty H, Vehik K, Krischer JP, Petrosino JF

Temporal development of the gut microbiome in early childhood from the TEDDY study.
Nature. 2018;562(7728):583-588 - PMID: 30356187 - PMCID: PMC6415775 - DOI: 10.1038/s41586-018-0617-x

Lin XX, Sen I, Janssens GE, Zhou X, Fonslow BR, Edgar D, Stroustrup N, Swoboda P, Yates JR, Ruvkun G, Riedel CG

DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity.
Nat Commun. 2018;9(1):4400 - PMID: 30353013 - PMCID: PMC6199276 - DOI: 10.1038/s41467-018-06624-0

Graham DB, Luo C, O'Connell DJ, Lefkovith A, Brown EM, Yassour M, Varma M, Abelin JG, Conway KL, Jasso GJ, Matar CG, Carr SA, Xavier RJ

Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes.
Nat Med. 2018;24(11):1762-1772 - PMID: 30349087 - PMCID: PMC6312190 - DOI: 10.1038/s41591-018-0203-7

Jin L, Engelhart AE, Zhang W, Adamala KP, Szostak JW

Catalysis of Template-directed Nonenzymatic RNA Copying by Iron (II).
J Am Chem Soc. 2018;140(44):15016-15021 - PMID: 30335371 - PMCID: PMC7547886 - DOI: 10.1021/jacs.8b09617

Dong D, Zhou H, Na SY, Niedra R, Peng Y, Wang H, Seed B, Zhou GL

GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses.
PLoS One. 2018;13(10):e0205303 - PMID: 30332431 - PMCID: PMC6192633 - DOI: 10.1371/journal.pone.0205303

Tillman EJ, Richardson CE, Cattie DJ, Reddy KC, Lehrbach NJ, Droste R, Ruvkun G, Kim DH

Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.
Genetics. 2018;210(4):1329-1337 - PMID: 30287474 - PMCID: PMC6283152 - DOI: 10.1534/genetics.118.301450

Schirmer M, Denson L, Vlamakis H, Franzosa EA, Thomas S, Gotman NM, Rufo P, Baker SS, Sauer C, Markowitz J, Pfefferkorn M, Oliva-Hemker M, Rosh J, Otley A, Boyle B, Mack D, Baldassano R, Keljo D, LeLeiko N, Heyman M, Griffiths A, Patel AS, Noe J, Kugathasan S, Walters T, Huttenhower C, Hyams J, Xavier RJ

Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course.
Cell Host Microbe. 2018;24(4):600-610.e4 - PMID: 30308161 - PMCID: PMC6277984 - DOI: 10.1016/j.chom.2018.09.009

Fang C, Lee KK, Nietupski R, Bates RH, Fernandez-Menendez R, Lopez-Roman EM, Guijarro-Lopez L, Yin Y, Peng Z, Gomez JE, Fisher S, Barros-Aguirre D, Hubbard BK, Serrano-Wu MH, Hung DT

Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors.
Bioorg Med Chem Lett. 2018;28(22):3529-3533 - PMID: 30316633 - PMCID: PMC6233306 - DOI: 10.1016/j.bmcl.2018.09.037

Akcakaya P, Bobbin ML, Guo JA, Malagon-Lopez J, Clement K, Garcia SP, Fellows MD, Porritt MJ, Firth MA, Carreras A, Baccega T, Seeliger F, Bjursell M, Tsai SQ, Nguyen NT, Nitsch R, Mayr LM, Pinello L, Bohlooly-Y M, Aryee MJ, Maresca M, Joung JK

In vivo CRISPR editing with no detectable genome-wide off-target mutations.
Nature. 2018;561(7723):416-419 - PMID: 30209390 - PMCID: PMC6194229 - DOI: 10.1038/s41586-018-0500-9

Ausubel FM

Tracing My Roots: How I Became a Plant Biologist.
Annu Rev Genet. 2018;52:1-20 - PMID: 30192637 - DOI: 10.1146/annurev-genet-120417-031722

Joyce GF, Szostak JW

Protocells and RNA Self-Replication.
Cold Spring Harb Perspect Biol. 2018;10(9):ePub - PMID: 30181195 - PMCID: PMC6120706 - DOI: 10.1101/cshperspect.a034801

Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HM

Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential.
Trends Endocrinol Metab. 2018;29(10):723-735 - PMID: 30150136 - PMCID: PMC6151151 - DOI: 10.1016/j.tem.2018.08.004

Kim W, Steele AD, Zhu W, Csatary EE, Fricke N, Dekarske MM, Jayamani E, Pan W, Kwon B, Sinitsa IF, Rosen JL, Conery AL, Fuchs BB, Vlahovska PM, Ausubel FM, Gao H, Wuest WM, Mylonakis E

Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters.
ACS Infect Dis. 2018;4(11):1540-1545 - PMID: 30132650 - PMCID: PMC6468991 - DOI: 10.1021/acsinfecdis.8b00161

Moretti F, Bergman P, Dodgson S, Marcellin D, Claerr I, Goodwin JM, DeJesus R, Kang Z, Antczak C, Begue D, Bonenfant D, Graff A, Genoud C, Reece-Hoyes JS, Russ C, Yang Z, Hoffman GR, Mueller M, Murphy LO, Xavier RJ, Nyfeler B

TMEM41B is a novel regulator of autophagy and lipid mobilization.
EMBO Rep. 2018;19(9):ePub - PMID: 30126924 - PMCID: PMC6123663 - DOI: 10.15252/embr.201845889

Ma P, Laibinis HH, Ernst CM, Hung DT

Carbapenem resistance caused by high-level expression of OXA-663 β-lactamase in an OmpK36-deficient Klebsiella pneumoniae clinical isolate.
Antimicrob Agents Chemother. 2018;62(11):ePub - PMID: 30126962 - PMCID: PMC6201135 - DOI: 10.1128/AAC.01281-18

Bhattacharyya RP, Thakku SG, Hung DT

Harnessing CRISPR Effectors for Infectious Disease Diagnostics.
ACS Infect Dis. 2018;4(9):1278-1282 - PMID: 30113801 - DOI: 10.1021/acsinfecdis.8b00170

Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT

Acceleration profiles and processing methods for parabolic flight.
NPJ Microgravity. 2018;4:14 - PMID: 30109261 - PMCID: PMC6081456 - DOI: 10.1038/s41526-018-0050-3

Gehrke JM, Cervantes O, Clement MK, Wu Y, Zeng J, Bauer DE, Pinello L, Joung JK

An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities.
Nat Biotechnol. 2018;36(10):977-982 - PMID: 30059493 - PMCID: PMC6181770 - DOI: 10.1038/nbt.4199

Natividad JM, Agus A, Planchais J, Lamas B, Jarry AC, Martin R, Michel ML, Chong-Nguyen C, Roussel R, Straube M, Jegou S, McQuitty C, Le Gall M, da Costa G, Lecornet E, Michaudel C, Modoux M, Glodt J, Bridonneau C, Sovran B, Dupraz L, Bado A, Richard ML, Langella P, Hansel B, Launay JM, Xavier RJ, Duboc H, Sokol H

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome.
Cell Metab. 2018;28(5):737-749.e4 - PMID: 30057068 - DOI: 10.1016/j.cmet.2018.07.001

Shi L, Wu Y, Sheen J

TOR signaling in plants: conservation and innovation.
Development. 2018;145(13):ePub - PMID: 29986898 - PMCID: PMC6053665 - DOI: 10.1242/dev.160887

Ambros V, Ruvkun G

Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs.
Genetics. 2018;209(3):651-673 - PMID: 29967059 - PMCID: PMC6028246 - DOI: 10.1534/genetics.118.300291

Graham DB, Jasso GJ, Mok A, Goel G, Ng ACY, Kolde R, Varma M, Doench JG, Root DE, Clish CB, Carr SA, Xavier RJ

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.
Cell Rep. 2018;24(4):838-850 - PMID: 30044981 - PMCID: PMC6156773 - DOI: 10.1016/j.celrep.2018.06.081

Yassour M, Jason E, Hogstrom LJ, Arthur TD, Tripathi S, Siljander H, Selvenius J, Oikarinen S, Hyöty H, Virtanen SM, Ilonen J, Ferretti P, Pasolli E, Tett A, Asnicar F, Segata N, Vlamakis H, Lander ES, Huttenhower C, Knip M, Xavier RJ

Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.
Cell Host Microbe. 2018;24(1):146-154.e4 - PMID: 30001517 - PMCID: PMC6091882 - DOI: 10.1016/j.chom.2018.06.007

Schirmer M, Kumar V, Netea MG, Xavier RJ

The causes and consequences of variation in human cytokine production in health.
Curr Opin Immunol. 2018;54:50-58 - PMID: 29913309 - DOI: 10.1016/j.coi.2018.05.012

Zhang W, Walton T, Li L, Szostak JW

Crystallographic observation of nonenzymatic RNA primer extension.
Elife. 2018;7:ePub - PMID: 29851379 - PMCID: PMC5980232 - DOI: 10.7554/eLife.36422

Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM, Kurki M, Ganna A, Graham D, Glaser B, Peter I, Atzmon G, Barzilai N, Levine AP, Schiff E, Pontikos N, Weisburd B, Lek M, Karczewski KJ, Bloom J, Minikel EV, Petersen BS, Beaugerie L, Seksik P, Cosnes J, Schreiber S, Bokemeyer B, Bethge J, International IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-GENES Consortium, Heap G, Ahmad T, Plagnol V, Segal AW, Targan S, Turner D, Saavalainen P, Farkkila M, Kontula K, Palotie A, Brant SR, Duerr RH, Silverberg MS, Rioux JD, Weersma RK, Franke A, Jostins L, Anderson CA, Barrett JC, MacArthur DG, Jalas C, Sokol H, Xavier RJ, Pulver A, Cho JH, McGovern DPB, Daly MJ

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.
PLoS Genet. 2018;14(5):e1007329 - PMID: 29795570 - PMCID: PMC5967709 - DOI: 10.1371/journal.pgen.1007329

Bakker OB, Aguirre-Gamboa R, Sanna S, Oosting M, Smeekens SP, Jaeger M, Zorro M, Võsa U, Withoff S, Netea-Maier RT, Koenen HJPM, Joosten I, Xavier RJ, Franke L, Joosten LAB, Kumar V, Wijmenga C, Netea MG, Li Y

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses.
Nat Immunol. 2018;19(7):776-786 - PMID: 29784908 - PMCID: PMC6022810 - DOI: 10.1038/s41590-018-0121-3

Pitt B, Bakris GL, Weir MR, Freeman MW, Lainscak M, Mayo MR, Garza D, Zawadzki R, Berman L, Bushinsky DA

Long-term effects of patiromer for hyperkalaemia treatment in patients with mild heart failure and diabetic nephropathy on angiotensin-converting enzymes/angiotensin receptor blockers: results from AMETHYST-DN.
ESC Heart Fail. 2018;5(4):592-602 - PMID: 29767459 - PMCID: PMC6073017 - DOI: 10.1002/ehf2.12292

Pontefract A, Hachey J, Zuber MT, Ruvkun G, Carr CE

Sequencing nothing: Exploring failure modes of nanopore sensing and implications for life detection.
Life Sci Space Res (Amst). 2018;18:80-86 - PMID: 30100151 - DOI: 10.1016/j.lssr.2018.05.004

Newman MA, Ji F, Fischer SEJ, Anselmo A, Sadreyev RI, Ruvkun G

The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes.
Genes Dev. 2018;32(9-10):670-681 - PMID: 29739806 - PMCID: PMC6004069 - DOI: 10.1101/gad.311514.118

Burke KE, Khalili H, Garber JJ, Haritunians T, McGovern DPB, Xavier RJ, Ananthakrishnan AN

Genetic Markers Predict Primary Nonresponse and Durable Response to Anti-Tumor Necrosis Factor Therapy in Ulcerative Colitis.
Inflamm Bowel Dis. 2018;24(8):1840-1848 - PMID: 29718226 - PMCID: PMC6128143 - DOI: 10.1093/ibd/izy083

O'Flaherty DK, Kamat NP, Mirza FN, Li L, Prywes N, Szostak JW

Copying of mixed sequence RNA templates inside model protocells.
J Am Chem Soc. 2018;140(15):5171-5178 - PMID: 29608310 - PMCID: PMC7547884 - DOI: 10.1021/jacs.8b00639

Canver MC, Joung JK, Pinello L

Impact of Genetic Variation on CRISPR-Cas Targeting.
CRISPR J. 2018;1:159-170 - PMID: 31021199 - PMCID: PMC6319324 - DOI: 10.1089/crispr.2017.0016

Brown EM, Xavier RJ

Without Adaptive Immunity, There's a Cost to Responding STAT.
Cell Metab. 2018;27(4):705-707 - PMID: 29617636 - DOI: 10.1016/j.cmet.2018.03.011

Lareau CA, Clement K, Hsu JY, Pattanayak V, Joung JK, Aryee MJ, Pinello L

Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".
Nat Methods. 2018;15(4):238-239 - PMID: 29600992 - PMCID: PMC7784551 - DOI: 10.1038/nmeth.4541

Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N, Conery AL, Shen S, Pan W, Lee K, Rajamuthiah R, Fuchs BB, Vlahovska PM, Wuest WM, Gilmore MS, Gao H, Ausubel FM, Mylonakis E

A new class of synthetic retinoid antibiotics effective against bacterial persisters.
Nature. 2018;556(7699):103-107 - PMID: 29590091 - PMCID: PMC6462414 - DOI: 10.1038/nature26157

Mojarro A, Hachey J, Ruvkun G, Zuber MT, Carr CE

CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing.
BMC Bioinformatics. 2018;19(1):108 - PMID: 29587645 - PMCID: PMC5872496 - DOI: 10.1186/s12859-018-2124-3

Verma MS, Fink MJ, Salmon GL, Fornelos N, Ohara TE, Ryu SH, Vlamakis H, Xavier RJ, Stappenbeck TS, Whitesides GM

A common mechanism links activities of butyrate in the colon.
ACS Chem Biol. 2018;13(5):1291-1298 - PMID: 29584955 - DOI: 10.1021/acschembio.8b00073

Clatworthy AE, Romano KP, Hung DT

Whole-organism phenotypic screening for anti-infectives promoting host health.
Nat Chem Biol. 2018;14(4):331-341 - PMID: 29556098 - PMCID: PMC9843822 - DOI: 10.1038/s41589-018-0018-3

Johns NI, Gomes ALC, Yim SS, Yang A, Blazejewski T, Smillie CS, Smith MB, Alm EJ, Kosuri S, Wang HH

Metagenomic mining of regulatory elements enables programmable species-selective gene expression.
Nat Methods. 2018;15(5):323-329 - PMID: 30052624 - PMCID: PMC6065261 - DOI: 10.1038/nmeth.4633

Haller S, Franchet A, Hakkim A, Chen J, Drenkard E, Yu S, Schirmeier S, Li Z, Martins N, Ausubel FM, Liégeois S, Ferrandon D

Quorum-sensing regulator RhlR but not its autoinducer RhlI enablesPseudomonasto evade opsonization.
EMBO Rep. 2018;19(5):ePub - PMID: 29523648 - PMCID: PMC5934776 - DOI: 10.15252/embr.201744880

Jin L, Kamat NP, Jena S, Szostak JW

Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution.
Small. 2018;14(15):e1704077 - PMID: 29479815 - PMCID: PMC6278924 - DOI: 10.1002/smll.201704077

Yuen GJ, Ausubel FM

Both live and dead Enterococci activate Caenorhabditis elegans host defense via immune and stress pathways.
Virulence. 2018;9(1):0 - PMID: 29436902 - PMCID: PMC5955442 - DOI: 10.1080/21505594.2018.1438025

Jin L, Engelhart AE, Adamala KP, Szostak JW

Preparation, Purification, and Use of Fatty Acid-containing Liposomes.
J Vis Exp. 2018;(132):ePub - PMID: 29553563 - PMCID: PMC5912384 - DOI: 10.3791/57324

Zhang W, Tam CP, Zhou L, Oh SS, Wang J, Szostak JW

A structural rationale for the enhanced catalysis of nonenzymatic RNA primer extension by a downstream oligonucleotide.
J Am Chem Soc. 2018;140(8):2829-2840 - PMID: 29411978 - PMCID: PMC6326529 - DOI: 10.1021/jacs.7b11750

Wellington S, Hung DT

The expanding diversity of Mycobacterium tuberculosis drug targets.
ACS Infect Dis. 2018;4(5):696-714 - PMID: 29412643 - DOI: 10.1021/acsinfecdis.7b00255

Smillie CS, Sauk J, Gevers D, Friedman J, Sung J, Youngster I, Hohmann EL, Staley C, Khoruts A, Sadowsky MJ, Allegretti JR, Smith MB, Xavier RJ, Alm EJ

Strain Tracking Reveals the Determinants of Bacterial Engraftment in the Human Gut Following Fecal Microbiota Transplantation.
Cell Host Microbe. 2018;23(2):229-240.e5 - PMID: 29447696 - PMCID: PMC8318347 - DOI: 10.1016/j.chom.2018.01.003

Smillie CS, Sauk J, Gevers D, Friedman J, Sung J, Youngster I, Hohmann EL, Staley C, Khoruts A, Sadowsky MJ, Allegretti JR, Smith MB, Xavier RJ, Alm EJ

Strain Tracking Reveals the Determinants of Bacterial Engraftment in the Human Gut Following Fecal Microbiota Transplantation.
Cell Host Microbe. 2018;23(2):229-240.e5 - PMID: 29447696 - PMCID: PMC8318347 - DOI: 10.1016/j.chom.2018.01.003

Mohanan V, Nakata T, Desch AN, Lévesque C, Boroughs A, Guzman G, Cao Z, Creasey E, Yao J, Boucher G, Charron G, Bhan AK, Schenone M, Carr SA, Reinecker HC, Daly MJ, Rioux JD, Lassen KG, Xavier RJ

C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
Science. 2018;359(6380):1161-1166 - PMID: 29420262 - PMCID: PMC6008784 - DOI: 10.1126/science.aan0814

Kolde R, Franzosa EA, Rahnavard G, Hall AB, Vlamakis H, Stevens C, Daly MJ, Xavier RJ, Huttenhower C

Host genetic variation and its microbiome interactions within the Human Microbiome Project.
Genome Med. 2018;10(1):6 - PMID: 29378630 - PMCID: PMC5789541 - DOI: 10.1186/s13073-018-0515-8

Luther J, Gala M, Patel SJ, Dave M, Borren N, Xavier RJ, Ananthakrishnan AN

Loss of Response to Anti-Tumor Necrosis Factor Alpha Therapy in Crohn's Disease Is Not Associated with Emergence of Novel Inflammatory Pathways.
Dig Dis Sci. 2018;63(3):738-745 - PMID: 29372477 - PMCID: PMC6152907 - DOI: 10.1007/s10620-018-4932-8

Visschedijk MC, Spekhorst LM, Cheng SC, van Loo ES, Jansen BHD, Blokzijl T, Kil H, de Jong DJ, Pierik M, Maljaars JPWJ, van der Woude CJ, van Bodegraven AA, Oldenburg B, Löwenberg M, Nieuwenhuijs VB, Imhann F, van Sommeren S, Alberts R, Xavier RJ, Dijkstra G, Faber KN, Aldaz CM, Weersma RK, Festen EAM

Genomic and expression analyses identify a disease modifying variant for fibrostenotic Crohn's disease.
J Crohns Colitis. 2018;12(5):582-588 - PMID: 29361163 - DOI: 10.1093/ecco-jcc/jjy001

Datta S, Seed B

Influence of multiplicative stochastic variation on translational elongation rates.
PLoS One. 2018;13(1):e0191152 - PMID: 29351322 - PMCID: PMC5774726 - DOI: 10.1371/journal.pone.0191152

Todd ZR, Fahrenbach AC, Magnani CJ, Ranjan S, Björkbom A, Szostak JW, Sasselov DD

Solvated-electron production using cyanocuprates is compatible with the UV-environment on a Hadean-Archaean Earth.
Chem Commun (Camb). 2018;54(9):1121-1124 - PMID: 29334083 - PMCID: PMC9631354 - DOI: 10.1039/c7cc07748c

Schirmer M, Franzosa EA, Lloyd-Price J, McIver LJ, Schwager R, Poon TW, Ananthakrishnan AN, Andrews E, Barron G, Lake K, Prasad M, Sauk J, Stevens B, Wilson RG, Braun J, Denson LA, Kugathasan S, McGovern DPB, Vlamakis H, Xavier RJ, Huttenhower C

Dynamics of metatranscription in the inflammatory bowel disease gut microbiome.
Nat Microbiol. 2018;3(3):337-346 - PMID: 29311644 - PMCID: PMC6131705 - DOI: 10.1038/s41564-017-0089-z

Dunbar CE, High KA, Joung JK, Kohn DB, Ozawa K, Sadelain M

Gene therapy comes of age.
Science. 2018;359(6372):ePub - PMID: 29326244 - DOI: 10.1126/science.aan4672

Tam CP, Zhou L, Fahrenbach AC, Zhang W, Walton T, Szostak JW

Synthesis of a nonhydrolyzable nucleotide phosphoroimidazolide analogue that catalyzes nonenzymatic RNA primer extension.
J Am Chem Soc. 2018;140(2):783-792 - PMID: 29251930 - PMCID: PMC6326531 - DOI: 10.1021/jacs.7b11623

Borren NZ, Conway G, Garber JJ, Khalili H, Budree S, Mallick H, Yajnik V, Xavier RJ, Ananthakrishnan AN

Difference in clinical course, genetics, and the microbiome between familial and sporadic inflammatory bowel diseases.
J Crohns Colitis. 2018;12(5):525-531 - PMID: 29145572 - PMCID: PMC6018966 - DOI: 10.1093/ecco-jcc/jjx154

Kazis LE, Sheridan RL, Shapiro GD, Lee AF, Liang MH, Ryan CM, Schneider JC, Lydon M, Soley-Bori M, Sonis LA, Dore EC, Palmieri T, Herndon D, Meyer W, Warner P, Kagan R, Stoddard FJ, Murphy M, Tompkins RG

Development of Clinical Process Measures for Pediatric Burn Care: Understanding Variation in Practice Patterns.
J Trauma Acute Care Surg. 2018;84(4):620-627 - PMID: 29140950 - DOI: 10.1097/TA.0000000000001737

Lassen KG, Xavier RJ

Mechanisms and Function of Autophagy in Intestinal Disease.
Autophagy. 2018;14(2):0 - PMID: 29130415 - PMCID: PMC5902220 - DOI: 10.1080/15548627.2017.1389358

Haney CH, Wiesmann CL, Shapiro LR, O'Sullivan LR, Khorasani S, Melnyk RA, Xiao L, Han J, Bush J, Carrillo J, Pierce NE, Ausubel FM

Rhizosphere-associated Pseudomonas induce systemic resistance to herbivores at the cost of susceptibility to bacterial pathogens.
Mol Ecol. 2018;27(8):1833-1847 - PMID: 29087012 - DOI: 10.1111/mec.14400

Imhann F, Vich Vila A, Bonder MJ, Fu J, Gevers D, Visschedijk MC, Spekhorst LM, Alberts R, Franke L, van Dullemen HM, Ter Steege RW, Huttenhower C, Dijkstra G, Xavier RJ, Festen EA, Wijmenga C, Zhernakova A, Weersma RK

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease.
Gut. 2018;67(1):108-119 - PMID: 27802154 - PMCID: PMC5699972 - DOI: 10.1136/gutjnl-2016-312135
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