Publications for All Faculty
Nodal patterning without Lefty inhibitory feedback is functional but fragile.
A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients.
A potent Cas9-derived gene activator for plant and mammalian cells.
A single-cell survey of the small intestinal epithelium
A single-cell survey of the small intestinal epithelium.
A single-cell survey of the small intestinal epithelium.
A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension.
Retraction: Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication.
A role for bacterial urease in gut dysbiosis and Crohn's disease.
Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors.
scDual-Seq: mapping the gene regulatory program of Salmonella infection by host and pathogen single-cell RNA-sequencing.
Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo.
A kinetic model of nonenzymatic RNA polymerization by cytidine-5'-phosphoro-2-aminoimidazolide.
p40 (phox) -Deficient Mice Exhibit Impaired Bacterial Clearance and Enhanced Pro-inflammatory Responses during Salmonella enterica serovar Typhimurium Infection.
Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease.
Dual CLAVATA3 Peptides in Arabidopsis Shoot Stem Cell Signaling.
Dual CLAVATA3 Peptides in Arabidopsis Shoot Stem Cell Signaling
SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCε-dependent Pathway.
Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation.
Microbial Diversity in a Hypersaline Sulfate Lake: A Terrestrial Analog of Ancient Mars.
Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution.
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
An Anti-Persister Strategy for the Treatment of Chronic Pseudomonas aeruginosa Infections.
Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.
The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.
Investment in secreted enzymes during nutrient-limited growth is utility dependent.
SHANK3 Regulates Intestinal Barrier Function Through Modulating ZO-1 Expression Through the PKCε-dependent Pathway.
Human genetic variation and the gut microbiome in disease.
Erratum: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges.
A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres.
Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine.
Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation.
Nucleic Acid Extraction from Synthetic Mars Analog Soils for in situ Life Detection.
UV-light-driven prebiotic synthesis of iron-sulfur clusters.
Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children.
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.
Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.
Characterization of a Francisella tularensis-Caenorhabditis elegans pathosystem for the evaluation of therapeutic compounds.
Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation.
Dissecting the human microbiome with single-cell genomics.
Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway.
Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota.
Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides.
Adult-onset, chronic, cyclic thrombocytopenia in a Rhesus macaque (Macaca mulatta) after dengue virus vaccination and viral challenge.
The Narrow Road to the Deep Past.
Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence.
Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies.
Discovery of nitrate-CPK-NLP signalling in central nutrient-growth networks.
CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets.
Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases.
Nucleic acid detection with CRISPR-Cas13a/C2c2.
Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.
Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.
An Alpha7 Nicotinic Acetylcholine Receptor Agonist (GTS-21) Promotes C2C12 Myonuclear Accretion in Association with Release of Interleukin-6 (IL-6) and Improves Survival in Burned Mice.
Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140.
Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study.
US immigration order strikes against biotech.
A Microbiome Foundation for the Study of Crohn's Disease.
Local and Systemic Changes Associated with Long-term, Percutaneous, Static Implantation of Titanium Alloys in Rhesus Macaques (Macaca mulatta).
Unraveling the processes shaping mammalian gut microbiomes over evolutionary time.
Corrigendum: SIKs control osteocyte responses to parathyroid hormone.
Two dynamic regimes in the human gut microbiome.
Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment.
MAPK Assays in Arabidopsis MAMP-PRR Signal Transduction.
Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides.
iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-?B and p53.
Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks.
The NBS-LRR architectures of plant R-proteins and metazoan NLRs evolved in independent events.
ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content.
Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes.
The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.
The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD).
Visceral Adiposity, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.
Erratum to: Vedolizumab Therapy Is Associated with an Improvement in Sleep Quality and Mood in Inflammatory Bowel Diseases.
Vedolizumab Therapy Is Associated with an Improvement in Sleep Quality and Mood in Inflammatory Bowel Diseases.
KERIS: kaleidoscope of gene responses to inflammation between species.
Changes in neutrophil migration patterns upon contact with platelets in a microfluidic assay.
Prevention of Burn-Induced Inflammatory Responses and Muscle Wasting By GTS-21, A Specific Agonist for ?7 Nicotinic Acetylcholine Receptors.
Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.
