Publications for All Faculty
TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation
Cell Rep. 2016;17(11):2955-2965 - PMID: 27974209 - PMCID: PMC5661940 - DOI: 10.1016/j.celrep.2016.11.042
Influence of maternal breast milk ingestion on acquisition of the intestinal microbiome in preterm infants.
N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes.
J Am Chem Soc. 2016;138(51):16669-16676 - PMID: 27959544 - PMCID: PMC7547885 - DOI: 10.1021/jacs.6b08801
Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway.
DNA-binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases.
Mol Ther. 2016;16(2):352-358 - PMID: 28178540 - DOI: 10.1038/sj.mt.6300357
Genome Editing Technologies: Defining a Path to Clinic: Genomic Editing: Establishing Preclinical Toxicology Standards, Bethesda, Maryland 10 June 2014.
Mol Ther. 2016;23(5):796-806 - PMID: 28142000
Hold the Pendulum: Rates of Acute Kidney Injury are Increased in Patients Who Receive Resuscitation Volumes Less than Predicted by the Parkland Equation.
Ann Surg. 2016;264(6):1142-1147 - PMID: 27828823 - PMCID: PMC5111808 - DOI: 10.1097/SLA.0000000000001615
The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.
Cell Rep. 2016;17(10):2776-2788 - PMID: 27926878 - PMCID: PMC5656005 - DOI: 10.1016/j.celrep.2016.11.035
TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.
Cell Rep. 2016;17(11):2955-2965 - PMID: 27974209 - PMCID: PMC5661940 - DOI: 10.1016/j.celrep.2016.11.042
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.
Cell. 2016;167(7):1897 - PMID: 27984736 - DOI: 10.1016/j.cell.2016.11.046
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.
Cell Metab. 2016;24(6):807-819 - PMID: 27866838 - PMCID: PMC5742541 - DOI: 10.1016/j.cmet.2016.10.008
Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits.
Cell Rep. 2016;17(9):2474-2487 - PMID: 27818087 - PMCID: PMC5130901 - DOI: 10.1016/j.celrep.2016.10.053
Unusual Base-Pairing Interactions in Monomer-Template Complexes.
ACS Cent Sci. 2016;2(12):916-926 - PMID: 28058281 - PMCID: PMC5200924 - DOI: 10.1021/acscentsci.6b00278
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.
Cell. 2016;167(4):1125-1136.e8 - PMID: 27814509 - PMCID: PMC5131922 - DOI: 10.1016/j.cell.2016.10.020
Host and Environmental Factors Influencing Individual Human Cytokine Responses.
Cell. 2016;167(4):1111-1124.e13 - PMID: 27814508 - PMCID: PMC5787854 - DOI: 10.1016/j.cell.2016.10.018
A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.
Cell. 2016;167(4):1099-1110.e14 - PMID: 27814507 - DOI: 10.1016/j.cell.2016.10.017
RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy.
Cell Rep. 2016;17(9):2183-2194 - PMID: 27880896 - PMCID: PMC5192565 - DOI: 10.1016/j.celrep.2016.11.005
SIKs control osteocyte responses to parathyroid hormone.
TNF-?/IL-10 Ratio Correlates with Burn Severity and May Serve as a Risk Predictor of Increased Susceptibility to Infections.
Front Public Health. 2016;4:216 - PMID: 27761434 - PMCID: PMC5050217 - DOI: 10.3389/fpubh.2016.00216
Corrigendum: Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.
Nat Med. 2016;22(10):1192 - PMID: 27711068 - DOI: 10.1038/nm1016-1192b
The metabolic stress response to burn trauma: current understanding and therapies.
Lancet. 2016;388(10052):1417-1426 - PMID: 27707498 - PMCID: PMC5753602 - DOI: 10.1016/S0140-6736(16)31469-6
A perspective on single cell behavior during infection.
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.
Cell. 2016;167(2):457-470.e13 - PMID: 27667687 - PMCID: PMC5863951 - DOI: 10.1016/j.cell.2016.08.064
Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.
Increased Intestinal Microbial Diversity Following Fecal Microbiota Transplant for Active Crohn's Disease.
Inflamm Bowel Dis. 2016;22(9):2182-90 - PMID: 27542133 - PMCID: PMC4995064 - DOI: 10.1097/MIB.0000000000000893
Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension.
Chem Commun (Camb). 2016;52(80):11905-11907 - PMID: 27722518 - DOI: 10.1039/c6cc06925h
On the origin of life.
Medicina (B Aires). 2016;76(4):199-203 - PMID: 27576276
Genomic analysis of the evolution of fluoroquinolone resistance in Mycobacterium tuberculosis prior to tuberculosis diagnosis.
Antimicrob Agents Chemother. 2016;60(11):6600-6608 - PMID: 27572408 - PMCID: PMC5075065 - DOI: 10.1128/AAC.00664-16
A highly reactive imidazolium-bridged dinucleotide intermediate in nonenzymatic RNA primer extension.
J Am Chem Soc. 2016;138(36):11996-2002 - PMID: 27552367 - PMCID: PMC6326528 - DOI: 10.1021/jacs.6b07977
Characterization of candidate genes in inflammatory bowel disease-associated risk loci.
JCI Insight. 2016;1(13):e87899 - PMID: 27668286 - PMCID: PMC5033062 - DOI: 10.1172/jci.insight.87899
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.
A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.
Understanding human immune function using the resources from the Human Functional Genomics Project.
Nat Med. 2016;22(8):831-3 - PMID: 27490433 - DOI: 10.1038/nm.4140
A pleiotropic missense variant in SLC39A8 is associated with Crohn's disease and human gut microbiome composition.
Gastroenterology. 2016;151(4):724-32 - PMID: 27492617 - PMCID: PMC5037008 - DOI: 10.1053/j.gastro.2016.06.051
Accelerating global innovation to address antibacterial resistance: introducing CARB-X.
Nat Rev Drug Discov. 2016;15(9):589-590 - PMID: 27469032 - DOI: 10.1038/nrd.2016.155
A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes.
Nat Protoc. 2016;11(8):1477-91 - PMID: 27442864 - DOI: 10.1038/nprot.2016.090
Dynamic and diverse sugar signaling.
Curr Opin Plant Biol. 2016;33:116-125 - PMID: 27423125 - PMCID: PMC5050104 - DOI: 10.1016/j.pbi.2016.06.018
Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease.
Molecular Imaging of Smoke-Induced Changes in Nuclear Factor-Kappa B Expression in Murine Tissues Including the Lung.
J Burn Care Res. 2016;37(6):335-342 - PMID: 27437954 - DOI: 10.1097/BCR.0000000000000394
Mobile genes in the human microbiome are structured from global to individual scales.
Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.
Introduction to Gene Editing and Manipulation Using CRISPR/Cas9 Technology.
A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport.
Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62.
Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides.
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells.
Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication.
Microbiota as Therapeutic Targets.
Dig Dis. 2016;34(5):558-65 - PMID: 27331403 - DOI: 10.1159/000445263
Caenorhabditis elegans responses to bacteria from its natural habitats.
Proc Natl Acad Sci U S A. 2016;113(27):E3941-9 - PMID: 27317746 - PMCID: PMC4941482 - DOI: 10.1073/pnas.1607183113
Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors.
Cell Chem Biol. 2016;23(6):666-77 - PMID: 27321573 - PMCID: PMC4920728 - DOI: 10.1016/j.chembiol.2016.05.011
Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks.
Proc Natl Acad Sci U S A. 2016;113(26):E3667-75 - PMID: 27298372 - PMCID: PMC4932963 - DOI: 10.1073/pnas.1602827113
The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1.
Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.
Immunity. 2016;44(6):1392-1405 - PMID: 27287411 - PMCID: PMC4936415 - DOI: 10.1016/j.immuni.2016.05.007
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
Cell. 2016;165(6):1551 - PMID: 27259157 - DOI: 10.1016/j.cell.2016.05.056
Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability.
Sci Transl Med. 2016;8(343):343ra81 - PMID: 27306663 - PMCID: PMC5032909 - DOI: 10.1126/scitranslmed.aad0917
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC-dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 2016;6(7):727-39 - PMID: 27231123 - PMCID: PMC5458737 - DOI: 10.1158/2159-8290.CD-15-1442
Metagenomic Characterization of Microbial Communities In Situ Within the Deeper Layers of the Ileum in Crohn's Disease.
Cell Mol Gastroenterol Hepatol. 2016;2(5):563-566.e5 - PMID: 28174737 - PMCID: PMC5042890 - DOI: 10.1016/j.jcmgh.2016.05.011
Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function In Vivo.
ACS Chem Biol. 2016;11(8):2105-11 - PMID: 27224444 - PMCID: PMC4992440 - DOI: 10.1021/acschembio.6b00217
Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing.
Coagulation Biomarkers in Healthy Chinese-Origin Rhesus Macaques (Macaca mulatta).
J Am Assoc Lab Anim Sci. 2016;55(3):252-9 - PMID: 27177557 - PMCID: PMC4865685
Role of Elevated Fibrinogen in Burn-Induced Mitochondrial Dysfunction: Protective Effects of Glycyrrhizin.
CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.
Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn's Disease Phenotypes.
Dig Dis Sci. 2016;61(9):2627-35 - PMID: 27142671 - PMCID: PMC4982770 - DOI: 10.1007/s10620-016-4180-8
Open-source guideseq software for analysis of GUIDE-seq data.
Nat Biotechnol. 2016;34(5):483 - PMID: 27153277 - DOI: 10.1038/nbt.3534
Mechanisms of Pediatric Inflammatory Bowel Disease.
Annu Rev Immunol. 2016;34:31-64 - PMID: 27168239 - DOI: 10.1146/annurev-immunol-032414-112151
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying.
Chem Commun (Camb). 2016;52(39):6529-32 - PMID: 27109314 - DOI: 10.1039/c6cc02692c
Trained immunity: A program of innate immune memory in health and disease.
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming.
Sci Transl Med. 2016;8(333):333ra50 - PMID: 27053774 - PMCID: PMC4878149 - DOI: 10.1126/scitranslmed.aad6100
Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.
Timothy C. Wang, MD: Our next AGA President.
Gastroenterology. 2016;150(5):1231-1236 - PMID: 27018487 - DOI: 10.1053/j.gastro.2016.03.021
Collaboration between primitive cell membranes and soluble catalysts.
Experimental and computational evidence for a loose transition state in phosphoroimidazolide hydrolysis.
A simple physical mechanism enables homeostasis in primitive cells.
?v Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells.
Recovery Curves for Pediatric Burn Survivors: Advances in Patient-Oriented Outcomes.
JAMA Pediatr. 2016;170(6):534-42 - PMID: 26953515 - DOI: 10.1001/jamapediatrics.2015.4722
Mutation of the Glucosinolate Biosynthesis Enzyme Cytochrome P450 83A1 Monooxygenase Increases Camalexin Accumulation and Powdery Mildew Resistance.
ABCA7 Deficiency Accelerates Amyloid-? Generation and Alzheimer's Neuronal Pathology.
J Neurosci. 2016;36(13):3848-59 - PMID: 27030769 - PMCID: PMC4812140 - DOI: 10.1523/JNEUROSCI.3757-15.2016
New Regulatory Roles of Galectin-3 in the High-affinity IgE Receptor Signaling.
NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption.
Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes.
Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates.
Chem Commun (Camb). 2016;52(18):3684-6 - PMID: 26857159 - DOI: 10.1039/c5cc10317g
Planetary Protection and Mars Special Regions-A Suggestion for Updating the Definition.
Astrobiology. 2016;16(2):119-25 - PMID: 26848950 - DOI: 10.1089/ast.2016.1472
DNA damage signalling targets the kinetochore to promote chromatin mobility.
Nat Cell Biol. 2016;18(3):281-90 - PMID: 26829389 - DOI: 10.1038/ncb3308
On the Mechanism of Berberine-INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials.
The burn outcome questionnaires: Patient and family reported outcome metrics for children of all ages.
Burns. 2016;42(5):1144-1145 - PMID: 26803370 - PMCID: PMC10001424 - DOI: 10.1016/j.burns.2015.10.033
Hold the Pendulum: Rates of Acute Kidney Injury are Increased in Patients Who Receive Resuscitation Volumes Less than Predicted by the Parkland Equation.
Ann Surg. 2016;:ePub - PMID: 26764868
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy. 2016;12(1):1-222 - PMID: 26799652 - PMCID: PMC4835977 - DOI: 10.1080/15548627.2015.1100356
Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity.
Proc Natl Acad Sci U S A. 2016;113(1):122-7 - PMID: 26699463 - PMCID: PMC4711836 - DOI: 10.1073/pnas.1522401112
Loss of a Class A Penicillin-Binding Protein Alters ?-Lactam Susceptibilities in Mycobacterium tuberculosis.
ACS Infect Dis. 2016;2(2):104-10 - PMID: 27624961 - DOI: 10.1021/acsinfecdis.5b00119
Proton pump inhibitors affect the gut microbiome.
In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury.
Int J Mol Med. 2016;37(2):299-308 - PMID: 26648055 - PMCID: PMC4716799 - DOI: 10.3892/ijmm.2015.2426
Flow Cytometric Analysis of Mononuclear Phagocytes in Non-diseased Human Lung and Lung-draining Lymph Nodes.
Am J Respir Crit Care Med. 2016;193(6):614-626 - PMID: 26551758 - PMCID: PMC4824940 - DOI: 10.1164/rccm.201507-1376OC
Early Leukocyte Gene Expression Associated with Age, Burn Size, and Inhalation Injury in Severely Burned Adults.
J Trauma Acute Care Surg. 2016;80(2):250-7 - PMID: 26517785 - PMCID: PMC4731271 - DOI: 10.1097/TA.0000000000000905
Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2.
Crit Care Med. 2016;44(5):e241-52 - PMID: 26509319 - PMCID: PMC4833510 - DOI: 10.1097/CCM.0000000000001397
Pseudomonas syringae enhances herbivory by suppressing the reactive oxygen burst in Arabidopsis.
J Insect Physiol. 2016;84:90-102 - PMID: 26205072 - PMCID: PMC4721946 - DOI: 10.1016/j.jinsphys.2015.07.011
Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease.
Total: 101


