Publications for All Faculty - 2014

  • Lo J, Rosenberg ES, Fitzgerald ML, Bazner SB, Ihenachor EJ, Hawxhurst V, Borkowska AH, Wei J, Zimmerman CO, Burdo TH, Williams KC, Freeman MW, Grinspoon SK High-density lipoprotein-mediated cholesterol efflux capacity is improved by treatment with antiretroviral therapy in acute human immunodeficiency virus infection. Open Forum Infect Dis. 2014;1(3):ofu108 - PMID: 25734176 - PMCID: PMC4324225 - DOI: 10.1093/ofid/ofu108

  • Knights D, Silverberg MS, Weersma RK, Gevers D, Dijkstra G, Huang H, Tyler AD, van Sommeren S, Imhann F, Stempak JM, Huang H, Vangay P, Al-Ghalith GA, Russell C, Sauk J, Knight J, Daly MJ, Huttenhower C, Xavier RJ Complex host genetics influence the microbiome in inflammatory bowel disease. Genome Med. 2014;6(12):107 - PMID: 25587358 - PMCID: PMC4292994 - DOI: 10.1186/s13073-014-0107-1

  • Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, Mitchell A, Ma J, Dubrulle J, Reyon D, Tsai SQ, Joung JK, Saghatelian A, Schier AF Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science. 2014;343(6172):1248636 - PMID: 24407481 - PMCID: PMC4107353 - DOI: 10.1126/science.1248636

  • Fu Y, Sander JD, Reyon D, Cascio VM, Joung JK Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat Biotechnol. 2014;32(3):279-84 - PMID: 24463574 - PMCID: PMC3988262 - DOI: 10.1038/nbt.2808

  • Carter EA, Paul K, Bonab AA, Tompkins RG, Fischman AJ Effect of exercise on burn-induced changes in tissue-specific glucose metabolism. J Burn Care Res. 2014;35(6):470-3 - PMID: 24476988 - PMCID: PMC4113562 - DOI: 10.1097/BCR.0000000000000036

  • Gupta A, Christensen RG, Bell HA, Goodwin M, Patel RY, Pandey M, Enuameh MS, Rayla AL, Zhu C, Thibodeau-Beganny S, Brodsky MH, Joung JK, Wolfe SA, Stormo GD An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins. Nucleic Acids Res. 2014;42(8):4800-12 - PMID: 24523353 - PMCID: PMC4005693 - DOI: 10.1093/nar/gku132

  • Guilinger JP, Pattanayak V, Reyon D, Tsai SQ, Sander JD, Joung JK, Liu DR Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity. Nat Methods. 2014;11(4):429-35 - PMID: 24531420 - PMCID: PMC4010127 - DOI: 10.1038/nmeth.2845

  • Sander JD, Joung JK CRISPR-Cas systems for editing, regulating and targeting genomes. Nat Biotechnol. 2014;32(4):347-55 - PMID: 24584096 - PMCID: PMC4022601 - DOI: 10.1038/nbt.2842

  • Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 2014;14(6):781-95 - PMID: 24704492 - PMCID: PMC4653065 - DOI: 10.1016/j.stem.2014.03.004

  • Tsai SQ, Wyvekens N, Khayter C, Foden JA, Thapar V, Reyon D, Goodwin MJ, Aryee MJ, Joung JK Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. Nat Biotechnol. 2014;32(6):569-76 - PMID: 24770325 - PMCID: PMC4090141 - DOI: 10.1038/nbt.2908

  • Liu Y, Kretz CA, Maeder ML, Richter CE, Tsao P, Vo AH, Huarng MC, Rode T, Hu Z, Mehra R, Olson ST, Joung JK, Shavit JA Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function. Blood. 2014;124(1):142-50 - PMID: 24782510 - PMCID: PMC4125349 - DOI: 10.1182/blood-2014-03-561027

  • Tsai SQ, Joung JK What's changed with genome editing?. Cell Stem Cell. 2014;15(1):3-4 - PMID: 24996161 - DOI: 10.1016/j.stem.2014.06.017

  • Kai X, Chellappa V, Donado C, Reyon D, Sekigami Y, Ataca D, Louissaint A, Mattoo H, Joung JK, Pillai S I?B kinase ? (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor ?B (NF?B) signaling. J Biol Chem. 2014;289(39):26960-72 - PMID: 25107905 - PMCID: PMC4175336 - DOI: 10.1074/jbc.M114.598763

  • Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Genes Dev. 2014;28(17):1957-75 - PMID: 25184681 - PMCID: PMC4197947 - DOI: 10.1101/gad.241620.114

  • Tsai SQ, Iafrate AJ, Joung JK Genome editing: a tool for research and therapy: towards a functional understanding of variants for molecular diagnostics using genome editing. Nat Med. 2014;20(10):1103-4 - PMID: 25295940 - DOI: 10.1038/nm.3722

  • Fu Y, Reyon D, Joung JK Targeted genome editing in human cells using CRISPR/Cas nucleases and truncated guide RNAs. Methods Enzymol. 2014;546:21-45 - PMID: 25398334 - DOI: 10.1016/B978-0-12-801185-0.00002-7

  • O'Rourke EJ, Ruvkun G Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2014;17(1):104 - PMID: 25534088

  • Ryan CM, Lee A, Kazis LE, Schneider JC, Shapiro GD, Sheridan RL, Meyer WJ, Palmieri T, Pidcock FS, Reilly D, Tompkins RG, Recovery Trajectories After Burn Injury in Young Adults: Does Burn Size Matter?. J Burn Care Res. 2014;36(1):118-29 - PMID: 25501787 - DOI: 10.1097/BCR.0000000000000214

  • Guo AY, Stevens BW, Wilson RG, Russell CN, Cohen MA, Sturgeon HC, Thornton A, Giallourakis C, Khalili H, Nguyen DD, Sauk J, Yajnik V, Xavier RJ, Ananthakrishnan AN Early life environment and natural history of inflammatory bowel diseases. BMC Gastroenterol. 2014;14(1):216 - PMID: 25510175 - PMCID: PMC4300207 - DOI: 10.1186/s12876-014-0216-8

  • Govindan JA, Ruvkun G Pathogens. Virulence. 2014;5(7):695-696 - PMID: 25513769 - PMCID: PMC4189874 - DOI: 10.4161/viru.36667

  • Jones CN, Moore M, Dimisko L, Alexander A, Ibrahim A, Hassell BA, Warren HS, Tompkins RG, Fagan SP, Irimia D Spontaneous Neutrophil Migration Patterns during Sepsis after Major Burns. PLoS One. 2014;9(12):e114509 - PMID: 25489947 - PMCID: PMC4260850 - DOI: 10.1371/journal.pone.0114509

  • Wang MC, Oakley HD, Carr CE, Sowa JN, Ruvkun G Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence. PLoS Genet. 2014;10(12):e1004752 - PMID: 25474471 - PMCID: PMC4256158 - DOI: 10.1371/journal.pgen.1004752

  • Kleinnijenhuis J, Quintin J, Preijers F, Joosten LA, Jacobs C, Xavier RJ, van der Meer JW, van Crevel R, Netea MG BCG-induced trained immunity in NK cells: Role for non-specific protection to infection. Clin Immunol. 2014;155(2):213-219 - PMID: 25451159 - PMCID: PMC5084088 - DOI: 10.1016/j.clim.2014.10.005

  • Kumar V, Wijmenga C, Xavier RJ Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism. Curr Opin Immunol. 2014;31C:51-57 - PMID: 25458995 - PMCID: PMC5080657 - DOI: 10.1016/j.coi.2014.09.007

  • Hentrich C, Szostak JW Controlled growth of filamentous fatty acid vesicles under flow. Langmuir. 2014;30(49):14916-25 - PMID: 25402759 - PMCID: PMC4985002 - DOI: 10.1021/la503933x

  • Li JF, Zhang D, Sheen J Cas9-Based Genome Editing in Arabidopsis and Tobacco. Methods Enzymol. 2014;546:459-72 - PMID: 25398353 - DOI: 10.1016/B978-0-12-801185-0.00022-2

  • Buffen K, Oosting M, Quintin J, Ng A, Kleinnijenhuis J, Kumar V, van de Vosse E, Wijmenga C, van Crevel R, Oosterwijk E, Grotenhuis AJ, Vermeulen SH, Kiemeney LA, van de Veerdonk FL, Chamilos G, Xavier RJ, van der Meer JW, Netea MG, Joosten LA Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer. PLoS Pathog. 2014;10(10):e1004485 - PMID: 25356988 - PMCID: PMC4214925 - DOI: 10.1371/journal.ppat.1004485

  • Kotz KT, Petrofsky AC, Haghgooie R, Granier R, Toner M, Tompkins RG Inertial focusing cytometer with integrated optics for particle characterization. Technology (Singap World Sci). 2014;1(1):27-36 - PMID: 25346940 - PMCID: PMC4206911 - DOI: 10.1142/S233954781350009X

  • Ausubel FM Twists and turns: my career path and concerns about the future. Genetics. 2014;198(2):431-4 - PMID: 25316778 - PMCID: PMC4196596 - DOI: 10.1534/genetics.114.169102

  • Budin I, Prwyes N, Zhang N, Szostak JW Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions. Biophys J. 2014;107(7):1582-1590 - PMID: 25296310 - PMCID: PMC4190651 - DOI: 10.1016/j.bpj.2014.07.067

  • Govindan JA, Ruvkun G Pathogens. Virulence. 2014;5(7):ePub - PMID: 25290904 - PMCID: PMC4189874

  • Zhang XC, Millet Y, Ausubel FM, Borowsky M Next-Gen Sequencing-Based Mapping and Identification of Ethyl Methanesulfonate-Induced Mutations in Arabidopsis thaliana. Curr Protoc Mol Biol. 2014;108:7.18.1-16 - PMID: 25271717 - DOI: 10.1002/0471142727.mb0718s108

  • Liao J, Jijon HB, Kim IR, Goel G, Doan A, Sokol H, Bauer H, Herrmann BG, Lassen KG, Xavier RJ An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse. PLoS One. 2014;9(9):e108777 - PMID: 25268627 - PMCID: PMC4182575 - DOI: 10.1371/journal.pone.0108777

  • Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling. Cell. 2014;159(2):440-55 - PMID: 25263330 - PMCID: PMC4265475 - DOI: 10.1016/j.cell.2014.09.014

  • Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG mTOR- and HIF-1?-mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 2014;345(6204):1250684 - PMID: 25258083 - PMCID: PMC4226238 - DOI: 10.1126/science.1250684

  • Saeed S, Quintin J, Kerstens HH, Rao NA, Aghajanirefah A, Matarese F, Cheng SC, Ratter J, Berentsen K, van der Ent MA, Sharifi N, Janssen-Megens EM, Ter Huurne M, Mandoli A, van Schaik T, Ng A, Burden F, Downes K, Frontini M, Kumar V, Giamarellos-Bourboulis EJ, Ouwehand WH, van der Meer JW, Joosten LA, Wijmenga C, Martens JH, Xavier RJ, Logie C, Netea MG, Stunnenberg HG Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity. Science. 2014;345(6204):1251086 - PMID: 25258085 - PMCID: PMC4242194 - DOI: 10.1126/science.1251086

  • Peterson JR, De La Rosa S, Eboda O, Cilwa KE, Agarwal S, Buchman SR, Cederna PS, Xi C, Morris MD, Herndon DN, Xiao W, Tompkins RG, Krebsbach PH, Wang SC, Levi B Treatment of heterotopic ossification through remote ATP hydrolysis. Sci Transl Med. 2014;6(255):255ra132 - PMID: 25253675 - PMCID: PMC4353731 - DOI: 10.1126/scitranslmed.3008810

  • Draberova L, Bugajev V, Potuckova L, Halova I, Bambouskova M, Polakovicova I, Xavier RJ, Seed B, Draber P Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling. Mol Cell Biol. 2014;34(23):4285-300 - PMID: 25246632 - PMCID: PMC4248753 - DOI: 10.1128/MCB.00983-14

  • Sundberg TB, Xavier RJ, Schreiber SL, Shamji AF Small-molecule control of cytokine function: new opportunities for treating immune disorders. Curr Opin Chem Biol. 2014;23C:23-30 - PMID: 25222143 - PMCID: PMC5087273 - DOI: 10.1016/j.cbpa.2014.08.013

  • Kumar V, Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A, Giamarellos-Bourboulis E, Karjalainen J, Franke L, Withoff S, Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H, Bauer H, Herrmann BG, Bochud PY, Marchetti O, Perfect JR, Xavier RJ, Kullberg BJ, Wijmenga C, Netea MG Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia. Nat Commun. 2014;5:4675 - PMID: 25197941 - PMCID: PMC5142444 - DOI: 10.1038/ncomms5675

  • Sheng J, Larsen A, Heuberger BD, Blain JC, Szostak JW Crystal Structure Studies of RNA Duplexes Containing s2U:A and s2U:U Base Pairs. J Am Chem Soc. 2014;136(39):13916-24 - PMID: 25188906 - PMCID: PMC4183603 - DOI: 10.1021/ja508015a

  • Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier RJ, Root DE Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation. Nat Biotechnol. 2014;32(12):1262-1267 - PMID: 25184501 - PMCID: PMC4262738 - DOI: 10.1038/nbt.3026

  • Jennelle L, Hunegnaw R, Dubrovsky L, Pushkarsky T, Fitzgerald ML, Sviridov D, Popratiloff A, Brichacek B, Bukrinsky M HIV-1 Protein Nef Inhibits Activity of ATP Binding Cassette Transporter A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin. J Biol Chem. 2014;289(42):28870-84 - PMID: 25170080 - PMCID: PMC4200247 - DOI: 10.1074/jbc.M114.583591

  • Goel G, Conway KL, Jaeger M, Netea MG, Xavier RJ Multivariate inference of pathway activity in host immunity and response to therapeutics. Nucleic Acids Res. 2014;42(16):10288-306 - PMID: 25147207 - PMCID: PMC4176341 - DOI: 10.1093/nar/gku722

  • Lassen KG, Xavier RJ An alteration in ATG16L1 stability in Crohn disease. Autophagy. 2014;10(10):1858-1860 - PMID: 25136803 - PMCID: PMC4198368 - DOI: 10.4161/auto.29963

  • Sundberg TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B, Gagnon J, O'Connell DJ, Narayan K, Dan?ík V, Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, Shamji AF Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc Natl Acad Sci U S A. 2014;111(34):12468-12473 - PMID: 25114223 - PMCID: PMC4151730 - DOI: 10.1073/pnas.1412308111

  • Carter EA, Hamrahi V, Paul K, Bonab AA, Jung W, Tompkins RG, Fischman AJ Single Hind Limb Burn Injury to Mice Alters Nuclear Factor-?B Expression and [18F] 2-Fluoro-2-Deoxy-D-Glucose Uptake. J Burn Care Res. 2014;35(6):e373-e378 - PMID: 25100541 - PMCID: PMC4229441 - DOI: 10.1097/BCR.0000000000000035

  • Wolf SE, Tompkins RG, Herndon DN On the Horizon: Research Priorities in Burns for the Next Decade. Surg Clin North Am. 2014;94(4):917-30 - PMID: 25085097 - DOI: 10.1016/j.suc.2014.05.012

  • Wivagg CN, Bhattacharyya RP, Hung DT Mechanisms of ?-lactam killing and resistance in the context of Mycobacterium tuberculosis. J Antibiot (Tokyo). 2014;67(9):645-54 - PMID: 25052484 - DOI: 10.1038/ja.2014.94

  • Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans. Nat Struct Mol Biol. 2014;21(8):712-720 - PMID: 25038802 - PMCID: PMC4125460 - DOI: 10.1038/nsmb.2858

  • Luft C, Freeman J, Elliott D, Al-Tamimi N, Kriston-Vizi J, Heintze J, Lindenschmidt I, Seed B, Ketteler R Application of Gaussia luciferase in bicistronic and non-conventional secretion reporter constructs. BMC Biochem. 2014;15(1):14 - PMID: 25007711 - PMCID: PMC4099409 - DOI: 10.1186/1471-2091-15-14

  • Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest. 2014;124(8):3617-33 - PMID: 25003194 - PMCID: PMC4109533 - DOI: 10.1172/JCI75436

  • Wu HY, Liu KH, Wang YC, Wu JF, Chiu WL, Chen CY, Wu SH, Sheen J, Lai EM AGROBEST: an efficient Agrobacterium-mediated transient expression method for versatile gene function analyses in Arabidopsis seedlings. Plant Methods. 2014;10:19 - PMID: 24987449 - PMCID: PMC4076510 - DOI: 10.1186/1746-4811-10-19

  • Huttenhower C, Kostic AD, Xavier RJ Inflammatory Bowel Disease as a Model for Translating the Microbiome. Immunity. 2014;40(6):843-854 - PMID: 24950204 - PMCID: PMC4135443 - DOI: 10.1016/j.immuni.2014.05.013

  • Wei SC, Tan YY, Weng MT, Lai LC, Hsiao JH, Chuang EY, Shun CT, Wu DC, Kao AW, Chuang CS, Ni YH, Shieh MJ, Tung CC, Chen Y, Wang CY, Xavier RJ, Podolsky DK, Wong JM SLCO3A1, a Novel Crohn's Disease-Associated Gene, Regulates NF-?B Activity and Associates with Intestinal Perforation. PLoS One. 2014;9(6):e100515 - PMID: 24945726 - PMCID: PMC4063938 - DOI: 10.1371/journal.pone.0100515

  • Ryu SY, Qian WJ, Camp DG, Smith RD, Tompkins RG, Davis RW, Xiao W Detecting differential protein expression in large-scale population proteomics. Bioinformatics. 2014;30(19):2741-6 - PMID: 24928210 - PMCID: PMC4173009 - DOI: 10.1093/bioinformatics/btu341

  • Pukkila-Worley R, Feinbaum RL, McEwan DL, Conery AL, Ausubel FM The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification. PLoS Pathog. 2014;10(5):e1004143 - PMID: 24875643 - PMCID: PMC4038581 - DOI: 10.1371/journal.ppat.1004143

  • Zhou GL, Na SY, Niedra R, Seed B Deficits in receptor-mediated endocytosis and recycling in cells from mice bearing a disruption of the Gpr107 locus. J Cell Sci. 2014;127(Pt 18):3916-27 - PMID: 24849652 - DOI: 10.1242/jcs.135269

  • Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM Dectin-1 dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages. J Infect Dis. 2014;210(11):1844-54 - PMID: 24842831 - PMCID: PMC4271056 - DOI: 10.1093/infdis/jiu290

  • Kirienko NV, Cezairliyan BO, Ausubel FM, Powell JR Pseudomonas aeruginosa PA14 Pathogenesis in Caenorhabditis elegans. Methods Mol Biol. 2014;1149:653-69 - PMID: 24818940 - DOI: 10.1007/978-1-4939-0473-0_50

  • Pan CY, Chen JC, Sheen JF, Lin TL, Chen JY Epinecidin-1 has immunomodulatory effects, facilitating its therapeutic use in a mouse model of Pseudomonas aeruginosa sepsis. Antimicrob Agents Chemother. 2014;58(8):4264-4274 - PMID: 24820078 - PMCID: PMC4135991 - DOI: 10.1128/AAC.02958-14

  • Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense. Proc Natl Acad Sci U S A. 2014;111(21):7741-7746 - PMID: 24821797 - PMCID: PMC4040621 - DOI: 10.1073/pnas.1407001111

  • Righi V, Apidianakis Y, Psychogios N, Rahme LG, Tompkins RG, Tzika AA In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants. Int J Mol Med. 2014;34(1):327-33 - PMID: 24789699 - DOI: 10.3892/ijmm.2014.1757

  • Klein MB, Goverman J, Hayden DL, Fagan SP, McDonald-Smith GP, Alexander AK, Gamelli RL, Gibran NS, Finnerty CC, Jeschke MG, Arnoldo B, Wispelwey B, Mindrinos MN, Xiao W, Honari SE, Mason PH, Schoenfeld DA, Herndon DN, Tompkins RG, Benchmarking outcomes in the critically injured burn patient. Ann Surg. 2014;259(5):833-41 - PMID: 24722222 - PMCID: PMC4283803 - DOI: 10.1097/SLA.0000000000000438

  • Liu Y, Samuel BS, Breen PC, Ruvkun G Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature. 2014;508(7496):406-10 - PMID: 24695221 - PMCID: PMC4102179 - DOI: 10.1038/nature13204

  • Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation. Curr Biol. 2014;24(8):839-44 - PMID: 24684932 - PMCID: PMC4010136 - DOI: 10.1016/j.cub.2014.02.060

  • Li JF, Zhang D, Sheen J Epitope-tagged protein-based artificial miRNA screens for optimized gene silencing in plants. Nat Protoc. 2014;9(4):939-49 - PMID: 24675734 - PMCID: PMC4208271 - DOI: 10.1038/nprot.2014.061

  • Ananthakrishnan AN, Nguyen DD, Sauk J, Yajnik V, Xavier RJ Genetic Polymorphisms in Metabolizing Enzymes Modifying the Association Between Smoking and Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2014;20(5):783-9 - PMID: 24651583 - PMCID: PMC4113010 - DOI: 10.1097/MIB.0000000000000014

  • Conery AL, Larkins-Ford J, Ausubel FM, Kirienko NV High-Throughput Screening for Novel Anti-Infectives Using a C. elegans Pathogenesis Model. Curr Protoc Chem Biol. 2014;6(1):25-37 - PMID: 24652621 - PMCID: PMC4021578 - DOI: 10.1002/9780470559277.ch130160

  • Gevers D, Kugathasan S, Denson LA, Vázquez-Baeza Y, Van Treuren W, Ren B, Schwager E, Knights D, Song SJ, Yassour M, Morgan XC, Kostic AD, Luo C, González A, McDonald D, Haberman Y, Walters T, Baker S, Rosh J, Stephens M, Heyman M, Markowitz J, Baldassano R, Griffiths A, Sylvester F, Mack D, Kim S, Crandall W, Hyams J, Huttenhower C, Knight R, Xavier RJ The treatment-naive microbiome in new-onset Crohn's disease. Cell Host Microbe. 2014;15(3):382-92 - PMID: 24629344 - PMCID: PMC4059512 - DOI: 10.1016/j.chom.2014.02.005

  • Blain JC, Szostak JW Progress Toward Synthetic Cells. Annu Rev Biochem. 2014;83:615-40 - PMID: 24606140 - DOI: 10.1146/annurev-biochem-080411-124036

  • Zhao G, Yu YM, Shoup TM, Elmaleh DR, Bonab AA, Tompkins RG, Fischman AJ Membrane potential-dependent uptake of (18)F-triphenylphosphonium-a new voltage sensor as an imaging agent for detecting burn-induced apoptosis. J Surg Res. 2014;188(2):473-9 - PMID: 24582214 - PMCID: PMC3988254 - DOI: 10.1016/j.jss.2014.01.011

  • Yuen GJ, Ausubel FM Enterococcus infection biology: Lessons from invertebrate host models. J Microbiol. 2014;52(3):200-10 - PMID: 24585051 - PMCID: PMC4556283 - DOI: 10.1007/s12275-014-4011-6

  • Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth. PLoS Pathog. 2014;10(2):e1003946 - PMID: 24586159 - PMCID: PMC3930586 - DOI: 10.1371/journal.ppat.1003946

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