High-density lipoprotein-mediated cholesterol efflux capacity is improved by treatment with antiretroviral therapy in acute human immunodeficiency virus infection.
Complex host genetics influence the microbiome in inflammatory bowel disease.
Morbidity and Survival Probability in Burn Patients in Modern Burn Care.
Toddler: an embryonic signal that promotes cell movement via Apelin receptors.
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs.
Effect of exercise on burn-induced changes in tissue-specific glucose metabolism.
An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins.
Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity.
CRISPR-Cas systems for editing, regulating and targeting genomes.
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing.
Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.
What's changed with genome editing?
Cell Stem Cell. 2014;15(1):3-4 - PMID: 24996161
I?B kinase ? (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor ?B (NF?B) signaling.
Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.
Genome editing: a tool for research and therapy: towards a functional understanding of variants for molecular diagnostics using genome editing.
Nat Med. 2014;20(10):1103-4 - PMID: 25295940
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo.
Targeted genome editing in human cells using CRISPR/Cas nucleases and truncated guide RNAs.
Methods Enzymol. 2014;546:21-45 - PMID: 25398334
A Zebrafish Model of Myelodysplastic Syndrome Produced Through tet2 Genomic Editing.
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases.
Fanconi Anemia Gene Editing by the CRISPR/Cas9 System.
Mice are not men.
Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.
Nat Cell Biol. 2014;17(1):104 - PMID: 25534088
Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension.
Recovery Trajectories After Burn Injury in Young Adults: Does Burn Size Matter?
J Burn Care Res. 2014;36(1):118-29 - PMID: 25501787
Early life environment and natural history of inflammatory bowel diseases.
Spontaneous Neutrophil Migration Patterns during Sepsis after Major Burns.
Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence.
BCG-induced trained immunity in NK cells: Role for non-specific protection to infection.
Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism.
Controlled growth of filamentous fatty acid vesicles under flow.
Cas9-Based Genome Editing in Arabidopsis and Tobacco.
Methods Enzymol. 2014;546C:459-472 - PMID: 25398353
Autophagy and checkpoints for intracellular pathogen defense.
Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer.
Inertial focusing cytometer with integrated optics for particle characterization.
Twists and turns: my career path and concerns about the future.
Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions.
Next-Gen Sequencing-Based Mapping and Identification of Ethyl Methanesulfonate-Induced Mutations in Arabidopsis thaliana.
Curr Protoc Mol Biol. 2014;108:7.18.1-7.18.16 - PMID: 25271717
An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse.
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.
mTOR- and HIF-1?-mediated aerobic glycolysis as metabolic basis for trained immunity.
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.
Treatment of heterotopic ossification through remote ATP hydrolysis.
Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.
Small-molecule control of cytokine function: new opportunities for treating immune disorders.
Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.
Crystal Structure Studies of RNA Duplexes Containing s2U:A and s2U:U Base Pairs.
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.
HIV-1 Protein Nef Inhibits Activity of ATP Binding Cassette Transporter A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin.
Multivariate inference of pathway activity in host immunity and response to therapeutics.
An alteration in ATG16L1 stability in Crohn disease.
Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.
Single Hind Limb Burn Injury to Mice Alters Nuclear Factor-?B Expression and [18F] 2-Fluoro-2-Deoxy-D-Glucose Uptake.
Apoplastic peroxidases are required for salicylic acid-mediated defense against Pseudomonas syringae.
On the Horizon: Research Priorities in Burns for the Next Decade.
Surg Clin North Am. 2014;94(4):917-930 - PMID: 25085097
Mechanisms of ?-lactam killing and resistance in the context of Mycobacterium tuberculosis.
J Antibiot (Tokyo). 2014;67(9):645-654 - PMID: 25052484
Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.
Application of Gaussia luciferase in bicistronic and non-conventional secretion reporter constructs.
Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.
AGROBEST: an efficient Agrobacterium-mediated transient expression method for versatile gene function analyses in Arabidopsis seedlings.
Inflammatory Bowel Disease as a Model for Translating the Microbiome.
Prediction of Multiple Infections After Severe Burn Trauma: A Prospective Cohort Study.
Simvastatin Reduces Burn Injury-Induced Splenic Apoptosis via Downregulation of the TNF-?/NF-?B Pathway.
SLCO3A1, a Novel Crohn's Disease-Associated Gene, Regulates NF-?B Activity and Associates with Intestinal Perforation.
Detecting differential protein expression in large-scale population proteomics.
The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification.
Deficits in receptor-mediated endocytosis and recycling in cells from mice bearing a disruption of the Gpr107 locus.
J Cell Sci. 2014;127(Pt 18):3916-27 - PMID: 24849652
Dectin-1 dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages.
Pseudomonas aeruginosa PA14 Pathogenesis in Caenorhabditis elegans.
Methods Mol Biol. 2014;1149:653-69 - PMID: 24818940
Epinecidin-1 has immunomodulatory effects, facilitating its therapeutic use in a mouse model of Pseudomonas aeruginosa sepsis.
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.
In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants.
Int J Mol Med. 2014;34(1):327-33 - PMID: 24789699
Benchmarking outcomes in the critically injured burn patient.
Caenorhabditis elegans pathways that surveil and defend mitochondria.
MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation.
Survival From Burns in the New Millennium: 70 Years' Experience From a Single Institution.
Epitope-tagged protein-based artificial miRNA screens for optimized gene silencing in plants.
Genetic Polymorphisms in Metabolizing Enzymes Modifying the Association Between Smoking and Inflammatory Bowel Diseases.
High-Throughput Screening for Novel Anti-Infectives Using a C. elegans Pathogenesis Model.
The treatment-naive microbiome in new-onset Crohn's disease.
Progress Toward Synthetic Cells.
Annu Rev Biochem. 2014;83:615-640 - PMID: 24606140
Membrane potential-dependent uptake of (18)F-triphenylphosphonium-a new voltage sensor as an imaging agent for detecting burn-induced apoptosis.
Enterococcus infection biology: Lessons from invertebrate host models.
Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth.
Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response.
Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus.
Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets.
The Microbiome in Inflammatory Bowel Diseases: Current Status and the Future Ahead.
Long-term posttraumatic stress symptoms vary inversely with early opiate dosing in children recovering from serious burns: Effects durable at 4 years.
J Trauma Acute Care Surg. 2014;76(3):828-832 - PMID: 24553556