Publications for All Faculty
High-density lipoprotein-mediated cholesterol efflux capacity is improved by treatment with antiretroviral therapy in acute human immunodeficiency virus infection.
Early life environment and natural history of inflammatory bowel diseases.
Recovery Trajectories After Burn Injury in Young Adults: Does Burn Size Matter?
Spontaneous Neutrophil Migration Patterns during Sepsis after Major Burns.
Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence.
Complex host genetics influence the microbiome in inflammatory bowel disease.
Corrigendum: MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.
Controlled growth of filamentous fatty acid vesicles under flow.
Cas9-Based Genome Editing in Arabidopsis and Tobacco.
Targeted genome editing in human cells using CRISPR/Cas nucleases and truncated guide RNAs.
Effect of exercise on burn-induced changes in tissue-specific glucose metabolism.
Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer.
Inertial focusing cytometer with integrated optics for particle characterization.
BCG-induced trained immunity in NK cells: Role for non-specific protection to infection.
Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism.
Pathogens.
Next-Gen Sequencing-Based Mapping and Identification of Ethyl Methanesulfonate-Induced Mutations in Arabidopsis thaliana.
Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions.
Twists and turns: my career path and concerns about the future.
Pathogens.
Genome editing: a tool for research and therapy: towards a functional understanding of variants for molecular diagnostics using genome editing.
An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse.
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.
Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.
Small-molecule control of cytokine function: new opportunities for treating immune disorders.
Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.
Crystal Structure Studies of RNA Duplexes Containing s2U:A and s2U:U Base Pairs.
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.
Treatment of heterotopic ossification through remote ATP hydrolysis.
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.
mTOR- and HIF-1?-mediated aerobic glycolysis as metabolic basis for trained immunity.
Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.
HIV-1 Protein Nef Inhibits Activity of ATP Binding Cassette Transporter A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin.
Multivariate inference of pathway activity in host immunity and response to therapeutics.
An alteration in ATG16L1 stability in Crohn disease.
Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.
I?B kinase ? (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor ?B (NF?B) signaling.
Single Hind Limb Burn Injury to Mice Alters Nuclear Factor-?B Expression and [18F] 2-Fluoro-2-Deoxy-D-Glucose Uptake.
Mechanisms of ?-lactam killing and resistance in the context of Mycobacterium tuberculosis.
Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.
Application of Gaussia luciferase in bicistronic and non-conventional secretion reporter constructs.
Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.
What's changed with genome editing?
SLCO3A1, a Novel Crohn's Disease-Associated Gene, Regulates NF-?B Activity and Associates with Intestinal Perforation.
AGROBEST: an efficient Agrobacterium-mediated transient expression method for versatile gene function analyses in Arabidopsis seedlings.
On the Horizon: Research Priorities in Burns for the Next Decade.
Detecting differential protein expression in large-scale population proteomics.
Inflammatory Bowel Disease as a Model for Translating the Microbiome.
The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification.
Deficits in receptor-mediated endocytosis and recycling in cells from mice bearing a disruption of the Gpr107 locus.
Dectin-1 dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages.
Pseudomonas aeruginosa PA14 Pathogenesis in Caenorhabditis elegans.
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.
Epinecidin-1 has immunomodulatory effects, facilitating its therapeutic use in a mouse model of Pseudomonas aeruginosa sepsis.
Benchmarking outcomes in the critically injured burn patient.
Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing.
In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants.
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.
Caenorhabditis elegans pathways that surveil and defend mitochondria.
Epitope-tagged protein-based artificial miRNA screens for optimized gene silencing in plants.
MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation.
Genetic Polymorphisms in Metabolizing Enzymes Modifying the Association Between Smoking and Inflammatory Bowel Diseases.
High-Throughput Screening for Novel Anti-Infectives Using a C. elegans Pathogenesis Model.
Progress Toward Synthetic Cells.
CRISPR-Cas systems for editing, regulating and targeting genomes.
Long-term posttraumatic stress symptoms vary inversely with early opiate dosing in children recovering from serious burns: Effects durable at 4 years.
Enterococcus infection biology: Lessons from invertebrate host models.
The treatment-naive microbiome in new-onset Crohn's disease.
Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets.
Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response.
Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth.
Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus.
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans.
The Microbiome in Inflammatory Bowel Diseases: Current Status and the Future Ahead.
HDL redox activity is increased in HIV-infected men in association with macrophage activation and noncalcified coronary atherosclerotic plaque.
Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity.
An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins.
Structural insights into the effects of 2'-5' linkages on the RNA duplex.
The Free Energy Landscape of Pseudorotation in 3'-5' and 2'-5' Linked Nucleic Acids.
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs.
SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.
Differential Effect of Genetic Burden on Disease Phenotypes in Crohn's Disease and Ulcerative Colitis: Analysis of a North American Cohort.
Autophagy is essential for cardiac morphogenesis during vertebrate development.
Membrane potential-dependent uptake of (18)F-triphenylphosphonium-a new voltage sensor as an imaging agent for detecting burn-induced apoptosis.
Synthesis and Non-Enzymatic Template-Directed Polymerization of 2'-Amino-2'-Deoxythreose Nucleotides.
Toddler: an embryonic signal that promotes cell movement via Apelin receptors.
TOR Signaling Networks in Plant Growth and Metabolism.
Bacterial toxins and small molecules elucidate endosomal trafficking.
Correction of Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair.
Ancient signals: comparative genomics of green plant CDPKs.
High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.
Endogenous ?-glucocerebrosidase activity in Abca12-/-epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.
Pseudomonas syringae Effector HopF2 Suppresses Arabidopsis Immunity by Targeting BAK1.
Autophagy is redundant for the host defense against systemic Candida albicans infections.
mRNA display: from basic principles to macrocycle drug discovery.
Genetic Variants Synthesize to Produce Paneth Cell Phenotypes that Define Subtypes of Crohn's Disease.
Out of Context: Clinical Practice Guidelines and Patients With Multiple Chronic Conditions: A Systematic Review.
