Publications for All Faculty
Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans.
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.
Pathogen-Triggered Ethylene Signaling Mediates Systemic-Induced Susceptibility to Herbivory in Arabidopsis.
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
Deletion of the Murine Cytochrome P450 Cyp2j Locus by Fused BAC-Mediated Recombination Identifies a Role for Cyp2j in the Pulmonary Vascular Response to Hypoxia.
High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis.
Preparation of Fatty Acid micelles.
Vesicle Extrusion Through Polycarbonate Track-etched Membranes using a Hand-held Mini-extruder.
Preparation of Fatty Acid or Phospholipid Vesicles by Thin-film Rehydration.
Autophagy at the crossroads of metabolism and cellular defense.
Nonenzymatic template-directed RNA synthesis inside model protocells.
The cytokinin side chain commands shooting.
Virulence profile: Frederick M Ausubel.
Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity.
Selective Modulation of Autophagy, Innate Immunity, and Adaptive Immunity by Small Molecules.
Genetic Regulation of Caenorhabditis elegans Lysosome Related Organelle Function.
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.
Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer.
Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL.
Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome.
Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling.
A Small Volatile Bacterial Molecule Triggers Mitochondrial Dysfunction in Murine Skeletal Muscle.
Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32.
Dual Regulation of the lin-14 Target mRNA by the lin-4 miRNA.
Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis.
Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib.
Locus-specific editing of histone modifications at endogenous enhancers.
Plant immune response to pathogens differs with changing temperatures.
Reply to Osterburg et al.: To study human inflammatory diseases in humans.
Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases.
Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice from Salmonella Infection.
Differences in Resuscitation in Morbidly Obese Burn Patients May Contribute to High Mortality.
In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites.
Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism.
Dislodgement of port-A catheters in pediatric oncology patients: 11 years of experience.
Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9.
Reply to Cauwels et al.: Of men, not mice, and inflammation.
Functional profiling of the gut microbiome in disease-associated inflammation.
Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients.
Identification of novel inhibitors of non-replicating M. tuberculosis using a carbon starvation model.
CRISPR RNA-guided activation of endogenous human genes.
Mild Obesity Is Protective After Severe Burn Injury.
Genetic risk factors for Clostridium difficile infection in ulcerative colitis.
Microbial reprogramming inhibits Western diet-associated obesity.
Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System.
Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.
Competition between model protocells driven by an encapsulated catalyst.
Engineering Customized TALE Nucleases (TALENs) and TALE Transcription Factors by Fast Ligation-Based Automatable Solid-Phase High-Throughput (FLASH) Assembly.
Natural selection in a bangladeshi population from the cholera-endemic ganges river delta.
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32.
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.
Skin Microbiome Imbalance in Patients with STAT1/STAT3 Defects Impairs Innate Host Defense Responses.
Moving beyond translation: glucose-TOR signaling in the transcriptional control of cell cycle.
Radiation Resistance of Sequencing Chips for in situ Life Detection.
Card9 Mediates Intestinal Epithelial Cell Restitution, T-helper 17 Responses, and Control of Bacterial Infection in Mice.
piggyBac transposase tools for genome engineering.
A cytoprotective perspective on longevity regulation.
CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.
RhoGTPases - NODes for effector-triggered immunity in animals.
Competition between model protocells driven by an encapsulated catalyst.
The hybrid four-CBS-domain KIN?? subunit functions as the canonical ? subunit of the plant energy sensor SnRK1.
Conformational stability, vibrational spectra, HOMO-LUMO and NBO analysis of 1,3,4-thiadiazolidine-2,5-dithione with experimental (FT-IR and FT-Raman) techniques and scaled quantum mechanical calculations.
Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.
Comprehensive Protein-Based Artificial MicroRNA Screens for Effective Gene Silencing in Plants.
How Does Genotype Influence Disease Phenotype in Inflammatory Bowel Disease?
Concomitant BRAF and PI3K/mTOR Blockade Is Required for Effective Treatment of BRAFV600E Colorectal Cancer.
How antibiotics kill bacteria: new models needed?
From genetics of inflammatory bowel disease towards mechanistic insights.
Benchmarks for Multidimensional Recovery After Burn Injury in Young Adults: The Development, Validation, and Testing of the American Burn Association/Shriners Hospitals for Children Young Adult Burn Outcome Questionnaire.
Genome-wide Analysis of Immune System Genes by Expressed Sequence Tag Profiling.
Dectin-1 activation controls maturation of ?-1,3-glucan-containing phagosomes.
Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.
Trauma-associated Human Neutrophil Alterations Revealed by Comparative Proteomics Profiling.
Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity.
Succinate is an inflammatory signal that induces
IL-1β through HIF-1α
Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response.
TALEN-based Gene Correction for Epidermolysis Bullosa.
Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death.
Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death.
MicroRNAs Visit the ER.
Glucose-TOR signalling reprograms the transcriptome and activates meristems.
Succinate is an inflammatory signal that induces IL-1? through HIF-1?.
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.
Mitochondria-targeted antioxidant promotes recovery of skeletal muscle mitochondrial function after burn trauma assessed by in vivo 31P nuclear magnetic resonance and electron paramagnetic resonance spectroscopy.
Efficacy of Phosphodiesterase 5 inhibitor on distant burn-induced muscle autophagy, microcirculation and survival rate.
Evaluation of Intragastric Vs Intraperitoneal Glucose Tolerance Tests in the Evaluation of Insulin Resistance in a Rodent Model of Burn Injury and Glucagon-Like Polypeptide-1 Treatment.
Determination of Burn Patient Outcome by Large-Scale Quantitative Discovery Proteomics.
Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants.
Polarity gene discs large homolog 1 regulates the generation of memory T cells.
Resolvin D2 restores neutrophil directionality and improves survival after burns.
Cutting Edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells.
Effector-triggered versus pattern-triggered immunity: how animals sense pathogens.
Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation.
Genomic responses in mouse models poorly mimic human inflammatory diseases.
Robust, synergistic regulation of human gene expression using TALE activators.
Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing.
Phosphorylation of D-allose by hexokinase involved in regulation of OsABF1 expression for growth inhibition in Oryza sativa L.
?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.
Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1? (IL-1?).
Development of a Genomic Metric That Can Be Rapidly Used to Predict Clinical Outcome in Severely Injured Trauma Patients.
Translating the Genomics Revolution: The Need for an International Gene Therapy Consortium for Monogenic Diseases.
Bifurcation of Arabidopsis NLR Immune Signaling via Ca(2+)-Dependent Protein Kinases.
Identification of a candidate therapeutic autophagy-inducing peptide.
High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes.
Efficient genome editing in zebrafish using a CRISPR-Cas system.
Burn injury-induced IRS-1 degradation in mouse skeletal muscle.
Identification of Novel Host-Targeted Compounds That Protect From Anthrax Lethal Toxin-Induced Cell Death.
ATG5 regulates plasma cell differentiation.
Probiotic bacteria induce a 'glow of health'.
Angiotensin II Drives the Production of Tumor-Promoting Macrophages.
Nitric oxide activates intradomain disulfide bond formation in the kinase loop of Akt1/PKB? after burn injury.
Synthesis of N3'-P5'-linked phosphoramidate DNA by nonenzymatic template-directed primer extension.
Identification of Pseudomonas aeruginosa Phenazines that Kill Caenorhabditis elegans.
Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans.
Radiation resistance of biological reagents for in situ life detection.
Simvastatin Protects Hepatocytes From Apoptosis by Suppressing the TNF-?/Caspase-3 Signaling Pathway in Mice With Burn Injury.
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence.
Synthesis of N3´-P5´-Phosphoramidate DNA by Non-enzymatic Template-directed Primer Extension.
TALENs: a widely applicable technology for targeted genome editing.
Brown Adipose Tissue and Its Modulation by a Mitochondria-targeted Peptide in Rat Burn Injury Induced Hypermetabolism.
CDPKs in immune and stress signaling.
Glucose metabolism during the early after burn injury.
