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Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G

Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans.
Genes Dev. 2013;27(24):2678-95 - PMID: 24352423 - PMCID: PMC3877757 - DOI: 10.1101/gad.233254.113

Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grøntved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kovalchuk AL, Zou J, Joung JK, Sartorelli V, Wei CL, Ruan X, Hager GL, Ruan Y, Casellas R

Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.
Cell. 2013;155(7):1507-20 - PMID: 24360274 - PMCID: PMC3905448 - DOI: 10.1016/j.cell.2013.11.039

Groen SC, Whiteman NK, Bahrami AK, Wilczek AM, Cui J, Russell JA, Cibrian-Jaramillo A, Butler IA, Rana JD, Huang GH, Bush J, Ausubel FM, Pierce NE

Pathogen-Triggered Ethylene Signaling Mediates Systemic-Induced Susceptibility to Herbivory in Arabidopsis.
Plant Cell. 2013;25(11):4755-66 - PMID: 24285796 - PMCID: PMC3875748 - DOI: 10.1105/tpc.113.113415

Liu Y, Shoji-Kawata S, Sumpter RM, Wei Y, Ginet V, Zhang L, Posner B, Tran KA, Green DR, Xavier RJ, Shaw SY, Clarke PG, Puyal J, Levine B

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
Proc Natl Acad Sci U S A. 2013;110(51):20364-71 - PMID: 24277826 - PMCID: PMC3870705 - DOI: 10.1073/pnas.1319661110

Zhou GL, Beloiartsev A, Yu B, Baron DM, Zhou W, Niedra R, Lu N, Tainsh LT, Zapol WM, Seed B, Bloch KD

Deletion of the Murine Cytochrome P450 Cyp2j Locus by Fused BAC-Mediated Recombination Identifies a Role for Cyp2j in the Pulmonary Vascular Response to Hypoxia.
PLoS Genet. 2013;9(11):e1003950 - PMID: 24278032 - PMCID: PMC3836722 - DOI: 10.1371/journal.pgen.1003950

Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A

High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis.
Cell. 2013;155(6):1409-21 - PMID: 24269006 - PMCID: PMC3956118 - DOI: 10.1016/j.cell.2013.10.047

Zhu TF, Budin I, Szostak JW

Preparation of Fatty Acid micelles.
Methods Enzymol. 2013;533:283-8 - PMID: 24182934 - PMCID: PMC4310231 - DOI: 10.1016/B978-0-12-420067-8.00022-2

Zhu TF, Budin I, Szostak JW

Vesicle Extrusion Through Polycarbonate Track-etched Membranes using a Hand-held Mini-extruder.
Methods Enzymol. 2013;533:275-82 - PMID: 24182933 - PMCID: PMC4310236 - DOI: 10.1016/B978-0-12-420067-8.00021-0

Zhu TF, Budin I, Szostak JW

Preparation of Fatty Acid or Phospholipid Vesicles by Thin-film Rehydration.
Methods Enzymol. 2013;533:267-74 - PMID: 24182932 - PMCID: PMC4310237 - DOI: 10.1016/B978-0-12-420067-8.00020-9

Begun J, Xavier RJ

Autophagy at the crossroads of metabolism and cellular defense.
Curr Opin Gastroenterol. 2013;29(6):588-96 - PMID: 24100719 - DOI: 10.1097/MOG.0b013e328365d34d

Adamala K, Szostak JW

Nonenzymatic template-directed RNA synthesis inside model protocells.
Science. 2013;342(6162):1098-100 - PMID: 24288333 - PMCID: PMC4104020 - DOI: 10.1126/science.1241888

Sheen J

The cytokinin side chain commands shooting.
Dev Cell. 2013;27(4):371-2 - PMID: 24286823 - PMCID: PMC3887519 - DOI: 10.1016/j.devcel.2013.11.008

Ausubel FM

Virulence profile: Frederick M Ausubel.
Virulence. 2013;4(8):730-3 - PMID: 24481134 - PMCID: PMC3925705 - DOI: 10.4161/viru.26579

Kleinnijenhuis J, Quintin J, Preijers F, Benn CS, Joosten LA, Jacobs C, van Loenhout J, Xavier RJ, Aaby P, van der Meer JW, van Crevel R, Netea MG

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity.
J Innate Immun. 2013;6(2):152-8 - PMID: 24192057 - PMCID: PMC3944069 - DOI: 10.1159/000355628

Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ

Selective Modulation of Autophagy, Innate Immunity, and Adaptive Immunity by Small Molecules.
ACS Chem Biol. 2013;8(12):2724-33 - PMID: 24168452 - PMCID: PMC3951132 - DOI: 10.1021/cb400352d

Soukas AA, Carr CE, Ruvkun G

Genetic Regulation of Caenorhabditis elegans Lysosome Related Organelle Function.
PLoS Genet. 2013;9(10):e1003908 - PMID: 24204312 - PMCID: PMC3812091 - DOI: 10.1371/journal.pgen.1003908

Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson MF, Joung JK

Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.
Nat Biotechnol. 2013;31(12):1137-42 - PMID: 24108092 - PMCID: PMC3858462 - DOI: 10.1038/nbt.2726

Zhang S, Blain JC, Zielinska D, Gryaznov SM, Szostak JW

Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer.
Proc Natl Acad Sci U S A. 2013;110(44):17732-7 - PMID: 24101473 - PMCID: PMC3816440 - DOI: 10.1073/pnas.1312329110

Sandoval GJ, Graham DB, Gmyrek GB, Akilesh HM, Fujikawa K, Sammut B, Bhattacharya D, Srivatsan S, Kim A, Shaw AS, Yang-Iott K, Bassing CH, Duncavage E, Xavier RJ, Swat W

Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL.
Cancer Immunol Res. 2013;1(6):426-37 - PMID: 24778134 - PMCID: PMC4006353 - DOI: 10.1158/2326-6066.CIR-13-0065

Knights D, Lassen KG, Xavier RJ

Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome.
Gut. 2013;62(10):1505-10 - PMID: 24037875 - PMCID: PMC3822528 - DOI: 10.1136/gutjnl-2012-303954

Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G

Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling.
Mol Syst Biol. 2013;9:692 - PMID: 24084807 - PMCID: PMC3817400 - DOI: 10.1038/msb.2013.50

Tzika AA, Constantinou C, Bandyopadhaya A, Psychogios N, Lee S, Mindrinos M, Martyn JA, Tompkins RG, Rahme LG

A Small Volatile Bacterial Molecule Triggers Mitochondrial Dysfunction in Murine Skeletal Muscle.
PLoS One. 2013;8(9):e74528 - PMID: 24098655 - PMCID: PMC3787027 - DOI: 10.1371/journal.pone.0074528

Kawate T, Iwase N, Shimizu M, Stanley SA, Wellington S, Kazyanskaya E, Hung DT

Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32.
Bioorg Med Chem Lett. 2013;23(22):6052-9 - PMID: 24103299 - DOI: 10.1016/j.bmcl.2013.09.035

Shi Z, Hayes G, Ruvkun G

Dual Regulation of the lin-14 Target mRNA by the lin-4 miRNA.
PLoS One. 2013;8(9):e75475 - PMID: 24058689 - PMCID: PMC3772890 - DOI: 10.1371/journal.pone.0075475

Beaudoin M, Goyette P, Boucher G, Lo KS, Rivas MA, Stevens C, Alikashani A, Ladouceur M, Ellinghaus D, Törkvist L, Goel G, Lagacé C, Annese V, Bitton A, Begun J, Brant SR, Bresso F, Cho JH, Duerr RH, Halfvarson J, McGovern DP, Radford-Smith G, Schreiber S, Schumm PL, Sharma Y, Silverberg MS, Weersma RK, , , , D'Amato M, Vermeire S, Franke A, Lettre G, Xavier RJ, Daly MJ, Rioux JD

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis.
PLoS Genet. 2013;9(9):e1003723 - PMID: 24068945 - PMCID: PMC3772057 - DOI: 10.1371/journal.pgen.1003723

Giles KM, Kalinowski FC, Candy PA, Epis MR, Zhang PM, Redfern AD, Stuart LM, Goodall GJ, Leedman PJ

Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib.
Mol Cancer Ther. 2013;12(11):2541-58 - PMID: 24026012 - DOI: 10.1158/1535-7163.MCT-13-0170

Mendenhall EM, Williamson KE, Reyon D, Zou JY, Ram O, Joung JK, Bernstein BE

Locus-specific editing of histone modifications at endogenous enhancers.
Nat Biotechnol. 2013;31(12):1133-6 - PMID: 24013198 - PMCID: PMC3858395 - DOI: 10.1038/nbt.2701

Cheng C, Gao X, Feng B, Sheen J, Shan L, He P

Plant immune response to pathogens differs with changing temperatures.
Nat Commun. 2013;4:2530 - PMID: 24067909 - PMCID: PMC3901997 - DOI: 10.1038/ncomms3530

Tompkins RG, Warren HS, Mindrinos MN, Xiao W, Davis RW

Reply to Osterburg et al.: To study human inflammatory diseases in humans.
Proc Natl Acad Sci U S A. 2013;110(36):E3371 - PMID: 24137798 - PMCID: PMC3767510 - DOI: 10.1073/pnas.1307452110

Qi Y, Li X, Zhang Y, Starker CG, Baltes NJ, Zhang F, Sander JD, Reyon D, Joung JK, Voytas DF

Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases.
G3 (Bethesda). 2013;3(10):1707-1715 - PMID: 23979943 - PMCID: PMC3789795 - DOI: 10.1534/g3.113.006270

Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ

Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice from Salmonella Infection.
Gastroenterology. 2013;145(6):1347-57 - PMID: 23973919 - PMCID: PMC3840157 - DOI: 10.1053/j.gastro.2013.08.035

Rae L, Pham TN, Carrougher G, Honari S, Gibran NS, Arnoldo BD, Gamelli RL, Tompkins RG, Herndon DN

Differences in Resuscitation in Morbidly Obese Burn Patients May Contribute to High Mortality.
J Burn Care Res. 2013;34(5):507-14 - PMID: 23966116 - PMCID: PMC3800202 - DOI: 10.1097/BCR.0b013e3182a2a771

Sander JD, Ramirez CL, Linder SJ, Pattanayak V, Shoresh N, Ku M, Foden JA, Reyon D, Bernstein BE, Liu DR, Joung JK

In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites.
Nucleic Acids Res. 2013;41(19):e181 - PMID: 23945932 - PMCID: PMC3799455 - DOI: 10.1093/nar/gkt716

He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B

Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism.
Cell. 2013;154(5):1085-99 - PMID: 23954414 - PMCID: PMC4231430 - DOI: 10.1016/j.cell.2013.07.035

Wang SC, Tsai CH, Hou CP, Lee SY, Ko SF, Hsiao CC, Chen YC, Chuang JH, Sheen JM

Dislodgement of port-A catheters in pediatric oncology patients: 11 years of experience.
World J Surg Oncol. 2013;11(1):191 - PMID: 23941644 - PMCID: PMC3765137 - DOI: 10.1186/1477-7819-11-191

Li JF, Norville JE, Aach J, McCormack M, Zhang D, Bush J, Church GM, Sheen J

Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9.
Nat Biotechnol. 2013;31(8):688-91 - PMID: 23929339 - PMCID: PMC4078740 - DOI: 10.1038/nbt.2654

Warren HS, Tompkins RG, Mindrinos MN, Xiao W, Davis RW

Reply to Cauwels et al.: Of men, not mice, and inflammation.
Proc Natl Acad Sci U S A. 2013;110(34):E3151 - PMID: 24137663 - PMCID: PMC3752239 - DOI: 10.1073/pnas.1308943110

Börnigen D, Morgan XC, Franzosa EA, Ren B, Xavier RJ, Garrett WS, Huttenhower C

Functional profiling of the gut microbiome in disease-associated inflammation.
Genome Med. 2013;5(7):65 - PMID: 23906180 - PMCID: PMC3978847 - DOI: 10.1186/gm469

Candy PA, Phillips MR, Redfern AD, Colley SM, Davidson JA, Stuart LM, Wood BA, Zeps N, Leedman PJ

Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients.
Br J Cancer. 2013;109(4):1023-30 - PMID: 23900217 - PMCID: PMC3749585 - DOI: 10.1038/bjc.2013.431

Grant SS, Kawate T, Nag PP, Silvis MR, Gordon K, Stanley SA, Kazyanskaya E, Nietupski R, Golas A, Fitzgerald M, Cho S, Franzblau SG, Hung DT

Identification of novel inhibitors of non-replicating M. tuberculosis using a carbon starvation model.
ACS Chem Biol. 2013;8(10):2224-34 - PMID: 23898841 - PMCID: PMC3864639 - DOI: 10.1021/cb4004817

Maeder ML, Linder SJ, Cascio VM, Fu Y, Ho QH, Joung JK

CRISPR RNA-guided activation of endogenous human genes.
Nat Methods. 2013;10(10):977-9 - PMID: 23892898 - PMCID: PMC3794058 - DOI: 10.1038/nmeth.2598

Jeschke MG, Finnerty CC, Emdad F, Rivero HG, Kraft R, Williams FN, Gamelli RL, Gibran NS, Klein MB, Arnoldo BD, Tompkins RG, Herndon DN

Mild Obesity Is Protective After Severe Burn Injury.
Ann Surg. 2013;258(6):1119-29 - PMID: 23877367 - PMCID: PMC3963145 - DOI: 10.1097/SLA.0b013e3182984d19

Ananthakrishnan AN, Oxford EC, Nguyen DD, Sauk J, Yajnik V, Xavier RJ

Genetic risk factors for Clostridium difficile infection in ulcerative colitis.
Aliment Pharmacol Ther. 2013;38(5):522-30 - PMID: 23848254 - PMCID: PMC3755009 - DOI: 10.1111/apt.12425

Poutahidis T, Kleinewietfeld M, Smillie C, Levkovich T, Perrotta A, Bhela S, Varian BJ, Ibrahim YM, Lakritz JR, Kearney SM, Chatzigiagkos A, Hafler DA, Alm EJ, Erdman SE

Microbial reprogramming inhibits Western diet-associated obesity.
PLoS One. 2013;8(7):e68596 - PMID: 23874682 - PMCID: PMC3707834 - DOI: 10.1371/journal.pone.0068596

Hwang WY, Fu Y, Reyon D, Maeder ML, Kaini P, Sander JD, Joung JK, Peterson RT, Yeh JR

Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System.
PLoS One. 2013;8(7):e68708 - PMID: 23874735 - PMCID: PMC3706373 - DOI: 10.1371/journal.pone.0068708

Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.
Nat Chem Biol. 2013;9(7):466 - PMID: 23774875

Adamala K, Szostak JW

Competition between model protocells driven by an encapsulated catalyst.
Nat Chem. 2013;5(7):634 - PMID: 23787756

Reyon D, Maeder ML, Khayter C, Tsai SQ, Foley JE, Sander JD, Joung JK

Engineering Customized TALE Nucleases (TALENs) and TALE Transcription Factors by Fast Ligation-Based Automatable Solid-Phase High-Throughput (FLASH) Assembly.
Curr Protoc Mol Biol. 2013;Chapter 12:Unit12.16 - PMID: 23821439 - PMCID: PMC3767754 - DOI: 10.1002/0471142727.mb1216s103

Karlsson EK, Harris JB, Tabrizi S, Rahman A, Shlyakhter I, Patterson N, O'Dushlaine C, Schaffner SF, Gupta S, Chowdhury F, Sheikh A, Shin OS, Ellis C, Becker CE, Stuart LM, Calderwood SB, Ryan ET, Qadri F, Sabeti PC, Larocque RC

Natural selection in a bangladeshi population from the cholera-endemic ganges river delta.
Sci Transl Med. 2013;5(192):192ra86 - PMID: 23825302 - PMCID: PMC4367964 - DOI: 10.1126/scitranslmed.3006338

Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, Stuart LM, Latz E, Fitzgerald KA, Moore KJ

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
Nat Immunol. 2013;14(8):812-20 - PMID: 23812099 - PMCID: PMC3720827 - DOI: 10.1038/ni.2639

Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Schmidt Grant S, Rubin EJ, Hung DT

Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32.
Proc Natl Acad Sci U S A. 2013;110(28):11565-70 - PMID: 23798446 - PMCID: PMC3710825 - DOI: 10.1073/pnas.1302114110

Fu Y, Foden JA, Khayter C, Maeder ML, Reyon D, Joung JK, Sander JD

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.
Nat Biotechnol. 2013;31(9):822-6 - PMID: 23792628 - PMCID: PMC3773023 - DOI: 10.1038/nbt.2623

Smeekens SP, Huttenhower C, Riza A, van de Veerdonk FL, Zeeuwen PL, Schalkwijk J, van der Meer JW, Xavier RJ, Netea MG, Gevers D

Skin Microbiome Imbalance in Patients with STAT1/STAT3 Defects Impairs Innate Host Defense Responses.
J Innate Immun. 2013;6(3):253-62 - PMID: 23796786 - PMCID: PMC4045018 - DOI: 10.1159/000351912

Xiong Y, Sheen J

Moving beyond translation: glucose-TOR signaling in the transcriptional control of cell cycle.
Cell Cycle. 2013;12(13):1989-90 - PMID: 23759578 - PMCID: PMC3737295 - DOI: 10.4161/cc.25308

Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, Ruvkun G

Radiation Resistance of Sequencing Chips for in situ Life Detection.
Astrobiology. 2013;13(6):560-9 - PMID: 23734755 - DOI: 10.1089/ast.2012.0923

Sokol H, Conway KL, Zhang M, Choi M, Morin B, Cao Z, Villablanca EJ, Li C, Wijmenga C, Yun SH, Shi HN, Xavier RJ

Card9 Mediates Intestinal Epithelial Cell Restitution, T-helper 17 Responses, and Control of Bacterial Infection in Mice.
Gastroenterology. 2013;145(3):591-601.e3 - PMID: 23732773 - PMCID: PMC3781941 - DOI: 10.1053/j.gastro.2013.05.047

Li X, Burnight ER, Cooney AL, Malani N, Brady T, Sander JD, Staber J, Wheelan SJ, Joung JK, McCray PB, Bushman FD, Sinn PL, Craig NL

piggyBac transposase tools for genome engineering.
Proc Natl Acad Sci U S A. 2013;110(25):E2279-87 - PMID: 23723351 - PMCID: PMC3690869 - DOI: 10.1073/pnas.1305987110

Shore DE, Ruvkun G

A cytoprotective perspective on longevity regulation.
Trends Cell Biol. 2013;23(9):409-20 - PMID: 23726168 - PMCID: PMC4057428 - DOI: 10.1016/j.tcb.2013.04.007

Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.
Proc Natl Acad Sci U S A. 2013;110(24):9932-7 - PMID: 23716698 - PMCID: PMC3683768 - DOI: 10.1073/pnas.1302257110

Stuart LM, Boyer L

RhoGTPases - NODes for effector-triggered immunity in animals.
Cell Res. 2013;23(8):980-1 - PMID: 23689278 - PMCID: PMC3731559 - DOI: 10.1038/cr.2013.68

Adamala K, Szostak JW

Competition between model protocells driven by an encapsulated catalyst.
Nat Chem. 2013;5(6):495-501 - PMID: 23695631 - PMCID: PMC4041014 - DOI: 10.1038/nchem.1650

Ramon M, Ruelens P, Li Y, Sheen J, Geuten K, Rolland F

The hybrid four-CBS-domain KIN?? subunit functions as the canonical ? subunit of the plant energy sensor SnRK1.
Plant J. 2013;75(1):11-25 - PMID: 23551663 - PMCID: PMC6599549 - DOI: 10.1111/tpj.12192

Xavier RJ, Dinesh P

Conformational stability, vibrational spectra, HOMO-LUMO and NBO analysis of 1,3,4-thiadiazolidine-2,5-dithione with experimental (FT-IR and FT-Raman) techniques and scaled quantum mechanical calculations.
Spectrochim Acta A Mol Biomol Spectrosc. 2013;113:171-81 - PMID: 23727670 - DOI: 10.1016/j.saa.2013.04.108

Sokolovska A, Becker CE, Ip WK, Rathinam VA, Brudner M, Paquette N, Tanne A, Vanaja SK, Moore KJ, Fitzgerald KA, Lacy-Hulbert A, Stuart LM

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.
Nat Immunol. 2013;14(6):543-553 - PMID: 23644505 - PMCID: PMC3708594 - DOI: 10.1038/ni.2595

Li JF, Chung HS, Niu Y, Bush J, McCormack M, Sheen J

Comprehensive Protein-Based Artificial MicroRNA Screens for Effective Gene Silencing in Plants.
Plant Cell. 2013;25(5):1507-22 - PMID: 23645631 - PMCID: PMC3694689 - DOI: 10.1105/tpc.113.112235

Ananthakrishnan AN, Xavier RJ

How Does Genotype Influence Disease Phenotype in Inflammatory Bowel Disease?
Inflamm Bowel Dis. 2013;19(9):2021-30 - PMID: 23644824 - PMCID: PMC3720704 - DOI: 10.1097/MIB.0b013e318281f5c5

Coffee EM, Faber AC, Roper J, Sinnamon MJ, Goel G, Keung L, Wang WV, Vecchione L, de Vriendt V, Weinstein BJ, Bronson RT, Tejpar S, Xavier RJ, Engelman JA, Martin ES, Hung KE

Concomitant BRAF and PI3K/mTOR Blockade Is Required for Effective Treatment of BRAFV600E Colorectal Cancer.
Clin Cancer Res. 2013;19(10):2688-98 - PMID: 23549875 - PMCID: PMC3815598 - DOI: 10.1158/1078-0432.CCR-12-2556

Wright GD, Hung DT, Helmann JD

How antibiotics kill bacteria: new models needed?
Nat Med. 2013;19(5):544-5 - PMID: 23652106 - DOI: 10.1038/nm.3198

Graham DB, Xavier RJ

From genetics of inflammatory bowel disease towards mechanistic insights.
Trends Immunol. 2013;34(8):371-8 - PMID: 23639549 - PMCID: PMC3735683 - DOI: 10.1016/j.it.2013.04.001

Ryan CM, Schneider JC, Kazis LE, Lee A, Li NC, Hinson M, Bauk H, Peck M, Meyer WJ, Palmieri T, Pidcock FS, Reilly D, Tompkins RG,

Benchmarks for Multidimensional Recovery After Burn Injury in Young Adults: The Development, Validation, and Testing of the American Burn Association/Shriners Hospitals for Children Young Adult Burn Outcome Questionnaire.
J Burn Care Res. 2013;34(3):e121-42 - PMID: 23511284 - DOI: 10.1097/BCR.0b013e31827e7ecf

Giallourakis CC, Benita Y, Molinie B, Cao Z, Despo O, Pratt HE, Zukerberg LR, Daly MJ, Rioux JD, Xavier RJ

Genome-wide Analysis of Immune System Genes by Expressed Sequence Tag Profiling.
J Immunol. 2013;190(11):5578-5587 - PMID: 23616578 - PMCID: PMC3703829 - DOI: 10.4049/jimmunol.1203471

Mansour MK, Tam JM, Khan NS, Seward M, Davids PJ, Puranam S, Sokolovska A, Sykes DB, Dagher Z, Becker C, Tanne A, Reedy JL, Stuart LM, Vyas JM

Dectin-1 activation controls maturation of ?-1,3-glucan-containing phagosomes.
J Biol Chem. 2013;288(22):16043-54 - PMID: 23609446 - PMCID: PMC3668760 - DOI: 10.1074/jbc.M113.473223

Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.
Nat Chem Biol. 2013;9(6):398-405 - PMID: 23603659 - PMCID: PMC6615456 - DOI: 10.1038/nchembio.1236

O'Rourke EJ, Ruvkun G

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.
Nat Cell Biol. 2013;15(6):668-676 - PMID: 23604316 - PMCID: PMC3723461 - DOI: 10.1038/ncb2741

Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G

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Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM

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Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM

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Righi V, Constantinou C, Mintzopoulos D, Khan N, Mupparaju SP, Rahme LG, Swartz HM, Szeto HH, Tompkins RG, Tzika AA

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Efficacy of Phosphodiesterase 5 inhibitor on distant burn-induced muscle autophagy, microcirculation and survival rate.
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Watada S, Yu YM, Fischman AJ, Kurihara T, Shen CA, Tompkins RG, Fagan S

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Determination of Burn Patient Outcome by Large-Scale Quantitative Discovery Proteomics.
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Djonovi? S, Urbach JM, Drenkard E, Bush J, Feinbaum R, Ausubel JL, Traficante D, Risech M, Kocks C, Fischbach MA, Priebe GP, Ausubel FM

Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants.
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Gmyrek GB, Graham DB, Sandoval G, Blaufuss GS, Akilesh HM, Fujikawa K, Xavier RJ, Swat W

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Kurihara T, Jones CN, Yu YM, Fischman AJ, Watada S, Tompkins RG, Fagan SP, Irimia D

Resolvin D2 restores neutrophil directionality and improves survival after burns.
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Cutting Edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells.
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Genomic responses in mouse models poorly mimic human inflammatory diseases.
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Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing.
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Development of a Genomic Metric That Can Be Rapidly Used to Predict Clinical Outcome in Severely Injured Trauma Patients.
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Translating the Genomics Revolution: The Need for an International Gene Therapy Consortium for Monogenic Diseases.
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Gao X, Chen X, Lin W, Chen S, Lu D, Niu Y, Li L, Cheng C, McCormack M, Sheen J, Shan L, He P

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Shi Z, Montgomery TA, Qi Y, Ruvkun G

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Identification of a candidate therapeutic autophagy-inducing peptide.
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Hwang WY, Fu Y, Reyon D, Maeder ML, Tsai SQ, Sander JD, Peterson RT, Yeh JR, Joung JK

Efficient genome editing in zebrafish using a CRISPR-Cas system.
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Lu XM, Tompkins R, Fischman A

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Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT

Identification of Novel Host-Targeted Compounds That Protect From Anthrax Lethal Toxin-Induced Cell Death.
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ATG5 regulates plasma cell differentiation.
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Probiotic bacteria induce a 'glow of health'.
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Angiotensin II Drives the Production of Tumor-Promoting Macrophages.
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Lu XM, Tompkins RG, Fischman AJ

Nitric oxide activates intradomain disulfide bond formation in the kinase loop of Akt1/PKB? after burn injury.
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Zhang S, Zhang N, Blain JC, Szostak JW

Synthesis of N3'-P5'-linked phosphoramidate DNA by nonenzymatic template-directed primer extension.
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Cezairliyan B, Vinayavekhin N, Grenfell-Lee D, Yuen GJ, Saghatelian A, Ausubel FM

Identification of Pseudomonas aeruginosa Phenazines that Kill Caenorhabditis elegans.
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Smeekens SP, Ng A, Kumar V, Johnson MD, Plantinga TS, van Diemen C, Arts P, Verwiel ET, Gresnigt MS, Fransen K, van Sommeren S, Oosting M, Cheng SC, Joosten LA, Hoischen A, Kullberg BJ, Scott WK, Perfect JR, van der Meer JW, Wijmenga C, Netea MG, Xavier RJ

Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans.
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Carr CE, Rowedder H, Vafadari C, Lui CS, Cascio E, Zuber MT, Ruvkun G

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Zhao G, Yu YM, Kaneki M, Tompkins RG, Fischman AJ

Simvastatin Protects Hepatocytes From Apoptosis by Suppressing the TNF-?/Caspase-3 Signaling Pathway in Mice With Burn Injury.
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Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G

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Zhang S, Zhang N, Blain JC, Szostak JW

Synthesis of N3´-P5´-Phosphoramidate DNA by Non-enzymatic Template-directed Primer Extension.
J Am Chem Soc. 2013;135(2):924-32 - PMID: 23252395 - PMCID: PMC3548433 - DOI: 10.1021/ja311164j

Joung JK, Sander JD

TALENs: a widely applicable technology for targeted genome editing.
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Yo K, Yu YM, Zhao G, Bonab AA, Aikawa N, Tompkins RG, Fischman AJ

Brown Adipose Tissue and Its Modulation by a Mitochondria-targeted Peptide in Rat Burn Injury Induced Hypermetabolism.
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Boudsocq M, Sheen J

CDPKs in immune and stress signaling.
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Xu H, Yu YM, Ma H, Carter EA, Fagan S, Tompkins RG, Fischman AJ

Glucose metabolism during the early after burn injury.
J Surg Res. 2013;179(1):e83-90 - PMID: 22459295 - PMCID: PMC4074901 - DOI: 10.1016/j.jss.2012.02.037
Total: 125