Publications

Imaging C-Fos Gene Expression in Burns Using Lipid Coated Spion Nanoparticles.

Papagiannaros A, Righi V, Day GG, Rahme LG, Liu PK, Fischman AJ, Tompkins RG, Tzika AA
Adv J Mol Imaging. 2012;2(4):31-37 - PMID: 24995147 - PMCID: PMC4076698

Multicomponent assembly of proposed DNA precursors in water.

Powner MW, Zheng SL, Szostak JW
J Am Chem Soc. 2012;134(33):13889-95 - PMID: 22839703 - PMCID: PMC3424849

Concentration-driven growth of model protocell membranes.

Budin I, Debnath A, Szostak JW
J Am Chem Soc. 2012;134(51):20812-9 - PMID: 23198690 - PMCID: PMC3530389

Enhanced Tim3 activity improves survival after influenza infection.

Cho JL, Roche MI, Sandall B, Brass AL, Seed B, Xavier RJ, Medoff BD
J Immunol. 2012;189(6):2879-89 - PMID: 22875804 - PMCID: PMC3436990

A high-content imaging workflow to study Grb2 signaling complexes by expression cloning.

Freeman J, Kriston-Vizi J, Seed B, Ketteler R
J Vis Exp. 2012;(68):ePub - PMID: 23150065 - PMCID: PMC3499067

Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany.

Grad YH, Lipsitch M, Griggs AD, Haas BJ, Shea TP, McCowan C, Montmayeur A, FitzGerald M, Wortman JR, Krogfelt KA, Bingen E, Weill FX, Tietze E, Flieger A, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP
Proc Natl Acad Sci U S A. 2012;109(52):E3629-30 - PMID: 23479789 - PMCID: PMC3535640

Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence.

Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, Kamath R, Yacoby K, Chapman B, Garcia SM, Borowsky M, Kim JK, Ruvkun G
Nature. 2012;493(7434):694-8 - PMID: 23364702 - PMCID: PMC3762460

Simvastatin Protects Hepatocytes From Apoptosis by Suppressing the TNF-?/Caspase-3 Signaling Pathway in Mice With Burn Injury.

Zhao G, Yu YM, Kaneki M, Tompkins RG, Fischman AJ
Ann Surg. 2012;257(6):1129-36 - PMID: 23275311 - PMCID: PMC4102342

Synthesis of N3´-P5´-Phosphoramidate DNA by Non-enzymatic Template-directed Primer Extension.

Zhang S, Zhang N, Blain JC, Szostak JW
J Am Chem Soc. 2012;135(2):924-32 - PMID: 23252395 - PMCID: PMC3548433

The LRR and RING Domain Protein LRSAM1 Is an E3 Ligase Crucial for Ubiquitin-Dependent Autophagy of Intracellular Salmonella Typhimurium.

Huett A, Heath RJ, Begun J, Sassi SO, Baxt LA, Vyas JM, Goldberg MB, Xavier RJ
Cell Host Microbe. 2012;12(6):778-90 - PMID: 23245322 - PMCID: PMC3785244

Concentration-driven growth of model protocell membranes.

Budin I, Debnath A, Szostak JW
J Am Chem Soc. 2012;134(51):20812-9 - PMID: 23198690 - PMCID: PMC3530389

Stem Cell Signaling in Immunity and Development.

Lee H, Chah OK, Plotnikov J, Sheen J
Cold Spring Harb Symp Quant Biol. 2012;77:75-81 - PMID: 23174766

TALENs: a widely applicable technology for targeted genome editing.

Joung JK, Sander JD
Nat Rev Mol Cell Biol. 2012;14(1):49-55 - PMID: 23169466 - PMCID: PMC3547402

Brown Adipose Tissue and Its Modulation by a Mitochondria-targeted Peptide in Rat Burn Injury Induced Hypermetabolism.

Yo K, Yu YM, Zhao G, Bonab AA, Aikawa N, Tompkins RG, Fischman AJ
Am J Physiol Endocrinol Metab. 2012;304(4):E331-41 - PMID: 23169784 - PMCID: PMC3566510

A High-content Imaging Workflow to Study Grb2 Signaling Complexes by Expression Cloning.

Freeman J, Kriston-Vizi J, Seed B, Ketteler R
J Vis Exp. 2012;(68):ePub - PMID: 23150065 - PMCID: PMC3499067

Combination of Radiation and Burn Injury Alters [18F] 2-Fluoro-2-Deoxy-D-Glucose Uptake in Mice.

Carter EA, Winter D, Tolman C, Paul K, Hamrahi V, Tompkins RG, Fischman AJ
J Burn Care Res. 2012;33(6):723-30 - PMID: 23143615 - PMCID: PMC3673011

Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.

Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP
PLoS One. 2012;7(10):e48282 - PMID: 23144747 - PMCID: PMC3483217

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Büning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Ge ...
Nature. 2012;491(7422):119-24 - PMID: 23128233 - PMCID: PMC3491803

Measurement of Phagocytosis, Phagosome Acidification, and Intracellular Killing of Staphylococcus aureus.

Sokolovska A, Becker CE, Stuart LM
Curr Protoc Immunol. 2012;Chapter 14:Unit14.30 - PMID: 23129153

Essential cell autonomous role for interferon regulatory factor 1 in interferon-?-mediated inhibition of norovirus replication in macrophages.

Maloney NS, Thackray LB, Goel G, Hwang S, Duan E, Vachharajani P, Xavier R, Virgin HW
J Virol. 2012;86(23):12655-64 - PMID: 22973039 - PMCID: PMC3497668

Common alleles that influence autophagy and the risk for inflammatory bowel disease.

Gardet A, Xavier RJ
Curr Opin Immunol. 2012;24(5):522-9 - PMID: 23041451

Engineering Designer Transcription Activator--Like Effector Nucleases (TALENs) by REAL or REAL-Fast Assembly.

Reyon D, Khayter C, Regan MR, Joung JK, Sander JD
Curr Protoc Mol Biol. 2012;Chapter 12:Unit12.15 - PMID: 23026907 - PMCID: PMC3753116

Clinical review. Comparative effectiveness of drug treatments to prevent fragility fractures: a systematic review and network meta-analysis.

Murad MH, Drake MT, Mullan RJ, Mauck KF, Stuart LM, Lane MA, Abu Elnour NO, Erwin PJ, Hazem A, Puhan MA, Li T, Montori VM
J Clin Endocrinol Metab. 2012;97(6):1871-80 - PMID: 22466336

Clinical review. Risk factors for low bone mass-related fractures in men: a systematic review and meta-analysis.

Drake MT, Murad MH, Mauck KF, Lane MA, Undavalli C, Elraiyah T, Stuart LM, Prasad C, Shahrour A, Mullan RJ, Hazem A, Erwin PJ, Montori VM
J Clin Endocrinol Metab. 2012;97(6):1861-70 - PMID: 22466344

The Two-Component Sensor KinB Acts as a Phosphatase to Regulate Pseudomonas aeruginosa Virulence.

Chand NS, Clatworthy AE, Hung DT
J Bacteriol. 2012;194(23):6537-47 - PMID: 23024348 - PMCID: PMC3497526

Safety and dosing of bevacizumab (avastin) for the treatment of recurrent respiratory papillomatosis.

Best SR, Friedman AD, Landau-Zemer T, Barbu AM, Burns JA, Freeman MW, Halvorsen YD, Hillman RE, Zeitels SM
Ann Otol Rhinol Laryngol. 2012;121(9):587-93 - PMID: 23012897

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment.

Morgan XC, Tickle TL, Sokol H, Gevers D, Devaney KL, Ward DV, Reyes JA, Shah SA, Leleiko N, Snapper SB, Bousvaros A, Korzenik J, Sands BE, Xavier RJ, Huttenhower C
Genome Biol. 2012;13(9):R79 - PMID: 23013615 - PMCID: PMC3506950

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes.

Kleinnijenhuis J, Quintin J, Preijers F, Joosten LA, Ifrim DC, Saeed S, Jacobs C, van Loenhout J, de Jong D, Stunnenberg HG, Xavier RJ, van der Meer JW, van Crevel R, Netea MG
Proc Natl Acad Sci U S A. 2012;109(43):17537-42 - PMID: 22988082 - PMCID: PMC3491454

CDPKs in immune and stress signaling.

Boudsocq M, Sheen J
Trends Plant Sci. 2012;18(1):30-40 - PMID: 22974587 - PMCID: PMC3534830

Evaluation of OPEN Zinc Finger Nucleases for Direct Gene Targeting of the ROSA26 Locus in Mouse Embryos.

Hermann M, Maeder ML, Rector K, Ruiz J, Becher B, Bürki K, Khayter C, Aguzzi A, Joung JK, Buch T, Pelczar P
PLoS One. 2012;7(9):e41796 - PMID: 22970113 - PMCID: PMC3435328

Guidelines for the use and interpretation of assays for monitoring autophagy.

Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai ...
Autophagy. 2012;8(4):445-544 - PMID: 22966490 - PMCID: PMC3404883

Previous burn injury predisposes mice to lipopolysaccharide-induced changes in glucose metabolism.

Carter EA, Paul KW, Barrow SA, Fischman AJ, Tompkins RG
J Burn Care Res. 2012;33(5):683-9 - PMID: 22961012 - PMCID: PMC3441057

The American Burn Association/Shriners Hospitals for Children Burn Outcomes Program: A progress report at 15 years.

Tompkins RG, Liang MH, Lee AF, Kazis LE,
J Trauma Acute Care Surg. 2012;73(3 Suppl 2):S173-8 - PMID: 22929544

Impact of hand burns on health-related quality of life in children younger than 5 years.

Palmieri TL, Nelson-Mooney K, Kagan RJ, Stubbs TK, Meyer WJ, Herndon DN, Hinson MI, Lee AF, Li NC, Kazis LE, Tompkins RG,
J Trauma Acute Care Surg. 2012;73(3 Suppl 2):S197-204 - PMID: 22929547

Measuring the cost of care for children with acute burn injury.

Carey K, Kazis LE, Lee AF, Liang MH, Li NC, Hinson MI, Lydon MK, Bauk H, Shapiro GD, Tompkins RG,
J Trauma Acute Care Surg. 2012;73(3 Suppl 2):S229-33 - PMID: 22929551

FLS2-Mediated Responses to Ax21-Derived Peptides: Response to the Mueller et al. Commentary.

Danna CH, Zhang XC, Khatri A, Bent AF, Ronald PC, Ausubel FM
Plant Cell. 2012;24(8):3174-6 - PMID: 22923675 - PMCID: PMC3462622

Complexity in Differential Peptide-Receptor Signaling: Response to Segonzac et al. and Mueller et al. Commentaries.

Lee H, Khatri A, Plotnikov JM, Zhang XC, Sheen J
Plant Cell. 2012;24(8):3177-85 - PMID: 22923676 - PMCID: PMC3462623

p40phox Expression Regulates Neutrophil Recruitment and Function during the Resolution Phase of Intestinal Inflammation.

Conway KL, Goel G, Sokol H, Manocha M, Mizoguchi E, Terhorst C, Bhan AK, Gardet A, Xavier RJ
J Immunol. 2012;189(7):3631-40 - PMID: 22914050 - PMCID: PMC3780969

Genome-Wide Identification of Pseudomonas aeruginosa Virulence-Related Genes Using a Caenorhabditis elegans Infection Model.

Feinbaum RL, Urbach JM, Liberati NT, Djonovic S, Adonizio A, Carvunis AR, Ausubel FM
PLoS Pathog. 2012;8(7):e1002813 - PMID: 22911607 - PMCID: PMC3406104

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes.

Quintin J, Saeed S, Martens JH, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C, Jacobs L, Jansen T, Kullberg BJ, Wijmenga C, Joosten LA, Xavier RJ, van der Meer JW, Stunnenberg HG, Netea MG
Cell Host Microbe. 2012;12(2):223-32 - PMID: 22901542 - PMCID: PMC3864037

Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth.

Hamrahi V, Hamblin MR, Jung W, Benjamin JB, Paul KW, Fischman AJ, Tompkins RG, Carter EA
Interdiscip Perspect Infect Dis. 2012;2012:567140 - PMID: 22899912 - PMCID: PMC3412104

Enhanced Tim3 Activity Improves Survival after Influenza Infection.

Cho JL, Roche MI, Sandall B, Brass AL, Seed B, Xavier RJ, Medoff BD
J Immunol. 2012;189(6):2879-89 - PMID: 22875804 - PMCID: PMC3436990

A synthetic biology framework for programming eukaryotic transcription functions.

Khalil AS, Lu TK, Bashor CJ, Ramirez CL, Pyenson NC, Joung JK, Collins JJ
Cell. 2012;150(3):647-58 - PMID: 22863014 - PMCID: PMC3653585

New insights into siRNA amplification and RNAi.

Zhang C, Ruvkun G
RNA Biol. 2012;9(8):1045-9 - PMID: 22858672 - PMCID: PMC3551858

An interview with Jen Sheen.

Sheen J
Trends Plant Sci. 2012;17(6):321-2 - PMID: 22860262

Multicomponent assembly of proposed DNA precursors in water.

Powner MW, Zheng SL, Szostak JW
J Am Chem Soc. 2012;134(33):13889-95 - PMID: 22839703 - PMCID: PMC3424849

Case 23-2012.

Xavier RJ, Gala MK, Bronzo BK, Kelly PJ
N Engl J Med. 2012;367(4):363-73 - PMID: 22830467

Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways.

Shore DE, Carr CE, Ruvkun G
PLoS Genet. 2012;8(7):e1002792 - PMID: 22829775 - PMCID: PMC3400582

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria.

Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
Cell. 2012;150(3):606-19 - PMID: 22819539 - PMCID: PMC3660860

Genes Involved in the Evolution of Herbivory By A Leaf-Mining, Drosophilid Fly.

Whiteman NK, Gloss AD, Sackton TB, Groen SC, Humphrey PT, Lapoint RT, Sønderby IE, Halkier BA, Kocks C, Ausubel FM, Pierce NE
Genome Biol Evol. 2012;4(9):900-16 - PMID: 22813779 - PMCID: PMC3516228

EGL-9 Controls C. elegans Host Defense Specificity through Prolyl Hydroxylation-Dependent and -Independent HIF-1 Pathways.

Luhachack LG, Visvikis O, Wollenberg AC, Lacy-Hulbert A, Stuart LM, Irazoqui JE
PLoS Pathog. 2012;8(7):e1002798 - PMID: 22792069 - PMCID: PMC3390412

Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.

Schmidt Grant S, Kaufmann BB, Chand NS, Haseley N, Hung DT
Proc Natl Acad Sci U S A. 2012;109(30):12147-52 - PMID: 22778419 - PMCID: PMC3409745

Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease.

Papa E, Docktor M, Smillie C, Weber S, Preheim SP, Gevers D, Giannoukos G, Ciulla D, Tabbaa D, Ingram J, Schauer DB, Ward DV, Korzenik JR, Xavier RJ, Bousvaros A, Alm EJ
PLoS One. 2012;7(6):e39242 - PMID: 22768065 - PMCID: PMC3387146

Helminth Infection Impairs Autophagy-Mediated Killing of Bacterial Enteropathogens by Macrophages.

Su CW, Cao Y, Zhang M, Kaplan J, Su L, Fu Y, Walker WA, Xavier R, Cherayil BJ, Shi HN
J Immunol. 2012;189(3):1459-66 - PMID: 22732589 - PMCID: PMC3423331

Perception of volatiles produced by UVC-irradiated plants alters the response to viral infection in naïve neighboring plants.

Yao Y, Danna CH, Ausubel FM, Kovalchuk I
Plant Signal Behav. 2012;7(7):741-5 - PMID: 22751319 - PMCID: PMC3583953

Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection.

Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL, Ausubel FM
PLoS Genet. 2012;8(6):e1002733 - PMID: 22719261 - PMCID: PMC3375230

MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline.

Phillips CM, Montgomery TA, Breen PC, Ruvkun G
Genes Dev. 2012;26(13):1433-44 - PMID: 22713602 - PMCID: PMC3403012

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs.

Cade L, Reyon D, Hwang WY, Tsai SQ, Patel S, Khayter C, Joung JK, Sander JD, Peterson RT, Yeh JR
Nucleic Acids Res. 2012;40(16):8001-10 - PMID: 22684503 - PMCID: PMC3439908

Photochemically driven redox chemistry induces protocell membrane pearling and division.

Zhu TF, Adamala K, Zhang N, Szostak JW
Proc Natl Acad Sci U S A. 2012;109(25):9828-32 - PMID: 22665773 - PMCID: PMC3382484

Improved Somatic Mutagenesis in Zebrafish Using Transcription Activator-Like Effector Nucleases (TALENs).

Moore FE, Reyon D, Sander JD, Martinez SA, Blackburn JS, Khayter C, Ramirez CL, Joung JK, Langenau DM
PLoS One. 2012;7(5):e37877 - PMID: 22655075 - PMCID: PMC3360007

Cytokinin signaling networks

Hwang I., Sheen J., Mueller B.
Annu Rev Plant Biology. . 2012;63:353-380

Penetration Resistance: PKR's Other Talent.

Lacy-Hulbert A, Stuart LM
Immunity. 2012;36(5):695-6 - PMID: 22633454

Tribbles 2 (Trib2) is a novel regulator of toll-like receptor 5 signaling.

Wei SC, Rosenberg IM, Cao Z, Huett AS, Xavier RJ, Podolsky DK
Inflamm Bowel Dis. 2012;18(5):877-88 - PMID: 22271508 - PMCID: PMC3881418

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma.

Hwang S, Maloney NS, Bruinsma MW, Goel G, Duan E, Zhang L, Shrestha B, Diamond MS, Dani A, Sosnovtsev SV, Green KY, Lopez-Otin C, Xavier RJ, Thackray LB, Virgin HW
Cell Host Microbe. 2012;11(4):397-409 - PMID: 22520467 - PMCID: PMC3348177

Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.

Stanley SA, Schmidt Grant S, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT
ACS Chem Biol. 2012;7(8):1377-84 - PMID: 22577943 - PMCID: PMC3560293

Transient expression assays for quantifying signaling output.

Niu Y, Sheen J
Methods Mol Biol. 2012;876:195-206 - PMID: 22576097

DNA purification from multiple sources in plant research with homemade silica resins.

Li JF, Sheen J
Methods Mol Biol. 2012;862:53-9 - PMID: 22419488

Targeted parallel sequencing of large genetically-defined genomic regions for identifying mutations in Arabidopsis.

Liu KH, McCormack M, Sheen J
Plant Methods. 2012;8(1):12 - PMID: 22462410 - PMCID: PMC3348062

In vitro selection of functional lantipeptides.

Hofmann FT, Szostak JW, Seebeck FP
J Am Chem Soc. 2012;134(19):8038-41 - PMID: 22545861 - PMCID: PMC3353655

Regulation of monocyte functional heterogeneity by miR-146a and Relb.

Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier R, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ
Cell Rep. 2012;1(4):317-324 - PMID: 22545247 - PMCID: PMC3334310

The Caenorhabditis elegans RDE-10/RDE-11 Complex Regulates RNAi by Promoting Secondary siRNA Amplification.

Zhang C, Montgomery TA, Fischer SE, Garcia SM, Riedel CG, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G
Curr Biol. 2012;22(10):881-90 - PMID: 22542102 - PMCID: PMC3371361

In vivo molecular imaging of murine embryonic stem cells delivered to a burn wound surface via Integra® scaffolding.

Hamrahi VF, Goverman J, Jung W, Wu JC, Fischman AJ, Tompkins RG, Yu YY, Fagan SP, Carter EA
J Burn Care Res. 2012;33(2):e49-54 - PMID: 22540138 - PMCID: PMC3311992

PIWI Associated siRNAs and piRNAs Specifically Require the Caenorhabditis elegans HEN1 Ortholog henn-1.

Montgomery TA, Rim YS, Zhang C, Dowen RH, Phillips CM, Fischer SE, Ruvkun G
PLoS Genet. 2012;8(4):e1002616 - PMID: 22536158 - PMCID: PMC3334881

Host Translational Inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an Immune Response in Caenorhabditis elegans.

McEwan DL, Kirienko NV, Ausubel FM
Cell Host Microbe. 2012;11(4):364-74 - PMID: 22520464 - PMCID: PMC3334877

An image analysis toolbox for high-throughput C. elegans assays.

Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE
Nat Methods. 2012;9(7):714-6 - PMID: 22522656 - PMCID: PMC3433711

Establishment and characterization of a novel chordoma cell line: CH22.

Liu X, Nielsen GP, Rosenberg AE, Waterman PR, Yang W, Choy E, Sassi S, Yang S, Harmon DC, Yang C, Schwab JH, Kobayashi E, Mankin HJ, Xavier R, Weissleder R, Duan Z, Hornicek FJ
J Orthop Res. 2012;30(10):1666-73 - PMID: 22504929

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses.

Melo JA, Ruvkun G
Cell. 2012;149(2):452-66 - PMID: 22500807 - PMCID: PMC3613046

FLASH assembly of TALENs for high-throughput genome editing.

Reyon D, Tsai SQ, Khayter C, Foden JA, Sander JD, Joung JK
Nat Biotechnol. 2012;30(5):460-5 - PMID: 22484455 - PMCID: PMC3558947

The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock*

Minei JP, Cuschieri J, Sperry J, Moore EE, West MA, Harbrecht BG, O'Keefe GE, Cohen MJ, Moldawer LL, Tompkins RG, Maier RV
Crit Care Med. 2012;40(4):1129-1135 - PMID: 22020243 - PMCID: PMC3343366

Attempts to define life do not help to understand the origin of life.

Szostak JW
J Biomol Struct Dyn. 2012;29(4):599-600 - PMID: 22208251 - PMCID: PMC4208307

Incidence of Catheter-Associated Bloodstream Infection After Introduction of Minocycline and Rifampin Antimicrobial-Coated Catheters in a Pediatric Burn Population.

Weber JM, Sheridan RL, Fagan S, Ryan CM, Pasternack MS, Tompkins RG
J Burn Care Res. 2012;33(4):539-43 - PMID: 22210071

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.

van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ray TD, Rayner KJ, Parathath S, Distel E, Feig JL, Alvarez-Leite JI, Rayner AJ, McDonald TO, O'Brien KD, Stuart LM, Fisher EA, Lacy-Hulbert A, Moore KJ
Nat Immunol. 2012;13(2):136-43 - PMID: 22231519 - PMCID: PMC3262880

Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium.

Pukkila-Worley R, Ausubel FM
Curr Opin Immunol. 2012;24(1):3-9 - PMID: 22236697 - PMCID: PMC3660727

Severe injury is associated with insulin resistance, endoplasmic reticulum stress response, and unfolded protein response.

Jeschke MG, Finnerty CC, Herndon DN, Song J, Boehning D, Tompkins RG, Baker HV, Gauglitz GG
Ann Surg. 2012;255(2):370-8 - PMID: 22241293 - PMCID: PMC3395076

The apoplastic oxidative burst peroxidase in Arabidopsis is a major component of pattern-triggered immunity.

Daudi A, Cheng Z, O'Brien JA, Mammarella N, Khan S, Ausubel FM, Bolwell GP
Plant Cell. 2012;24(1):275-87 - PMID: 22247251 - PMCID: PMC3289579

HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux.

Cui HL, Grant A, Mukhamedova N, Pushkarsky T, Jennelle L, Dubrovsky L, Gaus K, Fitzgerald ML, Sviridov D, Bukrinsky M
J Lipid Res. 2012;53(4):696-708 - PMID: 22262807 - PMCID: PMC3307646

Thermal Injury Activates eEF2k-Dependent eEF2 Pathway in Pediatric Patients.

Song J, Finnerty CC, Herndon DN, Kraft R, Boehning D, Brooks NC, Tompkins RG, Jeschke MG
JPEN J Parenter Enteral Nutr. 2012;36(5):596-602 - PMID: 22269896 - PMCID: PMC3580832

Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template.

Zhang N, Zhang S, Szostak JW
J Am Chem Soc. 2012;134(8):3691-4 - PMID: 22296305 - PMCID: PMC3448298

Survival of children with burn injuries.

Tompkins RG
Lancet. 2012;379(9820):983-4 - PMID: 22296811 - PMCID: PMC4019221

Genome-wide siRNA screen for mediators of NF-?B activation.

Gewurz BE, Towfic F, Mar JC, Shinners NP, Takasaki K, Zhao B, Cahir-McFarland ED, Quackenbush J, Xavier RJ, Kieff E
Proc Natl Acad Sci U S A. 2012;109(7):2467-72 - PMID: 22308454 - PMCID: PMC3289371

Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011.

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A Peroxidase-Dependent Apoplastic Oxidative Burst in Cultured Arabidopsis Cells Functions in MAMP-Elicited Defense.

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Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects.

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ONCOGENIC KRAS REGULATES BMP4 EXPRESSION IN COLON CANCER CELL LINES.

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The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans.

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Repression of Germline RNAi Pathways in Somatic Cells by Retinoblastoma Pathway Chromatin Complexes.

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Integration of architectural and cytologic driven image algorithms for prostate adenocarcinoma identification.

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In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors.

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Apoptotic cells can deliver chemotherapeutics to engulfing macrophages and suppress inflammatory cytokine production.

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In Vivo Molecular Imaging of Murine Embryonic Stem Cells Delivered to a Burn Wound Surface via Integra® Scaffolding.

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Autophagy and the immune system.

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Glucose metabolism during the early after burn injury.

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Benchmarking Outcomes in the Critically Injured Trauma Patient and the Effect of Implementing Standard Operating Procedures.

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Patterns of Care at End of Life in Children With Advanced Heart Disease.

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RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities.

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