The Glue Grant experience: characterizing the post injury genomic response.
Eur J Trauma Emerg Surg. 2011;37(6):549-58 - PMID: 26815465
Systematics-guided bioprospecting for bioactive microbial natural products.
Antonie Van Leeuwenhoek. 2011;101(1):55-66 - PMID: 22086462
C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Bioorg Med Chem Lett. 2011;21(15):4465-70 - PMID: 21737266
EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.
Pharmacol Res. 2011;63(4):284-93 - PMID: 21215314
A high-resolution map of human evolutionary constraint using 29 mammals.
Autophagy suppresses interleukin-1? (IL-1?) signaling by activation of p62 degradation via lysosomal and proteasomal pathways.
Caspase 8 inhibits programmed necrosis by processing CYLD.
Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.
Stem-cell-triggered immunity through CLV3p-FLS2 signalling.
Protein kinase signaling networks in plant innate immunity.
Stress-responsive mitogen-activated protein kinases interact with the EAR motif of a poplar zinc finger protein and mediate its degradation through the 26S proteasome.
Rapamycin and glucose-target of rapamycin (TOR) protein signaling in plants.
Embryonal Stem (ES) Cell-Derived Macrophages : A Cellular System that Facilitates the Genetic Dissection of Macrophage Function.
Methods Mol Med. 2011;30:343-55 - PMID: 21341038
Isolation and long-term maintenance of adult rat hepatocytes in culture.
Methods Mol Med. 2011;18:447-56 - PMID: 21370195
Targeting Innate Immunity for CV Benefit.
Crohn disease: a current perspective on genetics, autophagy and immunity.
Early enteral nutrition in burns: compliance with guidelines and associated outcomes in a multicenter study.
RNAi screening for fat regulatory genes with SRS microscopy.
mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.
Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.
Crit Rev Biochem Mol Biol. 2011;46(1):41-66 - PMID: 21250782
ZFNGenome: a comprehensive resource for locating zinc finger nuclease target sites in model organisms.
A high throughput amenable Arabidopsis-P. aeruginosa system reveals a rewired regulatory module and the utility to identify potent anti-infectives.
Effects of glucagon-like peptide 1 on glycemia control and its metabolic consequence after severe thermal injury--studies in an animal model.
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Human transcriptome array for high-throughput clinical studies.
Microfluidics for T- lymphocyte cell separation and inflammation monitoring in burn patients.
Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation.
Spatially Invariant Vector Quantization: A pattern matching algorithm for multiple classes of image subject matter including pathology.
Physical effects underlying the transition from primitive to modern cell membranes.
The path from bench to bedside: considerations before starting the journey.
Decreased parvalbumin immunoreactivity in the cortex and striatum of mice lacking the CB1 receptor.
Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases.
Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.
The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection.
Artificial lantipeptides from in vitro translations.
Chem Commun (Camb). 2011;47(21):6141-3 - PMID: 21528125
Effects of burn injury, cold stress and cutaneous wound injury on the morphology and energy metabolism of murine brown adipose tissue (BAT) in vivo.
The Arabidopsis flagellin receptor FLS2 mediates the perception of Xanthomonas Ax21 secreted peptides.
Recurrent chromosomal copy number alterations in sporadic chordomas.
Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.
Zinc-finger nucleases for somatic gene therapy: the next frontier.
MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.
A Francisella tularensis locus required for spermine responsiveness is necessary for virulence.
Genetics and pathogenesis of inflammatory bowel disease.
Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses.
Preferential expression of integrin avb8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells.
HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.
Considerations for preparedness for a pediatric burn disaster.
J Burn Care Res. 2011;32(5):e165-6 - PMID: 21772149
Computer aided diagnostic tools aim to empower rather than replace pathologists: Lessons learned from computational chess.
Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response.
GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro.
Evaluation of the antioxidant peptide SS31 for treatment of burn-induced insulin resistance.
Patterns of medication administration from 2001 to 2009 in the treatment of children with acute burn injuries: a multicenter study.
J Burn Care Res. 2011;32(5):519-28 - PMID: 21811176
Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library.
Targeted gene disruption in somatic zebrafish cells using engineered TALENs.
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection.
Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity.
Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging.
Acetylcholine ?7 nicotinic and dopamine D(2) receptors are targeted to many of the same postsynaptic dendrites and astrocytes in the rodent prefrontal cortex.
Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-? production independent of cholesterol efflux activity.
J Alzheimers Dis. 2011;27(2):441-52 - PMID: 21860089
Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.
In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases.
Association of heat production with 18F-FDG accumulation in murine brown adipose tissue after stress.
Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.
Engineering zinc finger nucleases for targeted mutagenesis of zebrafish.
Methods Cell Biol. 2011;104:51-8 - PMID: 21924156
An optimal degree of physical and chemical heterogeneity for the origin of life?
Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage.
Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study.
Novel mitochondria-targeted antioxidant peptide ameliorates burn-induced apoptosis and endoplasmic reticulum stress in the skeletal muscle of mice.
HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.
The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection.
Virulence. 2011;2(6):553-8 - PMID: 21971182
The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Engineering designer nucleases with customized cleavage specificities.
automated DNA sequencing technology.
Curr Protoc Mol Biol. 2011;Chapter 7:Unit7.2 - PMID: 21987057
Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model.
Regulation of the C. elegans molt by pqn-47.
Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients.
Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.
Image-based genome-wide siRNA screen identifies selective autophagy factors.
UV-C-irradiated Arabidopsis and tobacco emit volatiles that trigger genomic instability in neighboring plants.
Down-regulation of glutatione S-transferase ? 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection.
CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.
PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update.
Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study.
Ann Otol Rhinol Laryngol. 2011;120(10):627-34 - PMID: 22097147
The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.
A genomic storm in critically injured humans.
The Creating an Optimal Warfarin Nomogram (CROWN) Study.
The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status.
Cold Spring Harb Symp Quant Biol. 2011;76:113-20 - PMID: 22123849
Bacterial effectors: learning on the fly.
Resuscitation-promoting factors are required for ?-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis.
SILAM for quantitative proteomics of liver Akt1/PKB? after burn injury.
STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells.
Bioorg Med Chem. 2011;20(2):750-8 - PMID: 22217933