Publications for All Faculty - 2011

The Glue Grant experience: characterizing the post injury genomic response.

Cuenca AG, Maier RV, Cuschieri J, Moore EE, Moldawer LL, Tompkins RG,
Eur J Trauma Emerg Surg. 2011;37(6):549-58 - PMID: 26815465 - DOI: 10.1007/s00068-011-0148-8

Systematics-guided bioprospecting for bioactive microbial natural products.

Liu X, Bolla K, Ashforth EJ, Zhuo Y, Gao H, Huang P, Stanley SA, Hung DT, Zhang L
Antonie Van Leeuwenhoek. 2011;101(1):55-66 - PMID: 22086462 - DOI: 10.1007/s10482-011-9671-1

C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

Xu B, Feng Y, Cheng H, Song Y, Lv B, Wu Y, Wang C, Li S, Xu M, Du J, Peng K, Dong J, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Roberge JY, Seed B, Chen Y
Bioorg Med Chem Lett. 2011;21(15):4465-70 - PMID: 21737266 - DOI: 10.1016/j.bmcl.2011.06.032

EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.

Zhang W, Welihinda A, Mechanic J, Ding H, Zhu L, Lu Y, Deng Z, Sheng Z, Lv B, Chen Y, Roberge JY, Seed B, Wang YX
Pharmacol Res. 2011;63(4):284-93 - PMID: 21215314 - DOI: 10.1016/j.phrs.2011.01.001

A high-resolution map of human evolutionary constraint using 29 mammals.

Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, Washietl S, Kheradpour P, Ernst J, Jordan G, Mauceli E, Ward LD, Lowe CB, Holloway AK, Clamp M, Gnerre S, Alföldi J, Beal K, Chang J, Clawson H, Cuff J, Di Palma F, Fitzgerald S, Flicek P, Guttman M, Hubisz MJ, Jaffe DB, Jungreis I, Kent WJ, Kostka D, Lara M, Martins AL, Massingham T, Moltke I, Raney BJ, Rasmussen MD, Robinson J, Stark A, Vilella AJ, Wen J, Xie X, Zody MC; Broad Institute Sequencing Platform and Whole Genome Assembly Team, ...
Nature. 2011;478(7370):476-82 - PMID: 21993624 - PMCID: PMC3207357 - DOI: 10.1038/nature10530

Autophagy suppresses interleukin-1? (IL-1?) signaling by activation of p62 degradation via lysosomal and proteasomal pathways.

Lee J, Kim HR, Quinley C, Kim J, Gonzalez-Navajas J, Xavier R, Raz E
J Biol Chem. 2011;287(6):4033-40 - PMID: 22167182 - PMCID: PMC3281713 - DOI: 10.1074/jbc.M111.280065

Caspase 8 inhibits programmed necrosis by processing CYLD.

O'Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, Ting AT
Nat Cell Biol. 2011;13(12):1437-42 - PMID: 22037414 - PMCID: PMC3229661 - DOI: 10.1038/ncb2362

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.

Zhao Y, Alonso C, Ballester I, Song JH, Chang SY, Guleng B, Arihiro S, Murray PJ, Xavier R, Kobayashi KS, Reinecker HC
Inflamm Bowel Dis. 2011;18(4):603-12 - PMID: 21887730 - PMCID: PMC3594873 - DOI: 10.1002/ibd.21851

Stem-cell-triggered immunity through CLV3p-FLS2 signalling.

Lee H, Chah OK, Sheen J
Nature. 2011;473(7347):376-9 - PMID: 21499263 - PMCID: PMC3098311 - DOI: 10.1038/nature09958

Protein kinase signaling networks in plant innate immunity.

Tena G, Boudsocq M, Sheen J
Curr Opin Plant Biol. 2011;14(5):519-29 - PMID: 21704551 - PMCID: PMC3191242 - DOI: 10.1016/j.pbi.2011.05.006

Stress-responsive mitogen-activated protein kinases interact with the EAR motif of a poplar zinc finger protein and mediate its degradation through the 26S proteasome.

Hamel LP, Benchabane M, Nicole MC, Major IT, Morency MJ, Pelletier G, Beaudoin N, Sheen J, Séguin A
Plant Physiol. 2011;157(3):1379-93 - PMID: 21873571 - PMCID: PMC3252155 - DOI: 10.1104/pp.111.178343

Rapamycin and glucose-target of rapamycin (TOR) protein signaling in plants.

Xiong Y, Sheen J
J Biol Chem. 2011;287(4):2836-42 - PMID: 22134914 - PMCID: PMC3268441 - DOI: 10.1074/jbc.M111.300749

Embryonal Stem (ES) Cell-Derived Macrophages : A Cellular System that Facilitates the Genetic Dissection of Macrophage Function.

Moore KJ, Freeman MW
Methods Mol Med. 2011;30:343-55 - PMID: 21341038 - DOI: 10.1385/1-59259-247-3:343

Isolation and long-term maintenance of adult rat hepatocytes in culture.

Berthiaume F, Tompkins RG, Yarmush ML
Methods Mol Med. 2011;18:447-56 - PMID: 21370195 - DOI: 10.1385/0-89603-516-6:447

Targeting Innate Immunity for CV Benefit.

Moore KJ, Freeman MW
Drug Discov Today Ther Strateg. 2011;5(1):15-23 - PMID: 19430537 - PMCID: PMC2678718 - DOI: 10.1016/j.ddstr.2008.05.007

Crohn disease: a current perspective on genetics, autophagy and immunity.

Stappenbeck TS, Rioux JD, Mizoguchi A, Saitoh T, Huett A, Darfeuille-Michaud A, Wileman T, Mizushima N, Carding S, Akira S, Parkes M, Xavier RJ
Autophagy. 2011;7(4):355-74 - PMID: 20729636 - PMCID: PMC3842289 - DOI: 10.4161/auto.7.2.13074

Early enteral nutrition in burns: compliance with guidelines and associated outcomes in a multicenter study.

Mosier MJ, Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Tompkins RG, Herndon DN
J Burn Care Res. 2011;32(1):104-9 - PMID: 21116188 - PMCID: PMC3850279 - DOI: 10.1097/BCR.0b013e318204b3be

RNAi screening for fat regulatory genes with SRS microscopy.

Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS
Nat Methods. 2011;8(2):135-8 - PMID: 21240281 - PMCID: PMC3061290 - DOI: 10.1038/nmeth.1556

mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.

Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G
Proc Natl Acad Sci U S A. 2011;108(4):1201-8 - PMID: 21245313 - PMCID: PMC3029761 - DOI: 10.1073/pnas.1018695108

Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.

Rossin EJ, Lage K, Raychaudhuri S, Xavier RJ, Tatar D, Benita Y, , Cotsapas C, Daly MJ
PLoS Genet. 2011;7(1):e1001273 - PMID: 21249183 - PMCID: PMC3020935 - DOI: 10.1371/journal.pgen.1001273

Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.

Gomez JE, Clatworthy A, Hung DT
Crit Rev Biochem Mol Biol. 2011;46(1):41-66 - PMID: 21250782 - DOI: 10.3109/10409238.2010.538663

ZFNGenome: a comprehensive resource for locating zinc finger nuclease target sites in model organisms.

Reyon D, Kirkpatrick JR, Sander JD, Zhang F, Voytas DF, Joung JK, Dobbs D, Coffman CR
BMC Genomics. 2011;12:83 - PMID: 21276248 - PMCID: PMC3042413 - DOI: 10.1186/1471-2164-12-83

A high throughput amenable Arabidopsis-P. aeruginosa system reveals a rewired regulatory module and the utility to identify potent anti-infectives.

Gopalan S, Ausubel FM
PLoS One. 2011;6(1):e16381 - PMID: 21283656 - PMCID: PMC3025032 - DOI: 10.1371/journal.pone.0016381

Effects of glucagon-like peptide 1 on glycemia control and its metabolic consequence after severe thermal injury--studies in an animal model.

Shen CA, Fagan S, Fischman AJ, Carter EE, Chai JK, Lu XM, Yu YM, Tompkins RG
Surgery. 2011;149(5):635-44 - PMID: 21295809 - PMCID: PMC3079016 - DOI: 10.1016/j.surg.2010.11.017

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, L ...
Nat Genet. 2011;43(3):246-52 - PMID: 21297633 - PMCID: PMC3084597 - DOI: 10.1038/ng.764

Human transcriptome array for high-throughput clinical studies.

Xu W, Seok J, Mindrinos MN, Schweitzer AC, Jiang H, Wilhelmy J, Clark TA, Kapur K, Xing Y, Faham M, Storey JD, Moldawer LL, Maier RV, Tompkins RG, Wong WH, Davis RW, Xiao W,
Proc Natl Acad Sci U S A. 2011;108(9):3707-12 - PMID: 21317363 - PMCID: PMC3048146 - DOI: 10.1073/pnas.1019753108

Microfluidics for T- lymphocyte cell separation and inflammation monitoring in burn patients.

Rosenbach AE, Koria P, Goverman J, Kotz KT, Gupta A, Yu M, Fagan SP, Irimia D, Tompkins RG
Clin Transl Sci. 2011;4(1):63-8 - PMID: 21348958 - PMCID: PMC3057059 - DOI: 10.1111/j.1752-8062.2010.00255.x

Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation.

Subtelny AO, Hartman MC, Szostak JW
Angew Chem Int Ed Engl. 2011;50(14):3164-7 - PMID: 21381166 - PMCID: PMC4006073 - DOI: 10.1002/anie.201007686

Spatially Invariant Vector Quantization: A pattern matching algorithm for multiple classes of image subject matter including pathology.

Hipp JD, Cheng JY, Toner M, Tompkins RG, Balis UJ
J Pathol Inform. 2011;2:13 - PMID: 21383936 - PMCID: PMC3049270 - DOI: 10.4103/2153-3539.77175

Physical effects underlying the transition from primitive to modern cell membranes.

Budin I, Szostak JW
Proc Natl Acad Sci U S A. 2011;108(13):5249-54 - PMID: 21402937 - PMCID: PMC3069173 - DOI: 10.1073/pnas.1100498108

The path from bench to bedside: considerations before starting the journey.

Freeman MW, Dervan AP
J Investig Med. 2011;59(5):746-51 - PMID: 21441830 - PMCID: PMC4255460 - DOI: 10.2310/JIM.0b013e3182160d70

Decreased parvalbumin immunoreactivity in the cortex and striatum of mice lacking the CB1 receptor.

Fitzgerald ML, Lupica CR, Pickel VM
Synapse. 2011;65(8):827-31 - PMID: 21445945 - PMCID: PMC3107909 - DOI: 10.1002/syn.20911

Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases.

Curtin SJ, Zhang F, Sander JD, Haun WJ, Starker C, Baltes NJ, Reyon D, Dahlborg EJ, Goodwin MJ, Coffman AP, Dobbs D, Joung JK, Voytas DF, Stupar RM
Plant Physiol. 2011;156(2):466-73 - PMID: 21464476 - PMCID: PMC3177250 - DOI: 10.1104/pp.111.172981

Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.

Heath RJ, Leong JM, Visegrády B, Machesky LM, Xavier RJ
PLoS Pathog. 2011;7(4):e1001332 - PMID: 21490959 - PMCID: PMC3072376 - DOI: 10.1371/journal.ppat.1001332

The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection.

Chand NS, Lee JS, Clatworthy AE, Golas AJ, Smith RS, Hung DT
J Bacteriol. 2011;193(12):2989-99 - PMID: 21515773 - PMCID: PMC3133189 - DOI: 10.1128/JB.01546-10

Artificial lantipeptides from in vitro translations.

Seebeck FP, Ricardo A, Szostak JW
Chem Commun (Camb). 2011;47(21):6141-3 - PMID: 21528125 - DOI: 10.1039/c0cc05663d

Effects of burn injury, cold stress and cutaneous wound injury on the morphology and energy metabolism of murine brown adipose tissue (BAT) in vivo.

Carter EA, Bonab AA, Hamrahi V, Pitman J, Winter D, Macintosh LJ, Cyr EM, Paul K, Yerxa J, Jung W, Tompkins RG, Fischman AJ
Life Sci. 2011;89(3-4):78-85 - PMID: 21565200 - PMCID: PMC4081480 - DOI: 10.1016/j.lfs.2011.04.014

The Arabidopsis flagellin receptor FLS2 mediates the perception of Xanthomonas Ax21 secreted peptides.

Danna CH, Millet YA, Koller T, Han SW, Bent AF, Ronald PC, Ausubel FM
Proc Natl Acad Sci U S A. 2011;108(22):9286-91 - PMID: 21576467 - PMCID: PMC3107323 - DOI: 10.1073/pnas.1106366108

Recurrent chromosomal copy number alterations in sporadic chordomas.

Le LP, Nielsen GP, Rosenberg AE, Thomas D, Batten JM, Deshpande V, Schwab J, Duan Z, Xavier RJ, Hornicek FJ, Iafrate AJ
PLoS One. 2011;6(5):e18846 - PMID: 21602918 - PMCID: PMC3094331 - DOI: 10.1371/journal.pone.0018846

Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.

Ng A, Xavier RJ
Autophagy. 2011;7(9):1082-4 - PMID: 21606681 - PMCID: PMC3901792

Zinc-finger nucleases for somatic gene therapy: the next frontier.

Rahman SH, Maeder ML, Joung JK, Cathomen T
Hum Gene Ther. 2011;22(8):925-33 - PMID: 21631241 - PMCID: PMC3159524 - DOI: 10.1089/hum.2011.087

MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.

Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, Mora JR
J Immunol. 2011;187(1):141-50 - PMID: 21646294 - PMCID: PMC3119749 - DOI: 10.4049/jimmunol.1003740

A Francisella tularensis locus required for spermine responsiveness is necessary for virulence.

Russo BC, Horzempa J, O'Dee DM, Schmitt DM, Brown MJ, Carlson PE, Xavier RJ, Nau GJ
Infect Immun. 2011;79(9):3665-76 - PMID: 21670171 - PMCID: PMC3165480 - DOI: 10.1128/IAI.00135-11

Genetics and pathogenesis of inflammatory bowel disease.

Khor B, Gardet A, Xavier RJ
Nature. 2011;474(7351):307-17 - PMID: 21677747 - PMCID: PMC3204665 - DOI: 10.1038/nature10209

Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses.

Pukkila-Worley R, Ausubel FM, Mylonakis E
PLoS Pathog. 2011;7(6):e1002074 - PMID: 21731485 - PMCID: PMC3121877 - DOI: 10.1371/journal.ppat.1002074

Preferential expression of integrin avb8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells.

Païdassi H, Acharya M, Zhang A, Mukhopadhyay S, Kwon M, Chow C, Stuart LM, Savill J, Lacy-Hulbert A
Gastroenterology. 2011;141(5):1813-20 - PMID: 21745448 - PMCID: PMC3202651 - DOI: 10.1053/j.gastro.2011.06.076

HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.

Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S
Atherosclerosis. 2011;217(2):407-14 - PMID: 21762915 - PMCID: PMC3150192 - DOI: 10.1016/j.atherosclerosis.2011.06.031

Considerations for preparedness for a pediatric burn disaster.

Ryan CM, Antoon A, Fagan SP, Goverman J, Lawlor D, Sheridan RL, Tompkins RG
J Burn Care Res. 2011;32(5):e165-6 - PMID: 21772149 - DOI: 10.1097/BCR.0b013e31822ac9a4

Computer aided diagnostic tools aim to empower rather than replace pathologists: Lessons learned from computational chess.

Hipp J, Flotte T, Monaco J, Cheng J, Madabhushi A, Yagi Y, Rodriguez-Canales J, Emmert-Buck M, Dugan MC, Hewitt S, Toner M, Tompkins RG, Lucas D, Gilbertson JR, Balis UJ
J Pathol Inform. 2011;2:25 - PMID: 21773056 - PMCID: PMC3132993 - DOI: 10.4103/2153-3539.82050

Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response.

Hill MN, McLaughlin RJ, Pan B, Fitzgerald ML, Roberts CJ, Lee TT, Karatsoreos IN, Mackie K, Viau V, Pickel VM, McEwen BS, Liu QS, Gorzalka BB, Hillard CJ
J Neurosci. 2011;31(29):10506-15 - PMID: 21775596 - PMCID: PMC3179266 - DOI: 10.1523/JNEUROSCI.0496-11.2011

GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro.

Tamayo AG, Slater L, Taylor-Parker J, Bharti A, Harrison R, Hung DT, Murphy JR
Mol Microbiol. 2011;81(5):1390-401 - PMID: 21797942 - PMCID: PMC4041151 - DOI: 10.1111/j.1365-2958.2011.07770.x

Evaluation of the antioxidant peptide SS31 for treatment of burn-induced insulin resistance.

Carter EA, Bonab AA, Goverman J, Paul K, Yerxa J, Tompkins RG, Fischman AJ
Int J Mol Med. 2011;28(4):589-94 - PMID: 21805045 - PMCID: PMC4090514 - DOI: 10.3892/ijmm.2011.752

Patterns of medication administration from 2001 to 2009 in the treatment of children with acute burn injuries: a multicenter study.

Stoddard FJ, White GW, Kazis LE, Murphy JM, Sorrentino EA, Hinson M, Kim Stubbs T, Chan G, Sheridan RL, Palmieri T, Kagan R, Herndon D, Tompkins RG
J Burn Care Res. 2011;32(5):519-28 - PMID: 21811176 - DOI: 10.1097/BCR.0b013e31822bef92

Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library.

Lee J, Hirsh AS, Wittner BS, Maeder ML, Singavarapu R, Lang M, Janarthanan S, McDermott U, Yajnik V, Ramaswamy S, Joung JK, Sgroi DC
PLoS One. 2011;6(7):e21112 - PMID: 21818254 - PMCID: PMC3139592 - DOI: 10.1371/journal.pone.0021112

Targeted gene disruption in somatic zebrafish cells using engineered TALENs.

Sander JD, Cade L, Khayter C, Reyon D, Peterson RT, Joung JK, Yeh JR
Nat Biotechnol. 2011;29(8):697-8 - PMID: 21822241 - PMCID: PMC3154023 - DOI: 10.1038/nbt.1934

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection.

Pattanayak V, Ramirez CL, Joung JK, Liu DR
Nat Methods. 2011;8(9):765-70 - PMID: 21822273 - PMCID: PMC3164905 - DOI: 10.1038/nmeth.1670

Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity.

Trevino SG, Zhang N, Elenko MP, Lupták A, Szostak JW
Proc Natl Acad Sci U S A. 2011;108(33):13492-7 - PMID: 21825162 - PMCID: PMC3158193 - DOI: 10.1073/pnas.1107113108

Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging.

Tam JM, Castro CE, Heath RJ, Mansour MK, Cardenas ML, Xavier RJ, Lang MJ, Vyas JM
J Vis Exp. 2011;(53):ePub - PMID: 21841755 - PMCID: PMC3197446 - DOI: 10.3791/3123

Acetylcholine ?7 nicotinic and dopamine D(2) receptors are targeted to many of the same postsynaptic dendrites and astrocytes in the rodent prefrontal cortex.

Duffy AM, Fitzgerald ML, Chan J, Robinson DC, Milner TA, Mackie K, Pickel VM
Synapse. 2011;65(12):1350-67 - PMID: 21858872 - PMCID: PMC3356922 - DOI: 10.1002/syn.20977

Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-? production independent of cholesterol efflux activity.

Kim WS, Hill AF, Fitzgerald ML, Freeman MW, Evin G, Garner B
J Alzheimers Dis. 2011;27(2):441-52 - PMID: 21860089 - DOI: 10.3233/JAD-2011-110521

Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.

Yang W, Yamada M, Tamura Y, Chang K, Mao J, Zou L, Feng Y, Kida K, Scherrer-Crosbie M, Chao W, Ichinose F, Yu YM, Fischman AJ, Tompkins RG, Yao S, Kaneki M
J Pharmacol Exp Ther. 2011;339(3):832-41 - PMID: 21873557 - PMCID: PMC3226365 - DOI: 10.1124/jpet.111.183558

In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases.

Sebastiano V, Maeder ML, Angstman JF, Haddad B, Khayter C, Yeo DT, Goodwin MJ, Hawkins JS, Ramirez CL, Batista LF, Artandi SE, Wernig M, Joung JK
Stem Cells. 2011;29(11):1717-26 - PMID: 21898685 - PMCID: PMC3285772 - DOI: 10.1002/stem.718

Association of heat production with 18F-FDG accumulation in murine brown adipose tissue after stress.

Carter EA, Bonab AA, Paul K, Yerxa J, Tompkins RG, Fischman AJ
J Nucl Med. 2011;52(10):1616-20 - PMID: 21914754 - PMCID: PMC4082963 - DOI: 10.2967/jnumed.111.090175

Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.

Lindquist S, Karitkina D, Langnaese K, Posevitz-Fejfar A, Schraven B, Xavier R, Seed B, Lindquist JA
PLoS One. 2011;6(9):e23978 - PMID: 21915273 - PMCID: PMC3167820 - DOI: 10.1371/journal.pone.0023978

Engineering zinc finger nucleases for targeted mutagenesis of zebrafish.

Sander JD, Yeh JR, Peterson RT, Joung JK
Methods Cell Biol. 2011;104:51-8 - PMID: 21924156 - DOI: 10.1016/B978-0-12-374814-0.00003-3

An optimal degree of physical and chemical heterogeneity for the origin of life?

Szostak JW
Philos Trans R Soc Lond B Biol Sci. 2011;366(1580):2894-901 - PMID: 21930580 - PMCID: PMC3158921 - DOI: 10.1098/rstb.2011.0140

Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage.

Warner EA, Kotz KT, Ungaro RF, Abouhamze AS, Lopez MC, Cuenca AG, Kelly-Scumpia KM, Moreno C, O'Malley KA, Lanz JD, Baker HV, Martin LC, Toner M, Tompkins RG, Efron PA, Moldawer LL
Lab Invest. 2011;91(12):1787-95 - PMID: 21931299 - PMCID: PMC3957199 - DOI: 10.1038/labinvest.2011.94

Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study.

Desai KH, Tan CS, Leek JT, Maier RV, Tompkins RG, Storey JD,
PLoS Med. 2011;8(9):e1001093 - PMID: 21931541 - PMCID: PMC3172280 - DOI: 10.1371/journal.pmed.1001093

Novel mitochondria-targeted antioxidant peptide ameliorates burn-induced apoptosis and endoplasmic reticulum stress in the skeletal muscle of mice.

Lee HY, Kaneki M, Andreas J, Tompkins RG, Martyn JA
Shock. 2011;36(6):580-5 - PMID: 21937949 - PMCID: PMC3230221 - DOI: 10.1097/SHK.0b013e3182366872

HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.

Merquiol E, Uzi D, Mueller T, Goldenberg D, Nahmias Y, Xavier RJ, Tirosh B, Shibolet O
PLoS One. 2011;6(9):e24660 - PMID: 21949742 - PMCID: PMC3176279 - DOI: 10.1371/journal.pone.0024660

The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection.

Chand NS, Hung DT
Virulence. 2011;2(6):553-8 - PMID: 21971182 - DOI: 10.4161/viru.2.6.17987

The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.

Hayes GD, Riedel CG, Ruvkun G
Genes Dev. 2011;25(19):2079-92 - PMID: 21979920 - PMCID: PMC3197206 - DOI: 10.1101/gad.17153811

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.

Rivas MA, Beaudoin M, Gardet A, Stevens C, Sharma Y, Zhang CK, Boucher G, Ripke S, Ellinghaus D, Burtt N, Fennell T, Kirby A, Latiano A, Goyette P, Green T, Halfvarson J, Haritunians T, Korn JM, Kuruvilla F, Lagacé C, Neale B, Lo KS, Schumm P, Törkvist L, , , , Dubinsky MC, Brant SR, Silverberg MS, Duerr RH, Altshuler D, Gabriel S, Lettre G, Franke A, D'Amato M, McGovern DP, Cho JH, Rioux JD, Xavier RJ, Daly MJ
Nat Genet. 2011;43(11):1066-73 - PMID: 21983784 - PMCID: PMC3378381 - DOI: 10.1038/ng.952

Engineering designer nucleases with customized cleavage specificities.

Sander JD, Maeder ML, Joung JK
Curr Protoc Mol Biol. 2011;Chapter 12:Unit12.13 - PMID: 21987054 - PMCID: PMC3379964 - DOI: 10.1002/0471142727.mb1213s96

automated DNA sequencing technology.

Slatko BE, Kieleczawa J, Ju J, Gardner AF, Hendrickson CL, Ausubel FM
Curr Protoc Mol Biol. 2011;Chapter 7:Unit7.2 - PMID: 21987057 - DOI: 10.1002/0471142727.mb0702s96

Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model.

Limmer S, Haller S, Drenkard E, Lee J, Yu S, Kocks C, Ausubel FM, Ferrandon D
Proc Natl Acad Sci U S A. 2011;108(42):17378-83 - PMID: 21987808 - PMCID: PMC3198323 - DOI: 10.1073/pnas.1114907108

Regulation of the C. elegans molt by pqn-47.

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Down-regulation of glutatione S-transferase ? 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection.

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CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.

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The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status.

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Resuscitation-promoting factors are required for ?-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis.

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STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells.

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