Publications for All Faculty
Image-based genome-wide siRNA screen identifies selective autophagy factors.
Novel mitochondria-targeted antioxidant peptide ameliorates burn-induced apoptosis and endoplasmic reticulum stress in the skeletal muscle of mice.
Acetylcholine ?7 nicotinic and dopamine D(2) receptors are targeted to many of the same postsynaptic dendrites and astrocytes in the rodent prefrontal cortex.
Bacterial effectors: learning on the fly.
The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status.
A genomic storm in critically injured humans.
Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-? production independent of cholesterol efflux activity.
The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.
CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.
The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection.
In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases.
Ecology drives a global network of gene exchange connecting the human microbiome.
Caspase 8 inhibits programmed necrosis by processing CYLD.
UV-C-irradiated Arabidopsis and tobacco emit volatiles that trigger genomic instability in neighboring plants.
Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.
A high-resolution map of human evolutionary constraint using 29 mammals.
Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model.
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study.
Regulation of the C. elegans molt by pqn-47.
automated DNA sequencing technology.
Engineering designer nucleases with customized cleavage specificities.
The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.
An optimal degree of physical and chemical heterogeneity for the origin of life?
HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.
Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage.
Engineering zinc finger nucleases for targeted mutagenesis of zebrafish.
Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study.
Association of heat production with 18F-FDG accumulation in murine brown adipose tissue after stress.
Patterns of medication administration from 2001 to 2009 in the treatment of children with acute burn injuries: a multicenter study.
Considerations for preparedness for a pediatric burn disaster.
Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.
The Glue Grant experience: characterizing the post injury genomic response.
Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.
Stress-responsive mitogen-activated protein kinases interact with the EAR motif of a poplar zinc finger protein and mediate its degradation through the 26S proteasome.
Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.
Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity.
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection.
Targeted gene disruption in somatic zebrafish cells using engineered TALENs.
GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro.
Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging.
Zinc-finger nucleases for somatic gene therapy: the next frontier.
Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library.
Evaluation of the antioxidant peptide SS31 for treatment of burn-induced insulin resistance.
Targeting Innate Immunity for CV Benefit.
Preferential expression of integrin avb8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells.
Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response.
Protein kinase signaling networks in plant innate immunity.
HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.
Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses.
C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Genetics and pathogenesis of inflammatory bowel disease.
Computer aided diagnostic tools aim to empower rather than replace pathologists: Lessons learned from computational chess.
A Francisella tularensis locus required for spermine responsiveness is necessary for virulence.
MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.
The path from bench to bedside: considerations before starting the journey.
The Arabidopsis flagellin receptor FLS2 mediates the perception of Xanthomonas Ax21 secreted peptides.
Recurrent chromosomal copy number alterations in sporadic chordomas.
Effects of burn injury, cold stress and cutaneous wound injury on the morphology and energy metabolism of murine brown adipose tissue (BAT) in vivo.
Artificial lantipeptides from in vitro translations.
The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection.
Stem-cell-triggered immunity through CLV3p-FLS2 signalling.
Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.
Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases.
Crohn disease: a current perspective on genetics, autophagy and immunity.
Decreased parvalbumin immunoreactivity in the cortex and striatum of mice lacking the CB1 receptor.
Physical effects underlying the transition from primitive to modern cell membranes.
Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation.
Isolation and long-term maintenance of adult rat hepatocytes in culture.
Spatially Invariant Vector Quantization: A pattern matching algorithm for multiple classes of image subject matter including pathology.
Embryonal Stem (ES) Cell-Derived Macrophages : A Cellular System that Facilitates the Genetic Dissection of Macrophage Function.
Human transcriptome array for high-throughput clinical studies.
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Effects of glucagon-like peptide 1 on glycemia control and its metabolic consequence after severe thermal injury--studies in an animal model.
Microfluidics for T- lymphocyte cell separation and inflammation monitoring in burn patients.
Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.
ZFNGenome: a comprehensive resource for locating zinc finger nuclease target sites in model organisms.
A high throughput amenable Arabidopsis-P. aeruginosa system reveals a rewired regulatory module and the utility to identify potent anti-infectives.
mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.
RNAi screening for fat regulatory genes with SRS microscopy.
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.
Early enteral nutrition in burns: compliance with guidelines and associated outcomes in a multicenter study.
EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA).
Simvastatin treatment improves survival in a murine model of burn sepsis: Role of interleukin 6.
Mining the plant-herbivore interface with a leafmining Drosophila of Arabidopsis.
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.
Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.
