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Orvedahl A, Sumpter R, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier RJ, Xie Y, Levine B

Image-based genome-wide siRNA screen identifies selective autophagy factors.
Nature. 2011;480(7375):113-7 - PMID: 22020285 - PMCID: PMC3229641 - DOI: 10.1038/nature10546

Duffy AM, Fitzgerald ML, Chan J, Robinson DC, Milner TA, Mackie K, Pickel VM

Acetylcholine ?7 nicotinic and dopamine D(2) receptors are targeted to many of the same postsynaptic dendrites and astrocytes in the rodent prefrontal cortex.
Synapse. 2011;65(12):1350-67 - PMID: 21858872 - PMCID: PMC3356922 - DOI: 10.1002/syn.20977

Lee HY, Kaneki M, Andreas J, Tompkins RG, Martyn JA

Novel mitochondria-targeted antioxidant peptide ameliorates burn-induced apoptosis and endoplasmic reticulum stress in the skeletal muscle of mice.
Shock. 2011;36(6):580-5 - PMID: 21937949 - PMCID: PMC3230221 - DOI: 10.1097/SHK.0b013e3182366872

Boyer L, Paquette N, Silverman N, Stuart LM

Bacterial effectors: learning on the fly.
Adv Exp Med Biol. 2011;710:29-36 - PMID: 22127883 - PMCID: PMC3427734 - DOI: 10.1007/978-1-4419-5638-5_4

Kimura KD, Riddle DL, Ruvkun G

The C. elegans DAF-2 Insulin-Like Receptor is Abundantly Expressed in the Nervous System and Regulated by Nutritional Status.
Cold Spring Harb Symp Quant Biol. 2011;76:113-20 - PMID: 22123849 - DOI: 10.1101/sqb.2011.76.010660

Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, Hayden DL, Hennessy L, Moore EE, Minei JP, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Brownstein BH, Mason PH, Baker HV, Finnerty CC, Jeschke MG, López MC, Klein MB, Gamelli RL, Gibran NS, Arnoldo B, Xu W, Zhang Y, Calvano SE, McDonald-Smith GP, Schoenfeld DA, Storey JD, Cobb JP, Warren HS, Moldawer LL, Herndon DN, Lowry SF, Maier RV, Davis RW, Tompkins RG,

A genomic storm in critically injured humans.
J Exp Med. 2011;208(13):2581-90 - PMID: 22110166 - PMCID: PMC3244029 - DOI: 10.1084/jem.20111354

Kim WS, Hill AF, Fitzgerald ML, Freeman MW, Evin G, Garner B

Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-? production independent of cholesterol efflux activity.
J Alzheimers Dis. 2011;27(2):441-52 - PMID: 21860089 - DOI: 10.3233/JAD-2011-110521

Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G

The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.
PLoS Genet. 2011;7(11):e1002369 - PMID: 22102828 - PMCID: PMC3213143 - DOI: 10.1371/journal.pgen.1002369

Ramadas RA, Roche MI, Moon JJ, Ludwig T, Xavier RJ, Medoff BD

CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.
J Immunol. 2011;187(12):6197-207 - PMID: 22075698 - PMCID: PMC3237896 - DOI: 10.4049/jimmunol.1101348

Sebastiano V, Maeder ML, Angstman JF, Haddad B, Khayter C, Yeo DT, Goodwin MJ, Hawkins JS, Ramirez CL, Batista LF, Artandi SE, Wernig M, Joung JK

In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases.
Stem Cells. 2011;29(11):1717-26 - PMID: 21898685 - PMCID: PMC3285772 - DOI: 10.1002/stem.718

Chand NS, Hung DT

The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection.
Virulence. 2011;2(6):553-8 - PMID: 21971182 - DOI: 10.4161/viru.2.6.17987

Smillie CS, Smith MB, Friedman J, Cordero OX, David LA, Alm EJ

Ecology drives a global network of gene exchange connecting the human microbiome.
Nature. 2011;480(7376):241-4 - PMID: 22037308 - DOI: 10.1038/nature10571

O'Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, Ting AT

Caspase 8 inhibits programmed necrosis by processing CYLD.
Nat Cell Biol. 2011;13(12):1437-42 - PMID: 22037414 - PMCID: PMC3229661 - DOI: 10.1038/ncb2362

Yao Y, Danna CH, Zemp FJ, Titov V, Ciftci ON, Przybylski R, Ausubel FM, Kovalchuk I

UV-C-irradiated Arabidopsis and tobacco emit volatiles that trigger genomic instability in neighboring plants.
Plant Cell. 2011;23(10):3842-52 - PMID: 22028460 - PMCID: PMC3229153 - DOI: 10.1105/tpc.111.089003

Boyer L, Magoc L, Dejardin S, Cappillino M, Paquette N, Hinault C, Charriere GM, Ip WK, Fracchia S, Hennessy E, Erturk-Hasdemir D, Reichhart JM, Silverman N, Lacy-Hulbert A, Stuart LM

Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.
Immunity. 2011;35(4):536-49 - PMID: 22018470 - PMCID: PMC3258503 - DOI: 10.1016/j.immuni.2011.08.015

Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, Washietl S, Kheradpour P, Ernst J, Jordan G, Mauceli E, Ward LD, Lowe CB, Holloway AK, Clamp M, Gnerre S, Alföldi J, Beal K, Chang J, Clawson H, Cuff J, Di Palma F, Fitzgerald S, Flicek P, Guttman M, Hubisz MJ, Jaffe DB, Jungreis I, Kent WJ, Kostka D, Lara M, Martins AL, Massingham T, Moltke I, Raney BJ, Rasmussen MD, Robinson J, Stark A, Vilella AJ, Wen J, Xie X, Zody MC; Broad Institute Sequencing Platform and Whole Genome Assembly Team, Baldwin J, Bloom T, Chin CW, Heiman D, Nicol R, Nusbaum C, Young S, Wilkinson J, Worley KC, Kovar CL, Muzny DM, Gibbs RA; Baylor College of Medicine Human Genome Sequencing Center Sequencing Team, Cree A, Dihn HH, Fowler G, Jhangiani S, Joshi V, Lee S, Lewis LR, Nazareth LV, Okwuonu G, Santibanez J, Warren WC, Mardis ER, Weinstock GM, Wilson RK; Genome Institute at Washington University, Delehaunty K, Dooling D, Fronik C, Fulton L, Fulton B, Graves T, Minx P, Sodergren E, Birney E, Margulies EH, Herrero J, Green ED, Haussler D, Siepel A, Goldman N, Pollard KS, Pedersen JS, Lander ES, Kellis M

A high-resolution map of human evolutionary constraint using 29 mammals.
Nature. 2011;478(7370):476-82 - PMID: 21993624 - PMCID: PMC3207357 - DOI: 10.1038/nature10530

Limmer S, Haller S, Drenkard E, Lee J, Yu S, Kocks C, Ausubel FM, Ferrandon D

Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model.
Proc Natl Acad Sci U S A. 2011;108(42):17378-83 - PMID: 21987808 - PMCID: PMC3198323 - DOI: 10.1073/pnas.1114907108

Rivas MA, Beaudoin M, Gardet A, Stevens C, Sharma Y, Zhang CK, Boucher G, Ripke S, Ellinghaus D, Burtt N, Fennell T, Kirby A, Latiano A, Goyette P, Green T, Halfvarson J, Haritunians T, Korn JM, Kuruvilla F, Lagacé C, Neale B, Lo KS, Schumm P, Törkvist L, , , , Dubinsky MC, Brant SR, Silverberg MS, Duerr RH, Altshuler D, Gabriel S, Lettre G, Franke A, D'Amato M, McGovern DP, Cho JH, Rioux JD, Xavier RJ, Daly MJ

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Nat Genet. 2011;43(11):1066-73 - PMID: 21983784 - PMCID: PMC3378381 - DOI: 10.1038/ng.952

Hayes GD, Riedel CG, Ruvkun G

The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.
Genes Dev. 2011;25(19):2079-92 - PMID: 21979920 - PMCID: PMC3197206 - DOI: 10.1101/gad.17153811

Zeitels SM, Barbu AM, Landau-Zemer T, Lopez-Guerra G, Burns JA, Friedman AD, Freeman MW, Halvorsen YD, Hillman RE

Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study.
Ann Otol Rhinol Laryngol. 2011;120(10):627-34 - PMID: 22097147 - DOI: 10.1177/000348941112001001

Russel S, Frand AR, Ruvkun G

Regulation of the C. elegans molt by pqn-47.
Dev Biol. 2011;360(2):297-309 - PMID: 21989027 - PMCID: PMC3618673 - DOI: 10.1016/j.ydbio.2011.09.025

Szostak JW

An optimal degree of physical and chemical heterogeneity for the origin of life?
Philos Trans R Soc Lond B Biol Sci. 2011;366(1580):2894-901 - PMID: 21930580 - PMCID: PMC3158921 - DOI: 10.1098/rstb.2011.0140

Sander JD, Maeder ML, Joung JK

Engineering designer nucleases with customized cleavage specificities.
Curr Protoc Mol Biol. 2011;Chapter 12:Unit12.13 - PMID: 21987054 - PMCID: PMC3379964 - DOI: 10.1002/0471142727.mb1213s96

Slatko BE, Kieleczawa J, Ju J, Gardner AF, Hendrickson CL, Ausubel FM

automated DNA sequencing technology.
Curr Protoc Mol Biol. 2011;Chapter 7:Unit7.2 - PMID: 21987057 - DOI: 10.1002/0471142727.mb0702s96

Sander JD, Yeh JR, Peterson RT, Joung JK

Engineering zinc finger nucleases for targeted mutagenesis of zebrafish.
Methods Cell Biol. 2011;104:51-8 - PMID: 21924156 - DOI: 10.1016/B978-0-12-374814-0.00003-3

Warner EA, Kotz KT, Ungaro RF, Abouhamze AS, Lopez MC, Cuenca AG, Kelly-Scumpia KM, Moreno C, O'Malley KA, Lanz JD, Baker HV, Martin LC, Toner M, Tompkins RG, Efron PA, Moldawer LL

Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage.
Lab Invest. 2011;91(12):1787-95 - PMID: 21931299 - PMCID: PMC3957199 - DOI: 10.1038/labinvest.2011.94

Merquiol E, Uzi D, Mueller T, Goldenberg D, Nahmias Y, Xavier RJ, Tirosh B, Shibolet O

HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.
PLoS One. 2011;6(9):e24660 - PMID: 21949742 - PMCID: PMC3176279 - DOI: 10.1371/journal.pone.0024660

Carter EA, Bonab AA, Paul K, Yerxa J, Tompkins RG, Fischman AJ

Association of heat production with 18F-FDG accumulation in murine brown adipose tissue after stress.
J Nucl Med. 2011;52(10):1616-20 - PMID: 21914754 - PMCID: PMC4082963 - DOI: 10.2967/jnumed.111.090175

Desai KH, Tan CS, Leek JT, Maier RV, Tompkins RG, Storey JD,

Dissecting inflammatory complications in critically injured patients by within-patient gene expression changes: a longitudinal clinical genomics study.
PLoS Med. 2011;8(9):e1001093 - PMID: 21931541 - PMCID: PMC3172280 - DOI: 10.1371/journal.pmed.1001093

Ryan CM, Antoon A, Fagan SP, Goverman J, Lawlor D, Sheridan RL, Tompkins RG

Considerations for preparedness for a pediatric burn disaster.
J Burn Care Res. 2011;32(5):e165-6 - PMID: 21772149 - DOI: 10.1097/BCR.0b013e31822ac9a4

Stoddard FJ, White GW, Kazis LE, Murphy JM, Sorrentino EA, Hinson M, Kim Stubbs T, Chan G, Sheridan RL, Palmieri T, Kagan R, Herndon D, Tompkins RG

Patterns of medication administration from 2001 to 2009 in the treatment of children with acute burn injuries: a multicenter study.
J Burn Care Res. 2011;32(5):519-28 - PMID: 21811176 - DOI: 10.1097/BCR.0b013e31822bef92

Lindquist S, Karitkina D, Langnaese K, Posevitz-Fejfar A, Schraven B, Xavier R, Seed B, Lindquist JA

Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.
PLoS One. 2011;6(9):e23978 - PMID: 21915273 - PMCID: PMC3167820 - DOI: 10.1371/journal.pone.0023978

Cuenca AG, Maier RV, Cuschieri J, Moore EE, Moldawer LL, Tompkins RG,

The Glue Grant experience: characterizing the post injury genomic response.
Eur J Trauma Emerg Surg. 2011;37(6):549-58 - PMID: 26815465 - PMCID: PMC6541206 - DOI: 10.1007/s00068-011-0148-8

Ng A, Xavier RJ

Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.
Autophagy. 2011;7(9):1082-4 - PMID: 21606681 - PMCID: PMC3901792 - DOI: 10.4161/auto.7.9.16464

Yang W, Yamada M, Tamura Y, Chang K, Mao J, Zou L, Feng Y, Kida K, Scherrer-Crosbie M, Chao W, Ichinose F, Yu YM, Fischman AJ, Tompkins RG, Yao S, Kaneki M

Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.
J Pharmacol Exp Ther. 2011;339(3):832-41 - PMID: 21873557 - PMCID: PMC3226365 - DOI: 10.1124/jpet.111.183558

Hamel LP, Benchabane M, Nicole MC, Major IT, Morency MJ, Pelletier G, Beaudoin N, Sheen J, Séguin A

Stress-responsive mitogen-activated protein kinases interact with the EAR motif of a poplar zinc finger protein and mediate its degradation through the 26S proteasome.
Plant Physiol. 2011;157(3):1379-93 - PMID: 21873571 - PMCID: PMC3252155 - DOI: 10.1104/pp.111.178343

Trevino SG, Zhang N, Elenko MP, Lupták A, Szostak JW

Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity.
Proc Natl Acad Sci U S A. 2011;108(33):13492-7 - PMID: 21825162 - PMCID: PMC3158193 - DOI: 10.1073/pnas.1107113108

Pattanayak V, Ramirez CL, Joung JK, Liu DR

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection.
Nat Methods. 2011;8(9):765-70 - PMID: 21822273 - PMCID: PMC3164905 - DOI: 10.1038/nmeth.1670

Sander JD, Cade L, Khayter C, Reyon D, Peterson RT, Joung JK, Yeh JR

Targeted gene disruption in somatic zebrafish cells using engineered TALENs.
Nat Biotechnol. 2011;29(8):697-8 - PMID: 21822241 - PMCID: PMC3154023 - DOI: 10.1038/nbt.1934

Tamayo AG, Slater L, Taylor-Parker J, Bharti A, Harrison R, Hung DT, Murphy JR

GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro.
Mol Microbiol. 2011;81(5):1390-401 - PMID: 21797942 - PMCID: PMC4041151 - DOI: 10.1111/j.1365-2958.2011.07770.x

Tam JM, Castro CE, Heath RJ, Mansour MK, Cardenas ML, Xavier RJ, Lang MJ, Vyas JM

Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging.
J Vis Exp. 2011;(53):ePub - PMID: 21841755 - PMCID: PMC3197446 - DOI: 10.3791/3123

Rahman SH, Maeder ML, Joung JK, Cathomen T

Zinc-finger nucleases for somatic gene therapy: the next frontier.
Hum Gene Ther. 2011;22(8):925-33 - PMID: 21631241 - PMCID: PMC3159524 - DOI: 10.1089/hum.2011.087

Lee J, Hirsh AS, Wittner BS, Maeder ML, Singavarapu R, Lang M, Janarthanan S, McDermott U, Yajnik V, Ramaswamy S, Joung JK, Sgroi DC

Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library.
PLoS One. 2011;6(7):e21112 - PMID: 21818254 - PMCID: PMC3139592 - DOI: 10.1371/journal.pone.0021112

Carter EA, Bonab AA, Goverman J, Paul K, Yerxa J, Tompkins RG, Fischman AJ

Evaluation of the antioxidant peptide SS31 for treatment of burn-induced insulin resistance.
Int J Mol Med. 2011;28(4):589-94 - PMID: 21805045 - PMCID: PMC4090514 - DOI: 10.3892/ijmm.2011.752

Moore KJ, Freeman MW

Targeting Innate Immunity for CV Benefit.
Drug Discov Today Ther Strateg. 2011;5(1):15-23 - PMID: 19430537 - PMCID: PMC2678718 - DOI: 10.1016/j.ddstr.2008.05.007

Païdassi H, Acharya M, Zhang A, Mukhopadhyay S, Kwon M, Chow C, Stuart LM, Savill J, Lacy-Hulbert A

Preferential expression of integrin avb8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells.
Gastroenterology. 2011;141(5):1813-20 - PMID: 21745448 - PMCID: PMC3202651 - DOI: 10.1053/j.gastro.2011.06.076

Hill MN, McLaughlin RJ, Pan B, Fitzgerald ML, Roberts CJ, Lee TT, Karatsoreos IN, Mackie K, Viau V, Pickel VM, McEwen BS, Liu QS, Gorzalka BB, Hillard CJ

Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response.
J Neurosci. 2011;31(29):10506-15 - PMID: 21775596 - PMCID: PMC3179266 - DOI: 10.1523/JNEUROSCI.0496-11.2011

Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S

HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.
Atherosclerosis. 2011;217(2):407-14 - PMID: 21762915 - PMCID: PMC3150192 - DOI: 10.1016/j.atherosclerosis.2011.06.031

Pukkila-Worley R, Ausubel FM, Mylonakis E

Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses.
PLoS Pathog. 2011;7(6):e1002074 - PMID: 21731485 - PMCID: PMC3121877 - DOI: 10.1371/journal.ppat.1002074

Tena G, Boudsocq M, Sheen J

Protein kinase signaling networks in plant innate immunity.
Curr Opin Plant Biol. 2011;14(5):519-29 - PMID: 21704551 - PMCID: PMC3191242 - DOI: 10.1016/j.pbi.2011.05.006

Xu B, Feng Y, Cheng H, Song Y, Lv B, Wu Y, Wang C, Li S, Xu M, Du J, Peng K, Dong J, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Roberge JY, Seed B, Chen Y

C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Bioorg Med Chem Lett. 2011;21(15):4465-70 - PMID: 21737266 - DOI: 10.1016/j.bmcl.2011.06.032

Khor B, Gardet A, Xavier RJ

Genetics and pathogenesis of inflammatory bowel disease.
Nature. 2011;474(7351):307-17 - PMID: 21677747 - PMCID: PMC3204665 - DOI: 10.1038/nature10209

Hipp J, Flotte T, Monaco J, Cheng J, Madabhushi A, Yagi Y, Rodriguez-Canales J, Emmert-Buck M, Dugan MC, Hewitt S, Toner M, Tompkins RG, Lucas D, Gilbertson JR, Balis UJ

Computer aided diagnostic tools aim to empower rather than replace pathologists: Lessons learned from computational chess.
J Pathol Inform. 2011;2:25 - PMID: 21773056 - PMCID: PMC3132993 - DOI: 10.4103/2153-3539.82050

Russo BC, Horzempa J, O'Dee DM, Schmitt DM, Brown MJ, Carlson PE, Xavier RJ, Nau GJ

A Francisella tularensis locus required for spermine responsiveness is necessary for virulence.
Infect Immun. 2011;79(9):3665-76 - PMID: 21670171 - PMCID: PMC3165480 - DOI: 10.1128/IAI.00135-11

Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, Mora JR

MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.
J Immunol. 2011;187(1):141-50 - PMID: 21646294 - PMCID: PMC3119749 - DOI: 10.4049/jimmunol.1003740

Freeman MW, Dervan AP

The path from bench to bedside: considerations before starting the journey.
J Investig Med. 2011;59(5):746-51 - PMID: 21441830 - PMCID: PMC4255460 - DOI: 10.2310/JIM.0b013e3182160d70

Danna CH, Millet YA, Koller T, Han SW, Bent AF, Ronald PC, Ausubel FM

The Arabidopsis flagellin receptor FLS2 mediates the perception of Xanthomonas Ax21 secreted peptides.
Proc Natl Acad Sci U S A. 2011;108(22):9286-91 - PMID: 21576467 - PMCID: PMC3107323 - DOI: 10.1073/pnas.1106366108

Le LP, Nielsen GP, Rosenberg AE, Thomas D, Batten JM, Deshpande V, Schwab J, Duan Z, Xavier RJ, Hornicek FJ, Iafrate AJ

Recurrent chromosomal copy number alterations in sporadic chordomas.
PLoS One. 2011;6(5):e18846 - PMID: 21602918 - PMCID: PMC3094331 - DOI: 10.1371/journal.pone.0018846

Carter EA, Bonab AA, Hamrahi V, Pitman J, Winter D, Macintosh LJ, Cyr EM, Paul K, Yerxa J, Jung W, Tompkins RG, Fischman AJ

Effects of burn injury, cold stress and cutaneous wound injury on the morphology and energy metabolism of murine brown adipose tissue (BAT) in vivo.
Life Sci. 2011;89(3-4):78-85 - PMID: 21565200 - PMCID: PMC4081480 - DOI: 10.1016/j.lfs.2011.04.014

Seebeck FP, Ricardo A, Szostak JW

Artificial lantipeptides from in vitro translations.
Chem Commun (Camb). 2011;47(21):6141-3 - PMID: 21528125 - DOI: 10.1039/c0cc05663d

Chand NS, Lee JS, Clatworthy AE, Golas AJ, Smith RS, Hung DT

The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection.
J Bacteriol. 2011;193(12):2989-99 - PMID: 21515773 - PMCID: PMC3133189 - DOI: 10.1128/JB.01546-10

Lee H, Chah OK, Sheen J

Stem-cell-triggered immunity through CLV3p-FLS2 signalling.
Nature. 2011;473(7347):376-9 - PMID: 21499263 - PMCID: PMC3098311 - DOI: 10.1038/nature09958

Heath RJ, Leong JM, Visegrády B, Machesky LM, Xavier RJ

Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.
PLoS Pathog. 2011;7(4):e1001332 - PMID: 21490959 - PMCID: PMC3072376 - DOI: 10.1371/journal.ppat.1001332

Curtin SJ, Zhang F, Sander JD, Haun WJ, Starker C, Baltes NJ, Reyon D, Dahlborg EJ, Goodwin MJ, Coffman AP, Dobbs D, Joung JK, Voytas DF, Stupar RM

Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases.
Plant Physiol. 2011;156(2):466-73 - PMID: 21464476 - PMCID: PMC3177250 - DOI: 10.1104/pp.111.172981

Stappenbeck TS, Rioux JD, Mizoguchi A, Saitoh T, Huett A, Darfeuille-Michaud A, Wileman T, Mizushima N, Carding S, Akira S, Parkes M, Xavier RJ

Crohn disease: a current perspective on genetics, autophagy and immunity.
Autophagy. 2011;7(4):355-74 - PMID: 20729636 - PMCID: PMC3842289 - DOI: 10.4161/auto.7.2.13074

Fitzgerald ML, Lupica CR, Pickel VM

Decreased parvalbumin immunoreactivity in the cortex and striatum of mice lacking the CB1 receptor.
Synapse. 2011;65(8):827-31 - PMID: 21445945 - PMCID: PMC3107909 - DOI: 10.1002/syn.20911

Budin I, Szostak JW

Physical effects underlying the transition from primitive to modern cell membranes.
Proc Natl Acad Sci U S A. 2011;108(13):5249-54 - PMID: 21402937 - PMCID: PMC3069173 - DOI: 10.1073/pnas.1100498108

Subtelny AO, Hartman MC, Szostak JW

Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation.
Angew Chem Int Ed Engl. 2011;50(14):3164-7 - PMID: 21381166 - PMCID: PMC4006073 - DOI: 10.1002/anie.201007686

Berthiaume F, Tompkins RG, Yarmush ML

Isolation and long-term maintenance of adult rat hepatocytes in culture.
Methods Mol Med. 2011;18:447-56 - PMID: 21370195 - DOI: 10.1385/0-89603-516-6:447

Hipp JD, Cheng JY, Toner M, Tompkins RG, Balis UJ

Spatially Invariant Vector Quantization: A pattern matching algorithm for multiple classes of image subject matter including pathology.
J Pathol Inform. 2011;2:13 - PMID: 21383936 - PMCID: PMC3049270 - DOI: 10.4103/2153-3539.77175

Moore KJ, Freeman MW

Embryonal Stem (ES) Cell-Derived Macrophages : A Cellular System that Facilitates the Genetic Dissection of Macrophage Function.
Methods Mol Med. 2011;30:343-55 - PMID: 21341038 - DOI: 10.1385/1-59259-247-3:343

Xu W, Seok J, Mindrinos MN, Schweitzer AC, Jiang H, Wilhelmy J, Clark TA, Kapur K, Xing Y, Faham M, Storey JD, Moldawer LL, Maier RV, Tompkins RG, Wong WH, Davis RW, Xiao W,

Human transcriptome array for high-throughput clinical studies.
Proc Natl Acad Sci U S A. 2011;108(9):3707-12 - PMID: 21317363 - PMCID: PMC3048146 - DOI: 10.1073/pnas.1019753108

Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Nat Genet. 2011;43(3):246-52 - PMID: 21297633 - PMCID: PMC3084597 - DOI: 10.1038/ng.764

Shen CA, Fagan S, Fischman AJ, Carter EE, Chai JK, Lu XM, Yu YM, Tompkins RG

Effects of glucagon-like peptide 1 on glycemia control and its metabolic consequence after severe thermal injury--studies in an animal model.
Surgery. 2011;149(5):635-44 - PMID: 21295809 - PMCID: PMC3079016 - DOI: 10.1016/j.surg.2010.11.017

Rosenbach AE, Koria P, Goverman J, Kotz KT, Gupta A, Yu M, Fagan SP, Irimia D, Tompkins RG

Microfluidics for T- lymphocyte cell separation and inflammation monitoring in burn patients.
Clin Transl Sci. 2011;4(1):63-8 - PMID: 21348958 - PMCID: PMC3057059 - DOI: 10.1111/j.1752-8062.2010.00255.x

Gomez JE, Clatworthy A, Hung DT

Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.
Crit Rev Biochem Mol Biol. 2011;46(1):41-66 - PMID: 21250782 - DOI: 10.3109/10409238.2010.538663

Reyon D, Kirkpatrick JR, Sander JD, Zhang F, Voytas DF, Joung JK, Dobbs D, Coffman CR

ZFNGenome: a comprehensive resource for locating zinc finger nuclease target sites in model organisms.
BMC Genomics. 2011;12:83 - PMID: 21276248 - PMCID: PMC3042413 - DOI: 10.1186/1471-2164-12-83

Gopalan S, Ausubel FM

A high throughput amenable Arabidopsis-P. aeruginosa system reveals a rewired regulatory module and the utility to identify potent anti-infectives.
PLoS One. 2011;6(1):e16381 - PMID: 21283656 - PMCID: PMC3025032 - DOI: 10.1371/journal.pone.0016381

Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G

mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.
Proc Natl Acad Sci U S A. 2011;108(4):1201-8 - PMID: 21245313 - PMCID: PMC3029761 - DOI: 10.1073/pnas.1018695108

Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS

RNAi screening for fat regulatory genes with SRS microscopy.
Nat Methods. 2011;8(2):135-8 - PMID: 21240281 - PMCID: PMC3061290 - DOI: 10.1038/nmeth.1556

Rossin EJ, Lage K, Raychaudhuri S, Xavier RJ, Tatar D, Benita Y, , Cotsapas C, Daly MJ

Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.
PLoS Genet. 2011;7(1):e1001273 - PMID: 21249183 - PMCID: PMC3020935 - DOI: 10.1371/journal.pgen.1001273

Mosier MJ, Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Tompkins RG, Herndon DN

Early enteral nutrition in burns: compliance with guidelines and associated outcomes in a multicenter study.
J Burn Care Res. 2011;32(1):104-9 - PMID: 21116188 - PMCID: PMC3850279 - DOI: 10.1097/BCR.0b013e318204b3be

Zhang W, Welihinda A, Mechanic J, Ding H, Zhu L, Lu Y, Deng Z, Sheng Z, Lv B, Chen Y, Roberge JY, Seed B, Wang YX

EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.
Pharmacol Res. 2011;63(4):284-93 - PMID: 21215314 - DOI: 10.1016/j.phrs.2011.01.001

Sander JD, Dahlborg EJ, Goodwin MJ, Cade L, Zhang F, Cifuentes D, Curtin SJ, Blackburn JS, Thibodeau-Beganny S, Qi Y, Pierick CJ, Hoffman E, Maeder ML, Khayter C, Reyon D, Dobbs D, Langenau DM, Stupar RM, Giraldez AJ, Voytas DF, Peterson RT, Yeh JR, Joung JK

Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA).
Nat Methods. 2011;8(1):67-9 - PMID: 21151135 - PMCID: PMC3018472 - DOI: 10.1038/nmeth.1542

Beffa DC, Fischman AJ, Fagan SP, Hamrahi VF, Paul KW, Kaneki M, Yu YM, Tompkins RG, Carter EA

Simvastatin treatment improves survival in a murine model of burn sepsis: Role of interleukin 6.
Burns. 2011;37(2):222-6 - PMID: 21145172 - PMCID: PMC4085785 - DOI: 10.1016/j.burns.2010.10.010

Whiteman NK, Groen SC, Chevasco D, Bear A, Beckwith N, Gregory TR, Denoux C, Mammarella N, Ausubel FM, Pierce NE

Mining the plant-herbivore interface with a leafmining Drosophila of Arabidopsis.
Mol Ecol. 2011;20(5):995-1014 - PMID: 21073583 - PMCID: PMC3062943 - DOI: 10.1111/j.1365-294X.2010.04901.x

Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, MacDonald JA, Beck PL

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.
Inflamm Bowel Dis. 2011;17(6):1359-72 - PMID: 20872834 - PMCID: PMC3026862 - DOI: 10.1002/ibd.21478

Ng AC, Eisenberg JM, Heath RJ, Huett A, Robinson CM, Nau GJ, Xavier RJ

Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.
Proc Natl Acad Sci U S A. 2011;108 Suppl 1:4631-8 - PMID: 20616063 - PMCID: PMC3063585 - DOI: 10.1073/pnas.1000093107
Total: 88