Publications for All Faculty - 2010

ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

Xu B, Feng Y, Lv B, Xu G, Zhang L, Du J, Peng K, Xu M, Dong J, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Seed B, Chen Y
Bioorg Med Chem. 2010;18(12):4422-32 - PMID: 20576578 - DOI: 10.1016/j.bmc.2010.04.088

Conformationally constrained spiro C-arylglucosides as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

Lv B, Feng Y, Dong J, Xu M, Xu B, Zhang W, Sheng Z, Welihinda A, Seed B, Chen Y
ChemMedChem. 2010;5(6):827-31 - PMID: 20414917 - DOI: 10.1002/cmdc.201000051

Lipoprotein Metabolism and the Treatment of Lipid Disorders, Chapter 42. In: DeGroot LJ and JL Jameson, eds

MW Freeman
Endocrinology, 6th edition. 2010;:ePub

Analysis of high-throughput sequencing and annotation strategies for phage genomes.

Henn MR, Sullivan MB, Stange-Thomann N, Osburne MS, Berlin AM, Kelly L, Yandava C, Kodira C, Zeng Q, Weiand M, Sparrow T, Saif S, Giannoukos G, Young SK, Nusbaum C, Birren BW, Chisholm SW
PLoS One. 2010;5(2):e9083 - PMID: 20140207 - PMCID: PMC2816706 - DOI: 10.1371/journal.pone.0009083

Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression.

Duan Z, Choy E, Nielsen GP, Rosenberg A, Iafrate J, Yang C, Schwab J, Mankin H, Xavier R, Hornicek FJ
J Orthop Res. 2010;28(6):746-52 - PMID: 20041488 - DOI: 10.1002/jor.21055

Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.

Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, Head RD, Xavier R, Stappenbeck TS, Virgin HW
Cell. 2010;141(7):1135-45 - PMID: 20602997 - PMCID: PMC2908380 - DOI: 10.1016/j.cell.2010.05.009

Differential innate immune signalling via Ca(2+) sensor protein kinases.

Boudsocq M, Willmann MR, McCormack M, Lee H, Shan L, He P, Bush J, Cheng SH, Sheen J
Nature. 2010;464(7287):418-22 - PMID: 20164835 - PMCID: PMC2841715 - DOI: 10.1038/nature08794

Protocol: a rapid and economical procedure for purification of plasmid or plant DNA with diverse applications in plant biology.

Li JF, Li L, Sheen J
Plant Methods. 2010;6(1):1 - PMID: 20180960 - PMCID: PMC2829548 - DOI: 10.1186/1746-4811-6-1

Discover and connect cellular signaling.

Sheen J
Plant Physiol. 2010;154(2):562-6 - PMID: 20921185 - PMCID: PMC2949017 - DOI: 10.1104/pp.110.161364

Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases.

Huett A, Xavier RJ
Inflamm Bowel Dis. 2010;16(1):152-74 - PMID: 19575363 - PMCID: PMC3954538 - DOI: 10.1002/ibd.20991

Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates.

Irazoqui JE, Urbach JM, Ausubel FM
Nat Rev Immunol. 2010;10(1):47-58 - PMID: 20029447 - PMCID: PMC2965059 - DOI: 10.1038/nri2689

Fluorosomes: a convenient new reagent to detect and block multivalent and complex receptor-ligand interactions.

Kueng HJ, Manta C, Haiderer D, Leb VM, Schmetterer KG, Neunkirchner A, Byrne RA, Scheinecker C, Steinberger P, Seed B, Pickl WF
FASEB J. 2010;24(5):1572-82 - PMID: 20056716 - PMCID: PMC2879947 - DOI: 10.1096/fj.09-137281

Early acute kidney injury predicts progressive renal dysfunction and higher mortality in severely burned adults.

Mosier MJ, Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Tompkins RG, Herndon DN
J Burn Care Res. 2010;31(1):83-92 - PMID: 20061841 - PMCID: PMC3045668 - DOI: 10.1097/BCR.0b013e3181cb8c87

bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans.

Estes KA, Dunbar TL, Powell JR, Ausubel FM, Troemel ER
Proc Natl Acad Sci U S A. 2010;107(5):2153-8 - PMID: 20133860 - PMCID: PMC2836710 - DOI: 10.1073/pnas.0914643107

ABC transporters, atherosclerosis and inflammation.

Fitzgerald ML, Mujawar Z, Tamehiro N
Atherosclerosis. 2010;211(2):361-70 - PMID: 20138281 - PMCID: PMC2888932 - DOI: 10.1016/j.atherosclerosis.2010.01.011

The fast track to multidrug resistance.

Kaufmann BB, Hung DT
Mol Cell. 2010;37(3):297-8 - PMID: 20159549 - DOI: 10.1016/j.molcel.2010.01.027

Expanding roles for diverse physical phenomena during the origin of life.

Budin I, Szostak JW
Annu Rev Biophys. 2010;39:245-63 - PMID: 20192779 - PMCID: PMC4992673 - DOI: 10.1146/annurev.biophys.050708.133753

Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

McGovern DP, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagacé C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, D'Amato M, Halfvarson J, Hibberd ML, Lördal M, Padyukov L, Andriulli A, Colombo E, Latiano A, Palmieri O, Bernard EJ, Deslandres C, Hommes DW, de Jong DJ, Stokkers PC, Weersma RK, , Sharma Y, Silverberg MS, Cho JH, Wu J, Roeder K, Brant SR, Schumm LP, Duerr RH, Dubinsky MC, Glazer NL, Haritunians T, Ippoliti A, Melmed GY, Siscovick DS ...
Nat Genet. 2010;42(4):332-7 - PMID: 20228799 - PMCID: PMC3087600 - DOI: 10.1038/ng.549

Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.

Beck PL, Ihara E, Hirota SA, MacDonald JA, Meng D, Nanthakumar NN, Podolsky DK, Xavier RJ
Am J Physiol Gastrointest Liver Physiol. 2010;299(1):G43-53 - PMID: 20299601 - PMCID: PMC2904110 - DOI: 10.1152/ajpgi.00228.2009

MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans.

Meli VS, Osuna B, Ruvkun G, Frand AR
Mol Biol Cell. 2010;21(10):1648-61 - PMID: 20335506 - PMCID: PMC2869372 - DOI: 10.1091/mbc.E08-07-0708

Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation.

Okuhira K, Fitzgerald ML, Tamehiro N, Ohoka N, Suzuki K, Sawada J, Naito M, Nishimaki-Mogami T
J Biol Chem. 2010;285(21):16369-77 - PMID: 20348106 - PMCID: PMC2871504 - DOI: 10.1074/jbc.M109.061424

Innate immune responses activated in Arabidopsis roots by microbe-associated molecular patterns.

Millet YA, Danna CH, Clay NK, Songnuan W, Simon MD, Werck-Reichhart D, Ausubel FM
Plant Cell. 2010;22(3):973-90 - PMID: 20348432 - PMCID: PMC2861455 - DOI: 10.1105/tpc.109.069658

Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication.

Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA
J Am Chem Soc. 2010;132(16):5880-5 - PMID: 20359213 - PMCID: PMC2857888 - DOI: 10.1021/ja100780p

Host-encoded reporters for the detection and purification of multiple enveloped viruses.

Ketteler R, Tomov V, Neunkirchner A, Xie Q, Pickl WF, Seed B
J Virol Methods. 2010;167(2):178-85 - PMID: 20399809 - PMCID: PMC2916077 - DOI: 10.1016/j.jviromet.2010.04.002

Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters.

Charrière GM, Ip WE, Dejardin S, Boyer L, Sokolovska A, Cappillino MP, Cherayil BJ, Podolsky DK, Kobayashi KS, Silverman N, Lacy-Hulbert A, Stuart LM
J Biol Chem. 2010;285(26):20147-54 - PMID: 20406817 - PMCID: PMC2888427 - DOI: 10.1074/jbc.M110.115584

Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor.

Benita Y, Cao Z, Giallourakis C, Li C, Gardet A, Xavier RJ
Blood. 2010;115(26):5376-84 - PMID: 20410506 - PMCID: PMC2902135 - DOI: 10.1182/blood-2010-01-263855

99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Caenorhabditis elegans as a model to study tissues involved in host immunity and microbial pathogenesis.

Irazoqui JE, Ausubel FM
Clin Exp Immunol. 2010;160(1):48-57 - PMID: 20415851 - PMCID: PMC2841835 - DOI: 10.1111/j.1365-2249.2010.04122.x

Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer.

Stott SL, Lee RJ, Nagrath S, Yu M, Miyamoto DT, Ulkus L, Inserra EJ, Ulman M, Springer S, Nakamura Z, Moore AL, Tsukrov DI, Kempner ME, Dahl DM, Wu CL, Iafrate AJ, Smith MR, Tompkins RG, Sequist LV, Toner M, Haber DA, Maheswaran S
Sci Transl Med. 2010;2(25):25ra23 - PMID: 20424012 - PMCID: PMC3141292 - DOI: 10.1126/scitranslmed.3000403

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool.

Sander JD, Maeder ML, Reyon D, Voytas DF, Joung JK, Dobbs D
Nucleic Acids Res. 2010;38(Web Server issue):W462-8 - PMID: 20435679 - PMCID: PMC2896148 - DOI: 10.1093/nar/gkq319

Characterization and analysis of human chordoma cell lines.

Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Iafrate J, Rosenberg A, Nielsen GP, Xavier RJ, Mankin H, Duan Z
Spine (Phila Pa 1976). 2010;35(13):1257-64 - PMID: 20461036 - PMCID: PMC3769690 - DOI: 10.1097/BRS.0b013e3181c2a8b0

MiR-33 contributes to the regulation of cholesterol homeostasis.

Rayner KJ, Suárez Y, Dávalos A, Parathath S, Fitzgerald ML, Tamehiro N, Fisher EA, Moore KJ, Fernández-Hernando C
Science. 2010;328(5985):1570-3 - PMID: 20466885 - PMCID: PMC3114628 - DOI: 10.1126/science.1189862

Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus.

Ip WK, Sokolovska A, Charriere GM, Boyer L, Dejardin S, Cappillino MP, Yantosca LM, Takahashi K, Moore KJ, Lacy-Hulbert A, Stuart LM
J Immunol. 2010;184(12):7071-81 - PMID: 20483752 - PMCID: PMC2935932 - DOI: 10.4049/jimmunol.1000110

The origins of cellular life.

Schrum JP, Zhu TF, Szostak JW
Cold Spring Harb Perspect Biol. 2010;2(9):a002212 - PMID: 20484387 - PMCID: PMC2926753 - DOI: 10.1101/cshperspect.a002212

Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7.

Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S
J Lipid Res. 2010;51(9):2591-9 - PMID: 20495215 - PMCID: PMC2918442 - DOI: 10.1194/jlr.M006049

Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components.

Tomkiewicz D, Casadei G, Larkins-Ford J, Moy TI, Garner J, Bremner JB, Ausubel FM, Lewis K, Kelso MJ
Antimicrob Agents Chemother. 2010;54(8):3219-24 - PMID: 20498327 - PMCID: PMC2916310 - DOI: 10.1128/AAC.01715-09

High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases.

Zhang F, Maeder ML, Unger-Wallace E, Hoshaw JP, Reyon D, Christian M, Li X, Pierick CJ, Dobbs D, Peterson T, Joung JK, Voytas DF
Proc Natl Acad Sci U S A. 2010;107(26):12028-33 - PMID: 20508152 - PMCID: PMC2900673 - DOI: 10.1073/pnas.0914991107

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.

Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB
J Exp Med. 2010;207(6):1145-52 - PMID: 20513746 - PMCID: PMC2882832 - DOI: 10.1084/jem.20091245

Mesenchymal stem cells: Mechanisms of immunomodulation and homing.

Yagi H, Soto-Gutierrez A, Parekkadan B, Kitagawa Y, Tompkins RG, Kobayashi N, Yarmush ML
Cell Transplant. 2010;19(6):667-79 - PMID: 20525442 - PMCID: PMC2957533 - DOI: 10.3727/096368910X508762

Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.

Mashima R, Honda K, Yang Y, Morita Y, Inoue A, Arimura S, Nishina H, Ema H, Nakauchi H, Seed B, Oda H, Yamanashi Y
Lab Invest. 2010;90(9):1357-64 - PMID: 20548287 - DOI: 10.1038/labinvest.2010.121

A systems biology viewpoint on autophagy in health and disease.

Huett A, Goel G, Xavier RJ
Curr Opin Gastroenterol. 2010;26(4):302-9 - PMID: 20571384 - DOI: 10.1097/MOG.0b013e32833ae2ed

Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn.

Yagi H, Soto-Gutierrez A, Kitagawa Y, Tilles AW, Tompkins RG, Yarmush ML
Cell Transplant. 2010;19(6):823-30 - PMID: 20573305 - PMCID: PMC2957544 - DOI: 10.3727/096368910X508942

The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.

Kim H, Seed B
Nat Immunol. 2010;11(8):743-50 - PMID: 20581830 - PMCID: PMC3050627 - DOI: 10.1038/ni.1897

Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.

Ng AC, Eisenberg JM, Heath RJ, Huett A, Robinson CM, Nau GJ, Xavier RJ
Proc Natl Acad Sci U S A. 2010;108 Suppl 1:4631-8 - PMID: 20616063 - PMCID: PMC3063585 - DOI: 10.1073/pnas.1000093107

Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus.

Irazoqui JE, Troemel ER, Feinbaum RL, Luhachack LG, Cezairliyan BO, Ausubel FM
PLoS Pathog. 2010;6:e1000982 - PMID: 20617181 - PMCID: PMC2895663 - DOI: 10.1371/journal.ppat.1000982

Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux.

Asztalos BF, Mujawar Z, Morrow MP, Grant A, Pushkarsky T, Wanke C, Shannon R, Geyer M, Kirchhoff F, Sviridov D, Fitzgerald ML, Bukrinsky M, Mansfield KG
J Infect Dis. 2010;202(4):614-23 - PMID: 20617930 - PMCID: PMC2932757 - DOI: 10.1086/654817

A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.

Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, Xavier RJ, Yuan J
Dev Cell. 2010;18(6):1041-52 - PMID: 20627085 - PMCID: PMC2935848 - DOI: 10.1016/j.devcel.2010.05.005

Wnt signaling regulates mitochondrial physiology and insulin sensitivity.

Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ
Genes Dev. 2010;24(14):1507-18 - PMID: 20634317 - PMCID: PMC2904941 - DOI: 10.1101/gad.1924910

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.

Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J
Proc Natl Acad Sci U S A. 2010;107(32):14164-9 - PMID: 20660724 - PMCID: PMC2922576 - DOI: 10.1073/pnas.1009485107

Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1.

Yagi H, Soto-Gutierrez A, Navarro-Alvarez N, Nahmias Y, Goldwasser Y, Kitagawa Y, Tilles AW, Tompkins RG, Parekkadan B, Yarmush ML
Mol Ther. 2010;18(10):1857-64 - PMID: 20664529 - PMCID: PMC2951565 - DOI: 10.1038/mt.2010.155

Effect of simvastatin on burn-induced alterations in tissue specific glucose metabolism: implications for burn associated insulin resistance.

Bonab AA, Carter EA, Paul K, Kaneki M, Yu YM, Tompkins RG, Fischman AJ
Int J Mol Med. 2010;26(3):311-6 - PMID: 20664945 - PMCID: PMC4090513

Engineering single Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system.

Thibodeau-Beganny S, Maeder ML, Joung JK
Methods Mol Biol. 2010;649:31-50 - PMID: 20680826 - DOI: 10.1007/978-1-60761-753-2_2

Burn injury reduces neutrophil directional migration speed in microfluidic devices.

Butler KL, Ambravaneswaran V, Agrawal N, Bilodeau M, Toner M, Tompkins RG, Fagan S, Irimia D
PLoS One. 2010;5(7):e11921 - PMID: 20689600 - PMCID: PMC2912851 - DOI: 10.1371/journal.pone.0011921

Plasma proteome response to severe burn injury revealed by 18O-labeled "universal" reference-based quantitative proteomics.

Qian WJ, Petritis BO, Kaushal A, Finnerty CC, Jeschke MG, Monroe ME, Moore RJ, Schepmoes AA, Xiao W, Moldawer LL, Davis RW, Tompkins RG, Herndon DN, Camp DG, Smith RD,
J Proteome Res. 2010;9(9):4779-89 - PMID: 20698492 - PMCID: PMC2945297 - DOI: 10.1021/pr1005026

Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion.

Söllü C, Pars K, Cornu TI, Thibodeau-Beganny S, Maeder ML, Joung JK, Heilbronn R, Cathomen T
Nucleic Acids Res. 2010;38(22):8269-76 - PMID: 20716517 - PMCID: PMC3001086 - DOI: 10.1093/nar/gkq720

Mutation of the ATP cassette binding transporter A1 (ABCA1) C-terminus disrupts HIV-1 Nef binding but does not block the Nef enhancement of ABCA1 protein degradation.

Mujawar Z, Tamehiro N, Grant A, Sviridov D, Bukrinsky M, Fitzgerald ML
Biochemistry. 2010;49(38):8338-49 - PMID: 20731376 - PMCID: PMC2943568 - DOI: 10.1021/bi100466q

Human IRGM gene "to be or not to be".

Bekpen C, Xavier RJ, Eichler EE
Semin Immunopathol. 2010;32(4):437-44 - PMID: 20737271 - DOI: 10.1007/s00281-010-0224-x

Clinical microfluidics for neutrophil genomics and proteomics.

Kotz KT, Xiao W, Miller-Graziano C, Qian WJ, Russom A, Warner EA, Moldawer LL, De A, Bankey PE, Petritis BO, Camp DG, Rosenbach AE, Goverman J, Fagan SP, Brownstein BH, Irimia D, Xu W, Wilhelmy J, Mindrinos MN, Smith RD, Davis RW, Tompkins RG, Toner M,
Nat Med. 2010;16(9):1042-7 - PMID: 20802500 - PMCID: PMC3136804 - DOI: 10.1038/nm.2205

Single-molecule binding experiments on long time scales.

Elenko MP, Szostak JW, van Oijen AM
Rev Sci Instrum. 2010;81(8):083705 - PMID: 20815611 - DOI: 10.1063/1.3473936

DNA ends: just the beginning (Nobel lecture).

Szostak JW
Angew Chem Int Ed Engl. 2010;49(41):7386-404 - PMID: 20818632 - DOI: 10.1002/anie.201000635

Stem cells and burns: review and therapeutic implications.

Butler KL, Goverman J, Ma H, Fischman A, Yu YM, Bilodeau M, Rad AM, Bonab AA, Tompkins RG, Fagan SP
J Burn Care Res. 2010;31(6):874-81 - PMID: 20859216 - DOI: 10.1097/BCR.0b013e3181f9353a

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.

Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, MacDonald JA, Beck PL
Inflamm Bowel Dis. 2010;17(6):1359-72 - PMID: 20872834 - PMCID: PMC3026862 - DOI: 10.1002/ibd.21478

Morphology-guided graph search for untangling objects: C. elegans analysis.

Raviv TR, Ljosa V, Conery AL, Ausubel FM, Carpenter AE, Golland P, Wählby C
Med Image Comput Comput Assist Interv. 2010;13(Pt 3):634-41 - PMID: 20879454 - PMCID: PMC3050593

LRRK2 is involved in the IFN-gamma response and host response to pathogens.

Gardet A, Benita Y, Li C, Sands BE, Ballester I, Stevens C, Korzenik JR, Rioux JD, Daly MJ, Xavier RJ, Podolsky DK
J Immunol. 2010;185(9):5577-85 - PMID: 20921534 - PMCID: PMC3156100 - DOI: 10.4049/jimmunol.1000548

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.

Riley BE, Kaiser SE, Shaler TA, Ng AC, Hara T, Hipp MS, Lage K, Xavier RJ, Ryu KY, Taguchi K, Yamamoto M, Tanaka K, Mizushima N, Komatsu M, Kopito RR
J Cell Biol. 2010;191(3):537-52 - PMID: 21041446 - PMCID: PMC3003313 - DOI: 10.1083/jcb.201005012

Chemoselective multicomponent one-pot assembly of purine precursors in water.

Powner MW, Sutherland JD, Szostak JW
J Am Chem Soc. 2010;132(46):16677-88 - PMID: 21043502 - PMCID: PMC2984373 - DOI: 10.1021/ja108197s

Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences.

Sander JD, Reyon D, Maeder ML, Foley JE, Thibodeau-Beganny S, Li X, Regan MR, Dahlborg EJ, Goodwin MJ, Fu F, Voytas DF, Joung JK, Dobbs D
BMC Bioinformatics. 2010;11:543 - PMID: 21044337 - PMCID: PMC3098093 - DOI: 10.1186/1471-2105-11-543

Mining the plant-herbivore interface with a leafmining Drosophila of Arabidopsis.

Whiteman NK, Groen SC, Chevasco D, Bear A, Beckwith N, Gregory TR, Denoux C, Mammarella N, Ausubel FM, Pierce NE
Mol Ecol. 2010;20(5):995-1014 - PMID: 21073583 - PMCID: PMC3062943 - DOI: 10.1111/j.1365-294X.2010.04901.x

av Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice.

Acharya M, Mukhopadhyay S, Païdassi H, Jamil T, Chow C, Kissler S, Stuart LM, Hynes RO, Lacy-Hulbert A
J Clin Invest. 2010;120(12):4445-52 - PMID: 21099114 - PMCID: PMC2993596 - DOI: 10.1172/JCI43796

The contribution of muscle to whole-body protein turnover throughout the course of burn injury in children.

Prelack K, Yu YM, Dylewski M, Lydon M, Sheridan RL, Tompkins RG
J Burn Care Res. 2010;31(6):942-8 - PMID: 21105320 - PMCID: PMC4084779 - DOI: 10.1097/BCR.0b013e3181f938e1

Failure and exploitation of autophagy in human pathologies-cellular integrity between inflammation, infection, and cell survival.

Kuballa P, Xavier RJ
Semin Immunopathol. 2010;32(4):319-22 - PMID: 21107575 - DOI: 10.1007/s00281-010-0229-5

Simvastatin treatment improves survival in a murine model of burn sepsis: Role of interleukin 6.

Beffa DC, Fischman AJ, Fagan SP, Hamrahi VF, Paul KW, Kaneki M, Yu YM, Tompkins RG, Carter EA
Burns. 2010;37(2):222-6 - PMID: 21145172 - PMCID: PMC4085785 - DOI: 10.1016/j.burns.2010.10.010

Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA).

Sander JD, Dahlborg EJ, Goodwin MJ, Cade L, Zhang F, Cifuentes D, Curtin SJ, Blackburn JS, Thibodeau-Beganny S, Qi Y, Pierick CJ, Hoffman E, Maeder ML, Khayter C, Reyon D, Dobbs D, Langenau DM, Stupar RM, Giraldez AJ, Voytas DF, Peterson RT, Yeh JR, Joung JK
Nat Methods. 2010;8(1):67-9 - PMID: 21151135 - PMCID: PMC3018472 - DOI: 10.1038/nmeth.1542

Cancer. Germ cell genes and cancer.

Wu X, Ruvkun G
Science. 2010;330(6012):1761-2 - PMID: 21205660 - DOI: 10.1126/science.1200772

Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions.

Tam JM, Castro CE, Heath RJ, Cardenas ML, Xavier RJ, Lang MJ, Vyas JM
PLoS One. 2010;5(12):e15215 - PMID: 21217821 - PMCID: PMC3013098 - DOI: 10.1371/journal.pone.0015215


Wählby C, Riklin-Raviv T, Ljosa V, Conery AL, Golland P, Ausubel FM, Carpenter AE
Proc IEEE Int Symp Biomed Imaging. 2010;2010(14-17 April 2010):552-555 - PMID: 21383863 - PMCID: PMC3048333 - DOI: 10.1109/ISBI.2010.5490286