ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Bioorg Med Chem. 2010;18(12):4422-32 - PMID: 20576578
Conformationally constrained spiro C-arylglucosides as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
ChemMedChem. 2010;5(6):827-31 - PMID: 20414917
Lipoprotein Metabolism and the Treatment of Lipid Disorders, Chapter 42. In: DeGroot LJ and JL Jameson, eds
Endocrinology, 6th edition. 2010;:ePub
Analysis of high-throughput sequencing and annotation strategies for phage genomes.
Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression.
J Orthop Res. 2010;28(6):746-52 - PMID: 20041488
Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.
Differential innate immune signalling via Ca(2+) sensor protein kinases.
Protocol: a rapid and economical procedure for purification of plasmid or plant DNA with diverse applications in plant biology.
Discover and connect cellular signaling.
Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases.
Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates.
Fluorosomes: a convenient new reagent to detect and block multivalent and complex receptor-ligand interactions.
Early acute kidney injury predicts progressive renal dysfunction and higher mortality in severely burned adults.
bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans.
ABC transporters, atherosclerosis and inflammation.
The fast track to multidrug resistance.
Mol Cell. 2010;37(3):297-8 - PMID: 20159549
Expanding roles for diverse physical phenomena during the origin of life.
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.
MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans.
Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation.
Innate immune responses activated in Arabidopsis roots by microbe-associated molecular patterns.
Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication.
Host-encoded reporters for the detection and purification of multiple enveloped viruses.
Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters.
Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor.
99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Caenorhabditis elegans as a model to study tissues involved in host immunity and microbial pathogenesis.
Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer.
ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool.
Characterization and analysis of human chordoma cell lines.
MiR-33 contributes to the regulation of cholesterol homeostasis.
Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus.
The origins of cellular life.
Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7.
Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components.
High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases.
Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.
Mesenchymal stem cells: Mechanisms of immunomodulation and homing.
Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.
Lab Invest. 2010;90(9):1357-64 - PMID: 20548287
A systems biology viewpoint on autophagy in health and disease.
Curr Opin Gastroenterol. 2010;26(4):302-9 - PMID: 20571384
Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn.
The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.
Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.
Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus.
Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux.
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.
Wnt signaling regulates mitochondrial physiology and insulin sensitivity.
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.
Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1.
Effect of simvastatin on burn-induced alterations in tissue specific glucose metabolism: implications for burn associated insulin resistance.
Engineering single Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system.
Methods Mol Biol. 2010;649:31-50 - PMID: 20680826
Burn injury reduces neutrophil directional migration speed in microfluidic devices.
Plasma proteome response to severe burn injury revealed by 18O-labeled "universal" reference-based quantitative proteomics.
Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion.
Mutation of the ATP cassette binding transporter A1 (ABCA1) C-terminus disrupts HIV-1 Nef binding but does not block the Nef enhancement of ABCA1 protein degradation.
Human IRGM gene "to be or not to be".
Semin Immunopathol. 2010;32(4):437-44 - PMID: 20737271
Clinical microfluidics for neutrophil genomics and proteomics.
Single-molecule binding experiments on long time scales.
Rev Sci Instrum. 2010;81(8):083705 - PMID: 20815611
DNA ends: just the beginning (Nobel lecture).
Angew Chem Int Ed Engl. 2010;49(41):7386-404 - PMID: 20818632
Stem cells and burns: review and therapeutic implications.
J Burn Care Res. 2010;31(6):874-81 - PMID: 20859216
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.
Morphology-guided graph search for untangling objects: C. elegans analysis.
LRRK2 is involved in the IFN-gamma response and host response to pathogens.
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.
Chemoselective multicomponent one-pot assembly of purine precursors in water.
Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences.
Mining the plant-herbivore interface with a leafmining Drosophila of Arabidopsis.
av Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice.
The contribution of muscle to whole-body protein turnover throughout the course of burn injury in children.
Failure and exploitation of autophagy in human pathologies-cellular integrity between inflammation, infection, and cell survival.
Semin Immunopathol. 2010;32(4):319-22 - PMID: 21107575
Simvastatin treatment improves survival in a murine model of burn sepsis: Role of interleukin 6.
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA).
Cancer. Germ cell genes and cancer.
Science. 2010;330(6012):1761-2 - PMID: 21205660