Publications for All Faculty
Targeted mutagenesis in zebrafish using customized zinc-finger nucleases.
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.
Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells.
Targeting multiple biofilm pathways.
The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.
Plant science. DNA binding made easy.
Flip-flop-induced relaxation of bending energy: implications for membrane remodeling.
In vitro reconstitution of an abscisic acid signalling pathway.
Common variants at five new loci associated with early-onset inflammatory bowel disease.
C. elegans major fats are stored in vesicles distinct from lysosome-related organelles.
Autophagy, immunity and human disease.
Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure.
Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.
Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers.
Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury.
Effect of insulin levels on the phosphorylation of specific amino acid residues in IRS-1: implications for burn-induced insulin resistance.
Preliminary evidence for the effects of morphine on posttraumatic stress disorder symptoms in one- to four-year-olds with burns.
Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays.
Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.
Reconstructing the emergence of cellular life through the synthesis of model protocells.
Origin of life on earth.
Conformational analysis of DNA repair intermediates by time-resolved fluorescence spectroscopy.
Chemical tools for dissecting bacterial physiology and virulence.
Microarray analysis suggests that burn injury results in mitochondrial dysfunction in human skeletal muscle.
What to do about high cholesterol
Approach to the patient with hypercholesterolemia. In: Goroll A, May L, Mulley A, eds
Screening for hyperlipidemia. In: Goroll A and Mulley A, eds.
A genome-wide genetic screen for host factors required for hepatitis C virus propagation.
Building complex biological networks based upon model organisms: mapping the human autophagy interactome via a hybrid yeast-human protein interaction network.
O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Productive steps toward an antimicrobial targeting virulence.
Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis.
Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes.
Formation of protocell-like vesicles in a thermal diffusion column.
Mannose-binding lectin and innate immunity.
Single-molecule imaging of an in vitro-evolved RNA aptamer reveals homogeneous ligand binding kinetics.
High-throughput screen for novel antimicrobials using a whole animal infection model.
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells.
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.
Modulation of allergen-specific T-lymphocyte function by virus-like particles decorated with HLA class II molecules.
An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.
Origins of life: Systems chemistry on early Earth.
Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.
High-frequency modification of plant genes using engineered zinc-finger nucleases.
Retraction for Litovchick and Szostak. "Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display".
Emerging connections in the ethylene signaling network.
The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.
A genomic score prognostic of outcome in trauma patients.
Development of a second-generation antiandrogen for treatment of advanced prostate cancer.
Preparation of large monodisperse vesicles.
Regulation of signaling pathways downstream of IGF-I/insulin by androgen in skeletal muscle of glucocorticoid-treated rats.
Using PATIMDB to create bacterial transposon insertion mutant libraries.
A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.
Coupled growth and division of model protocell membranes.
Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates.
Selective activation of nuclear factor kappa B in the cochlea by sensory and inflammatory stress.
Selective activation of nuclear factor kappa B in the cochlea by sensory and inflammatory stress.
A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.
Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).
Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.
The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response.
Enhancing the performance of a point-of-care CD4+ T-cell counting microchip through monocyte depletion for HIV/AIDS diagnostics.
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.
N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system.
HIF-1alpha and HIF-2alpha have divergent roles in colon cancer.
Temporal global expression data reveal known and novel salicylate-impacted processes and regulators mediating powdery mildew growth and reproduction on Arabidopsis.
Biosynthesis of the Caenorhabditis elegans dauer pheromone.
On the level: IRGM gene function is all about expression.
Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants.
Are topical antimicrobials effective against bacteria that are highly resistant to systemic antibiotics?
Differential requirement for CARMA1 in agonist-selected T-cell development.
Large-scale multiplexed quantitative discovery proteomics enabled by the use of an (18)O-labeled "universal" reference sample.
Glucosinolate metabolites required for an Arabidopsis innate immune response.
Rassf family of tumor suppressor polypeptides.
Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing.
An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins.
Genome-wide transcriptome analysis of 150 cell samples.
Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination.
Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice.
Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays.
CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells.