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Spandidos A, Wang X, Wang H, Dragnev S, Thurber T, Seed B

A comprehensive collection of experimentally validated primers for Polymerase Chain Reaction quantitation of murine transcript abundance.
BMC Genomics. 2008;9:633 - PMID: 19108745 - PMCID: PMC2631021 - DOI: 10.1186/1471-2164-9-633

Neafsey DE, Schaffner SF, Volkman SK, Park D, Montgomery P, Milner DA, Lukens A, Rosen D, Daniels R, Houde N, Cortese JF, Tyndall E, Gates C, Stange-Thomann N, Sarr O, Ndiaye D, Ndir O, Mboup S, Ferreira MU, Moraes Sdo L, Dash AP, Chitnis CE, Wiegand RC, Hartl DL, Birren BW, Lander ES, Sabeti PC, Wirth DF

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.
Genome Biol. 2008;9(12):R171 - PMID: 19077304 - PMCID: PMC2646275 - DOI: 10.1186/gb-2008-9-12-r171

Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.
Proc Natl Acad Sci U S A. 2008;105(51):20321-6 - PMID: 19073936 - PMCID: PMC2600581 - DOI: 10.1073/pnas.0810773105

Gopalan S, Ausubel FM

A metasystem of framework model organisms to study emergence of new host-microbe adaptations.
PLoS One. 2008;3(12):e3891 - PMID: 19066631 - PMCID: PMC2588659 - DOI: 10.1371/journal.pone.0003891

Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.
Cell. 2008;135(7):1311-23 - PMID: 19109899 - PMCID: PMC2621059 - DOI: 10.1016/j.cell.2008.10.044

Troemel ER, Félix MA, Whiteman NK, Barrière A, Ausubel FM

Microsporidia are natural intracellular parasites of the nematode Caenorhabditis elegans.
PLoS Biol. 2008;6(12):2736-52 - PMID: 19071962 - PMCID: PMC2596862 - DOI: 10.1371/journal.pbio.0060309

Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Silver GM, Jeschke MG, Finnerty CC, Tompkins RG, Herndon DN

Impact of oxandrolone treatment on acute outcomes after severe burn injury.
J Burn Care Res. 2008;29(6):902-6 - PMID: 18849836 - PMCID: PMC3958934 - DOI: 10.1097/BCR.0b013e31818ba14d

Irazoqui JE, Ng A, Xavier RJ, Ausubel FM

Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.
Proc Natl Acad Sci U S A. 2008;105(45):17469-74 - PMID: 18981407 - PMCID: PMC2582251 - DOI: 10.1073/pnas.0809527105

Wang MC, O'Rourke EJ, Ruvkun G

Fat metabolism links germline stem cells and longevity in C. elegans.
Science. 2008;322(5903):957-60 - PMID: 18988854 - PMCID: PMC2760269 - DOI: 10.1126/science.1162011

Zuo Y, Zhuang DZ, Han R, Isaac G, Tobin JJ, McKee M, Welti R, Brissette JL, Fitzgerald ML, Freeman MW

ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters.
J Biol Chem. 2008;283(52):36624-35 - PMID: 18957418 - PMCID: PMC2605993 - DOI: 10.1074/jbc.M807377200

Ramon M, Rolland F, Sheen J

Sugar sensing and signaling.
Arabidopsis Book. 2008;6:e0117 - PMID: 22303242 - PMCID: PMC3243355 - DOI: 10.1199/tab.0117

Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G

The most conserved genome segments for life detection on Earth and other planets.
Orig Life Evol Biosph. 2008;38(6):517-33 - PMID: 18853276 - DOI: 10.1007/s11084-008-9148-z

Kuballa P, Huett A, Rioux JD, Daly MJ, Xavier RJ

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.
PLoS One. 2008;3(10):e3391 - PMID: 18852889 - PMCID: PMC2566595 - DOI: 10.1371/journal.pone.0003391

Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
Nature. 2008;456(7219):259-63 - PMID: 18849966 - PMCID: PMC2695978 - DOI: 10.1038/nature07416

Ruvkun G

The perfect storm of tiny RNAs.
Nat Med. 2008;14(10):1041-5 - PMID: 18841145 - DOI: 10.1038/nm1008-1041

Huang R, Barber TA, Schmidt MA, Tompkins RG, Toner M, Bianchi DW, Kapur R, Flejter WL

A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women.
Prenat Diagn. 2008;28(10):892-9 - PMID: 18821715 - PMCID: PMC4482103 - DOI: 10.1002/pd.2079

Litovchick A, Szostak JW

Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display.
Proc Natl Acad Sci U S A. 2008;105(40):15293-8 - PMID: 18824687 - PMCID: PMC2556359 - DOI: 10.1073/pnas.0805837105

Finnerty CC, Jeschke MG, Herndon DN, Gamelli R, Gibran N, Klein M, Silver G, Arnoldo B, Remick D, Tompkins RG,

Temporal cytokine profiles in severely burned patients: a comparison of adults and children.
Mol Med. 2008;14(9-10):553-60 - PMID: 18548133 - PMCID: PMC2424320 - DOI: 10.2119/2007-00132.Finnerty

Galletti R, Denoux C, Gambetta S, Dewdney J, Ausubel FM, De Lorenzo G, Ferrari S

The AtrbohD-mediated oxidative burst elicited by oligogalacturonides in Arabidopsis is dispensable for the activation of defense responses effective against Botrytis cinerea.
Plant Physiol. 2008;148(3):1695-706 - PMID: 18790995 - PMCID: PMC2577270 - DOI: 10.1104/pp.108.127845

Fischer SE, Butler MD, Pan Q, Ruvkun G

Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.
Nature. 2008;455(7212):491-6 - PMID: 18784652 - PMCID: PMC2756026 - DOI: 10.1038/nature07274

Thomson CE, McCulloch M, Sorenson A, Barnett SC, Seed BV, Griffiths IR, McLaughlin M

Myelinated, synapsing cultures of murine spinal cord--validation as an in vitro model of the central nervous system.
Eur J Neurosci. 2008;28(8):1518-35 - PMID: 18793322 - PMCID: PMC2777255 - DOI: 10.1111/j.1460-9568.2008.06415.x

Mansy SS, Szostak JW

Thermostability of model protocell membranes.
Proc Natl Acad Sci U S A. 2008;105(36):13351-5 - PMID: 18768808 - PMCID: PMC2528865 - DOI: 10.1073/pnas.0805086105

Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E

RNA interference screen for human genes associated with West Nile virus infection.
Nature. 2008;455(7210):242-5 - PMID: 18690214 - PMCID: PMC3136529 - DOI: 10.1038/nature07207

KJ Moore and MW Freeman

Targeting innate immunity for CV benefit
Drug Discovery Today: Therapeutic Strategies. 2008;5:15-23

McCarroll SA, Huett A, Kuballa P, Chilewski SD, Landry A, Goyette P, Zody MC, Hall JL, Brant SR, Cho JH, Duerr RH, Silverberg MS, Taylor KD, Rioux JD, Altshuler D, Daly MJ, Xavier RJ

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.
Nat Genet. 2008;40(9):1107-12 - PMID: 19165925 - PMCID: PMC2731799 - DOI: 10.1038/ng.215

Baena-González E, Sheen J

Convergent energy and stress signaling.
Trends Plant Sci. 2008;13(9):474-82 - PMID: 18701338 - PMCID: PMC3075853 - DOI: 10.1016/j.tplants.2008.06.006

Xavier RJ, Rioux JD

Genome-wide association studies: a new window into immune-mediated diseases.
Nat Rev Immunol. 2008;8(8):631-43 - PMID: 18654571 - PMCID: PMC2750781 - DOI: 10.1038/nri2361

Xavier RJ, Rioux JD

Genome-wide association studies: a new window into immune-mediated diseases.
Nat Rev Immunol. 2008;8(8):631-43 - PMID: 18654571 - PMCID: PMC2750781 - DOI: 10.1038/nri2361

Labbé C, Goyette P, Lefebvre C, Stevens C, Green T, Tello-Ruiz MK, Cao Z, Landry AL, Stempak J, Annese V, Latiano A, Brant SR, Duerr RH, Taylor KD, Cho JH, Steinhart AH, Daly MJ, Silverberg MS, Xavier RJ, Rioux JD

MAST3: a novel IBD risk factor that modulates TLR4 signaling.
Genes Immun. 2008;9(7):602-12 - PMID: 18650832 - PMCID: PMC2574831 - DOI: 10.1038/gene.2008.57

Fujiki K, Duerr EM, Kikuchi H, Ng A, Xavier RJ, Mizukami Y, Imamura T, Kulke MH, Chung DC

Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth.
Gastroenterology. 2008;135(3):907-16, 916.e1-2 - PMID: 18655788 - PMCID: PMC3777410 - DOI: 10.1053/j.gastro.2008.06.034

Upadhyay G, Goessling W, North TE, Xavier R, Zon LI, Yajnik V

Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling.
Oncogene. 2008;27(44):5845-55 - PMID: 18641688 - PMCID: PMC4774646 - DOI: 10.1038/onc.2008.202

Friedman CS, O'Donnell MA, Legarda-Addison D, Ng A, Cárdenas WB, Yount JS, Moran TM, Basler CF, Komuro A, Horvath CM, Xavier R, Ting AT

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.
EMBO Rep. 2008;9(9):930-6 - PMID: 18636086 - PMCID: PMC2529351 - DOI: 10.1038/embor.2008.136

Maheswaran S, Sequist LV, Nagrath S, Ulkus L, Brannigan B, Collura CV, Inserra E, Diederichs S, Iafrate AJ, Bell DW, Digumarthy S, Muzikansky A, Irimia D, Settleman J, Tompkins RG, Lynch TJ, Toner M, Haber DA

Detection of mutations in EGFR in circulating lung-cancer cells.
N Engl J Med. 2008;359(4):366-77 - PMID: 18596266 - PMCID: PMC3551471 - DOI: 10.1056/NEJMoa0800668

Adonizio A, Leal SM, Ausubel FM, Mathee K

Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system.
J Med Microbiol. 2008;57(Pt 7):809-813 - PMID: 18566137 - DOI: 10.1099/jmm.0.47802-0

Maeder ML, Thibodeau-Beganny S, Osiak A, Wright DA, Anthony RM, Eichtinger M, Jiang T, Foley JE, Winfrey RJ, Townsend JA, Unger-Wallace E, Sander JD, Müller-Lerch F, Fu F, Pearlberg J, Göbel C, Dassie JP, Pruett-Miller SM, Porteus MH, Sgroi DC, Iafrate AJ, Dobbs D, McCray PB, Cathomen T, Voytas DF, Joung JK

Rapid open-source engineering of customized zinc-finger nucleases for highly efficient gene modification.
Mol Cell. 2008;31(2):294-301 - PMID: 18657511 - PMCID: PMC2535758 - DOI: 10.1016/j.molcel.2008.06.016

Shan L, He P, Li J, Heese A, Peck SC, Nürnberger T, Martin GB, Sheen J

Bacterial effectors target the common signaling partner BAK1 to disrupt multiple MAMP receptor-signaling complexes and impede plant immunity.
Cell Host Microbe. 2008;4(1):17-27 - PMID: 18621007 - PMCID: PMC2830012 - DOI: 10.1016/j.chom.2008.05.017

Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, , Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, , , Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
Nat Genet. 2008;40(8):955-62 - PMID: 18587394 - PMCID: PMC2574810 - DOI: 10.1038/ng.175

Sena MJ, Utter GH, Cuschieri J, Maier RV, Tompkins RG, Harbrecht BG, Moore EE, O'Keefe GE

Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patients.
J Am Coll Surg. 2008;207(4):459-67 - PMID: 18926446 - PMCID: PMC4002002 - DOI: 10.1016/j.jamcollsurg.2008.04.028

Ruvkun G

Tiny RNA: Where do we come from? What are we? Where are we going?
Trends Plant Sci. 2008;13(7):313-6 - PMID: 18562240 - DOI: 10.1016/j.tplants.2008.05.005

Cathomen T, Joung JK

Zinc-finger nucleases: the next generation emerges.
Mol Ther. 2008;16(7):1200-7 - PMID: 18545224 - DOI: 10.1038/mt.2008.114

Lemaitre B, Ausubel FM

Animal models for host-pathogen interactions.
Curr Opin Microbiol. 2008;11(3):249-50 - PMID: 18539076 - DOI: 10.1016/j.mib.2008.05.002

Mansy SS, Schrum JP, Krishnamurthy M, Tobé S, Treco DA, Szostak JW

Template-directed synthesis of a genetic polymer in a model protocell.
Nature. 2008;454(7200):122-5 - PMID: 18528332 - PMCID: PMC2743009 - DOI: 10.1038/nature07018

Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G

Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.
Cold Spring Harb Symp Quant Biol. 2008;72:489-97 - PMID: 18419309 - DOI: 10.1101/sqb.2007.72.068

Ketteler R, Seed B

Quantitation of autophagy by luciferase release assay.
Autophagy. 2008;4(6):801-6 - PMID: 18641457 - PMCID: PMC2910585 - DOI: 10.4161/auto.6401

Tzika AA, Astrakas LG, Cao H, Mintzopoulos D, Zhang Q, Padfield K, Yu H, Mindrinos MN, Rahme LG, Tompkins RG

Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma.
Int J Mol Med. 2008;21(6):825-32 - PMID: 18506378

Freeman RM, Wu M, Cordonnier-Pratt MM, Pratt LH, Gruber CE, Smith M, Lander ES, Stange-Thomann N, Lowe CJ, Gerhart J, Kirschner M

cDNA sequences for transcription factors and signaling proteins of the hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence tag (EST) approach for evolutionary and developmental studies of a new organism.
Biol Bull. 2008;214(3):284-302 - PMID: 18574105 - DOI: 10.2307/25470670

Denoux C, Galletti R, Mammarella N, Gopalan S, Werck D, De Lorenzo G, Ferrari S, Ausubel FM, Dewdney J

Activation of defense response pathways by OGs and Flg22 elicitors in Arabidopsis seedlings.
Mol Plant. 2008;1(3):423-45 - PMID: 19825551 - PMCID: PMC2954645 - DOI: 10.1093/mp/ssn019

Patel DS, Fang LL, Svy DK, Ruvkun G, Li W

Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.
Development. 2008;135(13):2239-49 - PMID: 18495818 - DOI: 10.1242/dev.016972

Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML

SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.
Biochemistry. 2008;47(23):6138-47 - PMID: 18484747 - PMCID: PMC2504083 - DOI: 10.1021/bi800182t

Huett A, Xavier RJ

Neither hide nor hair: the difficulty of identifying useful disease biomarkers.
Gastroenterology. 2008;134(7):2164-8 - PMID: 18486617 - DOI: 10.1053/j.gastro.2008.04.013

Karve A, Rauh BL, Xia X, Kandasamy M, Meagher RB, Sheen J, Moore BD

Expression and evolutionary features of the hexokinase gene family in Arabidopsis.
Planta. 2008;228(3):411-25 - PMID: 18481082 - PMCID: PMC2953952 - DOI: 10.1007/s00425-008-0746-9

Müller B, Sheen J

Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis.
Nature. 2008;453(7198):1094-7 - PMID: 18463635 - PMCID: PMC2601652 - DOI: 10.1038/nature06943

Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK

The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.
Cell. 2008;133(5):903-15 - PMID: 18510933 - PMCID: PMC2553566 - DOI: 10.1016/j.cell.2008.04.035

Ramirez CL, Foley JE, Wright DA, Müller-Lerch F, Rahman SH, Cornu TI, Winfrey RJ, Sander JD, Fu F, Townsend JA, Cathomen T, Voytas DF, Joung JK

Unexpected failure rates for modular assembly of engineered zinc fingers.
Nat Methods. 2008;5(5):374-5 - PMID: 18446154 - PMCID: PMC7880305 - DOI: 10.1038/nmeth0508-374

Cabral CB, Bullock KH, Bischoff DJ, Tompkins RG, Yu YM, Kelleher JK

Estimating glutathione synthesis with deuterated water: a model for peptide biosynthesis.
Anal Biochem. 2008;379(1):40-4 - PMID: 18486587 - PMCID: PMC4065382 - DOI: 10.1016/j.ab.2008.04.042

Gabel HW, Ruvkun G

The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.
Nat Struct Mol Biol. 2008;15(5):531-3 - PMID: 18438419 - PMCID: PMC2910399 - DOI: 10.1038/nsmb.1411

Seed B, Xavier R

Spinophilin and the immune synapse.
J Cell Biol. 2008;181(2):181-3 - PMID: 18411314 - PMCID: PMC2315665 - DOI: 10.1083/jcb.200803120

Subtelny AO, Hartman MC, Szostak JW

Ribosomal synthesis of N-methyl peptides.
J Am Chem Soc. 2008;130(19):6131-6 - PMID: 18402453 - PMCID: PMC2728122 - DOI: 10.1021/ja710016v

Zhang Q, Carter EA, Ma B, Fischman AJ, Tompkins RG

Burn-related metabolic and signaling changes in rat brain.
J Burn Care Res. 2008;29(2):346-52 - PMID: 18354292 - DOI: 10.1097/BCR.0b013e3181667387

Zhang Q, Ma B, Fischman AJ, Tompkins RG, Carter EA

Increased uncoupling protein 1 mRNA expression in mice brown adipose tissue after burn injury.
J Burn Care Res. 2008;29(2):358-62 - PMID: 18354294 - DOI: 10.1097/BCR.0b013e318166739c

Liberati NT, Urbach JM, Thurber TK, Wu G, Ausubel FM

Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality.
Methods Mol Biol. 2008;416:153-69 - PMID: 18392966 - DOI: 10.1007/978-1-59745-321-9_10

Ketteler R, Sun Z, Kovacs KF, He WW, Seed B

A pathway sensor for genome-wide screens of intracellular proteolytic cleavage.
Genome Biol. 2008;9(4):R64 - PMID: 18387192 - PMCID: PMC2643935 - DOI: 10.1186/gb-2008-9-4-r64

Powell JR, Ausubel FM

Models of Caenorhabditis elegans infection by bacterial and fungal pathogens.
Methods Mol Biol. 2008;415:403-27 - PMID: 18370168 - DOI: 10.1007/978-1-59745-570-1_24

Russom A, Sethu P, Irimia D, Mindrinos MN, Calvano SE, Garcia I, Finnerty C, Tannahill C, Abouhamze A, Wilhelmy J, López MC, Baker HV, Herndon DN, Lowry SF, Maier RV, Davis RW, Moldawer LL, Tompkins RG, Toner M,

Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients.
Clin Chem. 2008;54(5):891-900 - PMID: 18375483 - PMCID: PMC4011019 - DOI: 10.1373/clinchem.2007.099150

Schöbel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C, Lichtenthaler SF

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.
J Biol Chem. 2008;283(21):14257-68 - PMID: 18353773 - DOI: 10.1074/jbc.M801531200

Thibodeau-Beganny S, Joung JK

Engineering Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system.
Methods Mol Biol. 2008;408:317-34 - PMID: 18314590 - DOI: 10.1007/978-1-59745-547-3_17

Pruett-Miller SM, Connelly JP, Maeder ML, Joung JK, Porteus MH

Comparison of zinc finger nucleases for use in gene targeting in mammalian cells.
Mol Ther. 2008;16(4):707-17 - PMID: 18334988 - DOI: 10.1038/mt.2008.20

Duerr EM, Mizukami Y, Ng A, Xavier RJ, Kikuchi H, Deshpande V, Warshaw AL, Glickman J, Kulke MH, Chung DC

Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.
Endocr Relat Cancer. 2008;15(1):243-56 - PMID: 18310291 - DOI: 10.1677/ERC-07-0194

Sims KB, Pastores GM, Weinreb NJ, Barranger J, Rosenbloom BE, Packman S, Kaplan P, Mankin H, Xavier R, Angell J, Fitzpatrick MA, Rosenthal D

Improvement of bone disease by imiglucerase (Cerezyme) therapy in patients with skeletal manifestations of type 1 Gaucher disease: results of a 48-month longitudinal cohort study.
Clin Genet. 2008;73(5):430-40 - PMID: 18312448 - PMCID: PMC2440418 - DOI: 10.1111/j.1399-0004.2008.00978.x

Di Carlo D, Edd JF, Irimia D, Tompkins RG, Toner M

Equilibrium separation and filtration of particles using differential inertial focusing.
Anal Chem. 2008;80(6):2204-11 - PMID: 18275222 - DOI: 10.1021/ac702283m

Xavier RJ, Huett A, Rioux JD

Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.
Gut. 2008;57(6):717-20 - PMID: 18272545 - PMCID: PMC2735854 - DOI: 10.1136/gut.2007.134254

Monnard PA, Szostak JW

Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization.
J Inorg Biochem. 2008;102(5-6):1104-11 - PMID: 18329104 - DOI: 10.1016/j.jinorgbio.2008.01.026

Miyata S, Begun J, Troemel ER, Ausubel FM

DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans.
Genetics. 2008;178(2):903-18 - PMID: 18245330 - PMCID: PMC2248360 - DOI: 10.1534/genetics.107.083923

Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ, Mizoguchi A

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.
J Clin Invest. 2008;118(2):534-44 - PMID: 18172556 - PMCID: PMC2157567 - DOI: 10.1172/JCI33194

Toner M, Tompkins RG

Invention, innovation, entrepreneurship in academic medical centers.
Surgery. 2008;143(2):168-71 - PMID: 18242329 - PMCID: PMC2408552 - DOI: 10.1016/j.surg.2007.11.004

Yoo SD, Cho YH, Tena G, Xiong Y, Sheen J

Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling.
Nature. 2008;451(7180):789-95 - PMID: 18273012 - PMCID: PMC3488589 - DOI: 10.1038/nature06543

Stuart LM, Ezekowitz RA

Phagocytosis and comparative innate immunity: learning on the fly.
Nat Rev Immunol. 2008;8(2):131-41 - PMID: 18219310 - DOI: 10.1038/nri2240

Tzika AA, Mintzopoulos D, Padfield K, Wilhelmy J, Mindrinos MN, Yu H, Cao H, Zhang Q, Astrakas LG, Zhang J, Yu YM, Rahme LG, Tompkins RG

Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn.
Int J Mol Med. 2008;21(2):201-8 - PMID: 18204786

Gavi S, Qurashi S, Stuart LM, Lau R, Melendez MM, Mynarcik DC, McNurlan MA, Gelato MC

Influence of age on the association of retinol-binding protein 4 with metabolic syndrome.
Obesity (Silver Spring). 2008;16(4):893-5 - PMID: 18239568 - DOI: 10.1038/oby.2007.138

Goyette P, Lefebvre C, Ng A, Brant SR, Cho JH, Duerr RH, Silverberg MS, Taylor KD, Latiano A, Aumais G, Deslandres C, Jobin G, Annese V, Daly MJ, Xavier RJ, Rioux JD

Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis.
Mucosal Immunol. 2008;1(2):131-8 - PMID: 19079170 - PMCID: PMC4550306 - DOI: 10.1038/mi.2007.15

Yagi T, Giallourakis C, Mohanty S, Scheidig C, Shen J, Zheng H, Xavier RJ, Shaw AC

Defective signal transduction in B lymphocytes lacking presenilin proteins.
Proc Natl Acad Sci U S A. 2008;105(3):979-84 - PMID: 18195359 - PMCID: PMC2242696 - DOI: 10.1073/pnas.0707755105

Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ

Identification of host proteins required for HIV infection through a functional genomic screen.
Science. 2008;319(5865):921-6 - PMID: 18187620 - DOI: 10.1126/science.1152725

Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA

MicroRNA-183 family conservation and ciliated neurosensory organ expression.
Evol Dev. 2008;10(1):106-13 - PMID: 18184361 - PMCID: PMC2637451 - DOI: 10.1111/j.1525-142X.2007.00217.x

Ip WK, Takahashi K, Moore KJ, Stuart LM, Ezekowitz RA

Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome.
J Exp Med. 2008;205(1):169-81 - PMID: 18180310 - PMCID: PMC2234382 - DOI: 10.1084/jem.20071164

Huett A, Xavier R

SNPping away at the pathogenesis of Crohn's disease.
Inflamm Bowel Dis. 2008;14(1):136-7 - PMID: 17941076 - DOI: 10.1002/ibd.20306

Isenbarger TA, Finney M, Ríos-Velázquez C, Handelsman J, Ruvkun G

Miniprimer PCR, a new lens for viewing the microbial world.
Appl Environ Microbiol. 2008;74(3):840-9 - PMID: 18083877 - PMCID: PMC2227730 - DOI: 10.1128/AEM.01933-07

Leb VM, Jahn-Schmid B, Schmetterer KG, Kueng HJ, Haiderer D, Neunkirchner A, Fischer GF, Nissler K, Hartl A, Thalhamer J, Bohle B, Seed B, Pickl WF

Molecular and functional analysis of the antigen receptor of Art v 1-specific helper T lymphocytes.
J Allergy Clin Immunol. 2008;121(1):64-71 - PMID: 18037161 - DOI: 10.1016/j.jaci.2007.10.006

Cornu TI, Thibodeau-Beganny S, Guhl E, Alwin S, Eichtinger M, Joung JK, Joung JK, Cathomen T

DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases.
Mol Ther. 2008;16(2):352-8 - PMID: 18026168 - DOI: 10.1038/sj.mt.6300357

Cao Z, Huett A, Kuballa P, Giallourakis C, Xavier RJ

DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.
Cell Signal. 2008;20(1):73-82 - PMID: 17980554 - PMCID: PMC2257480 - DOI: 10.1016/j.cellsig.2007.08.019
Total: 89