Publications

Genome-wide association studies: a new window into immune-mediated diseases.

Xavier RJ, Rioux JD
Nat Rev Immunol. 2008;8(8):631-43 - PMID: 18654571 - PMCID: PMC2750781

Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling.

Upadhyay G, Goessling W, North TE, Xavier R, Zon LI, Yajnik V
Oncogene. 2008;27(44):5845-55 - PMID: 18641688 - PMCID: PMC4774646

Improvement of bone disease by imiglucerase (Cerezyme) therapy in patients with skeletal manifestations of type 1 Gaucher disease: results of a 48-month longitudinal cohort study.

Sims KB, Pastores GM, Weinreb NJ, Barranger J, Rosenbloom BE, Packman S, Kaplan P, Mankin H, Xavier R, Angell J, Fitzpatrick MA, Rosenthal D
Clin Genet. 2008;73(5):430-40 - PMID: 18312448 - PMCID: PMC2440418

Myelinated, synapsing cultures of murine spinal cord--validation as an in vitro model of the central nervous system.

Thomson CE, McCulloch M, Sorenson A, Barnett SC, Seed BV, Griffiths IR, McLaughlin M
Eur J Neurosci. 2008;28(8):1518-35 - PMID: 18793322 - PMCID: PMC2777255

Targeting innate immunity for CV benefit

KJ Moore and MW Freeman
Drug Discovery Today: Therapeutic Strategies. 2008;5:15-23

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.

Neafsey DE, Schaffner SF, Volkman SK, Park D, Montgomery P, Milner DA, Lukens A, Rosen D, Daniels R, Houde N, Cortese JF, Tyndall E, Gates C, Stange-Thomann N, Sarr O, Ndiaye D, Ndir O, Mboup S, Ferreira MU, Moraes Sdo L, Dash AP, Chitnis CE, Wiegand RC, Hartl DL, Birren BW, Lander ES, Sabeti PC, Wirth DF
Genome Biol. 2008;9(12):R171 - PMID: 19077304 - PMCID: PMC2646275

cDNA sequences for transcription factors and signaling proteins of the hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence tag (EST) approach for evolutionary and developmental studies of a new organism.

Freeman RM, Wu M, Cordonnier-Pratt MM, Pratt LH, Gruber CE, Smith M, Lander ES, Stange-Thomann N, Lowe CJ, Gerhart J, Kirschner M
Biol Bull. 2008;214(3):284-302 - PMID: 18574105

SNPping away at the pathogenesis of Crohn's disease.

Huett A, Xavier R
Inflamm Bowel Dis. 2008;14(1):136-7 - PMID: 17941076

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.

Friedman CS, O'Donnell MA, Legarda-Addison D, Ng A, Cárdenas WB, Yount JS, Moran TM, Basler CF, Komuro A, Horvath CM, Xavier R, Ting AT
EMBO Rep. 2008;9(9):930-6 - PMID: 18636086 - PMCID: PMC2529351

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.

Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J
Proc Natl Acad Sci U S A. 2008;105(51):20321-6 - PMID: 19073936 - PMCID: PMC2600581

Rassf family of tumor suppressor polypeptides.

Avruch J, Xavier R, Bardeesy N, Zhang XF, Praskova M, Zhou D, Xia F
J Biol Chem. 2008;284(17):11001-5 - PMID: 19091744 - PMCID: PMC2670104

Sugar sensing and signaling.

Ramon M, Rolland F, Sheen J
Arabidopsis Book. 2008;6:e0117 - PMID: 22303242 - PMCID: PMC3243355

Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling.

Yoo SD, Cho YH, Tena G, Xiong Y, Sheen J
Nature. 2008;451(7180):789-95 - PMID: 18273012 - PMCID: PMC3488589

Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis.

Müller B, Sheen J
Nature. 2008;453(7198):1094-7 - PMID: 18463635 - PMCID: PMC2601652

Expression and evolutionary features of the hexokinase gene family in Arabidopsis.

Karve A, Rauh BL, Xia X, Kandasamy M, Meagher RB, Sheen J, Moore BD
Planta. 2008;228(3):411-25 - PMID: 18481082 - PMCID: PMC2953952

Bacterial effectors target the common signaling partner BAK1 to disrupt multiple MAMP receptor-signaling complexes and impede plant immunity.

Shan L, He P, Li J, Heese A, Peck SC, Nürnberger T, Martin GB, Sheen J
Cell Host Microbe. 2008;4(1):17-27 - PMID: 18621007 - PMCID: PMC2830012

Convergent energy and stress signaling.

Baena-González E, Sheen J
Trends Plant Sci. 2008;13(9):474-82 - PMID: 18701338 - PMCID: PMC3075853

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.

Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ, Mizoguchi A
J Clin Invest. 2008;118(2):534-44 - PMID: 18172556 - PMCID: PMC2157567

Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome.

Ip WK, Takahashi K, Moore KJ, Stuart LM, Ezekowitz RA
J Exp Med. 2008;205(1):169-81 - PMID: 18180310 - PMCID: PMC2234382

MicroRNA-183 family conservation and ciliated neurosensory organ expression.

Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA
Evol Dev. 2008;10(1):106-13 - PMID: 18184361 - PMCID: PMC2637451

Identification of host proteins required for HIV infection through a functional genomic screen.

Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ
Science. 2008;319(5865):921-6 - PMID: 18187620

Defective signal transduction in B lymphocytes lacking presenilin proteins.

Yagi T, Giallourakis C, Mohanty S, Scheidig C, Shen J, Zheng H, Xavier RJ, Shaw AC
Proc Natl Acad Sci U S A. 2008;105(3):979-84 - PMID: 18195359 - PMCID: PMC2242696

Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn.

Tzika AA, Mintzopoulos D, Padfield K, Wilhelmy J, Mindrinos MN, Yu H, Cao H, Zhang Q, Astrakas LG, Zhang J, Yu YM, Rahme LG, Tompkins RG
Int J Mol Med. 2008;21(2):201-8 - PMID: 18204786

Phagocytosis and comparative innate immunity: learning on the fly.

Stuart LM, Ezekowitz RA
Nat Rev Immunol. 2008;8(2):131-41 - PMID: 18219310

Influence of age on the association of retinol-binding protein 4 with metabolic syndrome.

Gavi S, Qurashi S, Stuart LM, Lau R, Melendez MM, Mynarcik DC, McNurlan MA, Gelato MC
Obesity (Silver Spring). 2008;16(4):893-5 - PMID: 18239568

Invention, innovation, entrepreneurship in academic medical centers.

Toner M, Tompkins RG
Surgery. 2008;143(2):168-71 - PMID: 18242329 - PMCID: PMC2408552

DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans.

Miyata S, Begun J, Troemel ER, Ausubel FM
Genetics. 2008;178(2):903-18 - PMID: 18245330 - PMCID: PMC2248360

Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.

Xavier RJ, Huett A, Rioux JD
Gut. 2008;57(6):717-20 - PMID: 18272545 - PMCID: PMC2735854

Equilibrium separation and filtration of particles using differential inertial focusing.

Di Carlo D, Edd JF, Irimia D, Tompkins RG, Toner M
Anal Chem. 2008;80(6):2204-11 - PMID: 18275222

Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.

Duerr EM, Mizukami Y, Ng A, Xavier RJ, Kikuchi H, Deshpande V, Warshaw AL, Glickman J, Kulke MH, Chung DC
Endocr Relat Cancer. 2008;15(1):243-56 - PMID: 18310291

Engineering Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system.

Thibodeau-Beganny S, Joung JK
Methods Mol Biol. 2008;408:317-34 - PMID: 18314590

Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization.

Monnard PA, Szostak JW
J Inorg Biochem. 2008;102(5-6):1104-11 - PMID: 18329104

Comparison of zinc finger nucleases for use in gene targeting in mammalian cells.

Pruett-Miller SM, Connelly JP, Maeder ML, Joung JK, Porteus MH
Mol Ther. 2008;16(4):707-17 - PMID: 18334988

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.

Schöbel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C, Lichtenthaler SF
J Biol Chem. 2008;283(21):14257-68 - PMID: 18353773

Burn-related metabolic and signaling changes in rat brain.

Zhang Q, Carter EA, Ma B, Fischman AJ, Tompkins RG
J Burn Care Res. 2008;29(2):346-52 - PMID: 18354292

Increased uncoupling protein 1 mRNA expression in mice brown adipose tissue after burn injury.

Zhang Q, Ma B, Fischman AJ, Tompkins RG, Carter EA
J Burn Care Res. 2008;29(2):358-62 - PMID: 18354294

Models of Caenorhabditis elegans infection by bacterial and fungal pathogens.

Powell JR, Ausubel FM
Methods Mol Biol. 2008;415:403-27 - PMID: 18370168

Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients.

Russom A, Sethu P, Irimia D, Mindrinos MN, Calvano SE, Garcia I, Finnerty C, Tannahill C, Abouhamze A, Wilhelmy J, López MC, Baker HV, Herndon DN, Lowry SF, Maier RV, Davis RW, Moldawer LL, Tompkins RG, Toner M,
Clin Chem. 2008;54(5):891-900 - PMID: 18375483 - PMCID: PMC4011019

A pathway sensor for genome-wide screens of intracellular proteolytic cleavage.

Ketteler R, Sun Z, Kovacs KF, He WW, Seed B
Genome Biol. 2008;9(4):R64 - PMID: 18387192 - PMCID: PMC2643935

Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality.

Liberati NT, Urbach JM, Thurber TK, Wu G, Ausubel FM
Methods Mol Biol. 2008;416:153-69 - PMID: 18392966

Ribosomal synthesis of N-methyl peptides.

Subtelny AO, Hartman MC, Szostak JW
J Am Chem Soc. 2008;130(19):6131-6 - PMID: 18402453 - PMCID: PMC2728122

Spinophilin and the immune synapse.

Seed B, Xavier R
J Cell Biol. 2008;181(2):181-3 - PMID: 18411314 - PMCID: PMC2315665

Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.

Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G
Cold Spring Harb Symp Quant Biol. 2008;72:489-97 - PMID: 18419309

The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.

Gabel HW, Ruvkun G
Nat Struct Mol Biol. 2008;15(5):531-3 - PMID: 18438419 - PMCID: PMC2910399

Activation of defense response pathways by OGs and Flg22 elicitors in Arabidopsis seedlings.

Denoux C, Galletti R, Mammarella N, Gopalan S, Werck D, De Lorenzo G, Ferrari S, Ausubel FM, Dewdney J
Mol Plant. 2008;1(3):423-45 - PMID: 19825551 - PMCID: PMC2954645

Unexpected failure rates for modular assembly of engineered zinc fingers.

Ramirez CL, Foley JE, Wright DA, Müller-Lerch F, Rahman SH, Cornu TI, Winfrey RJ, Sander JD, Fu F, Townsend JA, Cathomen T, Voytas DF, Joung JK
Nat Methods. 2008;5(5):374-5 - PMID: 18446154

SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.

Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML
Biochemistry. 2008;47(23):6138-47 - PMID: 18484747 - PMCID: PMC2504083

Estimating glutathione synthesis with deuterated water: a model for peptide biosynthesis.

Cabral CB, Bullock KH, Bischoff DJ, Tompkins RG, Yu YM, Kelleher JK
Anal Biochem. 2008;379(1):40-4 - PMID: 18486587 - PMCID: PMC4065382

Neither hide nor hair: the difficulty of identifying useful disease biomarkers.

Huett A, Xavier RJ
Gastroenterology. 2008;134(7):2164-8 - PMID: 18486617

Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.

Patel DS, Fang LL, Svy DK, Ruvkun G, Li W
Development. 2008;135(13):2239-49 - PMID: 18495818

Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma.

Tzika AA, Astrakas LG, Cao H, Mintzopoulos D, Zhang Q, Padfield K, Yu H, Mindrinos MN, Rahme LG, Tompkins RG
Int J Mol Med. 2008;21(6):825-32 - PMID: 18506378

The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.

Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK
Cell. 2008;133(5):903-15 - PMID: 18510933 - PMCID: PMC2553566

Template-directed synthesis of a genetic polymer in a model protocell.

Mansy SS, Schrum JP, Krishnamurthy M, Tobé S, Treco DA, Szostak JW
Nature. 2008;454(7200):122-5 - PMID: 18528332 - PMCID: PMC2743009

Animal models for host-pathogen interactions.

Lemaitre B, Ausubel FM
Curr Opin Microbiol. 2008;11(3):249-50 - PMID: 18539076

Zinc-finger nucleases: the next generation emerges.

Cathomen T, Joung JK
Mol Ther. 2008;16(7):1200-7 - PMID: 18545224

Temporal cytokine profiles in severely burned patients: a comparison of adults and children.

Finnerty CC, Jeschke MG, Herndon DN, Gamelli R, Gibran N, Klein M, Silver G, Arnoldo B, Remick D, Tompkins RG,
Mol Med. 2008;14(9-10):553-60 - PMID: 18548133 - PMCID: PMC2424320

Tiny RNA: Where do we come from? What are we? Where are we going?

Ruvkun G
Trends Plant Sci. 2008;13(7):313-6 - PMID: 18562240

Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system.

Adonizio A, Leal SM, Ausubel FM, Mathee K
J Med Microbiol. 2008;57(Pt 7):809-13 - PMID: 18566137

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, , Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, , , Cardon LR, Anderson CA, Drummond H, Nimm ...
Nat Genet. 2008;40(8):955-62 - PMID: 18587394 - PMCID: PMC2574810

Detection of mutations in EGFR in circulating lung-cancer cells.

Maheswaran S, Sequist LV, Nagrath S, Ulkus L, Brannigan B, Collura CV, Inserra E, Diederichs S, Iafrate AJ, Bell DW, Digumarthy S, Muzikansky A, Irimia D, Settleman J, Tompkins RG, Lynch TJ, Toner M, Haber DA
N Engl J Med. 2008;359(4):366-77 - PMID: 18596266 - PMCID: PMC3551471

Quantitation of autophagy by luciferase release assay.

Ketteler R, Seed B
Autophagy. 2008;4(6):801-6 - PMID: 18641457 - PMCID: PMC2910585

MAST3: a novel IBD risk factor that modulates TLR4 signaling.

Labbé C, Goyette P, Lefebvre C, Stevens C, Green T, Tello-Ruiz MK, Cao Z, Landry AL, Stempak J, Annese V, Latiano A, Brant SR, Duerr RH, Taylor KD, Cho JH, Steinhart AH, Daly MJ, Silverberg MS, Xavier RJ, Rioux JD
Genes Immun. 2008;9(7):602-12 - PMID: 18650832 - PMCID: PMC2574831

Genome-wide association studies: a new window into immune-mediated diseases.

Xavier RJ, Rioux JD
Nat Rev Immunol. 2008;8(8):631-43 - PMID: 18654571 - PMCID: PMC2750781

Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth.

Fujiki K, Duerr EM, Kikuchi H, Ng A, Xavier RJ, Mizukami Y, Imamura T, Kulke MH, Chung DC
Gastroenterology. 2008;135(3):907-16, 916.e1-2 - PMID: 18655788 - PMCID: PMC3777410

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.

Maeder ML, Thibodeau-Beganny S, Osiak A, Wright DA, Anthony RM, Eichtinger M, Jiang T, Foley JE, Winfrey RJ, Townsend JA, Unger-Wallace E, Sander JD, Müller-Lerch F, Fu F, Pearlberg J, Göbel C, Dassie JP, Pruett-Miller SM, Porteus MH, Sgroi DC, Iafrate AJ, Dobbs D, McCray PB, Cathomen T, Voytas DF, Joung JK
Mol Cell. 2008;31(2):294-301 - PMID: 18657511 - PMCID: PMC2535758

RNA interference screen for human genes associated with West Nile virus infection.

Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E
Nature. 2008;455(7210):242-5 - PMID: 18690214 - PMCID: PMC3136529

CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells.

Medoff BD, Landry AL, Wittbold KA, Sandall BP, Derby MC, Cao Z, Adams JC, Xavier RJ
Am J Respir Cell Mol Biol. 2008;40(3):286-94 - PMID: 18757306 - PMCID: PMC2645526

Thermostability of model protocell membranes.

Mansy SS, Szostak JW
Proc Natl Acad Sci U S A. 2008;105(36):13351-5 - PMID: 18768808 - PMCID: PMC2528865

Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.

Fischer SE, Butler MD, Pan Q, Ruvkun G
Nature. 2008;455(7212):491-6 - PMID: 18784652 - PMCID: PMC2756026

The AtrbohD-mediated oxidative burst elicited by oligogalacturonides in Arabidopsis is dispensable for the activation of defense responses effective against Botrytis cinerea.

Galletti R, Denoux C, Gambetta S, Dewdney J, Ausubel FM, De Lorenzo G, Ferrari S
Plant Physiol. 2008;148(3):1695-706 - PMID: 18790995 - PMCID: PMC2577270

Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays.

Fu F, Sander JD, Maeder M, Thibodeau-Beganny S, Joung JK, Dobbs D, Miller L, Voytas DF
Nucleic Acids Res. 2008;37(Database issue):D279-83 - PMID: 18812396 - PMCID: PMC2686427

A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women.

Huang R, Barber TA, Schmidt MA, Tompkins RG, Toner M, Bianchi DW, Kapur R, Flejter WL
Prenat Diagn. 2008;28(10):892-9 - PMID: 18821715 - PMCID: PMC4482103

Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display.

Litovchick A, Szostak JW
Proc Natl Acad Sci U S A. 2008;105(40):15293-8 - PMID: 18824687 - PMCID: PMC2556359

The perfect storm of tiny RNAs.

Ruvkun G
Nat Med. 2008;14(10):1041-5 - PMID: 18841145

Impact of oxandrolone treatment on acute outcomes after severe burn injury.

Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Silver GM, Jeschke MG, Finnerty CC, Tompkins RG, Herndon DN
J Burn Care Res. 2008;29(6):902-6 - PMID: 18849836 - PMCID: PMC3958934

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.

Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW
Nature. 2008;456(7219):259-63 - PMID: 18849966 - PMCID: PMC2695978

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

Kuballa P, Huett A, Rioux JD, Daly MJ, Xavier RJ
PLoS One. 2008;3(10):e3391 - PMID: 18852889 - PMCID: PMC2566595

The most conserved genome segments for life detection on Earth and other planets.

Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G
Orig Life Evol Biosph. 2008;38(6):517-33 - PMID: 18853276

Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patients.

Sena MJ, Utter GH, Cuschieri J, Maier RV, Tompkins RG, Harbrecht BG, Moore EE, O'Keefe GE
J Am Coll Surg. 2008;207(4):459-67 - PMID: 18926446 - PMCID: PMC4002002

Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice.

Manning-Tobin JJ, Moore KJ, Seimon TA, Bell SA, Sharuk M, Alvarez-Leite JI, de Winther MP, Tabas I, Freeman MW
Arterioscler Thromb Vasc Biol. 2008;29(1):19-26 - PMID: 18948635 - PMCID: PMC2666043

ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters.

Zuo Y, Zhuang DZ, Han R, Isaac G, Tobin JJ, McKee M, Welti R, Brissette JL, Fitzgerald ML, Freeman MW
J Biol Chem. 2008;283(52):36624-35 - PMID: 18957418 - PMCID: PMC2605993

Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.

Irazoqui JE, Ng A, Xavier RJ, Ausubel FM
Proc Natl Acad Sci U S A. 2008;105(45):17469-74 - PMID: 18981407 - PMCID: PMC2582251

Fat metabolism links germline stem cells and longevity in C. elegans.

Wang MC, O'Rourke EJ, Ruvkun G
Science. 2008;322(5903):957-60 - PMID: 18988854 - PMCID: PMC2760269

Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination.

Guttormsen HK, Stuart LM, Shi L, Carroll MC, Chen J, Kasper DL, Ezekowitz RA, Takahashi K
Clin Immunol. 2008;130(3):264-71 - PMID: 18996748 - PMCID: PMC2660855

An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins.

Sander JD, Zaback P, Joung JK, Voytas DF, Dobbs D
Nucleic Acids Res. 2008;37(2):506-15 - PMID: 19056825 - PMCID: PMC2632909

A metasystem of framework model organisms to study emergence of new host-microbe adaptations.

Gopalan S, Ausubel FM
PLoS One. 2008;3(12):e3891 - PMID: 19066631 - PMCID: PMC2588659

Microsporidia are natural intracellular parasites of the nematode Caenorhabditis elegans.

Troemel ER, Félix MA, Whiteman NK, Barrière A, Ausubel FM
PLoS Biol. 2008;6(12):2736-52 - PMID: 19071962 - PMCID: PMC2596862

Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis.

Goyette P, Lefebvre C, Ng A, Brant SR, Cho JH, Duerr RH, Silverberg MS, Taylor KD, Latiano A, Aumais G, Deslandres C, Jobin G, Annese V, Daly MJ, Xavier RJ, Rioux JD
Mucosal Immunol. 2008;1(2):131-8 - PMID: 19079170 - PMCID: PMC4550306

Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing.

Nusbaum C, Ohsumi TK, Gomez J, Aquadro J, Victor TC, Warren RM, Hung DT, Birren BW, Lander ES, Jaffe DB
Nat Methods. 2008;6(1):67-9 - PMID: 19079253 - PMCID: PMC2613166

Glucosinolate metabolites required for an Arabidopsis innate immune response.

Clay NK, Adio AM, Denoux C, Jander G, Ausubel FM
Science. 2008;323(5910):95-101 - PMID: 19095898 - PMCID: PMC2630859

A comprehensive collection of experimentally validated primers for Polymerase Chain Reaction quantitation of murine transcript abundance.

Spandidos A, Wang X, Wang H, Dragnev S, Thurber T, Seed B
BMC Genomics. 2008;9:633 - PMID: 19108745 - PMCID: PMC2631021

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.

Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J
Cell. 2008;135(7):1311-23 - PMID: 19109899 - PMCID: PMC2621059

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

McCarroll SA, Huett A, Kuballa P, Chilewski SD, Landry A, Goyette P, Zody MC, Hall JL, Brant SR, Cho JH, Duerr RH, Silverberg MS, Taylor KD, Rioux JD, Altshuler D, Daly MJ, Xavier RJ
Nat Genet. 2008;40(9):1107-12 - PMID: 19165925 - PMCID: PMC2731799

Genome-wide transcriptome analysis of 150 cell samples.

Irimia D, Mindrinos M, Russom A, Xiao W, Wilhelmy J, Wang S, Heath JD, Kurn N, Tompkins RG, Davis RW, Toner M
Integr Biol (Camb). 2008;1(1):99-107 - PMID: 20023796 - PMCID: PMC3763906