Genome-wide association studies: a new window into immune-mediated diseases.
Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling.
Improvement of bone disease by imiglucerase (Cerezyme) therapy in patients with skeletal manifestations of type 1 Gaucher disease: results of a 48-month longitudinal cohort study.
Myelinated, synapsing cultures of murine spinal cord--validation as an in vitro model of the central nervous system.
Targeting innate immunity for CV benefit
Drug Discovery Today: Therapeutic Strategies. 2008;5:15-23
Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.
cDNA sequences for transcription factors and signaling proteins of the hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence tag (EST) approach for evolutionary and developmental studies of a new organism.
Biol Bull. 2008;214(3):284-302 - PMID: 18574105
SNPping away at the pathogenesis of Crohn's disease.
Inflamm Bowel Dis. 2008;14(1):136-7 - PMID: 17941076
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.
Rassf family of tumor suppressor polypeptides.
Sugar sensing and signaling.
Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling.
Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis.
Expression and evolutionary features of the hexokinase gene family in Arabidopsis.
Bacterial effectors target the common signaling partner BAK1 to disrupt multiple MAMP receptor-signaling complexes and impede plant immunity.
Convergent energy and stress signaling.
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.
Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome.
MicroRNA-183 family conservation and ciliated neurosensory organ expression.
Identification of host proteins required for HIV infection through a functional genomic screen.
Science. 2008;319(5865):921-6 - PMID: 18187620
Defective signal transduction in B lymphocytes lacking presenilin proteins.
Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn.
Int J Mol Med. 2008;21(2):201-8 - PMID: 18204786
Phagocytosis and comparative innate immunity: learning on the fly.
Nat Rev Immunol. 2008;8(2):131-41 - PMID: 18219310
Influence of age on the association of retinol-binding protein 4 with metabolic syndrome.
Obesity (Silver Spring). 2008;16(4):893-5 - PMID: 18239568
Invention, innovation, entrepreneurship in academic medical centers.
DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans.
Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.
Equilibrium separation and filtration of particles using differential inertial focusing.
Anal Chem. 2008;80(6):2204-11 - PMID: 18275222
Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.
Endocr Relat Cancer. 2008;15(1):243-56 - PMID: 18310291
Engineering Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system.
Methods Mol Biol. 2008;408:317-34 - PMID: 18314590
Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization.
J Inorg Biochem. 2008;102(5-6):1104-11 - PMID: 18329104
Comparison of zinc finger nucleases for use in gene targeting in mammalian cells.
Mol Ther. 2008;16(4):707-17 - PMID: 18334988
A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.
J Biol Chem. 2008;283(21):14257-68 - PMID: 18353773
Burn-related metabolic and signaling changes in rat brain.
J Burn Care Res. 2008;29(2):346-52 - PMID: 18354292
Increased uncoupling protein 1 mRNA expression in mice brown adipose tissue after burn injury.
J Burn Care Res. 2008;29(2):358-62 - PMID: 18354294
Models of Caenorhabditis elegans infection by bacterial and fungal pathogens.
Methods Mol Biol. 2008;415:403-27 - PMID: 18370168
Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients.
A pathway sensor for genome-wide screens of intracellular proteolytic cleavage.
Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality.
Methods Mol Biol. 2008;416:153-69 - PMID: 18392966
Ribosomal synthesis of N-methyl peptides.
Spinophilin and the immune synapse.
Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.
Cold Spring Harb Symp Quant Biol. 2008;72:489-97 - PMID: 18419309
The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.
Activation of defense response pathways by OGs and Flg22 elicitors in Arabidopsis seedlings.
Unexpected failure rates for modular assembly of engineered zinc fingers.
Nat Methods. 2008;5(5):374-5 - PMID: 18446154
SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.
Estimating glutathione synthesis with deuterated water: a model for peptide biosynthesis.
Neither hide nor hair: the difficulty of identifying useful disease biomarkers.
Gastroenterology. 2008;134(7):2164-8 - PMID: 18486617
Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.
Development. 2008;135(13):2239-49 - PMID: 18495818
Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma.
Int J Mol Med. 2008;21(6):825-32 - PMID: 18506378
The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.
Template-directed synthesis of a genetic polymer in a model protocell.
Animal models for host-pathogen interactions.
Curr Opin Microbiol. 2008;11(3):249-50 - PMID: 18539076
Zinc-finger nucleases: the next generation emerges.
Mol Ther. 2008;16(7):1200-7 - PMID: 18545224
Temporal cytokine profiles in severely burned patients: a comparison of adults and children.
Tiny RNA: Where do we come from? What are we? Where are we going?
Trends Plant Sci. 2008;13(7):313-6 - PMID: 18562240
Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system.
J Med Microbiol. 2008;57(Pt 7):809-13 - PMID: 18566137
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
Detection of mutations in EGFR in circulating lung-cancer cells.
Quantitation of autophagy by luciferase release assay.
MAST3: a novel IBD risk factor that modulates TLR4 signaling.
Genome-wide association studies: a new window into immune-mediated diseases.
Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth.
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.
RNA interference screen for human genes associated with West Nile virus infection.
CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells.
Thermostability of model protocell membranes.
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.
The AtrbohD-mediated oxidative burst elicited by oligogalacturonides in Arabidopsis is dispensable for the activation of defense responses effective against Botrytis cinerea.
Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays.
A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women.
Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display.
The perfect storm of tiny RNAs.
Nat Med. 2008;14(10):1041-5 - PMID: 18841145
Impact of oxandrolone treatment on acute outcomes after severe burn injury.
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.
The most conserved genome segments for life detection on Earth and other planets.
Orig Life Evol Biosph. 2008;38(6):517-33 - PMID: 18853276