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Zhang W, Kim SC, Tam CP, Lelyveld VS, Bala S, Chaput JC, Szostak JW

Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization.
Nucleic Acids Res. 2021;49(2):646-656 - PMID: 33347562 - PMCID: PMC7826252 - DOI: 10.1093/nar/gkaa1215

Carey KL, Paulus GLC, Wang L, Balce DR, Luo JW, Bergman P, Ferder IC, Kong L, Renaud N, Singh S, Kost-Alimova M, Nyfeler B, Lassen KG, Virgin HW, Xavier RJ

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41.
Cell Rep. 2020;33(6):108371 - PMID: 33176151 - PMCID: PMC7686957 - DOI: 10.1016/j.celrep.2020.108371

Filbin MR, Mehta A, Schneider AM, Kays KR, Guess JR, Gentili M, Fenyves BG, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilly BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Rojas-Lopez M, Russo BC, Sharma N, Tantivit J, Thomas MF, Gerszten RE, Heimberg GS, Hoover PJ, Lieb DJ, Lin B, Ngo D, Pelka K, Reyes M, Smillie CS, Waghray A, Wood TE, Zajac AS, Jennings LL, Grundberg I, Bhattacharyya RP, Parry BA, Villani AC, Sade-Feldman M, Hacohen N, Goldberg MB

Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients.
bioRxiv. 2020;:ePub - PMID: 33173871 - PMCID: PMC7654866 - DOI: 10.1101/2020.11.02.365536

Xie F, Dai S, Zhao Y, Huang P, Yu S, Ren B, Wang Q, Ji Z, Alterovitz G, Zhang Q, Zhang J, Chen X, Jiang L, Song F, Liu H, Ausubel FM, Liu X, Dai H, Zhang L

Generation of Fluorinated Amychelin Siderophores against Pseudomonas aeruginosa Infections by a Combination of Genome Mining and Mutasynthesis.
Cell Chem Biol. 2020;27(12):1532-1543.e6 - PMID: 33186541 - DOI: 10.1016/j.chembiol.2020.10.009

Carey KL, Paulus GLC, Wang L, Balce DR, Luo JW, Bergman P, Ferder IC, Kong L, Renaud N, Singh S, Kost-Alimova M, Nyfeler B, Lassen KG, Virgin HW, Xavier RJ

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41.
Cell Rep. 2020;33(6):108371 - PMID: 33176151 - PMCID: PMC7686957 - DOI: 10.1016/j.celrep.2020.108371

Efron PA, Darden DB, Wang Z, Nacionales DC, Lopez MC, Hawkins RB, Cox MC, Rincon JC, Ungaro R, Dirain ML, Ghita GL, Chen T, Billiar TR, Delano MJ, Leeuwenburgh C, Bihorac A, Brakenridge SC, Moore FA, Mohr AM, Tompkins RG, Brumback BA, Baker HV, Upchurch GR, Moldawer LL

Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.
FASEB J. 2021;35(2):e21156 - PMID: 33140449 - PMCID: PMC7855423 - DOI: 10.1096/fj.202002150R

Nakata T, Creasey EA, Kadoki M, Lin H, Selig MK, Yao J, Lefkovith A, Daly MJ, Graham DB, Xavier RJ

A missense variant in SLC39A8 confers risk for Crohn's disease by disrupting manganese homeostasis and intestinal barrier integrity.
Proc Natl Acad Sci U S A. 2020;117(46):28930-28938 - PMID: 33139556 - PMCID: PMC7682327 - DOI: 10.1073/pnas.2014742117

Zhou L, Ding D, Szostak JW

The Virtual Circular Genome Model for Primordial RNA Replication.
RNA. 2021;27(1):1-11 - PMID: 33028653 - PMCID: PMC7749632 - DOI: 10.1261/rna.077693.120

Tsurumi A, Flaherty PJ, Que YA, Ryan CM, Mendoza AE, Almpani M, Bandyopadhaya A, Ogura A, Dhole YV, Goodfield LF, Tompkins RG, Rahme LG

Multi-biomarker Prediction Models for Multiple Infection Episodes Following Blunt Trauma.
iScience. 2020;23(11):101659 - PMID: 33047099 - PMCID: PMC7539926 - DOI: 10.1016/j.isci.2020.101659

Xu W, Rush JS, Graham DB, Cao Z, Xavier RJ

USP15 Deubiquitinates CARD9 to Downregulate C-Type Lectin Receptor-Mediated Signaling.
Immunohorizons. 2020;4(10):670-678 - PMID: 33093067 - PMCID: PMC7758836 - DOI: 10.4049/immunohorizons.2000036

Strom KR, Szostak JW

Solid-Phase Synthesis of Sequence-Defined Informational Oligomers.
J Org Chem. 2020;85(21):13929-13938 - PMID: 33064001 - PMCID: PMC9594334 - DOI: 10.1021/acs.joc.0c01977

Lee K, Escobar I, Jang Y, Kim W, Ausubel FM, Mylonakis E

In the Model Host Caenorhabditis elegans, Sphingosine-1-Phosphate-Mediated Signaling Increases Immunity toward Human Opportunistic Bacteria.
Int J Mol Sci. 2020;21(21):ePub - PMID: 33105563 - PMCID: PMC7672543 - DOI: 10.3390/ijms21217813

Carr CE, Bryan NC, Saboda KN, Bhattaru SA, Ruvkun G, Zuber MT

Nanopore sequencing at Mars, Europa, and microgravity conditions.
NPJ Microgravity. 2020;6(1):24 - PMID: 34489469 - DOI: 10.1038/s41526-020-00113-9

O'Flaherty DK, Zhou L, Szostak JW

Nonenzymatic RNA-templated Synthesis of N3'→P5' Phosphoramidate DNA.
Bio Protoc. 2020;10(17):e3734 - PMID: 33659395 - PMCID: PMC7842504 - DOI: 10.21769/BioProtoc.3734

Borren NZ, Plichta D, Joshi AD, Bonilla G, Sadreyev R, Vlamakis H, Xavier RJ, Ananthakrishnan AN

Multi-"-Omics" Profiling in Patients With Quiescent Inflammatory Bowel Disease Identifies Biomarkers Predicting Relapse.
Inflamm Bowel Dis. 2020;26(10):1524-1532 - PMID: 32766830 - PMCID: PMC7500522 - DOI: 10.1093/ibd/izaa183

Zhang SJ, Duzdevich D, Szostak JW

Potentially Prebiotic Activation Chemistry Compatible with Nonenzymatic RNA Copying.
J Am Chem Soc. 2020;142(35):14810-14813 - PMID: 32794700 - PMCID: PMC9594304 - DOI: 10.1021/jacs.0c05300

Zhou L, O'Flaherty DK, Szostak JW

Assembly of a ribozyme ligase from short oligomers by nonenzymatic ligation.
J Am Chem Soc. 2020;142(37):15961-15965 - PMID: 32820909 - PMCID: PMC9594310 - DOI: 10.1021/jacs.0c06722

Kong L, Lloyd-Price J, Vatanen T, Seksik P, Beaugerie L, Simon T, Vlamakis H, Sokol H, Xavier RJ

Linking strain engraftment in fecal microbiota transplantation with maintenance of remission in Crohn's disease.
Gastroenterology. 2020;159(6):2193-2202.e5 - PMID: 32860788 - PMCID: PMC7725862 - DOI: 10.1053/j.gastro.2020.08.045

Drokhlyansky E, Smillie CS, Van Wittenberghe N, Ericsson M, Griffin GK, Eraslan G, Dionne D, Cuoco MS, Goder-Reiser MN, Sharova T, Kuksenko O, Aguirre AJ, Boland GM, Graham D, Rozenblatt-Rosen O, Xavier RJ, Regev A

The Human and Mouse Enteric Nervous System at Single-Cell Resolution.
Cell. 2020;182(6):1606-1622.e23 - PMID: 32888429 - PMCID: PMC8358727 - DOI: 10.1016/j.cell.2020.08.003

Clement K, Hsu JY, Canver MC, Joung JK, Pinello L

Technologies and Computational Analysis Strategies for CRISPR Applications.
Mol Cell. 2020;79(1):11-29 - PMID: 32619467 - PMCID: PMC7497852 - DOI: 10.1016/j.molcel.2020.06.012

Kurt IC, Zhou R, Iyer S, Garcia SP, Miller BR, Langner LM, Grünewald J, Joung JK

CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells.
Nat Biotechnol. 2021;39(1):41-46 - PMID: 32690971 - PMCID: PMC7854778 - DOI: 10.1038/s41587-020-0609-x

Hu S, Vich Vila A, Gacesa R, Collij V, Stevens C, Fu JM, Wong I, Talkowski ME, Rivas MA, Imhann F, Bolte L, van Dullemen H, Dijkstra G, Visschedijk MC, Festen EA, Xavier RJ, Fu J, Daly MJ, Wijmenga C, Zhernakova A, Kurilshikov A, Weersma RK

Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.
Gut. 2021;70(2):285-296 - PMID: 32651235 - PMCID: PMC7815889 - DOI: 10.1136/gutjnl-2019-319706

Xavier RJ

Growth and the Microbiome - Integrating Global Health with Basic Science.
N Engl J Med. 2020;383(4):391-393 - PMID: 32706538 - DOI: 10.1056/NEJMe2017496

Virgin HW, Cuervo AM, Xavier RJ

Beth Cindy Levine (1960-2020).
Science. 2020;369(6502):378 - PMID: 32703867 - DOI: 10.1126/science.abd6216

Wei W, Ruvkun G

Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism.
Proc Natl Acad Sci U S A. 2020;117(33):19970-19981 - PMID: 32737159 - PMCID: PMC7443905 - DOI: 10.1073/pnas.2008021117
Total: 2498