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Kong L, Lloyd-Price J, Vatanen T, Seksik P, Beaugerie L, Simon T, Vlamakis H, Sokol H, Xavier RJ

Linking strain engraftment in fecal microbiota transplantation with maintenance of remission in Crohn's disease.
Gastroenterology. 2020;159(6):2193-2202.e5 - PMID: 32860788 - PMCID: PMC7725862 - DOI: 10.1053/j.gastro.2020.08.045

Drokhlyansky E, Smillie CS, Van Wittenberghe N, Ericsson M, Griffin GK, Eraslan G, Dionne D, Cuoco MS, Goder-Reiser MN, Sharova T, Kuksenko O, Aguirre AJ, Boland GM, Graham D, Rozenblatt-Rosen O, Xavier RJ, Regev A

The Human and Mouse Enteric Nervous System at Single-Cell Resolution.
Cell. 2020;182(6):1606-1622.e23 - PMID: 32888429 - PMCID: PMC8358727 - DOI: 10.1016/j.cell.2020.08.003

Clement K, Hsu JY, Canver MC, Joung JK, Pinello L

Technologies and Computational Analysis Strategies for CRISPR Applications.
Mol Cell. 2020;79(1):11-29 - PMID: 32619467 - PMCID: PMC7497852 - DOI: 10.1016/j.molcel.2020.06.012

Kurt IC, Zhou R, Iyer S, Garcia SP, Miller BR, Langner LM, Grünewald J, Joung JK

CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells.
Nat Biotechnol. 2021;39(1):41-46 - PMID: 32690971 - PMCID: PMC7854778 - DOI: 10.1038/s41587-020-0609-x

Hu S, Vich Vila A, Gacesa R, Collij V, Stevens C, Fu JM, Wong I, Talkowski ME, Rivas MA, Imhann F, Bolte L, van Dullemen H, Dijkstra G, Visschedijk MC, Festen EA, Xavier RJ, Fu J, Daly MJ, Wijmenga C, Zhernakova A, Kurilshikov A, Weersma RK

Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.
Gut. 2021;70(2):285-296 - PMID: 32651235 - PMCID: PMC7815889 - DOI: 10.1136/gutjnl-2019-319706

Xavier RJ

Growth and the Microbiome - Integrating Global Health with Basic Science.
N Engl J Med. 2020;383(4):391-393 - PMID: 32706538 - DOI: 10.1056/NEJMe2017496

Virgin HW, Cuervo AM, Xavier RJ

Beth Cindy Levine (1960-2020).
Science. 2020;369(6502):378 - PMID: 32703867 - DOI: 10.1126/science.abd6216

Wei W, Ruvkun G

Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism.
Proc Natl Acad Sci U S A. 2020;117(33):19970-19981 - PMID: 32737159 - PMCID: PMC7443905 - DOI: 10.1073/pnas.2008021117

Khader R, Tharmalingam N, Mishra B, Felix L, Ausubel FM, Kelso MJ, Mylonakis E

Characterization of Five Novel Anti-MRSA Compounds Identified Using a Whole-Animal Caenorhabditis elegans/Galleria mellonella Sequential-Screening Approach.
Antibiotics (Basel). 2020;9(8):ePub - PMID: 32726955 - PMCID: PMC7459823 - DOI: 10.3390/antibiotics9080449

Gomes ALC, Johns NI, Yang A, Velez-Cortes F, Smillie CS, Smith MB, Alm EJ, Wang HH

Genome and sequence determinants governing the expression of horizontally acquired DNA in bacteria.
ISME J. 2020;14(9):2347-2357 - PMID: 32514119 - PMCID: PMC7608860 - DOI: 10.1038/s41396-020-0696-1

Strecker J, Ladha A, Makarova KS, Koonin EV, Zhang F

Response to Comment on "RNA-guided DNA insertion with CRISPR-associated transposases".
Science. 2020;368(6495):ePub - PMID: 32499411 - DOI: 10.1126/science.abb2920

Grünewald J, Zhou R, Lareau CA, Garcia SP, Iyer S, Miller BR, Langner LM, Hsu JY, Aryee MJ, Joung JK

A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing.
Nat Biotechnol. 2020;38(7):861-864 - PMID: 32483364 - PMCID: PMC7723518 - DOI: 10.1038/s41587-020-0535-y

Zhou L, O'Flaherty DK, Szostak JW

Template-directed copying of RNA by non-enzymatic ligation.
Angew Chem Int Ed Engl. 2020;59(36):15682-15687 - PMID: 32558121 - PMCID: PMC7496532 - DOI: 10.1002/anie.202004934

Kenny DJ, Plichta DR, Shungin D, Koppel N, Hall AB, Fu B, Vasan RS, Shaw SY, Vlamakis H, Balskus EP, Xavier RJ

Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level.
Cell Host Microbe. 2020;28(2):245-257.e6 - PMID: 32544460 - PMCID: PMC7435688 - DOI: 10.1016/j.chom.2020.05.013

Varma M, Kadoki M, Lefkovith A, Conway KL, Gao K, Mohanan V, Tusi BK, Graham DB, Latorre IJ, Tolonen AC, Khor B, Ng A, Xavier RJ

Cell Type- and Stimulation-Dependent Transcriptional Programs Regulated by Atg16L1 and Its Crohn's Disease Risk Variant T300A.
J Immunol. 2020;205(2):414-424 - PMID: 32522834 - PMCID: PMC7364322 - DOI: 10.4049/jimmunol.1900750

Kim W, Zou G, Pan W, Fricke N, Faizi HA, Kim SM, Khader R, Li S, Lee K, Escorba I, Vlahovska PM, Gao H, Ausubel FM, Mylonakis E

The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus.
MBio. 2020;11(3):ePub - PMID: 32605985 - PMCID: PMC7327171 - DOI: 10.1128/mBio.01140-20

Kindt JT, Szostak JW, Wang A

Bulk Self-Assembly of Giant, Unilamellar Vesicles.
ACS Nano. 2020;14(11):14627-14634 - PMID: 32602696 - PMCID: PMC8172239 - DOI: 10.1021/acsnano.0c03125

Slyper M, Porter CBM, Ashenberg O, Waldman J, Drokhlyansky E, Wakiro I, Smillie C, Smith-Rosario G, Wu J, Dionne D, Vigneau S, Jané-Valbuena J, Tickle TL, Napolitano S, Su MJ, Patel AG, Karlstrom A, Gritsch S, Nomura M, Waghray A, Gohil SH, Tsankov AM, Jerby-Arnon L, Cohen O, Klughammer J, Rosen Y, Gould J, Nguyen L, Hofree M, Tramontozzi PJ, Li B, Wu CJ, Izar B, Haq R, Hodi FS, Yoon CH, Hata AN, Baker SJ, Suvà ML, Bueno R, Stover EH, Clay MR, Dyer MA, Collins NB, Matulonis UA, Wagle N, Johnson BE, Rotem A, Rozenblatt-Rosen O, Regev A

A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors.
Nat Med. 2020;26(5):792-802 - PMID: 32405060 - PMCID: PMC7220853 - DOI: 10.1038/s41591-020-0844-1

Duzdevich D, Carr CE, Szostak JW

Deep sequencing of non-enzymatic RNA primer extension.
Nucleic Acids Res. 2020;48(12):e70 - PMID: 32427335 - PMCID: PMC7337528 - DOI: 10.1093/nar/gkaa400

Ernst CM, Braxton JR, Rodriguez-Osorio CA, Zagieboylo AP, Li L, Pironti A, Manson AL, Nair AV, Benson M, Cummins K, Clatworthy AE, Earl AM, Cosimi LA, Hung DT

Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae.
Nat Med. 2020;26(5):705-711 - PMID: 32284589 - PMCID: PMC9194776 - DOI: 10.1038/s41591-020-0825-4

Todd ZR, Fahrenbach AC, Ranjan S, Magnani CJ, Szostak JW, Sasselov DD

Ultraviolet-Driven Deamination of Cytidine Ribonucleotides Under Planetary Conditions.
Astrobiology. 2020;20(7):878-888 - PMID: 32267736 - PMCID: PMC9634989 - DOI: 10.1089/ast.2019.2182

Ackerman CM, Myhrvold C, Thakku SG, Freije CA, Metsky HC, Yang DK, Ye SH, Boehm CK, Kosoko-Thoroddsen TF, Kehe J, Nguyen TG, Carter A, Kulesa A, Barnes JR, Dugan VG, Hung DT, Blainey PC, Sabeti PC

Massively multiplexed nucleic acid detection with Cas13.
Nature. 2020;582(7811):277-282 - PMID: 32349121 - PMCID: PMC7332423 - DOI: 10.1038/s41586-020-2279-8

Lelyveld VS, Zhang W, Szostak JW

Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase.
Proc Natl Acad Sci U S A. 2020;117(13):7276-7283 - PMID: 32188786 - PMCID: PMC7132125 - DOI: 10.1073/pnas.1922400117

Borren NZ, Plichta D, Joshi AD, Bonilla G, Peng V, Colizzo FP, Luther J, Khalili H, Garber JJ, van der Woude CJ, Sadreyev R, Vlamakis H, Xavier RJ, Ananthakrishnan AN

Alterations in Fecal Microbiomes and Serum Metabolomes of Fatigued Patients With Quiescent Inflammatory Bowel Diseases.
Clin Gastroenterol Hepatol. 2021;19(3):519-527.e5 - PMID: 32184182 - DOI: 10.1016/j.cgh.2020.03.013

Frydman GH, Tessier SN, Wong KHK, Vanderburg CR, Fox JG, Toner M, Tompkins RG, Irimia D

Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis.
Sci Rep. 2020;10(1):4621 - PMID: 32165642 - PMCID: PMC7067782 - DOI: 10.1038/s41598-020-61309-3
Total: 2481