Publications for All Faculty

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Shibolet O, Giallourakis C, Rosenberg I, Mueller T, Xavier RJ, Podolsky DK

AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling.

J Biol Chem. 2007;282(48):35308-17 - PMID: 17878165 - DOI: 10.1074/jbc.M704426200
Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB

Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.

Proc Natl Acad Sci U S A. 2007;104(39):15424-9 - PMID: 17878299 - PMCID: PMC2000553 - DOI: 10.1073/pnas.0706881104
Cao Z, Huett A, Kuballa P, Giallourakis C, Xavier RJ

DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.

Cell Signal. 2008;20(1):73-82 - PMID: 17980554 - PMCID: PMC2257480 - DOI: 10.1016/j.cellsig.2007.08.019
Tsai CH, Chen J, Szostak JW

Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template.

Proc Natl Acad Sci U S A. 2007;104(37):14598-603 - PMID: 17785419 - PMCID: PMC1976233 - DOI: 10.1073/pnas.0704211104
Lesic B, Lépine F, Déziel E, Zhang J, Zhang Q, Padfield K, Castonguay MH, Milot S, Stachel S, Tzika AA, Tompkins RG, Rahme LG

Inhibitors of pathogen intercellular signals as selective anti-infective compounds.

PLoS Pathog. 2007;3(9):1229-39 - PMID: 17941706 - PMCID: PMC2323289 - DOI: 10.1371/journal.ppat.0030126
Clatworthy AE, Pierson E, Hung DT

Targeting virulence: a new paradigm for antimicrobial therapy.

Nat Chem Biol. 2007;3(9):541-8 - PMID: 17710100 - DOI: 10.1038/nchembio.2007.24
Xiao F, He P, Abramovitch RB, Dawson JE, Nicholson LK, Sheen J, Martin GB

The N-terminal region of Pseudomonas type III effector AvrPtoB elicits Pto-dependent immunity and has two distinct virulence determinants.

Plant J. 2007;52(4):595-614 - PMID: 17764515 - PMCID: PMC2265002 - DOI: 10.1111/j.1365-313X.2007.03259.x
Stephenson LM, Sammut B, Graham DB, Chan-Wang J, Brim KL, Huett AS, Miletic AV, Kloeppel T, Landry A, Xavier R, Swat W

DLGH1 is a negative regulator of T-lymphocyte proliferation.

Mol Cell Biol. 2007;27(21):7574-81 - PMID: 17724087 - PMCID: PMC2169038 - DOI: 10.1128/MCB.00439-07
Kim N, Dempsey CM, Kuan CJ, Zoval JV, O'Rourke E, Ruvkun G, Madou MJ, Sze JY

Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans.

Genetics. 2007;177(2):835-45 - PMID: 17720915 - PMCID: PMC2034647 - DOI: 10.1534/genetics.107.076901
Seelig B, Szostak JW

Selection and evolution of enzymes from a partially randomized non-catalytic scaffold.

Nature. 2007;448(7155):828-31 - PMID: 17700701 - PMCID: PMC4476047 - DOI: 10.1038/nature06032
Baena-González E, Rolland F, Thevelein JM, Sheen J

A central integrator of transcription networks in plant stress and energy signalling.

Nature. 2007;448(7156):938-42 - PMID: 17671505 - DOI: 10.1038/nature06069
Stuart LM, Bell SA, Stewart CR, Silver JM, Richard J, Goss JL, Tseng AA, Zhang A, El Khoury JB, Moore KJ

CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex.

J Biol Chem. 2007;282(37):27392-27401 - PMID: 17623670 - DOI: 10.1074/jbc.M702887200
Mylonakis E, Casadevall A, Ausubel FM

Exploiting amoeboid and non-vertebrate animal model systems to study the virulence of human pathogenic fungi.

PLoS Pathog. 2007;3(7):e101 - PMID: 17676994 - PMCID: PMC1933451 - DOI: 10.1371/journal.ppat.0030101
Xavier RJ, Podolsky DK

Unravelling the pathogenesis of inflammatory bowel disease.

Nature. 2007;448(7152):427-34 - PMID: 17653185 - DOI: 10.1038/nature06005
Cheng X, Irimia D, Dixon M, Ziperstein JC, Demirci U, Zamir L, Tompkins RG, Toner M, Rodriguez WR

A microchip approach for practical label-free CD4+ T-cell counting of HIV-infected subjects in resource-poor settings.

J Acquir Immune Defic Syndr. 2007;45(3):257-61 - PMID: 17414933 - DOI: 10.1097/QAI.0b013e3180500303
Yoo SD, Cho YH, Sheen J

Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis.

Nat Protoc. 2007;2(7):1565-72 - PMID: 17585298 - DOI: 10.1038/nprot.2007.199
Kuchma SL, Brothers KM, Merritt JH, Liberati NT, Ausubel FM, O'Toole GA

BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14.

J Bacteriol. 2007;189(22):8165-78 - PMID: 17586641 - PMCID: PMC2168662 - DOI: 10.1128/JB.00586-07
Mooij MJ, Drenkard E, Llamas MA, Vandenbroucke-Grauls CM, Savelkoul PH, Ausubel FM, Bitter W

Characterization of the integrated filamentous phage Pf5 and its involvement in small-colony formation.

Microbiology. 2007;153(Pt 6):1790-8 - PMID: 17526836 - PMCID: PMC3820363 - DOI: 10.1099/mic.0.2006/003533-0
Kueng HJ, Leb VM, Haiderer D, Raposo G, Thery C, Derdak SV, Schmetterer KG, Neunkirchner A, Sillaber C, Seed B, Pickl WF

General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines.

J Virol. 2007;81(16):8666-76 - PMID: 17537846 - PMCID: PMC1951353 - DOI: 10.1128/JVI.00682-07
Meng X, Thibodeau-Beganny S, Jiang T, Joung JK, Wolfe SA

Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method.

Nucleic Acids Res. 2007;35(11):e81 - PMID: 17537811 - PMCID: PMC1920264 - DOI: 10.1093/nar/gkm385
Mansy SS, Zhang J, Kümmerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC

Structure and evolutionary analysis of a non-biological ATP-binding protein.

J Mol Biol. 2007;371(2):501-13 - PMID: 17583732 - DOI: 10.1016/j.jmb.2007.05.062
Sander JD, Zaback P, Joung JK, Voytas DF, Dobbs D

Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool.

Nucleic Acids Res. 2007;35(Web Server issue):W599-605 - PMID: 17526515 - PMCID: PMC1933188 - DOI: 10.1093/nar/gkm349
Smith MD, Rosenow MA, Wang M, Allen JP, Szostak JW, Chaput JC

Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization.

PLoS One. 2007;2(5):e467 - PMID: 17520026 - PMCID: PMC1867856 - DOI: 10.1371/journal.pone.0000467
Hazen RM, Griffin PL, Carothers JM, Szostak JW

Functional information and the emergence of biocomplexity.

Proc Natl Acad Sci U S A. 2007;104 Suppl 1:8574-81 - PMID: 17494745 - PMCID: PMC1876432 - DOI: 10.1073/pnas.0701744104
van Passel MW, Smillie CS, Ochman H

Gene decay in archaea.

Archaea. 2007;2(2):137-43 - PMID: 17350934 - PMCID: PMC2686384 - DOI: 10.1155/2007/165723
Total: 2467