Publications for All Faculty

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Nusbaum C, Ohsumi TK, Gomez J, Aquadro J, Victor TC, Warren RM, Hung DT, Birren BW, Lander ES, Jaffe DB

Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing.
Nat Methods. 2009;6(1):67-9 - PMID: 19079253 - PMCID: PMC2613166 - DOI: 10.1038/nmeth.1286

Gopalan S, Ausubel FM

A metasystem of framework model organisms to study emergence of new host-microbe adaptations.
PLoS One. 2008;3(12):e3891 - PMID: 19066631 - PMCID: PMC2588659 - DOI: 10.1371/journal.pone.0003891

Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.
Proc Natl Acad Sci U S A. 2008;105(51):20321-6 - PMID: 19073936 - PMCID: PMC2600581 - DOI: 10.1073/pnas.0810773105

Sander JD, Zaback P, Joung JK, Voytas DF, Dobbs D

An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins.
Nucleic Acids Res. 2009;37(2):506-15 - PMID: 19056825 - PMCID: PMC2632909 - DOI: 10.1093/nar/gkn962

Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.
Cell. 2008;135(7):1311-23 - PMID: 19109899 - PMCID: PMC2621059 - DOI: 10.1016/j.cell.2008.10.044

Troemel ER, Félix MA, Whiteman NK, Barrière A, Ausubel FM

Microsporidia are natural intracellular parasites of the nematode Caenorhabditis elegans.
PLoS Biol. 2008;6(12):2736-52 - PMID: 19071962 - PMCID: PMC2596862 - DOI: 10.1371/journal.pbio.0060309

Irimia D, Mindrinos M, Russom A, Xiao W, Wilhelmy J, Wang S, Heath JD, Kurn N, Tompkins RG, Davis RW, Toner M

Genome-wide transcriptome analysis of 150 cell samples.
Integr Biol (Camb). 2009;1(1):99-107 - PMID: 20023796 - PMCID: PMC3763906 - DOI: 10.1039/b814329c

Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, Silver GM, Jeschke MG, Finnerty CC, Tompkins RG, Herndon DN

Impact of oxandrolone treatment on acute outcomes after severe burn injury.
J Burn Care Res. 2008;29(6):902-6 - PMID: 18849836 - PMCID: PMC3958934 - DOI: 10.1097/BCR.0b013e31818ba14d

Guttormsen HK, Stuart LM, Shi L, Carroll MC, Chen J, Kasper DL, Ezekowitz RA, Takahashi K

Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination.
Clin Immunol. 2009;130(3):264-71 - PMID: 18996748 - PMCID: PMC2660855 - DOI: 10.1016/j.clim.2008.09.012

Irazoqui JE, Ng A, Xavier RJ, Ausubel FM

Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.
Proc Natl Acad Sci U S A. 2008;105(45):17469-74 - PMID: 18981407 - PMCID: PMC2582251 - DOI: 10.1073/pnas.0809527105

Wang MC, O'Rourke EJ, Ruvkun G

Fat metabolism links germline stem cells and longevity in C. elegans.
Science. 2008;322(5903):957-60 - PMID: 18988854 - PMCID: PMC2760269 - DOI: 10.1126/science.1162011

Zuo Y, Zhuang DZ, Han R, Isaac G, Tobin JJ, McKee M, Welti R, Brissette JL, Fitzgerald ML, Freeman MW

ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters.
J Biol Chem. 2008;283(52):36624-35 - PMID: 18957418 - PMCID: PMC2605993 - DOI: 10.1074/jbc.M807377200

Manning-Tobin JJ, Moore KJ, Seimon TA, Bell SA, Sharuk M, Alvarez-Leite JI, de Winther MP, Tabas I, Freeman MW

Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice.
Arterioscler Thromb Vasc Biol. 2009;29(1):19-26 - PMID: 18948635 - PMCID: PMC2666043 - DOI: 10.1161/ATVBAHA.108.176644

Ramon M, Rolland F, Sheen J

Sugar sensing and signaling.
Arabidopsis Book. 2008;6:e0117 - PMID: 22303242 - PMCID: PMC3243355 - DOI: 10.1199/tab.0117

Isenbarger TA, Carr CE, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G

The most conserved genome segments for life detection on Earth and other planets.
Orig Life Evol Biosph. 2008;38(6):517-33 - PMID: 18853276 - DOI: 10.1007/s11084-008-9148-z

Kuballa P, Huett A, Rioux JD, Daly MJ, Xavier RJ

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.
PLoS One. 2008;3(10):e3391 - PMID: 18852889 - PMCID: PMC2566595 - DOI: 10.1371/journal.pone.0003391

Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
Nature. 2008;456(7219):259-63 - PMID: 18849966 - PMCID: PMC2695978 - DOI: 10.1038/nature07416

Ruvkun G

The perfect storm of tiny RNAs.
Nat Med. 2008;14(10):1041-5 - PMID: 18841145 - DOI: 10.1038/nm1008-1041

Huang R, Barber TA, Schmidt MA, Tompkins RG, Toner M, Bianchi DW, Kapur R, Flejter WL

A microfluidics approach for the isolation of nucleated red blood cells (NRBCs) from the peripheral blood of pregnant women.
Prenat Diagn. 2008;28(10):892-9 - PMID: 18821715 - PMCID: PMC4482103 - DOI: 10.1002/pd.2079

Litovchick A, Szostak JW

Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display.
Proc Natl Acad Sci U S A. 2008;105(40):15293-8 - PMID: 18824687 - PMCID: PMC2556359 - DOI: 10.1073/pnas.0805837105

Finnerty CC, Jeschke MG, Herndon DN, Gamelli R, Gibran N, Klein M, Silver G, Arnoldo B, Remick D, Tompkins RG,

Temporal cytokine profiles in severely burned patients: a comparison of adults and children.
Mol Med. 2008;14(9-10):553-60 - PMID: 18548133 - PMCID: PMC2424320 - DOI: 10.2119/2007-00132.Finnerty

Fu F, Sander JD, Maeder M, Thibodeau-Beganny S, Joung JK, Dobbs D, Miller L, Voytas DF

Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays.
Nucleic Acids Res. 2009;37(Database issue):D279-83 - PMID: 18812396 - PMCID: PMC2686427 - DOI: 10.1093/nar/gkn606

Galletti R, Denoux C, Gambetta S, Dewdney J, Ausubel FM, De Lorenzo G, Ferrari S

The AtrbohD-mediated oxidative burst elicited by oligogalacturonides in Arabidopsis is dispensable for the activation of defense responses effective against Botrytis cinerea.
Plant Physiol. 2008;148(3):1695-706 - PMID: 18790995 - PMCID: PMC2577270 - DOI: 10.1104/pp.108.127845

Fischer SE, Butler MD, Pan Q, Ruvkun G

Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.
Nature. 2008;455(7212):491-6 - PMID: 18784652 - PMCID: PMC2756026 - DOI: 10.1038/nature07274

Thomson CE, McCulloch M, Sorenson A, Barnett SC, Seed BV, Griffiths IR, McLaughlin M

Myelinated, synapsing cultures of murine spinal cord--validation as an in vitro model of the central nervous system.
Eur J Neurosci. 2008;28(8):1518-35 - PMID: 18793322 - PMCID: PMC2777255 - DOI: 10.1111/j.1460-9568.2008.06415.x
Total: 2498