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Ding D, Zhou L, Mittal S, Szostak JW

Experimental Tests of the Virtual Circular Genome Model for Nonenzymatic RNA Replication.
J Am Chem Soc. 2023;145(13):7504-7515 - PMID: 36963403 - PMCID: PMC10080680 - DOI: 10.1021/jacs.3c00612

Huang XW, Pan W, Zhong MZ, Chhonker YS, Steele AD, Keohane CE, Mishra B, Felix Raj Lucas LO, Murry DJ, Ausubel FM, Wuest WM, Li CX, Mylonakis E

Biological Evaluation of the Antibacterial Retinoid CD437 in Cutibacterium acnes Infection.
Antimicrob Agents Chemother. 2023;67(4):e0167922 - PMID: 36943064 - PMCID: PMC10112217 - DOI: 10.1128/aac.01679-22

Halvorsen SC, Benita Y, Hopton M, Hoppe B, Gunnlaugsson HO, Korgaonkar P, Vanderburg CR, Nielsen GP, Trepanowski N, Cheah JH, Frosch MP, Schwab JH, Rosenberg AE, Hornicek FJ, Sassi S

Transcriptional Profiling Supports the Notochordal Origin of Chordoma and Its Dependence on a TGFΒ1-TBXT Network.
Am J Pathol. 2023;193(5):532-547 - PMID: 36804377 - DOI: 10.1016/j.ajpath.2023.01.014

Freeman MW, Bond M, Murphy B, Hui J, Isaacsohn J

Results From a Randomized, Open-Label, Crossover Study Evaluating the Effect of the Aldosterone Synthase Inhibitor Baxdrostat on the Pharmacokinetics of Metformin in Healthy Human Subjects.
Am J Cardiovasc Drugs. 2023;23(3):277-286 - PMID: 36790596 - PMCID: PMC9930700 - DOI: 10.1007/s40256-023-00572-x

Scheid JF, Eraslan B, Hudak A, Brown EM, Sergio D, Delorey TM, Phillips D, Lefkovith A, Jess AT, Duck LW, Elson CO, Vlamakis H, Plichta DR, Deguine J, Ananthakrishnan AN, Graham DB, Regev A, Xavier RJ

Remodeling of colon plasma cell repertoire within ulcerative colitis patients.
J Exp Med. 2023;220(4):ePub - PMID: 36752797 - PMCID: PMC9949229 - DOI: 10.1084/jem.20220538

Brown EM, Clardy J, Xavier RJ

Gut microbiome lipid metabolism and its impact on host physiology.
Cell Host Microbe. 2023;31(2):173-186 - PMID: 36758518 - PMCID: PMC10124142 - DOI: 10.1016/j.chom.2023.01.009

Ma P, Amemiya HM, He LL, Gandhi SJ, Nicol R, Bhattacharyya RP, Smillie CS, Hung DT

Bacterial droplet-based single-cell RNA-seq reveals antibiotic-associated heterogeneous cellular states.
Cell. 2023;186(4):877-891.e14 - PMID: 36708705 - PMCID: PMC10014032 - DOI: 10.1016/j.cell.2023.01.002

Kong L, Pokatayev V, Lefkovith A, Carter GT, Creasey EA, Krishna C, Subramanian S, Kochar B, Ashenberg O, Lau H, Ananthakrishnan AN, Graham DB, Deguine J, Xavier RJ

The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon.
Immunity. 2023;56(2):444-458.e5 - PMID: 36720220 - PMCID: PMC9957882 - DOI: 10.1016/j.immuni.2023.01.002

Vatanen T, Jabbar KS, Ruohtula T, Honkanen J, Avila-Pacheco J, Siljander H, Stražar M, Oikarinen S, Hyöty H, Ilonen J, Mitchell CM, Yassour M, Virtanen SM, Clish CB, Plichta DR, Vlamakis H, Knip M, Xavier RJ

Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism.
Cell. 2022;185(26):4921-4936.e15 - PMID: 36563663 - PMCID: PMC9869402 - DOI: 10.1016/j.cell.2022.11.023

Mao K, Breen P, Ruvkun G

The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways.
Proc Natl Acad Sci U S A. 2022;119(49):e2215966119 - PMID: 36445965 - PMCID: PMC9894117 - DOI: 10.1073/pnas.2215966119

Freeman MW, Halvorsen YD, Marshall W, Pater M, Isaacsohn J, Pearce C, Murphy B, Alp N, Srivastava A, Bhatt DL, Brown MJ, BrigHTN Investigators

Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension.
N Engl J Med. 2022;388(5):395-405 - PMID: 36342143 - DOI: 10.1056/NEJMoa2213169

Strecker J, Demircioglu FE, Li D, Faure G, Wilkinson ME, Gootenberg JS, Abudayyeh OO, Nishimasu H, Macrae RK, Zhang F

RNA-activated protein cleavage with a CRISPR-associated endopeptidase.
Science. 2022;378(6622):874-881 - PMID: 36423276 - PMCID: PMC10028731 - DOI: 10.1126/science.add7450

Vatanen T, Ang QY, Siegwald L, Sarker SA, Le Roy CI, Duboux S, Delannoy-Bruno O, Ngom-Bru C, Boulangé CL, Stražar M, Avila-Pacheco J, Deik A, Pierce K, Bullock K, Dennis C, Sultana S, Sayed S, Rahman M, Ahmed T, Modesto M, Mattarelli P, Clish CB, Vlamakis H, Plichta DR, Sakwinska O, Xavier RJ

A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning.
Cell. 2022;185(23):4280-4297.e12 - PMID: 36323316 - DOI: 10.1016/j.cell.2022.10.011

Peng V, Cao S, Trsan T, Bando JK, Avila-Pacheco J, Cleveland JL, Clish C, Xavier RJ, Colonna M

Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription.
Proc Natl Acad Sci U S A. 2022;119(45):e2214900119 - PMID: 36279426 - PMCID: PMC9659397 - DOI: 10.1073/pnas.2214900119

Freeman MW, Bond M, Murphy B, Hui J, Isaacsohn J

Results from a phase 1, randomized, double-blind, multiple ascending dose study characterizing the pharmacokinetics and demonstrating the safety and selectivity of the aldosterone synthase inhibitor baxdrostat in healthy volunteers.
Hypertens Res. 2022;46(1):108-118 - PMID: 36266539 - PMCID: PMC9747611 - DOI: 10.1038/s41440-022-01070-4

Halvorsen YD, Lock JP, Frias JP, Tinahones FJ, Dahl D, Conery AL, Freeman MW

A 96-Week, Double-Blind, Randomized, Controlled Trial Comparing Bexagliflozin to Glimepiride as an Adjunct to Metformin for the Treatment of Type 2 Diabetes in Adults.
Diabetes Obes Metab. 2022;25(1):293-301 - PMID: 36178197 - DOI: 10.1111/dom.14875

Jagadeesh KA, Dey KK, Montoro DT, Mohan R, Gazal S, Engreitz JM, Xavier RJ, Price AL, Regev A

Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics.
Nat Genet. 2022;54(10):1479-1492 - PMID: 36175791 - PMCID: PMC9910198 - DOI: 10.1038/s41588-022-01187-9

Strom KR, Szostak JW

Folding and Duplex Formation in Sequence-Defined Aniline Benzaldehyde Oligoarylacetylenes.
J Am Chem Soc. 2022;144(40):18350-18358 - PMID: 36174969 - PMCID: PMC9562438 - DOI: 10.1021/jacs.2c06268

Grünewald J, Miller BR, Szalay RN, Cabeceiras PK, Woodilla CJ, Holtz EJB, Petri K, Joung JK

Engineered CRISPR prime editors with compact, untethered reverse transcriptases.
Nat Biotechnol. 2022;41(3):337-343 - PMID: 36163548 - PMCID: PMC10023297 - DOI: 10.1038/s41587-022-01473-1

Liu KH, Liu M, Lin Z, Wang ZF, Chen B, Liu C, Guo A, Konishi M, Yanagisawa S, Wagner G, Sheen J

NIN-like protein 7 transcription factor is a plant nitrate sensor.
Science. 2022;377(6613):1419-1425 - PMID: 36137053 - PMCID: PMC9628810 - DOI: 10.1126/science.add1104

Rojas-Tapias DF, Brown EM, Temple ER, Onyekaba MA, Mohamed AMT, Duncan K, Schirmer M, Walker RL, Mayassi T, Pierce KA, Ávila-Pacheco J, Clish CB, Vlamakis H, Xavier RJ

Inflammation-associated nitrate facilitates ectopic colonization of oral bacterium Veillonella parvula in the intestine.
Nat Microbiol. 2022;7(10):1673-1685 - PMID: 36138166 - PMCID: PMC9728153 - DOI: 10.1038/s41564-022-01224-7

Ye R, Wang M, Du H, Chhajed S, Koh J, Liu KH, Shin J, Wu Y, Shi L, Xu L, Chen S, Zhang Y, Sheen J

Glucose-driven TOR-FIE-PRC2 signalling controls plant development.
Nature. 2022;609(7929):986-993 - PMID: 36104568 - PMCID: PMC9530021 - DOI: 10.1038/s41586-022-05171-5

Todisco M, Szostak JW

Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides.
Nucleic Acids Res. 2022;50(17):9647-9662 - PMID: 36099434 - PMCID: PMC9508827 - DOI: 10.1093/nar/gkac784

Pedersen TK, Brown EM, Plichta DR, Johansen J, Twardus SW, Delorey TM, Lau H, Vlamakis H, Moon JJ, Xavier RJ, Graham DB

The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn's disease.
Immunity. 2022;55(10):1909-1923.e6 - PMID: 36115338 - PMCID: PMC9890645 - DOI: 10.1016/j.immuni.2022.08.016

Li Y, Watanabe E, Kawashima Y, Plichta DR, Wang Z, Ujike M, Ang QY, Wu R, Furuichi M, Takeshita K, Yoshida K, Nishiyama K, Kearney SM, Suda W, Hattori M, Sasajima S, Matsunaga T, Zhang X, Watanabe K, Fujishiro J, Norman JM, Olle B, Matsuyama S, Namkoong H, Uwamino Y, Ishii M, Fukunaga K, Hasegawa N, Ohara O, Xavier RJ, Atarashi K, Honda K

Identification of trypsin-degrading commensals in the large intestine.
Nature. 2022;609(7927):582-589 - PMID: 36071157 - PMCID: PMC9477747 - DOI: 10.1038/s41586-022-05181-3
Total: 2498