Publications for All Faculty

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Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ

Wnt signaling regulates mitochondrial physiology and insulin sensitivity.
Genes Dev. 2010;24(14):1507-18 - PMID: 20634317 - PMCID: PMC2904941 - DOI: 10.1101/gad.1924910

Irazoqui JE, Troemel ER, Feinbaum RL, Luhachack LG, Cezairliyan BO, Ausubel FM

Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus.
PLoS Pathog. 2010;6:e1000982 - PMID: 20617181 - PMCID: PMC2895663 - DOI: 10.1371/journal.ppat.1000982

Huett A, Goel G, Xavier RJ

A systems biology viewpoint on autophagy in health and disease.
Curr Opin Gastroenterol. 2010;26(4):302-9 - PMID: 20571384 - DOI: 10.1097/MOG.0b013e32833ae2ed

Ng AC, Eisenberg JM, Heath RJ, Huett A, Robinson CM, Nau GJ, Xavier RJ

Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.
Proc Natl Acad Sci U S A. 2011;108 Suppl 1:4631-8 - PMID: 20616063 - PMCID: PMC3063585 - DOI: 10.1073/pnas.1000093107

Kim H, Seed B

The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3.
Nat Immunol. 2010;11(8):743-50 - PMID: 20581830 - PMCID: PMC3050627 - DOI: 10.1038/ni.1897

Yagi H, Soto-Gutierrez A, Kitagawa Y, Tilles AW, Tompkins RG, Yarmush ML

Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn.
Cell Transplant. 2010;19(6):823-30 - PMID: 20573305 - PMCID: PMC2957544 - DOI: 10.3727/096368910X508942

Mashima R, Honda K, Yang Y, Morita Y, Inoue A, Arimura S, Nishina H, Ema H, Nakauchi H, Seed B, Oda H, Yamanashi Y

Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.
Lab Invest. 2010;90(9):1357-64 - PMID: 20548287 - DOI: 10.1038/labinvest.2010.121

Yagi H, Soto-Gutierrez A, Parekkadan B, Kitagawa Y, Tompkins RG, Kobayashi N, Yarmush ML

Mesenchymal stem cells: Mechanisms of immunomodulation and homing.
Cell Transplant. 2010;19(6):667-79 - PMID: 20525442 - PMCID: PMC2957533 - DOI: 10.3727/096368910X508762

Wählby C, Riklin-Raviv T, Ljosa V, Conery AL, Golland P, Ausubel FM, Carpenter AE

RESOLVING CLUSTERED WORMS VIA PROBABILISTIC SHAPE MODELS.
Proc IEEE Int Symp Biomed Imaging. 2010;2010(14-17 April 2010):552-555 - PMID: 21383863 - PMCID: PMC3048333 - DOI: 10.1109/ISBI.2010.5490286

Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, Xavier RJ, Yuan J

A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.
Dev Cell. 2010;18(6):1041-52 - PMID: 20627085 - PMCID: PMC2935848 - DOI: 10.1016/j.devcel.2010.05.005

Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Iafrate J, Rosenberg A, Nielsen GP, Xavier RJ, Mankin H, Duan Z

Characterization and analysis of human chordoma cell lines.
Spine (Phila Pa 1976). 2010;35(13):1257-64 - PMID: 20461036 - PMCID: PMC3769690 - DOI: 10.1097/BRS.0b013e3181c2a8b0

Budin I, Szostak JW

Expanding roles for diverse physical phenomena during the origin of life.
Annu Rev Biophys. 2010;39:245-63 - PMID: 20192779 - PMCID: PMC4992673 - DOI: 10.1146/annurev.biophys.050708.133753

Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, Head RD, Xavier R, Stappenbeck TS, Virgin HW

Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine.
Cell. 2010;141(7):1135-45 - PMID: 20602997 - PMCID: PMC2908380 - DOI: 10.1016/j.cell.2010.05.009

Duan Z, Choy E, Nielsen GP, Rosenberg A, Iafrate J, Yang C, Schwab J, Mankin H, Xavier R, Hornicek FJ

Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression.
J Orthop Res. 2010;28(6):746-52 - PMID: 20041488 - DOI: 10.1002/jor.21055

Lv B, Feng Y, Dong J, Xu M, Xu B, Zhang W, Sheng Z, Welihinda A, Seed B, Chen Y

Conformationally constrained spiro C-arylglucosides as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
ChemMedChem. 2010;5(6):827-31 - PMID: 20414917 - DOI: 10.1002/cmdc.201000051

Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.
J Exp Med. 2010;207(6):1145-52 - PMID: 20513746 - PMCID: PMC2882832 - DOI: 10.1084/jem.20091245

Zhang F, Maeder ML, Unger-Wallace E, Hoshaw JP, Reyon D, Christian M, Li X, Pierick CJ, Dobbs D, Peterson T, Joung JK, Voytas DF

High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases.
Proc Natl Acad Sci U S A. 2010;107(26):12028-33 - PMID: 20508152 - PMCID: PMC2900673 - DOI: 10.1073/pnas.0914991107

Tomkiewicz D, Casadei G, Larkins-Ford J, Moy TI, Garner J, Bremner JB, Ausubel FM, Lewis K, Kelso MJ

Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components.
Antimicrob Agents Chemother. 2010;54(8):3219-24 - PMID: 20498327 - PMCID: PMC2916310 - DOI: 10.1128/AAC.01715-09

Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S

Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7.
J Lipid Res. 2010;51(9):2591-9 - PMID: 20495215 - PMCID: PMC2918442 - DOI: 10.1194/jlr.M006049

Schrum JP, Zhu TF, Szostak JW

The origins of cellular life.
Cold Spring Harb Perspect Biol. 2010;2(9):a002212 - PMID: 20484387 - PMCID: PMC2926753 - DOI: 10.1101/cshperspect.a002212

Ip WK, Sokolovska A, Charriere GM, Boyer L, Dejardin S, Cappillino MP, Yantosca LM, Takahashi K, Moore KJ, Lacy-Hulbert A, Stuart LM

Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus.
J Immunol. 2010;184(12):7071-81 - PMID: 20483752 - PMCID: PMC2935932 - DOI: 10.4049/jimmunol.1000110

Rayner KJ, Suárez Y, Dávalos A, Parathath S, Fitzgerald ML, Tamehiro N, Fisher EA, Moore KJ, Fernández-Hernando C

MiR-33 contributes to the regulation of cholesterol homeostasis.
Science. 2010;328(5985):1570-3 - PMID: 20466885 - PMCID: PMC3114628 - DOI: 10.1126/science.1189862

Sander JD, Maeder ML, Reyon D, Voytas DF, Joung JK, Dobbs D

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool.
Nucleic Acids Res. 2010;38(Web Server issue):W462-8 - PMID: 20435679 - PMCID: PMC2896148 - DOI: 10.1093/nar/gkq319

Xu B, Feng Y, Lv B, Xu G, Zhang L, Du J, Peng K, Xu M, Dong J, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Seed B, Chen Y

ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Bioorg Med Chem. 2010;18(12):4422-32 - PMID: 20576578 - DOI: 10.1016/j.bmc.2010.04.088

Ketteler R, Tomov V, Neunkirchner A, Xie Q, Pickl WF, Seed B

Host-encoded reporters for the detection and purification of multiple enveloped viruses.
J Virol Methods. 2010;167(2):178-85 - PMID: 20399809 - PMCID: PMC2916077 - DOI: 10.1016/j.jviromet.2010.04.002
Total: 2501