Publications for All Faculty

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Xu B, Feng Y, Cheng H, Song Y, Lv B, Wu Y, Wang C, Li S, Xu M, Du J, Peng K, Dong J, Zhang W, Zhang T, Zhu L, Ding H, Sheng Z, Welihinda A, Roberge JY, Seed B, Chen Y

C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Bioorg Med Chem Lett. 2011;21(15):4465-70 - PMID: 21737266 - DOI: 10.1016/j.bmcl.2011.06.032

Khor B, Gardet A, Xavier RJ

Genetics and pathogenesis of inflammatory bowel disease.
Nature. 2011;474(7351):307-17 - PMID: 21677747 - PMCID: PMC3204665 - DOI: 10.1038/nature10209

Hipp J, Flotte T, Monaco J, Cheng J, Madabhushi A, Yagi Y, Rodriguez-Canales J, Emmert-Buck M, Dugan MC, Hewitt S, Toner M, Tompkins RG, Lucas D, Gilbertson JR, Balis UJ

Computer aided diagnostic tools aim to empower rather than replace pathologists: Lessons learned from computational chess.
J Pathol Inform. 2011;2:25 - PMID: 21773056 - PMCID: PMC3132993 - DOI: 10.4103/2153-3539.82050

Russo BC, Horzempa J, O'Dee DM, Schmitt DM, Brown MJ, Carlson PE, Xavier RJ, Nau GJ

A Francisella tularensis locus required for spermine responsiveness is necessary for virulence.
Infect Immun. 2011;79(9):3665-76 - PMID: 21670171 - PMCID: PMC3165480 - DOI: 10.1128/IAI.00135-11

Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, Mora JR

MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.
J Immunol. 2011;187(1):141-50 - PMID: 21646294 - PMCID: PMC3119749 - DOI: 10.4049/jimmunol.1003740

Freeman MW, Dervan AP

The path from bench to bedside: considerations before starting the journey.
J Investig Med. 2011;59(5):746-51 - PMID: 21441830 - PMCID: PMC4255460 - DOI: 10.2310/JIM.0b013e3182160d70

Danna CH, Millet YA, Koller T, Han SW, Bent AF, Ronald PC, Ausubel FM

The Arabidopsis flagellin receptor FLS2 mediates the perception of Xanthomonas Ax21 secreted peptides.
Proc Natl Acad Sci U S A. 2011;108(22):9286-91 - PMID: 21576467 - PMCID: PMC3107323 - DOI: 10.1073/pnas.1106366108

Le LP, Nielsen GP, Rosenberg AE, Thomas D, Batten JM, Deshpande V, Schwab J, Duan Z, Xavier RJ, Hornicek FJ, Iafrate AJ

Recurrent chromosomal copy number alterations in sporadic chordomas.
PLoS One. 2011;6(5):e18846 - PMID: 21602918 - PMCID: PMC3094331 - DOI: 10.1371/journal.pone.0018846

Carter EA, Bonab AA, Hamrahi V, Pitman J, Winter D, Macintosh LJ, Cyr EM, Paul K, Yerxa J, Jung W, Tompkins RG, Fischman AJ

Effects of burn injury, cold stress and cutaneous wound injury on the morphology and energy metabolism of murine brown adipose tissue (BAT) in vivo.
Life Sci. 2011;89(3-4):78-85 - PMID: 21565200 - PMCID: PMC4081480 - DOI: 10.1016/j.lfs.2011.04.014

Seebeck FP, Ricardo A, Szostak JW

Artificial lantipeptides from in vitro translations.
Chem Commun (Camb). 2011;47(21):6141-3 - PMID: 21528125 - DOI: 10.1039/c0cc05663d

Chand NS, Lee JS, Clatworthy AE, Golas AJ, Smith RS, Hung DT

The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection.
J Bacteriol. 2011;193(12):2989-99 - PMID: 21515773 - PMCID: PMC3133189 - DOI: 10.1128/JB.01546-10

Lee H, Chah OK, Sheen J

Stem-cell-triggered immunity through CLV3p-FLS2 signalling.
Nature. 2011;473(7347):376-9 - PMID: 21499263 - PMCID: PMC3098311 - DOI: 10.1038/nature09958

Heath RJ, Leong JM, Visegrády B, Machesky LM, Xavier RJ

Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.
PLoS Pathog. 2011;7(4):e1001332 - PMID: 21490959 - PMCID: PMC3072376 - DOI: 10.1371/journal.ppat.1001332

Curtin SJ, Zhang F, Sander JD, Haun WJ, Starker C, Baltes NJ, Reyon D, Dahlborg EJ, Goodwin MJ, Coffman AP, Dobbs D, Joung JK, Voytas DF, Stupar RM

Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases.
Plant Physiol. 2011;156(2):466-73 - PMID: 21464476 - PMCID: PMC3177250 - DOI: 10.1104/pp.111.172981

Stappenbeck TS, Rioux JD, Mizoguchi A, Saitoh T, Huett A, Darfeuille-Michaud A, Wileman T, Mizushima N, Carding S, Akira S, Parkes M, Xavier RJ

Crohn disease: a current perspective on genetics, autophagy and immunity.
Autophagy. 2011;7(4):355-74 - PMID: 20729636 - PMCID: PMC3842289 - DOI: 10.4161/auto.7.2.13074

Fitzgerald ML, Lupica CR, Pickel VM

Decreased parvalbumin immunoreactivity in the cortex and striatum of mice lacking the CB1 receptor.
Synapse. 2011;65(8):827-31 - PMID: 21445945 - PMCID: PMC3107909 - DOI: 10.1002/syn.20911

Budin I, Szostak JW

Physical effects underlying the transition from primitive to modern cell membranes.
Proc Natl Acad Sci U S A. 2011;108(13):5249-54 - PMID: 21402937 - PMCID: PMC3069173 - DOI: 10.1073/pnas.1100498108

Subtelny AO, Hartman MC, Szostak JW

Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation.
Angew Chem Int Ed Engl. 2011;50(14):3164-7 - PMID: 21381166 - PMCID: PMC4006073 - DOI: 10.1002/anie.201007686

Berthiaume F, Tompkins RG, Yarmush ML

Isolation and long-term maintenance of adult rat hepatocytes in culture.
Methods Mol Med. 2011;18:447-56 - PMID: 21370195 - DOI: 10.1385/0-89603-516-6:447

Hipp JD, Cheng JY, Toner M, Tompkins RG, Balis UJ

Spatially Invariant Vector Quantization: A pattern matching algorithm for multiple classes of image subject matter including pathology.
J Pathol Inform. 2011;2:13 - PMID: 21383936 - PMCID: PMC3049270 - DOI: 10.4103/2153-3539.77175

Moore KJ, Freeman MW

Embryonal Stem (ES) Cell-Derived Macrophages : A Cellular System that Facilitates the Genetic Dissection of Macrophage Function.
Methods Mol Med. 2011;30:343-55 - PMID: 21341038 - DOI: 10.1385/1-59259-247-3:343

Xu W, Seok J, Mindrinos MN, Schweitzer AC, Jiang H, Wilhelmy J, Clark TA, Kapur K, Xing Y, Faham M, Storey JD, Moldawer LL, Maier RV, Tompkins RG, Wong WH, Davis RW, Xiao W,

Human transcriptome array for high-throughput clinical studies.
Proc Natl Acad Sci U S A. 2011;108(9):3707-12 - PMID: 21317363 - PMCID: PMC3048146 - DOI: 10.1073/pnas.1019753108

Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Nat Genet. 2011;43(3):246-52 - PMID: 21297633 - PMCID: PMC3084597 - DOI: 10.1038/ng.764

Shen CA, Fagan S, Fischman AJ, Carter EE, Chai JK, Lu XM, Yu YM, Tompkins RG

Effects of glucagon-like peptide 1 on glycemia control and its metabolic consequence after severe thermal injury--studies in an animal model.
Surgery. 2011;149(5):635-44 - PMID: 21295809 - PMCID: PMC3079016 - DOI: 10.1016/j.surg.2010.11.017

Rosenbach AE, Koria P, Goverman J, Kotz KT, Gupta A, Yu M, Fagan SP, Irimia D, Tompkins RG

Microfluidics for T- lymphocyte cell separation and inflammation monitoring in burn patients.
Clin Transl Sci. 2011;4(1):63-8 - PMID: 21348958 - PMCID: PMC3057059 - DOI: 10.1111/j.1752-8062.2010.00255.x
Total: 2489