Publications for All Faculty

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Kim WS, Hill AF, Fitzgerald ML, Freeman MW, Evin G, Garner B

Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-? production independent of cholesterol efflux activity.
J Alzheimers Dis. 2011;27(2):441-52 - PMID: 21860089 - DOI: 10.3233/JAD-2011-110521

Liu X, Bolla K, Ashforth EJ, Zhuo Y, Gao H, Huang P, Stanley SA, Hung DT, Zhang L

Systematics-guided bioprospecting for bioactive microbial natural products.
Antonie Van Leeuwenhoek. 2012;101(1):55-66 - PMID: 22086462 - DOI: 10.1007/s10482-011-9671-1

Wang X, Spandidos A, Wang H, Seed B

PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update.
Nucleic Acids Res. 2012;40(Database issue):D1144-9 - PMID: 22086960 - PMCID: PMC3245149 - DOI: 10.1093/nar/gkr1013

Fischer SE, Montgomery TA, Zhang C, Fahlgren N, Breen PC, Hwang A, Sullivan CM, Carrington JC, Ruvkun G

The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.
PLoS Genet. 2011;7(11):e1002369 - PMID: 22102828 - PMCID: PMC3213143 - DOI: 10.1371/journal.pgen.1002369

Ramadas RA, Roche MI, Moon JJ, Ludwig T, Xavier RJ, Medoff BD

CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma.
J Immunol. 2011;187(12):6197-207 - PMID: 22075698 - PMCID: PMC3237896 - DOI: 10.4049/jimmunol.1101348

Chand NS, Hung DT

The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection.
Virulence. 2011;2(6):553-8 - PMID: 21971182 - DOI: 10.4161/viru.2.6.17987

Sebastiano V, Maeder ML, Angstman JF, Haddad B, Khayter C, Yeo DT, Goodwin MJ, Hawkins JS, Ramirez CL, Batista LF, Artandi SE, Wernig M, Joung JK

In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases.
Stem Cells. 2011;29(11):1717-26 - PMID: 21898685 - PMCID: PMC3285772 - DOI: 10.1002/stem.718

O'Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, Ting AT

Caspase 8 inhibits programmed necrosis by processing CYLD.
Nat Cell Biol. 2011;13(12):1437-42 - PMID: 22037414 - PMCID: PMC3229661 - DOI: 10.1038/ncb2362

Smillie CS, Smith MB, Friedman J, Cordero OX, David LA, Alm EJ

Ecology drives a global network of gene exchange connecting the human microbiome.
Nature. 2011;480(7376):241-4 - PMID: 22037308 - DOI: 10.1038/nature10571

Apidianakis Y, Que YA, Xu W, Tegos GP, Zimniak P, Hamblin MR, Tompkins RG, Xiao W, Rahme LG

Down-regulation of glutatione S-transferase ? 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection.
FASEB J. 2012;26(2):730-7 - PMID: 22038048 - PMCID: PMC3290433 - DOI: 10.1096/fj.11-192484

Yao Y, Danna CH, Zemp FJ, Titov V, Ciftci ON, Przybylski R, Ausubel FM, Kovalchuk I

UV-C-irradiated Arabidopsis and tobacco emit volatiles that trigger genomic instability in neighboring plants.
Plant Cell. 2011;23(10):3842-52 - PMID: 22028460 - PMCID: PMC3229153 - DOI: 10.1105/tpc.111.089003

Boyer L, Magoc L, Dejardin S, Cappillino M, Paquette N, Hinault C, Charriere GM, Ip WK, Fracchia S, Hennessy E, Erturk-Hasdemir D, Reichhart JM, Silverman N, Lacy-Hulbert A, Stuart LM

Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway.
Immunity. 2011;35(4):536-49 - PMID: 22018470 - PMCID: PMC3258503 - DOI: 10.1016/j.immuni.2011.08.015

Labbé C, Boucher G, Foisy S, Alikashani A, Nkwimi H, David G, Beaudoin M, Goyette P, Charron G, Xavier RJ, Rioux JD

Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients.
Inflamm Bowel Dis. 2012;18(6):1072-80 - PMID: 21994190 - PMCID: PMC3269563 - DOI: 10.1002/ibd.21887

Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, Washietl S, Kheradpour P, Ernst J, Jordan G, Mauceli E, Ward LD, Lowe CB, Holloway AK, Clamp M, Gnerre S, Alföldi J, Beal K, Chang J, Clawson H, Cuff J, Di Palma F, Fitzgerald S, Flicek P, Guttman M, Hubisz MJ, Jaffe DB, Jungreis I, Kent WJ, Kostka D, Lara M, Martins AL, Massingham T, Moltke I, Raney BJ, Rasmussen MD, Robinson J, Stark A, Vilella AJ, Wen J, Xie X, Zody MC; Broad Institute Sequencing Platform and Whole Genome Assembly Team, Baldwin J, Bloom T, Chin CW, Heiman D, Nicol R, Nusbaum C, Young S, Wilkinson J, Worley KC, Kovar CL, Muzny DM, Gibbs RA; Baylor College of Medicine Human Genome Sequencing Center Sequencing Team, Cree A, Dihn HH, Fowler G, Jhangiani S, Joshi V, Lee S, Lewis LR, Nazareth LV, Okwuonu G, Santibanez J, Warren WC, Mardis ER, Weinstock GM, Wilson RK; Genome Institute at Washington University, Delehaunty K, Dooling D, Fronik C, Fulton L, Fulton B, Graves T, Minx P, Sodergren E, Birney E, Margulies EH, Herrero J, Green ED, Haussler D, Siepel A, Goldman N, Pollard KS, Pedersen JS, Lander ES, Kellis M

A high-resolution map of human evolutionary constraint using 29 mammals.
Nature. 2011;478(7370):476-82 - PMID: 21993624 - PMCID: PMC3207357 - DOI: 10.1038/nature10530

Limmer S, Haller S, Drenkard E, Lee J, Yu S, Kocks C, Ausubel FM, Ferrandon D

Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model.
Proc Natl Acad Sci U S A. 2011;108(42):17378-83 - PMID: 21987808 - PMCID: PMC3198323 - DOI: 10.1073/pnas.1114907108

Rivas MA, Beaudoin M, Gardet A, Stevens C, Sharma Y, Zhang CK, Boucher G, Ripke S, Ellinghaus D, Burtt N, Fennell T, Kirby A, Latiano A, Goyette P, Green T, Halfvarson J, Haritunians T, Korn JM, Kuruvilla F, Lagacé C, Neale B, Lo KS, Schumm P, Törkvist L, , , , Dubinsky MC, Brant SR, Silverberg MS, Duerr RH, Altshuler D, Gabriel S, Lettre G, Franke A, D'Amato M, McGovern DP, Cho JH, Rioux JD, Xavier RJ, Daly MJ

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Nat Genet. 2011;43(11):1066-73 - PMID: 21983784 - PMCID: PMC3378381 - DOI: 10.1038/ng.952

Zeitels SM, Barbu AM, Landau-Zemer T, Lopez-Guerra G, Burns JA, Friedman AD, Freeman MW, Halvorsen YD, Hillman RE

Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study.
Ann Otol Rhinol Laryngol. 2011;120(10):627-34 - PMID: 22097147 - DOI: 10.1177/000348941112001001

Russel S, Frand AR, Ruvkun G

Regulation of the C. elegans molt by pqn-47.
Dev Biol. 2011;360(2):297-309 - PMID: 21989027 - PMCID: PMC3618673 - DOI: 10.1016/j.ydbio.2011.09.025

Slatko BE, Kieleczawa J, Ju J, Gardner AF, Hendrickson CL, Ausubel FM

automated DNA sequencing technology.
Curr Protoc Mol Biol. 2011;Chapter 7:Unit7.2 - PMID: 21987057 - DOI: 10.1002/0471142727.mb0702s96

Sander JD, Maeder ML, Joung JK

Engineering designer nucleases with customized cleavage specificities.
Curr Protoc Mol Biol. 2011;Chapter 12:Unit12.13 - PMID: 21987054 - PMCID: PMC3379964 - DOI: 10.1002/0471142727.mb1213s96

Hayes GD, Riedel CG, Ruvkun G

The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.
Genes Dev. 2011;25(19):2079-92 - PMID: 21979920 - PMCID: PMC3197206 - DOI: 10.1101/gad.17153811

Szostak JW

An optimal degree of physical and chemical heterogeneity for the origin of life?
Philos Trans R Soc Lond B Biol Sci. 2011;366(1580):2894-901 - PMID: 21930580 - PMCID: PMC3158921 - DOI: 10.1098/rstb.2011.0140

Merquiol E, Uzi D, Mueller T, Goldenberg D, Nahmias Y, Xavier RJ, Tirosh B, Shibolet O

HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.
PLoS One. 2011;6(9):e24660 - PMID: 21949742 - PMCID: PMC3176279 - DOI: 10.1371/journal.pone.0024660

Warner EA, Kotz KT, Ungaro RF, Abouhamze AS, Lopez MC, Cuenca AG, Kelly-Scumpia KM, Moreno C, O'Malley KA, Lanz JD, Baker HV, Martin LC, Toner M, Tompkins RG, Efron PA, Moldawer LL

Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage.
Lab Invest. 2011;91(12):1787-95 - PMID: 21931299 - PMCID: PMC3957199 - DOI: 10.1038/labinvest.2011.94

Sander JD, Yeh JR, Peterson RT, Joung JK

Engineering zinc finger nucleases for targeted mutagenesis of zebrafish.
Methods Cell Biol. 2011;104:51-8 - PMID: 21924156 - DOI: 10.1016/B978-0-12-374814-0.00003-3
Total: 2489