Publications for All Faculty

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Mansour MK, Tam JM, Khan NS, Seward M, Davids PJ, Puranam S, Sokolovska A, Sykes DB, Dagher Z, Becker C, Tanne A, Reedy JL, Stuart LM, Vyas JM

Dectin-1 activation controls maturation of ?-1,3-glucan-containing phagosomes.

J Biol Chem. 2013;288(22):16043-54 - PMID: 23609446 - PMCID: PMC3668760 - DOI: 10.1074/jbc.M113.473223
Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.

Nat Chem Biol. 2013;9(6):398-405 - PMID: 23603659 - PMCID: PMC6615456 - DOI: 10.1038/nchembio.1236
O'Rourke EJ, Ruvkun G

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.

Nat Cell Biol. 2013;15(6):668-676 - PMID: 23604316 - PMCID: PMC3723461 - DOI: 10.1038/ncb2741
Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.

Nat Cell Biol. 2013;15(5):491-501 - PMID: 23604319 - PMCID: PMC3748955 - DOI: 10.1038/ncb2720
Zhou JY, Krovvidi RK, Gao Y, Gao H, Petritis BO, De A, Miller-Graziano C, Bankey PE, Petyuk VA, Nicora CD, Clauss TR, Moore RJ, Shi T, Brown JN, Kaushal A, Xiao W, Davis RW, Maier RV, Tompkins RG, Qian WJ, Camp DG, Smith RD,

Trauma-associated Human Neutrophil Alterations Revealed by Comparative Proteomics Profiling.

Proteomics Clin Appl. 2013;7(7-8):571-83 - PMID: 23589343 - PMCID: PMC3737403 - DOI: 10.1002/prca.201200109
Engelhart AE, Powner MW, Szostak JW

Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity.

Nat Chem. 2013;5(5):390-4 - PMID: 23609089 - PMCID: PMC4088963 - DOI: 10.1038/nchem.1623
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA

Succinate is an inflammatory signal that induces
IL-1β through HIF-1α

Nature. 2013;496(7444):238-42 - PMID: 23535595 - PMCID: PMC4031686 - DOI: 10.1038/nature11986
Grant SS, Hung DT

Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response.

Virulence. 2013;4(4):273-283 - PMID: 23563389 - PMCID: PMC3710330 - DOI: 10.4161/viru.23987
Osborn MJ, Starker CG, McElroy AN, Webber BR, Riddle MJ, Xia L, Defeo AP, Gabriel R, Schmidt M, Von Kalle C, Carlson DF, Maeder ML, Joung JK, Wagner JE, Voytas DF, Blazar BR, Tolar J

TALEN-based Gene Correction for Epidermolysis Bullosa.

Mol Ther. 2013;21(6):1151-1159 - PMID: 23546300 - PMCID: PMC3677309 - DOI: 10.1038/mt.2013.56
Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM

Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death.

Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003
Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM

Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death.

Cell Host Microbe. 2013;13(4):406-16 - PMID: 23601103 - PMCID: PMC3641844 - DOI: 10.1016/j.chom.2013.03.003
Montgomery TA, Ruvkun G

MicroRNAs Visit the ER.

Cell. 2013;153(3):511-2 - PMID: 23622236 - DOI: 10.1016/j.cell.2013.04.014
Xiong Y, McCormack M, Li L, Hall Q, Xiang C, Sheen J

Glucose-TOR signalling reprograms the transcriptome and activates meristems.

Nature. 2013;496(7444):181-6 - PMID: 23542588 - PMCID: PMC4140196 - DOI: 10.1038/nature12030
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA

Succinate is an inflammatory signal that induces IL-1? through HIF-1?.

Nature. 2013;496(7444):238-42 - PMID: 23535595 - PMCID: PMC4031686 - DOI: 10.1038/nature11986
Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.

Nat Immunol. 2013;14(5):480-8 - PMID: 23525089 - PMCID: PMC3631456 - DOI: 10.1038/ni.2563
Righi V, Constantinou C, Mintzopoulos D, Khan N, Mupparaju SP, Rahme LG, Swartz HM, Szeto HH, Tompkins RG, Tzika AA

Mitochondria-targeted antioxidant promotes recovery of skeletal muscle mitochondrial function after burn trauma assessed by in vivo 31P nuclear magnetic resonance and electron paramagnetic resonance spectroscopy.

FASEB J. 2013;27(6):2521-30 - PMID: 23482635 - PMCID: PMC3659352 - DOI: 10.1096/fj.12-220764
Hosokawa S, Nagashima M, Maeyama Y, Koseki H, Yomogida K, Mehr C, Rutledge M, Greenfeld H, Kaneki M, Tompkins RG, Martyn JJ, Yasuhara SE

Efficacy of Phosphodiesterase 5 inhibitor on distant burn-induced muscle autophagy, microcirculation and survival rate.

Am J Physiol Endocrinol Metab. 2013;304(9):E922-33 - PMID: 23512808 - DOI: 10.1152/ajpendo.00078.2013
Watada S, Yu YM, Fischman AJ, Kurihara T, Shen CA, Tompkins RG, Fagan S

Evaluation of Intragastric Vs Intraperitoneal Glucose Tolerance Tests in the Evaluation of Insulin Resistance in a Rodent Model of Burn Injury and Glucagon-Like Polypeptide-1 Treatment.

J Burn Care Res. 2013;35(1):e66-72 - PMID: 23511296 - PMCID: PMC4053788 - DOI: 10.1097/BCR.0b013e31828a8ede
Finnerty CC, Jeschke MG, Qian WJ, Kaushal A, Xiao W, Liu T, Gritsenko MA, Moore RJ, Camp DG, Moldawer LL, Elson C, Schoenfeld D, Gamelli R, Gibran N, Klein M, Arnoldo B, Remick D, Smith RD, Davis R, Tompkins RG, Herndon DN,

Determination of Burn Patient Outcome by Large-Scale Quantitative Discovery Proteomics.

Crit Care Med. 2013;41(6):1421-1434 - PMID: 23507713 - PMCID: PMC3660437 - DOI: 10.1097/CCM.0b013e31827c072e
Djonovi? S, Urbach JM, Drenkard E, Bush J, Feinbaum R, Ausubel JL, Traficante D, Risech M, Kocks C, Fischbach MA, Priebe GP, Ausubel FM

Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants.

PLoS Pathog. 2013;9(3):e1003217 - PMID: 23505373 - PMCID: PMC3591346 - DOI: 10.1371/journal.ppat.1003217
Gmyrek GB, Graham DB, Sandoval G, Blaufuss GS, Akilesh HM, Fujikawa K, Xavier RJ, Swat W

Polarity gene discs large homolog 1 regulates the generation of memory T cells.

Eur J Immunol. 2013;43(5):1185-94 - PMID: 23436244 - PMCID: PMC3894631 - DOI: 10.1002/eji.201142362
Kurihara T, Jones CN, Yu YM, Fischman AJ, Watada S, Tompkins RG, Fagan SP, Irimia D

Resolvin D2 restores neutrophil directionality and improves survival after burns.

FASEB J. 2013;27(6):2270-81 - PMID: 23430978 - PMCID: PMC3659356 - DOI: 10.1096/fj.12-219519
Sandoval GJ, Graham DB, Bhattacharya D, Sleckman BP, Xavier RJ, Swat W

Cutting Edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells.

J Immunol. 2013;190(6):2485-9 - PMID: 23420891 - PMCID: PMC3649847 - DOI: 10.4049/jimmunol.1203208
Stuart LM, Paquette N, Boyer L

Effector-triggered versus pattern-triggered immunity: how animals sense pathogens.

Nat Rev Immunol. 2013;13(3):199-206 - PMID: 23411798 - PMCID: PMC4121468 - DOI: 10.1038/nri3398
Martin ES, Belmont PJ, Sinnamon MJ, Georgeon Richard L, Yuan J, Coffee EM, Roper J, Lee L, Heidari P, Lunt SY, Goel G, Ji C, Xie J, Xie T, Lamb J, Weinrich S, Vanarsdale TL, Bronson RT, Xavier RJ, Vander Heiden M, Kan JL, Mahmood U, Hung KE

Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation.

Clin Cancer Res. 2013;19(11):2929-40 - PMID: 23403635 - PMCID: PMC3951107 - DOI: 10.1158/1078-0432.CCR-12-2307
Total: 2481