Publications for All Faculty

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Pulloor NK, Nair S, Kostic AD, Bist P, Weaver JD, Riley AM, Tyagi R, Uchil PD, York JD, Snyder SH, García-Sastre A, Potter BV, Lin R, Shears SB, Xavier RJ, Krishnan MN

Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response.
PLoS Pathog. 2014;10(2):e1003981 - PMID: 24586175 - PMCID: PMC3937324 - DOI: 10.1371/journal.ppat.1003981

Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth.
PLoS Pathog. 2014;10(2):e1003946 - PMID: 24586159 - PMCID: PMC3930586 - DOI: 10.1371/journal.ppat.1003946

Rajamuthiah R, Fuchs BB, Jayamani E, Kim Y, Larkins-Ford J, Conery A, Ausubel FM, Mylonakis E

Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus.
PLoS One. 2014;9(2):e89189 - PMID: 24586584 - PMCID: PMC3929655 - DOI: 10.1371/journal.pone.0089189

de Luca A, Smeekens SP, Casagrande A, Iannitti R, Conway KL, Gresnigt MS, Begun J, Plantinga TS, Joosten LA, van der Meer JW, Chamilos G, Netea MG, Xavier RJ, Dinarello CA, Romani L, van de Veerdonk FL

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans.
Proc Natl Acad Sci U S A. 2014;111(9):3526-31 - PMID: 24550444 - PMCID: PMC3948220 - DOI: 10.1073/pnas.1322831111

Kostic AD, Xavier RJ, Gevers D

The Microbiome in Inflammatory Bowel Diseases: Current Status and the Future Ahead.
Gastroenterology. 2014;146(6):1489-99 - PMID: 24560869 - PMCID: PMC4034132 - DOI: 10.1053/j.gastro.2014.02.009

Zanni MV, Kelesidis T, Fitzgerald ML, Lo J, Abbara S, Wai B, Marmarelis E, Hernandez NJ, Yang OO, Currier JS, Grinspoon SK

HDL redox activity is increased in HIV-infected men in association with macrophage activation and noncalcified coronary atherosclerotic plaque.
Antivir Ther. 2014;19(8):805-11 - PMID: 24535655 - PMCID: PMC4423391 - DOI: 10.3851/IMP2756

Guilinger JP, Pattanayak V, Reyon D, Tsai SQ, Sander JD, Joung JK, Liu DR

Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity.
Nat Methods. 2014;11(4):429-35 - PMID: 24531420 - PMCID: PMC4010127 - DOI: 10.1038/nmeth.2845

Gupta A, Christensen RG, Bell HA, Goodwin M, Patel RY, Pandey M, Enuameh MS, Rayla AL, Zhu C, Thibodeau-Beganny S, Brodsky MH, Joung JK, Wolfe SA, Stormo GD

An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins.
Nucleic Acids Res. 2014;42(8):4800-12 - PMID: 24523353 - PMCID: PMC4005693 - DOI: 10.1093/nar/gku132

Sheng J, Li L, Engelhart AE, Gan J, Wang J, Szostak JW

Structural insights into the effects of 2'-5' linkages on the RNA duplex.
Proc Natl Acad Sci U S A. 2014;111(8):3050-5 - PMID: 24516151 - PMCID: PMC3939906 - DOI: 10.1073/pnas.1317799111

Li L, Szostak JW

The Free Energy Landscape of Pseudorotation in 3'-5' and 2'-5' Linked Nucleic Acids.
J Am Chem Soc. 2014;136(7):2858-65 - PMID: 24499340 - PMCID: PMC3982932 - DOI: 10.1021/ja412079b

Fu Y, Sander JD, Reyon D, Cascio VM, Joung JK

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs.
Nat Biotechnol. 2014;32(3):279-84 - PMID: 24463574 - PMCID: PMC3988262 - DOI: 10.1038/nbt.2808

Fowler SA, Ananthakrishnan AN, Gardet A, Stevens CR, Korzenik JR, Sands BE, Daly MJ, Xavier RJ, Yajnik V

SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.
J Crohns Colitis. 2014;8(8):845-51 - PMID: 24461721 - PMCID: PMC4237062 - DOI: 10.1016/j.crohns.2014.01.003

Ananthakrishnan AN, Huang H, Nguyen DD, Sauk J, Yajnik V, Xavier RJ

Differential Effect of Genetic Burden on Disease Phenotypes in Crohn's Disease and Ulcerative Colitis: Analysis of a North American Cohort.
Am J Gastroenterol. 2014;109(3):395-400 - PMID: 24419484 - PMCID: PMC4225079 - DOI: 10.1038/ajg.2013.464

Lee E, Koo Y, Ng A, Wei Y, Luby-Phelps K, Juraszek A, Xavier RJ, Cleaver O, Levine B, Amatruda JF

Autophagy is essential for cardiac morphogenesis during vertebrate development.
Autophagy. 2014;10(4):572-87 - PMID: 24441423 - PMCID: PMC4091146 - DOI: 10.4161/auto.27649

Zhao G, Yu YM, Shoup TM, Elmaleh DR, Bonab AA, Tompkins RG, Fischman AJ

Membrane potential-dependent uptake of (18)F-triphenylphosphonium-a new voltage sensor as an imaging agent for detecting burn-induced apoptosis.
J Surg Res. 2014;188(2):473-9 - PMID: 24582214 - PMCID: PMC3988254 - DOI: 10.1016/j.jss.2014.01.011

Blain JC, Ricardo A, Szostak JW

Synthesis and Non-Enzymatic Template-Directed Polymerization of 2'-Amino-2'-Deoxythreose Nucleotides.
J Am Chem Soc. 2014;136(5):2033-9 - PMID: 24409991 - PMCID: PMC4105081 - DOI: 10.1021/ja411950n

Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, Mitchell A, Ma J, Dubrulle J, Reyon D, Tsai SQ, Joung JK, Saghatelian A, Schier AF

Toddler: an embryonic signal that promotes cell movement via Apelin receptors.
Science. 2014;343(6172):1248636 - PMID: 24407481 - PMCID: PMC4107353 - DOI: 10.1126/science.1248636

Xiong Y, Sheen J

TOR Signaling Networks in Plant Growth and Metabolism.
Plant Physiol. 2014;164(2):499-512 - PMID: 24385567 - PMCID: PMC3912084 - DOI: 10.1104/pp.113.229948

Slater LH, Clatworthy AE, Hung DT

Bacterial toxins and small molecules elucidate endosomal trafficking.
Trends Microbiol. 2014;22(2):53-5 - PMID: 24370463 - DOI: 10.1016/j.tim.2013.12.002

Low BE, Krebs MP, Joung JK, Tsai SQ, Nishina PM, Wiles MV

Correction of Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair.
Invest Ophthalmol Vis Sci. 2014;55(1):387-395 - PMID: 24346171 - PMCID: PMC3921157 - DOI: 10.1167/iovs.13-13278

Hamel LP, Sheen J, Séguin A

Ancient signals: comparative genomics of green plant CDPKs.
Trends Plant Sci. 2014;19(2):79-89 - PMID: 24342084 - PMCID: PMC3932502 - DOI: 10.1016/j.tplants.2013.10.009

De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, Röcken M, Lütjohann D, Wright SD, Schultze JL, Latz E

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.
Nat Immunol. 2014;15(2):152-60 - PMID: 24317040 - PMCID: PMC4009731 - DOI: 10.1038/ni.2784

Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G

Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans.
Genes Dev. 2013;27(24):2678-95 - PMID: 24352423 - PMCID: PMC3877757 - DOI: 10.1101/gad.233254.113

Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grøntved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kovalchuk AL, Zou J, Joung JK, Sartorelli V, Wei CL, Ruan X, Hager GL, Ruan Y, Casellas R

Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.
Cell. 2013;155(7):1507-20 - PMID: 24360274 - PMCID: PMC3905448 - DOI: 10.1016/j.cell.2013.11.039

Haller JF, Cavallaro P, Hernandez NJ, Dolat L, Soscia SJ, Welti R, Grabowski GA, Fitzgerald ML, Freeman MW

Endogenous ?-glucocerebrosidase activity in Abca12-/-epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.
J Lipid Res. 2014;55(3):493-503 - PMID: 24293640 - PMCID: PMC3934733 - DOI: 10.1194/jlr.M044941
Total: 2505