Publications for All Faculty

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Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G

Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling.

Mol Syst Biol. 2013;9:692 - PMID: 24084807 - PMCID: PMC3817400 - DOI: 10.1038/msb.2013.50
Tzika AA, Constantinou C, Bandyopadhaya A, Psychogios N, Lee S, Mindrinos M, Martyn JA, Tompkins RG, Rahme LG

A Small Volatile Bacterial Molecule Triggers Mitochondrial Dysfunction in Murine Skeletal Muscle.

PLoS One. 2013;8(9):e74528 - PMID: 24098655 - PMCID: PMC3787027 - DOI: 10.1371/journal.pone.0074528
Vandussen KL, Liu TC, Li D, Towfic F, Modiano N, Winter R, Haritunians T, Taylor KD, Dhall D, Targan SR, Xavier RJ, McGovern DP, Stappenbeck TS

Genetic Variants Synthesize to Produce Paneth Cell Phenotypes that Define Subtypes of Crohn's Disease.

Gastroenterology. 2014;146(1):200-9 - PMID: 24076061 - PMCID: PMC3899786 - DOI: 10.1053/j.gastro.2013.09.048
Kawate T, Iwase N, Shimizu M, Stanley SA, Wellington S, Kazyanskaya E, Hung DT

Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32.

Bioorg Med Chem Lett. 2013;23(22):6052-9 - PMID: 24103299 - DOI: 10.1016/j.bmcl.2013.09.035
Shi Z, Hayes G, Ruvkun G

Dual Regulation of the lin-14 Target mRNA by the lin-4 miRNA.

PLoS One. 2013;8(9):e75475 - PMID: 24058689 - PMCID: PMC3772890 - DOI: 10.1371/journal.pone.0075475
Beaudoin M, Goyette P, Boucher G, Lo KS, Rivas MA, Stevens C, Alikashani A, Ladouceur M, Ellinghaus D, Törkvist L, Goel G, Lagacé C, Annese V, Bitton A, Begun J, Brant SR, Bresso F, Cho JH, Duerr RH, Halfvarson J, McGovern DP, Radford-Smith G, Schreiber S, Schumm PL, Sharma Y, Silverberg MS, Weersma RK, , , , D'Amato M, Vermeire S, Franke A, Lettre G, Xavier RJ, Daly MJ, Rioux JD

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis.

PLoS Genet. 2013;9(9):e1003723 - PMID: 24068945 - PMCID: PMC3772057 - DOI: 10.1371/journal.pgen.1003723
Giles KM, Kalinowski FC, Candy PA, Epis MR, Zhang PM, Redfern AD, Stuart LM, Goodall GJ, Leedman PJ

Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib.

Mol Cancer Ther. 2013;12(11):2541-58 - PMID: 24026012 - DOI: 10.1158/1535-7163.MCT-13-0170
Mendenhall EM, Williamson KE, Reyon D, Zou JY, Ram O, Joung JK, Bernstein BE

Locus-specific editing of histone modifications at endogenous enhancers.

Nat Biotechnol. 2013;31(12):1133-6 - PMID: 24013198 - PMCID: PMC3858395 - DOI: 10.1038/nbt.2701
Cheng C, Gao X, Feng B, Sheen J, Shan L, He P

Plant immune response to pathogens differs with changing temperatures.

Nat Commun. 2013;4:2530 - PMID: 24067909 - PMCID: PMC3901997 - DOI: 10.1038/ncomms3530
Tompkins RG, Warren HS, Mindrinos MN, Xiao W, Davis RW

Reply to Osterburg et al.: To study human inflammatory diseases in humans.

Proc Natl Acad Sci U S A. 2013;110(36):E3371 - PMID: 24137798 - PMCID: PMC3767510 - DOI: 10.1073/pnas.1307452110
Qi Y, Li X, Zhang Y, Starker CG, Baltes NJ, Zhang F, Sander JD, Reyon D, Joung JK, Voytas DF

Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases.

G3 (Bethesda). 2013;3(10):1707-1715 - PMID: 23979943 - PMCID: PMC3789795 - DOI: 10.1534/g3.113.006270
Wyatt KD, Stuart LM, Brito JP, Carranza Leon B, Domecq JP, Prutsky GJ, Egginton JS, Calvin AD, Shah ND, Murad MH, Montori VM

Out of Context: Clinical Practice Guidelines and Patients With Multiple Chronic Conditions: A Systematic Review.

Med Care. 2014;52 Suppl 3:S92-S100 - PMID: 23969592 - DOI: 10.1097/MLR.0b013e3182a51b3d
Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ

Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice from Salmonella Infection.

Gastroenterology. 2013;145(6):1347-57 - PMID: 23973919 - PMCID: PMC3840157 - DOI: 10.1053/j.gastro.2013.08.035
Rae L, Pham TN, Carrougher G, Honari S, Gibran NS, Arnoldo BD, Gamelli RL, Tompkins RG, Herndon DN

Differences in Resuscitation in Morbidly Obese Burn Patients May Contribute to High Mortality.

J Burn Care Res. 2013;34(5):507-14 - PMID: 23966116 - PMCID: PMC3800202 - DOI: 10.1097/BCR.0b013e3182a2a771
Sander JD, Ramirez CL, Linder SJ, Pattanayak V, Shoresh N, Ku M, Foden JA, Reyon D, Bernstein BE, Liu DR, Joung JK

In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites.

Nucleic Acids Res. 2013;41(19):e181 - PMID: 23945932 - PMCID: PMC3799455 - DOI: 10.1093/nar/gkt716
He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B

Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism.

Cell. 2013;154(5):1085-99 - PMID: 23954414 - PMCID: PMC4231430 - DOI: 10.1016/j.cell.2013.07.035
Wang SC, Tsai CH, Hou CP, Lee SY, Ko SF, Hsiao CC, Chen YC, Chuang JH, Sheen JM

Dislodgement of port-A catheters in pediatric oncology patients: 11 years of experience.

World J Surg Oncol. 2013;11(1):191 - PMID: 23941644 - PMCID: PMC3765137 - DOI: 10.1186/1477-7819-11-191
Li JF, Norville JE, Aach J, McCormack M, Zhang D, Bush J, Church GM, Sheen J

Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9.

Nat Biotechnol. 2013;31(8):688-91 - PMID: 23929339 - PMCID: PMC4078740 - DOI: 10.1038/nbt.2654
Warren HS, Tompkins RG, Mindrinos MN, Xiao W, Davis RW

Reply to Cauwels et al.: Of men, not mice, and inflammation.

Proc Natl Acad Sci U S A. 2013;110(34):E3151 - PMID: 24137663 - PMCID: PMC3752239 - DOI: 10.1073/pnas.1308943110
Börnigen D, Morgan XC, Franzosa EA, Ren B, Xavier RJ, Garrett WS, Huttenhower C

Functional profiling of the gut microbiome in disease-associated inflammation.

Genome Med. 2013;5(7):65 - PMID: 23906180 - PMCID: PMC3978847 - DOI: 10.1186/gm469
Candy PA, Phillips MR, Redfern AD, Colley SM, Davidson JA, Stuart LM, Wood BA, Zeps N, Leedman PJ

Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients.

Br J Cancer. 2013;109(4):1023-30 - PMID: 23900217 - PMCID: PMC3749585 - DOI: 10.1038/bjc.2013.431
Grant SS, Kawate T, Nag PP, Silvis MR, Gordon K, Stanley SA, Kazyanskaya E, Nietupski R, Golas A, Fitzgerald M, Cho S, Franzblau SG, Hung DT

Identification of novel inhibitors of non-replicating M. tuberculosis using a carbon starvation model.

ACS Chem Biol. 2013;8(10):2224-34 - PMID: 23898841 - PMCID: PMC3864639 - DOI: 10.1021/cb4004817
Maeder ML, Linder SJ, Cascio VM, Fu Y, Ho QH, Joung JK

CRISPR RNA-guided activation of endogenous human genes.

Nat Methods. 2013;10(10):977-9 - PMID: 23892898 - PMCID: PMC3794058 - DOI: 10.1038/nmeth.2598
Jeschke MG, Finnerty CC, Emdad F, Rivero HG, Kraft R, Williams FN, Gamelli RL, Gibran NS, Klein MB, Arnoldo BD, Tompkins RG, Herndon DN

Mild Obesity Is Protective After Severe Burn Injury.

Ann Surg. 2013;258(6):1119-29 - PMID: 23877367 - PMCID: PMC3963145 - DOI: 10.1097/SLA.0b013e3182984d19
Ananthakrishnan AN, Oxford EC, Nguyen DD, Sauk J, Yajnik V, Xavier RJ

Genetic risk factors for Clostridium difficile infection in ulcerative colitis.

Aliment Pharmacol Ther. 2013;38(5):522-30 - PMID: 23848254 - PMCID: PMC3755009 - DOI: 10.1111/apt.12425
Total: 2459