Publications for All Faculty

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Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM

Dectin-1 dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages.
J Infect Dis. 2014;210(11):1844-54 - PMID: 24842831 - PMCID: PMC4271056 - DOI: 10.1093/infdis/jiu290

Kirienko NV, Cezairliyan BO, Ausubel FM, Powell JR

Pseudomonas aeruginosa PA14 Pathogenesis in Caenorhabditis elegans.
Methods Mol Biol. 2014;1149:653-69 - PMID: 24818940 - DOI: 10.1007/978-1-4939-0473-0_50

Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.
Proc Natl Acad Sci U S A. 2014;111(21):7741-7746 - PMID: 24821797 - PMCID: PMC4040621 - DOI: 10.1073/pnas.1407001111

Pan CY, Chen JC, Sheen JF, Lin TL, Chen JY

Epinecidin-1 has immunomodulatory effects, facilitating its therapeutic use in a mouse model of Pseudomonas aeruginosa sepsis.
Antimicrob Agents Chemother. 2014;58(8):4264-4274 - PMID: 24820078 - PMCID: PMC4135991 - DOI: 10.1128/AAC.02958-14

Klein MB, Goverman J, Hayden DL, Fagan SP, McDonald-Smith GP, Alexander AK, Gamelli RL, Gibran NS, Finnerty CC, Jeschke MG, Arnoldo B, Wispelwey B, Mindrinos MN, Xiao W, Honari SE, Mason PH, Schoenfeld DA, Herndon DN, Tompkins RG,

Benchmarking outcomes in the critically injured burn patient.
Ann Surg. 2014;259(5):833-41 - PMID: 24722222 - PMCID: PMC4283803 - DOI: 10.1097/SLA.0000000000000438

Liu Y, Kretz CA, Maeder ML, Richter CE, Tsao P, Vo AH, Huarng MC, Rode T, Hu Z, Mehra R, Olson ST, Joung JK, Shavit JA

Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.
Blood. 2014;124(1):142-50 - PMID: 24782510 - PMCID: PMC4125349 - DOI: 10.1182/blood-2014-03-561027

Tsai SQ, Wyvekens N, Khayter C, Foden JA, Thapar V, Reyon D, Goodwin MJ, Aryee MJ, Joung JK

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing.
Nat Biotechnol. 2014;32(6):569-76 - PMID: 24770325 - PMCID: PMC4090141 - DOI: 10.1038/nbt.2908

Righi V, Apidianakis Y, Psychogios N, Rahme LG, Tompkins RG, Tzika AA

In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants.
Int J Mol Med. 2014;34(1):327-33 - PMID: 24789699 - DOI: 10.3892/ijmm.2014.1757

Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.
Cell Stem Cell. 2014;14(6):781-95 - PMID: 24704492 - PMCID: PMC4653065 - DOI: 10.1016/j.stem.2014.03.004

Liu Y, Samuel BS, Breen PC, Ruvkun G

Caenorhabditis elegans pathways that surveil and defend mitochondria.
Nature. 2014;508(7496):406-10 - PMID: 24695221 - PMCID: PMC4102179 - DOI: 10.1038/nature13204

Li JF, Zhang D, Sheen J

Epitope-tagged protein-based artificial miRNA screens for optimized gene silencing in plants.
Nat Protoc. 2014;9(4):939-49 - PMID: 24675734 - PMCID: PMC4208271 - DOI: 10.1038/nprot.2014.061

Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA

MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation.
Curr Biol. 2014;24(8):839-44 - PMID: 24684932 - PMCID: PMC4010136 - DOI: 10.1016/j.cub.2014.02.060

Tompkins RG

Survival From Burns in the New Millennium: 70 Years' Experience From a Single Institution.
Ann Surg. 2015;261(2):263-268 - PMID: 24670865 - PMCID: PMC4372065 - DOI: 10.1097/SLA.0000000000000623

Ananthakrishnan AN, Nguyen DD, Sauk J, Yajnik V, Xavier RJ

Genetic Polymorphisms in Metabolizing Enzymes Modifying the Association Between Smoking and Inflammatory Bowel Diseases.
Inflamm Bowel Dis. 2014;20(5):783-9 - PMID: 24651583 - PMCID: PMC4113010 - DOI: 10.1097/MIB.0000000000000014

Conery AL, Larkins-Ford J, Ausubel FM, Kirienko NV

High-Throughput Screening for Novel Anti-Infectives Using a C. elegans Pathogenesis Model.
Curr Protoc Chem Biol. 2014;6(1):25-37 - PMID: 24652621 - PMCID: PMC4021578 - DOI: 10.1002/9780470559277.ch130160

Blain JC, Szostak JW

Progress Toward Synthetic Cells.
Annu Rev Biochem. 2014;83:615-40 - PMID: 24606140 - DOI: 10.1146/annurev-biochem-080411-124036

Sander JD, Joung JK

CRISPR-Cas systems for editing, regulating and targeting genomes.
Nat Biotechnol. 2014;32(4):347-55 - PMID: 24584096 - PMCID: PMC4022601 - DOI: 10.1038/nbt.2842

Sheridan RL, Stoddard FJ, Kazis LE, Lee A, Li NC, Kagan RJ, Palmieri TL, Meyer WJ, Nicolai M, Stubbs TK, Chan G, Hinson MI, Herndon DN, Tompkins RG,

Long-term posttraumatic stress symptoms vary inversely with early opiate dosing in children recovering from serious burns: Effects durable at 4 years.
J Trauma Acute Care Surg. 2014;76(3):828-32 - PMID: 24553556 - DOI: 10.1097/TA.0b013e3182ab111c

Yuen GJ, Ausubel FM

Enterococcus infection biology: Lessons from invertebrate host models.
J Microbiol. 2014;52(3):200-10 - PMID: 24585051 - PMCID: PMC4556283 - DOI: 10.1007/s12275-014-4011-6

Gevers D, Kugathasan S, Denson LA, Vázquez-Baeza Y, Van Treuren W, Ren B, Schwager E, Knights D, Song SJ, Yassour M, Morgan XC, Kostic AD, Luo C, González A, McDonald D, Haberman Y, Walters T, Baker S, Rosh J, Stephens M, Heyman M, Markowitz J, Baldassano R, Griffiths A, Sylvester F, Mack D, Kim S, Crandall W, Hyams J, Huttenhower C, Knight R, Xavier RJ

The treatment-naive microbiome in new-onset Crohn's disease.
Cell Host Microbe. 2014;15(3):382-92 - PMID: 24629344 - PMCID: PMC4059512 - DOI: 10.1016/j.chom.2014.02.005

Jia TZ, Hentrich C, Szostak JW

Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets.
Orig Life Evol Biosph. 2014;44(1):1-12 - PMID: 24577897 - PMCID: PMC4141154 - DOI: 10.1007/s11084-014-9355-8

Pulloor NK, Nair S, Kostic AD, Bist P, Weaver JD, Riley AM, Tyagi R, Uchil PD, York JD, Snyder SH, García-Sastre A, Potter BV, Lin R, Shears SB, Xavier RJ, Krishnan MN

Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response.
PLoS Pathog. 2014;10(2):e1003981 - PMID: 24586175 - PMCID: PMC3937324 - DOI: 10.1371/journal.ppat.1003981

Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth.
PLoS Pathog. 2014;10(2):e1003946 - PMID: 24586159 - PMCID: PMC3930586 - DOI: 10.1371/journal.ppat.1003946

Rajamuthiah R, Fuchs BB, Jayamani E, Kim Y, Larkins-Ford J, Conery A, Ausubel FM, Mylonakis E

Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus.
PLoS One. 2014;9(2):e89189 - PMID: 24586584 - PMCID: PMC3929655 - DOI: 10.1371/journal.pone.0089189

de Luca A, Smeekens SP, Casagrande A, Iannitti R, Conway KL, Gresnigt MS, Begun J, Plantinga TS, Joosten LA, van der Meer JW, Chamilos G, Netea MG, Xavier RJ, Dinarello CA, Romani L, van de Veerdonk FL

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans.
Proc Natl Acad Sci U S A. 2014;111(9):3526-31 - PMID: 24550444 - PMCID: PMC3948220 - DOI: 10.1073/pnas.1322831111
Total: 2501