Publications for All Faculty

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Liu Y, Samuel BS, Breen PC, Ruvkun G

Caenorhabditis elegans pathways that surveil and defend mitochondria.

Nature. 2014;508(7496):406-10 - PMID: 24695221 - PMCID: PMC4102179 - DOI: 10.1038/nature13204
Li JF, Zhang D, Sheen J

Epitope-tagged protein-based artificial miRNA screens for optimized gene silencing in plants.

Nat Protoc. 2014;9(4):939-49 - PMID: 24675734 - PMCID: PMC4208271 - DOI: 10.1038/nprot.2014.061
Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA

MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation.

Curr Biol. 2014;24(8):839-44 - PMID: 24684932 - PMCID: PMC4010136 - DOI: 10.1016/j.cub.2014.02.060
Tompkins RG

Survival From Burns in the New Millennium: 70 Years' Experience From a Single Institution.

Ann Surg. 2015;261(2):263-268 - PMID: 24670865 - PMCID: PMC4372065 - DOI: 10.1097/SLA.0000000000000623
Ananthakrishnan AN, Nguyen DD, Sauk J, Yajnik V, Xavier RJ

Genetic Polymorphisms in Metabolizing Enzymes Modifying the Association Between Smoking and Inflammatory Bowel Diseases.

Inflamm Bowel Dis. 2014;20(5):783-9 - PMID: 24651583 - PMCID: PMC4113010 - DOI: 10.1097/MIB.0000000000000014
Conery AL, Larkins-Ford J, Ausubel FM, Kirienko NV

High-Throughput Screening for Novel Anti-Infectives Using a C. elegans Pathogenesis Model.

Curr Protoc Chem Biol. 2014;6(1):25-37 - PMID: 24652621 - PMCID: PMC4021578 - DOI: 10.1002/9780470559277.ch130160
Blain JC, Szostak JW

Progress Toward Synthetic Cells.

Annu Rev Biochem. 2014;83:615-40 - PMID: 24606140 - DOI: 10.1146/annurev-biochem-080411-124036
Sander JD, Joung JK

CRISPR-Cas systems for editing, regulating and targeting genomes.

Nat Biotechnol. 2014;32(4):347-55 - PMID: 24584096 - PMCID: PMC4022601 - DOI: 10.1038/nbt.2842
Sheridan RL, Stoddard FJ, Kazis LE, Lee A, Li NC, Kagan RJ, Palmieri TL, Meyer WJ, Nicolai M, Stubbs TK, Chan G, Hinson MI, Herndon DN, Tompkins RG,

Long-term posttraumatic stress symptoms vary inversely with early opiate dosing in children recovering from serious burns: Effects durable at 4 years.

J Trauma Acute Care Surg. 2014;76(3):828-32 - PMID: 24553556 - DOI: 10.1097/TA.0b013e3182ab111c
Yuen GJ, Ausubel FM

Enterococcus infection biology: Lessons from invertebrate host models.

J Microbiol. 2014;52(3):200-10 - PMID: 24585051 - PMCID: PMC4556283 - DOI: 10.1007/s12275-014-4011-6
Gevers D, Kugathasan S, Denson LA, Vázquez-Baeza Y, Van Treuren W, Ren B, Schwager E, Knights D, Song SJ, Yassour M, Morgan XC, Kostic AD, Luo C, González A, McDonald D, Haberman Y, Walters T, Baker S, Rosh J, Stephens M, Heyman M, Markowitz J, Baldassano R, Griffiths A, Sylvester F, Mack D, Kim S, Crandall W, Hyams J, Huttenhower C, Knight R, Xavier RJ

The treatment-naive microbiome in new-onset Crohn's disease.

Cell Host Microbe. 2014;15(3):382-92 - PMID: 24629344 - PMCID: PMC4059512 - DOI: 10.1016/j.chom.2014.02.005
Jia TZ, Hentrich C, Szostak JW

Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets.

Orig Life Evol Biosph. 2014;44(1):1-12 - PMID: 24577897 - PMCID: PMC4141154 - DOI: 10.1007/s11084-014-9355-8
Pulloor NK, Nair S, Kostic AD, Bist P, Weaver JD, Riley AM, Tyagi R, Uchil PD, York JD, Snyder SH, García-Sastre A, Potter BV, Lin R, Shears SB, Xavier RJ, Krishnan MN

Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response.

PLoS Pathog. 2014;10(2):e1003981 - PMID: 24586175 - PMCID: PMC3937324 - DOI: 10.1371/journal.ppat.1003981
Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth.

PLoS Pathog. 2014;10(2):e1003946 - PMID: 24586159 - PMCID: PMC3930586 - DOI: 10.1371/journal.ppat.1003946
Rajamuthiah R, Fuchs BB, Jayamani E, Kim Y, Larkins-Ford J, Conery A, Ausubel FM, Mylonakis E

Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus.

PLoS One. 2014;9(2):e89189 - PMID: 24586584 - PMCID: PMC3929655 - DOI: 10.1371/journal.pone.0089189
de Luca A, Smeekens SP, Casagrande A, Iannitti R, Conway KL, Gresnigt MS, Begun J, Plantinga TS, Joosten LA, van der Meer JW, Chamilos G, Netea MG, Xavier RJ, Dinarello CA, Romani L, van de Veerdonk FL

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans.

Proc Natl Acad Sci U S A. 2014;111(9):3526-31 - PMID: 24550444 - PMCID: PMC3948220 - DOI: 10.1073/pnas.1322831111
Kostic AD, Xavier RJ, Gevers D

The Microbiome in Inflammatory Bowel Diseases: Current Status and the Future Ahead.

Gastroenterology. 2014;146(6):1489-99 - PMID: 24560869 - PMCID: PMC4034132 - DOI: 10.1053/j.gastro.2014.02.009
Zanni MV, Kelesidis T, Fitzgerald ML, Lo J, Abbara S, Wai B, Marmarelis E, Hernandez NJ, Yang OO, Currier JS, Grinspoon SK

HDL redox activity is increased in HIV-infected men in association with macrophage activation and noncalcified coronary atherosclerotic plaque.

Antivir Ther. 2014;19(8):805-11 - PMID: 24535655 - PMCID: PMC4423391 - DOI: 10.3851/IMP2756
Guilinger JP, Pattanayak V, Reyon D, Tsai SQ, Sander JD, Joung JK, Liu DR

Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity.

Nat Methods. 2014;11(4):429-35 - PMID: 24531420 - PMCID: PMC4010127 - DOI: 10.1038/nmeth.2845
Gupta A, Christensen RG, Bell HA, Goodwin M, Patel RY, Pandey M, Enuameh MS, Rayla AL, Zhu C, Thibodeau-Beganny S, Brodsky MH, Joung JK, Wolfe SA, Stormo GD

An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins.

Nucleic Acids Res. 2014;42(8):4800-12 - PMID: 24523353 - PMCID: PMC4005693 - DOI: 10.1093/nar/gku132
Sheng J, Li L, Engelhart AE, Gan J, Wang J, Szostak JW

Structural insights into the effects of 2'-5' linkages on the RNA duplex.

Proc Natl Acad Sci U S A. 2014;111(8):3050-5 - PMID: 24516151 - PMCID: PMC3939906 - DOI: 10.1073/pnas.1317799111
Li L, Szostak JW

The Free Energy Landscape of Pseudorotation in 3'-5' and 2'-5' Linked Nucleic Acids.

J Am Chem Soc. 2014;136(7):2858-65 - PMID: 24499340 - PMCID: PMC3982932 - DOI: 10.1021/ja412079b
Fu Y, Sander JD, Reyon D, Cascio VM, Joung JK

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs.

Nat Biotechnol. 2014;32(3):279-84 - PMID: 24463574 - PMCID: PMC3988262 - DOI: 10.1038/nbt.2808
Fowler SA, Ananthakrishnan AN, Gardet A, Stevens CR, Korzenik JR, Sands BE, Daly MJ, Xavier RJ, Yajnik V

SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.

J Crohns Colitis. 2014;8(8):845-51 - PMID: 24461721 - PMCID: PMC4237062 - DOI: 10.1016/j.crohns.2014.01.003
Ananthakrishnan AN, Huang H, Nguyen DD, Sauk J, Yajnik V, Xavier RJ

Differential Effect of Genetic Burden on Disease Phenotypes in Crohn's Disease and Ulcerative Colitis: Analysis of a North American Cohort.

Am J Gastroenterol. 2014;109(3):395-400 - PMID: 24419484 - PMCID: PMC4225079 - DOI: 10.1038/ajg.2013.464
Total: 2467