Publications for All Faculty
Transcriptional Profiling Supports the Notochordal Origin of Chordoma and Its Dependence on a TGFΒ1-TBXT Network.
Results From a Randomized, Open-Label, Crossover Study Evaluating the Effect of the Aldosterone Synthase Inhibitor Baxdrostat on the Pharmacokinetics of Metformin in Healthy Human Subjects.
Remodeling of colon plasma cell repertoire within ulcerative colitis patients.
Gut microbiome lipid metabolism and its impact on host physiology.
Bacterial droplet-based single-cell RNA-seq reveals antibiotic-associated heterogeneous cellular states.
The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon.
Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism.
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways.
Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension.
RNA-activated protein cleavage with a CRISPR-associated endopeptidase.
A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning.
Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription.
Results from a phase 1, randomized, double-blind, multiple ascending dose study characterizing the pharmacokinetics and demonstrating the safety and selectivity of the aldosterone synthase inhibitor baxdrostat in healthy volunteers.
A 96-Week, Double-Blind, Randomized, Controlled Trial Comparing Bexagliflozin to Glimepiride as an Adjunct to Metformin for the Treatment of Type 2 Diabetes in Adults.
Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics.
Folding and Duplex Formation in Sequence-Defined Aniline Benzaldehyde Oligoarylacetylenes.
Engineered CRISPR prime editors with compact, untethered reverse transcriptases.
NIN-like protein 7 transcription factor is a plant nitrate sensor.
Inflammation-associated nitrate facilitates ectopic colonization of oral bacterium Veillonella parvula in the intestine.
Glucose-driven TOR-FIE-PRC2 signalling controls plant development.
Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides.
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn's disease.
Identification of trypsin-degrading commensals in the large intestine.
Induction of a colitogenic phenotype in Th1-like cells depends on interleukin-23 receptor signaling.
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.
