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Neo DM, Clatworthy AE, Hung DT

A dual-plasmid CRISPR/Cas9-based method for rapid and efficient genetic disruption in Mycobacterium abscessus.
J Bacteriol. 2024;206(3):e0033523 - PMID: 38319218 - PMCID: PMC10955840 - DOI: 10.1128/jb.00335-23

Freeman MW, Halvorsen YD, Bond M, Murphy B, Isaacsohn J

Results from a Phase 1 Study Assessing the Pharmacokinetics of the Aldosterone Synthase Inhibitor Baxdrostat in Participants with Varying Degrees of Renal Function.
Clin Pharmacol Drug Dev. 2024;13(4):410-418 - PMID: 38311833 - DOI: 10.1002/cpdd.1371

Ding D, Fang Z, Kim SC, O'Flaherty DK, Jia X, Stone TB, Zhou L, Szostak JW

Unusual Base Pair between Two 2-Thiouridines and Its Implication for Nonenzymatic RNA Copying.
J Am Chem Soc. 2024;146(6):3861-3871 - PMID: 38293747 - PMCID: PMC10870715 - DOI: 10.1021/jacs.3c11158

Sturm A, Sun P, Avila-Pacheco J, Clatworthy AE, Bloom-Ackermann Z, Wuo MG, Gomez JE, Jin S, Clish CB, Kiessling LL, Hung DT

Genetic factors affecting storage and utilization of lipids during dormancy in Mycobacterium tuberculosis.
MBio. 2024;15(2):e0320823 - PMID: 38236034 - PMCID: PMC10865790 - DOI: 10.1128/mbio.03208-23

Sella Y, Broderick NA, Stouffer KM, McEwan DL, Ausubel FM, Casadevall A, Bergman A

Preliminary evidence for chaotic signatures in host-microbe interactions.
mSystems. 2024;9(2):e0111023 - PMID: 38197647 - PMCID: PMC10878097 - DOI: 10.1128/msystems.01110-23

Sheen J

The new horizon of plant auxin signaling via cell-surface co-receptors.
Cell Res. 2024;34(5):343-344 - PMID: 38182889 - PMCID: PMC11061107 - DOI: 10.1038/s41422-023-00921-0

Meisel JD, Miranda M, Skinner OS, Wiesenthal PP, Wellner SM, Jourdain AA, Ruvkun G, Mootha VK

Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism.
Cell. 2024;187(3):659-675.e18 - PMID: 38215760 - PMCID: PMC10919891 - DOI: 10.1016/j.cell.2023.12.010

Schirmer M, Stražar M, Avila-Pacheco J, Rojas-Tapias DF, Brown EM, Temple E, Deik A, Bullock K, Jeanfavre S, Pierce K, Jin S, Invernizzi R, Pust MM, Costliow Z, Mack DR, Griffiths AM, Walters T, Boyle BM, Kugathasan S, Vlamakis H, Hyams J, Denson L, Clish CB, Xavier RJ

Linking microbial genes to plasma and stool metabolites uncovers host-microbial interactions underlying ulcerative colitis disease course.
Cell Host Microbe. 2024;32(2):209-226.e7 - PMID: 38215740 - PMCID: PMC10923022 - DOI: 10.1016/j.chom.2023.12.013

Zhernakova DV, Wang D, Liu L, Andreu-Sánchez S, Zhang Y, Ruiz-Moreno AJ, Peng H, Plomp N, Del Castillo-Izquierdo Á, Gacesa R, Lopera-Maya EA, Temba GS, Kullaya VI, van Leeuwen SS, Lifelines Cohort Study, Xavier RJ, de Mast Q, Joosten LAB, Riksen NP, Rutten JHW, Netea MG, Sanna S, Wijmenga C, Weersma RK, Zhernakova A, Harmsen HJM, Fu J

Host genetic regulation of human gut microbial structural variation.
Nature. 2024;625(7996):813-821 - PMID: 38172637 - PMCID: PMC10808065 - DOI: 10.1038/s41586-023-06893-w

Tellier J, Tarasova I, Nie J, Smillie CS, Fedele PL, Cao WHJ, Groom JR, Belz GT, Bhattacharya D, Smyth GK, Nutt SL

Unraveling the diversity and functions of tissue-resident plasma cells.
Nat Immunol. 2024;25(2):330-342 - PMID: 38172260 - DOI: 10.1038/s41590-023-01712-w

McMurray JJV, Solomon SD, Lock JP, Massaro JM, Zhu F, Zhou W, Skali H, Lewis EF, Freeman MW, Halvorsen YC

Meta-analysis of risk of major adverse cardiovascular events in adults with type 2 diabetes treated with bexagliflozin.
Diabetes Obes Metab. 2023;26(3):971-979 - PMID: 38151752 - DOI: 10.1111/dom.15394

Babbe H, Sundberg TB, Tichenor M, Seierstad M, Bacani G, Berstler J, Chai W, Chang L, Chung M, Coe K, Collins B, Finley M, Guletsky A, Lemke CT, Mak PA, Mathur A, Mercado-Marin EV, Metkar S, Raymond DD, Rives ML, Rizzolio M, Shaffer PL, Smith R, Smith J, Steele R, Steffens H, Suarez J, Tian G, Majewski N, Volak LP, Wei J, Desai PT, Ong LL, Koudriakova T, Goldberg SD, Hirst G, Kaushik VK, Ort T, Seth N, Graham DB, Plevy S, Venable JD, Xavier RJ, Towne JE

Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Proc Natl Acad Sci U S A. 2023;121(1):e2307086120 - PMID: 38147543 - PMCID: PMC10769863 - DOI: 10.1073/pnas.2307086120

Heo HY, Zou G, Baek S, Kim JS, Mylonakis E, Ausubel FM, Gao H, Kim W

A Methylazanediyl Bisacetamide Derivative Sensitizes Staphylococcus aureus Persisters to a Combination of Gentamicin And Daptomycin.
Adv Sci (Weinh). 2023;11(9):e2306112 - PMID: 38126676 - PMCID: PMC10916567 - DOI: 10.1002/advs.202306112

Kong L, Pokatayev V, Lefkovith A, Carter GT, Creasey EA, Krishna C, Subramanian S, Kochar B, Ashenberg O, Lau H, Ananthakrishnan AN, Graham DB, Deguine J, Xavier RJ

The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon.
Immunity. 2023;56(12):2855 - PMID: 38091954 - DOI: 10.1016/j.immuni.2023.10.017

Stražar M, Xavier RJ

Cytotoxic Th1 cells mushroom after fungal exposures in Crohn's disease.
Immunity. 2023;56(12):2679-2681 - PMID: 38091949 - DOI: 10.1016/j.immuni.2023.11.012

Gentry EC, Collins SL, Panitchpakdi M, Belda-Ferre P, Stewart AK, Carrillo Terrazas M, Lu HH, Zuffa S, Yan T, Avila-Pacheco J, Plichta DR, Aron AT, Wang M, Jarmusch AK, Hao F, Syrkin-Nikolau M, Vlamakis H, Ananthakrishnan AN, Boland B, Hemperly A, Vande Casteele N, Gonzalez FJ, Clish CB, Xavier RJ, Chu H, Baker ES, Patterson AD, Knight R, Siegel D, Dorrestein PC

Reverse metabolomics for the discovery of chemical structures from humans.
Nature. 2023;626(7998):419-426 - PMID: 38052229 - PMCID: PMC10849969 - DOI: 10.1038/s41586-023-06906-8

Li W, Liu J, Li Z, Ye R, Chen W, Huang Y, Yuan Y, Zhang Y, Hu H, Zheng P, Fang Z, Tao Z, Song S, Pan R, Zhang J, Tu J, Sheen J, Du H

Mitigating growth-stress tradeoffs via elevated TOR signaling in rice.
Mol Plant. 2023;17(2):240-257 - PMID: 38053337 - PMCID: PMC11271712 - DOI: 10.1016/j.molp.2023.12.002

Fiskin E, Eraslan G, Alora-Palli MB, Leyva-Castillo JM, Kim S, Choe H, Lareau CA, Lau H, Finan EP, Teixeira-Soldano I, LaBere B, Chu A, Woods B, Chou J, Slyper M, Waldman J, Islam S, Schneider L, Phipatanakul W, Platt C, Rozenblatt-Rosen O, Delorey TM, Deguine J, Smith GP, Geha R, Regev A, Xavier RJ

Multi-modal skin atlas identifies a multicellular immune-stromal community associated with altered cornification and specific T cell expansion in atopic dermatitis
bioRxiv. 2023;:ePub - DOI: 10.1101/2023.10.29.563503

Lelyveld VS, Fang Z, Szostak JW

Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Science. 2023;382(6669):423-429 - PMID: 37883544 - PMCID: PMC10886449 - DOI: 10.1126/science.adh5339

Nakata T, Li C, Mayassi T, Lin H, Ghosh K, Segerstolpe Å, Diamond EL, Herbst P, Biancalani T, Gaddam S, Parkar S, Lu Z, Jaiswal A, Li B, Creasey EA, Lefkovith A, Daly MJ, Graham DB, Xavier RJ

Genetic vulnerability to Crohn's disease reveals a spatially resolved epithelial restitution program.
Sci Transl Med. 2023;15(719):eadg5252 - PMID: 37878672 - PMCID: PMC10798370 - DOI: 10.1126/scitranslmed.adg5252

Thurimella K, Mohamed AMT, Graham DB, Owens RM, Leanti La Rosa S, Plichta DR, Bacallado S, Xavier RJ

Protein Language Models Uncover Carbohydrate-Active Enzyme Function in Metagenomics
bioRxiv. 2023;:ePub - DOI: https://doi.org/10.1101/2023.10.23.563620

Shin YH, Bang S, Park SM, Ma X, Cassilly C, Graham D, Xavier R, Clardy J

Revisiting Coley's Toxins: Immunogenic Cardiolipins from Streptococcus pyogenes.
J Am Chem Soc. 2023;145(39):21183-21188 - PMID: 37738205 - PMCID: PMC10557101 - DOI: 10.1021/jacs.3c07727

Parada-Kusz M, Clatworthy AE, Goering ER, Blackwood SM, Salm EJ, Choi C, Combs S, Lee JSW, Rodriguez-Osorio C, Tomita S, Hung DT

A tryptophan metabolite modulates the host response to bacterial infection via kainate receptors.
bioRxiv. 2023;:ePub - PMID: 37645903 - PMCID: PMC10462041 - DOI: 10.1101/2023.08.16.553532

DasGupta S, Zhang S, Szostak JW

Molecular Crowding Facilitates Ribozyme-Catalyzed RNA Assembly.
ACS Cent Sci. 2023;9(8):1670-1678 - PMID: 37637737 - PMCID: PMC10451029 - DOI: 10.1021/acscentsci.3c00547

Ashwood B, Jones MS, Radakovic A, Khanna S, Lee Y, Sachleben JR, Szostak JW, Ferguson AL, Tokmakoff A

Thermodynamics and kinetics of DNA and RNA dinucleotide hybridization to gaps and overhangs.
Biophys J. 2023;122(16):3323-3339 - PMID: 37469144 - PMCID: PMC10465710 - DOI: 10.1016/j.bpj.2023.07.009
Total: 2489