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Draberova L, Bugajev V, Potuckova L, Halova I, Bambouskova M, Polakovicova I, Xavier RJ, Seed B, Draber P

Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.
Mol Cell Biol. 2014;34(23):4285-300 - PMID: 25246632 - PMCID: PMC4248753 - DOI: 10.1128/MCB.00983-14

Sundberg TB, Xavier RJ, Schreiber SL, Shamji AF

Small-molecule control of cytokine function: new opportunities for treating immune disorders.
Curr Opin Chem Biol. 2014;23C:23-30 - PMID: 25222143 - PMCID: PMC5087273 - DOI: 10.1016/j.cbpa.2014.08.013

Kumar V, Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A, Giamarellos-Bourboulis E, Karjalainen J, Franke L, Withoff S, Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H, Bauer H, Herrmann BG, Bochud PY, Marchetti O, Perfect JR, Xavier RJ, Kullberg BJ, Wijmenga C, Netea MG

Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.
Nat Commun. 2014;5:4675 - PMID: 25197941 - PMCID: PMC5142444 - DOI: 10.1038/ncomms5675

Sheng J, Larsen A, Heuberger BD, Blain JC, Szostak JW

Crystal Structure Studies of RNA Duplexes Containing s2U:A and s2U:U Base Pairs.
J Am Chem Soc. 2014;136(39):13916-24 - PMID: 25188906 - PMCID: PMC4183603 - DOI: 10.1021/ja508015a

Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier RJ, Root DE

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.
Nat Biotechnol. 2014;32(12):1262-1267 - PMID: 25184501 - PMCID: PMC4262738 - DOI: 10.1038/nbt.3026

Peterson JR, De La Rosa S, Eboda O, Cilwa KE, Agarwal S, Buchman SR, Cederna PS, Xi C, Morris MD, Herndon DN, Xiao W, Tompkins RG, Krebsbach PH, Wang SC, Levi B

Treatment of heterotopic ossification through remote ATP hydrolysis.
Sci Transl Med. 2014;6(255):255ra132 - PMID: 25253675 - PMCID: PMC4353731 - DOI: 10.1126/scitranslmed.3008810

Saeed S, Quintin J, Kerstens HH, Rao NA, Aghajanirefah A, Matarese F, Cheng SC, Ratter J, Berentsen K, van der Ent MA, Sharifi N, Janssen-Megens EM, Ter Huurne M, Mandoli A, van Schaik T, Ng A, Burden F, Downes K, Frontini M, Kumar V, Giamarellos-Bourboulis EJ, Ouwehand WH, van der Meer JW, Joosten LA, Wijmenga C, Martens JH, Xavier RJ, Logie C, Netea MG, Stunnenberg HG

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.
Science. 2014;345(6204):1251086 - PMID: 25258085 - PMCID: PMC4242194 - DOI: 10.1126/science.1251086

Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG

mTOR- and HIF-1?-mediated aerobic glycolysis as metabolic basis for trained immunity.
Science. 2014;345(6204):1250684 - PMID: 25258083 - PMCID: PMC4226238 - DOI: 10.1126/science.1250684

Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.
Genes Dev. 2014;28(17):1957-75 - PMID: 25184681 - PMCID: PMC4197947 - DOI: 10.1101/gad.241620.114

Jennelle L, Hunegnaw R, Dubrovsky L, Pushkarsky T, Fitzgerald ML, Sviridov D, Popratiloff A, Brichacek B, Bukrinsky M

HIV-1 Protein Nef Inhibits Activity of ATP Binding Cassette Transporter A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin.
J Biol Chem. 2014;289(42):28870-84 - PMID: 25170080 - PMCID: PMC4200247 - DOI: 10.1074/jbc.M114.583591

Goel G, Conway KL, Jaeger M, Netea MG, Xavier RJ

Multivariate inference of pathway activity in host immunity and response to therapeutics.
Nucleic Acids Res. 2014;42(16):10288-306 - PMID: 25147207 - PMCID: PMC4176341 - DOI: 10.1093/nar/gku722

Lassen KG, Xavier RJ

An alteration in ATG16L1 stability in Crohn disease.
Autophagy. 2014;10(10):1858-1860 - PMID: 25136803 - PMCID: PMC4198368 - DOI: 10.4161/auto.29963

Sundberg TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B, Gagnon J, O'Connell DJ, Narayan K, Dan?ík V, Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, Shamji AF

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.
Proc Natl Acad Sci U S A. 2014;111(34):12468-12473 - PMID: 25114223 - PMCID: PMC4151730 - DOI: 10.1073/pnas.1412308111

Kai X, Chellappa V, Donado C, Reyon D, Sekigami Y, Ataca D, Louissaint A, Mattoo H, Joung JK, Pillai S

I?B kinase ? (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor ?B (NF?B) signaling.
J Biol Chem. 2014;289(39):26960-72 - PMID: 25107905 - PMCID: PMC4175336 - DOI: 10.1074/jbc.M114.598763

Carter EA, Hamrahi V, Paul K, Bonab AA, Jung W, Tompkins RG, Fischman AJ

Single Hind Limb Burn Injury to Mice Alters Nuclear Factor-?B Expression and [18F] 2-Fluoro-2-Deoxy-D-Glucose Uptake.
J Burn Care Res. 2014;35(6):e373-e378 - PMID: 25100541 - PMCID: PMC4229441 - DOI: 10.1097/BCR.0000000000000035

Mammarella ND, Cheng Z, Fu ZQ, Daudi A, Bolwell GP, Dong X, Ausubel FM

Apoplastic peroxidases are required for salicylic acid-mediated defense against Pseudomonas syringae.
Phytochemistry. 2015;112:110-121 - PMID: 25096754 - PMCID: PMC4314520 - DOI: 10.1016/j.phytochem.2014.07.010

Wivagg CN, Bhattacharyya RP, Hung DT

Mechanisms of ?-lactam killing and resistance in the context of Mycobacterium tuberculosis.
J Antibiot (Tokyo). 2014;67(9):645-54 - PMID: 25052484 - DOI: 10.1038/ja.2014.94

Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G

Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.
Nat Struct Mol Biol. 2014;21(8):712-720 - PMID: 25038802 - PMCID: PMC4125460 - DOI: 10.1038/nsmb.2858

Luft C, Freeman J, Elliott D, Al-Tamimi N, Kriston-Vizi J, Heintze J, Lindenschmidt I, Seed B, Ketteler R

Application of Gaussia luciferase in bicistronic and non-conventional secretion reporter constructs.
BMC Biochem. 2014;15(1):14 - PMID: 25007711 - PMCID: PMC4099409 - DOI: 10.1186/1471-2091-15-14

Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.
J Clin Invest. 2014;124(8):3617-33 - PMID: 25003194 - PMCID: PMC4109533 - DOI: 10.1172/JCI75436

Tsai SQ, Joung JK

What's changed with genome editing?
Cell Stem Cell. 2014;15(1):3-4 - PMID: 24996161 - DOI: 10.1016/j.stem.2014.06.017

Wei SC, Tan YY, Weng MT, Lai LC, Hsiao JH, Chuang EY, Shun CT, Wu DC, Kao AW, Chuang CS, Ni YH, Shieh MJ, Tung CC, Chen Y, Wang CY, Xavier RJ, Podolsky DK, Wong JM

SLCO3A1, a Novel Crohn's Disease-Associated Gene, Regulates NF-?B Activity and Associates with Intestinal Perforation.
PLoS One. 2014;9(6):e100515 - PMID: 24945726 - PMCID: PMC4063938 - DOI: 10.1371/journal.pone.0100515

Zhao G, Yu YM, Kaneki M, Bonab AA, Tompkins RG, Fischman AJ

Simvastatin Reduces Burn Injury-Induced Splenic Apoptosis via Downregulation of the TNF-?/NF-?B Pathway.
Ann Surg. 2015;261(5):1006-12 - PMID: 24950285 - PMCID: PMC4272342 - DOI: 10.1097/SLA.0000000000000764

Yan S, Tsurumi A, Que YA, Ryan CM, Bandyopadhaya A, Morgan AA, Flaherty PJ, Tompkins RG, Rahme LG

Prediction of Multiple Infections After Severe Burn Trauma: A Prospective Cohort Study.
Ann Surg. 2015;261(4):781-792 - PMID: 24950278 - PMCID: PMC4284150 - DOI: 10.1097/SLA.0000000000000759

Wu HY, Liu KH, Wang YC, Wu JF, Chiu WL, Chen CY, Wu SH, Sheen J, Lai EM

AGROBEST: an efficient Agrobacterium-mediated transient expression method for versatile gene function analyses in Arabidopsis seedlings.
Plant Methods. 2014;10:19 - PMID: 24987449 - PMCID: PMC4076510 - DOI: 10.1186/1746-4811-10-19
Total: 2481