Publications for All Faculty

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Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY, Liu DR

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo.
Nat Biotechnol. 2015;33(1):73-80 - PMID: 25357182 - PMCID: PMC4289409 - DOI: 10.1038/nbt.3081

Kotz KT, Petrofsky AC, Haghgooie R, Granier R, Toner M, Tompkins RG

Inertial focusing cytometer with integrated optics for particle characterization.
Technology (Singap World Sci). 2014;1(1):27-36 - PMID: 25346940 - PMCID: PMC4206911 - DOI: 10.1142/S233954781350009X

Kleinnijenhuis J, Quintin J, Preijers F, Joosten LA, Jacobs C, Xavier RJ, van der Meer JW, van Crevel R, Netea MG

BCG-induced trained immunity in NK cells: Role for non-specific protection to infection.
Clin Immunol. 2014;155(2):213-219 - PMID: 25451159 - PMCID: PMC5084088 - DOI: 10.1016/j.clim.2014.10.005

Kumar V, Wijmenga C, Xavier RJ

Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism.
Curr Opin Immunol. 2014;31C:51-57 - PMID: 25458995 - PMCID: PMC5080657 - DOI: 10.1016/j.coi.2014.09.007

Govindan JA, Ruvkun G

Pathogens.
Virulence. 2014;5(7):ePub - PMID: 25290904 - PMCID: PMC4189874

Zhang XC, Millet Y, Ausubel FM, Borowsky M

Next-Gen Sequencing-Based Mapping and Identification of Ethyl Methanesulfonate-Induced Mutations in Arabidopsis thaliana.
Curr Protoc Mol Biol. 2014;108:7.18.1-7.18.16 - PMID: 25271717 - DOI: 10.1002/0471142727.mb0718s108

Budin I, Prwyes N, Zhang N, Szostak JW

Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions.
Biophys J. 2014;107(7):1582-1590 - PMID: 25296310 - PMCID: PMC4190651 - DOI: 10.1016/j.bpj.2014.07.067

Ausubel FM

Twists and turns: my career path and concerns about the future.
Genetics. 2014;198(2):431-4 - PMID: 25316778 - PMCID: PMC4196596 - DOI: 10.1534/genetics.114.169102

Govindan JA, Ruvkun G

Pathogens.
Virulence. 2014;5(7):695-696 - PMID: 25513769 - PMCID: PMC4189874 - DOI: 10.4161/viru.36667

Tsai SQ, Iafrate AJ, Joung JK

Genome editing: a tool for research and therapy: towards a functional understanding of variants for molecular diagnostics using genome editing.
Nat Med. 2014;20(10):1103-4 - PMID: 25295940 - DOI: 10.1038/nm.3722

Liao J, Jijon HB, Kim IR, Goel G, Doan A, Sokol H, Bauer H, Herrmann BG, Lassen KG, Xavier RJ

An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse.
PLoS One. 2014;9(9):e108777 - PMID: 25268627 - PMCID: PMC4182575 - DOI: 10.1371/journal.pone.0108777

Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.
Cell. 2014;159(2):440-55 - PMID: 25263330 - PMCID: PMC4265475 - DOI: 10.1016/j.cell.2014.09.014

Draberova L, Bugajev V, Potuckova L, Halova I, Bambouskova M, Polakovicova I, Xavier RJ, Seed B, Draber P

Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.
Mol Cell Biol. 2014;34(23):4285-300 - PMID: 25246632 - PMCID: PMC4248753 - DOI: 10.1128/MCB.00983-14

Sundberg TB, Xavier RJ, Schreiber SL, Shamji AF

Small-molecule control of cytokine function: new opportunities for treating immune disorders.
Curr Opin Chem Biol. 2014;23C:23-30 - PMID: 25222143 - PMCID: PMC5087273 - DOI: 10.1016/j.cbpa.2014.08.013

Kumar V, Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A, Giamarellos-Bourboulis E, Karjalainen J, Franke L, Withoff S, Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H, Bauer H, Herrmann BG, Bochud PY, Marchetti O, Perfect JR, Xavier RJ, Kullberg BJ, Wijmenga C, Netea MG

Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.
Nat Commun. 2014;5:4675 - PMID: 25197941 - PMCID: PMC5142444 - DOI: 10.1038/ncomms5675

Sheng J, Larsen A, Heuberger BD, Blain JC, Szostak JW

Crystal Structure Studies of RNA Duplexes Containing s2U:A and s2U:U Base Pairs.
J Am Chem Soc. 2014;136(39):13916-24 - PMID: 25188906 - PMCID: PMC4183603 - DOI: 10.1021/ja508015a

Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier RJ, Root DE

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.
Nat Biotechnol. 2014;32(12):1262-1267 - PMID: 25184501 - PMCID: PMC4262738 - DOI: 10.1038/nbt.3026

Peterson JR, De La Rosa S, Eboda O, Cilwa KE, Agarwal S, Buchman SR, Cederna PS, Xi C, Morris MD, Herndon DN, Xiao W, Tompkins RG, Krebsbach PH, Wang SC, Levi B

Treatment of heterotopic ossification through remote ATP hydrolysis.
Sci Transl Med. 2014;6(255):255ra132 - PMID: 25253675 - PMCID: PMC4353731 - DOI: 10.1126/scitranslmed.3008810

Saeed S, Quintin J, Kerstens HH, Rao NA, Aghajanirefah A, Matarese F, Cheng SC, Ratter J, Berentsen K, van der Ent MA, Sharifi N, Janssen-Megens EM, Ter Huurne M, Mandoli A, van Schaik T, Ng A, Burden F, Downes K, Frontini M, Kumar V, Giamarellos-Bourboulis EJ, Ouwehand WH, van der Meer JW, Joosten LA, Wijmenga C, Martens JH, Xavier RJ, Logie C, Netea MG, Stunnenberg HG

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.
Science. 2014;345(6204):1251086 - PMID: 25258085 - PMCID: PMC4242194 - DOI: 10.1126/science.1251086

Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG

mTOR- and HIF-1?-mediated aerobic glycolysis as metabolic basis for trained immunity.
Science. 2014;345(6204):1250684 - PMID: 25258083 - PMCID: PMC4226238 - DOI: 10.1126/science.1250684

Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.
Genes Dev. 2014;28(17):1957-75 - PMID: 25184681 - PMCID: PMC4197947 - DOI: 10.1101/gad.241620.114

Jennelle L, Hunegnaw R, Dubrovsky L, Pushkarsky T, Fitzgerald ML, Sviridov D, Popratiloff A, Brichacek B, Bukrinsky M

HIV-1 Protein Nef Inhibits Activity of ATP Binding Cassette Transporter A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin.
J Biol Chem. 2014;289(42):28870-84 - PMID: 25170080 - PMCID: PMC4200247 - DOI: 10.1074/jbc.M114.583591

Goel G, Conway KL, Jaeger M, Netea MG, Xavier RJ

Multivariate inference of pathway activity in host immunity and response to therapeutics.
Nucleic Acids Res. 2014;42(16):10288-306 - PMID: 25147207 - PMCID: PMC4176341 - DOI: 10.1093/nar/gku722

Lassen KG, Xavier RJ

An alteration in ATG16L1 stability in Crohn disease.
Autophagy. 2014;10(10):1858-1860 - PMID: 25136803 - PMCID: PMC4198368 - DOI: 10.4161/auto.29963

Sundberg TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B, Gagnon J, O'Connell DJ, Narayan K, Dan?ík V, Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, Shamji AF

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.
Proc Natl Acad Sci U S A. 2014;111(34):12468-12473 - PMID: 25114223 - PMCID: PMC4151730 - DOI: 10.1073/pnas.1412308111
Total: 2493