Publications for All Faculty

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Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

Genes Dev. 2014;28(17):1957-75 - PMID: 25184681 - PMCID: PMC4197947 - DOI: 10.1101/gad.241620.114
Jennelle L, Hunegnaw R, Dubrovsky L, Pushkarsky T, Fitzgerald ML, Sviridov D, Popratiloff A, Brichacek B, Bukrinsky M

HIV-1 Protein Nef Inhibits Activity of ATP Binding Cassette Transporter A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin.

J Biol Chem. 2014;289(42):28870-84 - PMID: 25170080 - PMCID: PMC4200247 - DOI: 10.1074/jbc.M114.583591
Goel G, Conway KL, Jaeger M, Netea MG, Xavier RJ

Multivariate inference of pathway activity in host immunity and response to therapeutics.

Nucleic Acids Res. 2014;42(16):10288-306 - PMID: 25147207 - PMCID: PMC4176341 - DOI: 10.1093/nar/gku722
Lassen KG, Xavier RJ

An alteration in ATG16L1 stability in Crohn disease.

Autophagy. 2014;10(10):1858-1860 - PMID: 25136803 - PMCID: PMC4198368 - DOI: 10.4161/auto.29963
Sundberg TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B, Gagnon J, O'Connell DJ, Narayan K, Dan?ík V, Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, Shamji AF

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.

Proc Natl Acad Sci U S A. 2014;111(34):12468-12473 - PMID: 25114223 - PMCID: PMC4151730 - DOI: 10.1073/pnas.1412308111
Kai X, Chellappa V, Donado C, Reyon D, Sekigami Y, Ataca D, Louissaint A, Mattoo H, Joung JK, Pillai S

I?B kinase ? (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor ?B (NF?B) signaling.

J Biol Chem. 2014;289(39):26960-72 - PMID: 25107905 - PMCID: PMC4175336 - DOI: 10.1074/jbc.M114.598763
Carter EA, Hamrahi V, Paul K, Bonab AA, Jung W, Tompkins RG, Fischman AJ

Single Hind Limb Burn Injury to Mice Alters Nuclear Factor-?B Expression and [18F] 2-Fluoro-2-Deoxy-D-Glucose Uptake.

J Burn Care Res. 2014;35(6):e373-e378 - PMID: 25100541 - PMCID: PMC4229441 - DOI: 10.1097/BCR.0000000000000035
Mammarella ND, Cheng Z, Fu ZQ, Daudi A, Bolwell GP, Dong X, Ausubel FM

Apoplastic peroxidases are required for salicylic acid-mediated defense against Pseudomonas syringae.

Phytochemistry. 2015;112:110-121 - PMID: 25096754 - PMCID: PMC4314520 - DOI: 10.1016/j.phytochem.2014.07.010
Wivagg CN, Bhattacharyya RP, Hung DT

Mechanisms of ?-lactam killing and resistance in the context of Mycobacterium tuberculosis.

J Antibiot (Tokyo). 2014;67(9):645-54 - PMID: 25052484 - DOI: 10.1038/ja.2014.94
Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G

Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.

Nat Struct Mol Biol. 2014;21(8):712-720 - PMID: 25038802 - PMCID: PMC4125460 - DOI: 10.1038/nsmb.2858
Luft C, Freeman J, Elliott D, Al-Tamimi N, Kriston-Vizi J, Heintze J, Lindenschmidt I, Seed B, Ketteler R

Application of Gaussia luciferase in bicistronic and non-conventional secretion reporter constructs.

BMC Biochem. 2014;15(1):14 - PMID: 25007711 - PMCID: PMC4099409 - DOI: 10.1186/1471-2091-15-14
Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.

J Clin Invest. 2014;124(8):3617-33 - PMID: 25003194 - PMCID: PMC4109533 - DOI: 10.1172/JCI75436
Tsai SQ, Joung JK

What's changed with genome editing?

Cell Stem Cell. 2014;15(1):3-4 - PMID: 24996161 - DOI: 10.1016/j.stem.2014.06.017
Wei SC, Tan YY, Weng MT, Lai LC, Hsiao JH, Chuang EY, Shun CT, Wu DC, Kao AW, Chuang CS, Ni YH, Shieh MJ, Tung CC, Chen Y, Wang CY, Xavier RJ, Podolsky DK, Wong JM

SLCO3A1, a Novel Crohn's Disease-Associated Gene, Regulates NF-?B Activity and Associates with Intestinal Perforation.

PLoS One. 2014;9(6):e100515 - PMID: 24945726 - PMCID: PMC4063938 - DOI: 10.1371/journal.pone.0100515
Zhao G, Yu YM, Kaneki M, Bonab AA, Tompkins RG, Fischman AJ

Simvastatin Reduces Burn Injury-Induced Splenic Apoptosis via Downregulation of the TNF-?/NF-?B Pathway.

Ann Surg. 2015;261(5):1006-12 - PMID: 24950285 - PMCID: PMC4272342 - DOI: 10.1097/SLA.0000000000000764
Yan S, Tsurumi A, Que YA, Ryan CM, Bandyopadhaya A, Morgan AA, Flaherty PJ, Tompkins RG, Rahme LG

Prediction of Multiple Infections After Severe Burn Trauma: A Prospective Cohort Study.

Ann Surg. 2015;261(4):781-792 - PMID: 24950278 - PMCID: PMC4284150 - DOI: 10.1097/SLA.0000000000000759
Wu HY, Liu KH, Wang YC, Wu JF, Chiu WL, Chen CY, Wu SH, Sheen J, Lai EM

AGROBEST: an efficient Agrobacterium-mediated transient expression method for versatile gene function analyses in Arabidopsis seedlings.

Plant Methods. 2014;10:19 - PMID: 24987449 - PMCID: PMC4076510 - DOI: 10.1186/1746-4811-10-19
Wolf SE, Tompkins RG, Herndon DN

On the Horizon: Research Priorities in Burns for the Next Decade.

Surg Clin North Am. 2014;94(4):917-30 - PMID: 25085097 - DOI: 10.1016/j.suc.2014.05.012
Ryu SY, Qian WJ, Camp DG, Smith RD, Tompkins RG, Davis RW, Xiao W

Detecting differential protein expression in large-scale population proteomics.

Bioinformatics. 2014;30(19):2741-6 - PMID: 24928210 - PMCID: PMC4173009 - DOI: 10.1093/bioinformatics/btu341
Huttenhower C, Kostic AD, Xavier RJ

Inflammatory Bowel Disease as a Model for Translating the Microbiome.

Immunity. 2014;40(6):843-854 - PMID: 24950204 - PMCID: PMC4135443 - DOI: 10.1016/j.immuni.2014.05.013
Pukkila-Worley R, Feinbaum RL, McEwan DL, Conery AL, Ausubel FM

The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification.

PLoS Pathog. 2014;10(5):e1004143 - PMID: 24875643 - PMCID: PMC4038581 - DOI: 10.1371/journal.ppat.1004143
Zhou GL, Na SY, Niedra R, Seed B

Deficits in receptor-mediated endocytosis and recycling in cells from mice bearing a disruption of the Gpr107 locus.

J Cell Sci. 2014;127(Pt 18):3916-27 - PMID: 24849652 - DOI: 10.1242/jcs.135269
Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM

Dectin-1 dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages.

J Infect Dis. 2014;210(11):1844-54 - PMID: 24842831 - PMCID: PMC4271056 - DOI: 10.1093/infdis/jiu290
Kirienko NV, Cezairliyan BO, Ausubel FM, Powell JR

Pseudomonas aeruginosa PA14 Pathogenesis in Caenorhabditis elegans.

Methods Mol Biol. 2014;1149:653-69 - PMID: 24818940 - DOI: 10.1007/978-1-4939-0473-0_50
Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

Proc Natl Acad Sci U S A. 2014;111(21):7741-7746 - PMID: 24821797 - PMCID: PMC4040621 - DOI: 10.1073/pnas.1407001111
Total: 2473