Publications for All Faculty

Sort by:
Reset
Tsai SQ, Iafrate AJ, Joung JK

Genome editing: a tool for research and therapy: towards a functional understanding of variants for molecular diagnostics using genome editing.

Nat Med. 2014;20(10):1103-4 - PMID: 25295940 - DOI: 10.1038/nm.3722
Liao J, Jijon HB, Kim IR, Goel G, Doan A, Sokol H, Bauer H, Herrmann BG, Lassen KG, Xavier RJ

An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse.

PLoS One. 2014;9(9):e108777 - PMID: 25268627 - PMCID: PMC4182575 - DOI: 10.1371/journal.pone.0108777
Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.

Cell. 2014;159(2):440-55 - PMID: 25263330 - PMCID: PMC4265475 - DOI: 10.1016/j.cell.2014.09.014
Draberova L, Bugajev V, Potuckova L, Halova I, Bambouskova M, Polakovicova I, Xavier RJ, Seed B, Draber P

Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.

Mol Cell Biol. 2014;34(23):4285-300 - PMID: 25246632 - PMCID: PMC4248753 - DOI: 10.1128/MCB.00983-14
Sundberg TB, Xavier RJ, Schreiber SL, Shamji AF

Small-molecule control of cytokine function: new opportunities for treating immune disorders.

Curr Opin Chem Biol. 2014;23C:23-30 - PMID: 25222143 - PMCID: PMC5087273 - DOI: 10.1016/j.cbpa.2014.08.013
Kumar V, Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A, Giamarellos-Bourboulis E, Karjalainen J, Franke L, Withoff S, Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H, Bauer H, Herrmann BG, Bochud PY, Marchetti O, Perfect JR, Xavier RJ, Kullberg BJ, Wijmenga C, Netea MG

Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.

Nat Commun. 2014;5:4675 - PMID: 25197941 - PMCID: PMC5142444 - DOI: 10.1038/ncomms5675
Sheng J, Larsen A, Heuberger BD, Blain JC, Szostak JW

Crystal Structure Studies of RNA Duplexes Containing s2U:A and s2U:U Base Pairs.

J Am Chem Soc. 2014;136(39):13916-24 - PMID: 25188906 - PMCID: PMC4183603 - DOI: 10.1021/ja508015a
Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier RJ, Root DE

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

Nat Biotechnol. 2014;32(12):1262-1267 - PMID: 25184501 - PMCID: PMC4262738 - DOI: 10.1038/nbt.3026
Peterson JR, De La Rosa S, Eboda O, Cilwa KE, Agarwal S, Buchman SR, Cederna PS, Xi C, Morris MD, Herndon DN, Xiao W, Tompkins RG, Krebsbach PH, Wang SC, Levi B

Treatment of heterotopic ossification through remote ATP hydrolysis.

Sci Transl Med. 2014;6(255):255ra132 - PMID: 25253675 - PMCID: PMC4353731 - DOI: 10.1126/scitranslmed.3008810
Saeed S, Quintin J, Kerstens HH, Rao NA, Aghajanirefah A, Matarese F, Cheng SC, Ratter J, Berentsen K, van der Ent MA, Sharifi N, Janssen-Megens EM, Ter Huurne M, Mandoli A, van Schaik T, Ng A, Burden F, Downes K, Frontini M, Kumar V, Giamarellos-Bourboulis EJ, Ouwehand WH, van der Meer JW, Joosten LA, Wijmenga C, Martens JH, Xavier RJ, Logie C, Netea MG, Stunnenberg HG

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.

Science. 2014;345(6204):1251086 - PMID: 25258085 - PMCID: PMC4242194 - DOI: 10.1126/science.1251086
Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG

mTOR- and HIF-1?-mediated aerobic glycolysis as metabolic basis for trained immunity.

Science. 2014;345(6204):1250684 - PMID: 25258083 - PMCID: PMC4226238 - DOI: 10.1126/science.1250684
Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

Genes Dev. 2014;28(17):1957-75 - PMID: 25184681 - PMCID: PMC4197947 - DOI: 10.1101/gad.241620.114
Jennelle L, Hunegnaw R, Dubrovsky L, Pushkarsky T, Fitzgerald ML, Sviridov D, Popratiloff A, Brichacek B, Bukrinsky M

HIV-1 Protein Nef Inhibits Activity of ATP Binding Cassette Transporter A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin.

J Biol Chem. 2014;289(42):28870-84 - PMID: 25170080 - PMCID: PMC4200247 - DOI: 10.1074/jbc.M114.583591
Goel G, Conway KL, Jaeger M, Netea MG, Xavier RJ

Multivariate inference of pathway activity in host immunity and response to therapeutics.

Nucleic Acids Res. 2014;42(16):10288-306 - PMID: 25147207 - PMCID: PMC4176341 - DOI: 10.1093/nar/gku722
Lassen KG, Xavier RJ

An alteration in ATG16L1 stability in Crohn disease.

Autophagy. 2014;10(10):1858-1860 - PMID: 25136803 - PMCID: PMC4198368 - DOI: 10.4161/auto.29963
Sundberg TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B, Gagnon J, O'Connell DJ, Narayan K, Dan?ík V, Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, Shamji AF

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.

Proc Natl Acad Sci U S A. 2014;111(34):12468-12473 - PMID: 25114223 - PMCID: PMC4151730 - DOI: 10.1073/pnas.1412308111
Kai X, Chellappa V, Donado C, Reyon D, Sekigami Y, Ataca D, Louissaint A, Mattoo H, Joung JK, Pillai S

I?B kinase ? (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor ?B (NF?B) signaling.

J Biol Chem. 2014;289(39):26960-72 - PMID: 25107905 - PMCID: PMC4175336 - DOI: 10.1074/jbc.M114.598763
Carter EA, Hamrahi V, Paul K, Bonab AA, Jung W, Tompkins RG, Fischman AJ

Single Hind Limb Burn Injury to Mice Alters Nuclear Factor-?B Expression and [18F] 2-Fluoro-2-Deoxy-D-Glucose Uptake.

J Burn Care Res. 2014;35(6):e373-e378 - PMID: 25100541 - PMCID: PMC4229441 - DOI: 10.1097/BCR.0000000000000035
Mammarella ND, Cheng Z, Fu ZQ, Daudi A, Bolwell GP, Dong X, Ausubel FM

Apoplastic peroxidases are required for salicylic acid-mediated defense against Pseudomonas syringae.

Phytochemistry. 2015;112:110-121 - PMID: 25096754 - PMCID: PMC4314520 - DOI: 10.1016/j.phytochem.2014.07.010
Wivagg CN, Bhattacharyya RP, Hung DT

Mechanisms of ?-lactam killing and resistance in the context of Mycobacterium tuberculosis.

J Antibiot (Tokyo). 2014;67(9):645-54 - PMID: 25052484 - DOI: 10.1038/ja.2014.94
Garcia SM, Tabach Y, Lourenço GF, Armakola M, Ruvkun G

Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.

Nat Struct Mol Biol. 2014;21(8):712-720 - PMID: 25038802 - PMCID: PMC4125460 - DOI: 10.1038/nsmb.2858
Luft C, Freeman J, Elliott D, Al-Tamimi N, Kriston-Vizi J, Heintze J, Lindenschmidt I, Seed B, Ketteler R

Application of Gaussia luciferase in bicistronic and non-conventional secretion reporter constructs.

BMC Biochem. 2014;15(1):14 - PMID: 25007711 - PMCID: PMC4099409 - DOI: 10.1186/1471-2091-15-14
Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.

J Clin Invest. 2014;124(8):3617-33 - PMID: 25003194 - PMCID: PMC4109533 - DOI: 10.1172/JCI75436
Tsai SQ, Joung JK

What's changed with genome editing?

Cell Stem Cell. 2014;15(1):3-4 - PMID: 24996161 - DOI: 10.1016/j.stem.2014.06.017
Wei SC, Tan YY, Weng MT, Lai LC, Hsiao JH, Chuang EY, Shun CT, Wu DC, Kao AW, Chuang CS, Ni YH, Shieh MJ, Tung CC, Chen Y, Wang CY, Xavier RJ, Podolsky DK, Wong JM

SLCO3A1, a Novel Crohn's Disease-Associated Gene, Regulates NF-?B Activity and Associates with Intestinal Perforation.

PLoS One. 2014;9(6):e100515 - PMID: 24945726 - PMCID: PMC4063938 - DOI: 10.1371/journal.pone.0100515
Total: 2459