Publications for All Faculty

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Korem T, Zeevi D, Suez J, Weinberger A, Avnit-Sagi T, Pompan-Lotan M, Matot E, Jona G, Harmelin A, Cohen N, Sirota-Madi A, Thaiss CA, Pevsner-Fischer M, Sorek R, Xavier R, Elinav E, Segal E

Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples.

Science. 2015;349(6252):1101-6 - PMID: 26229116 - PMCID: PMC5087275 - DOI: 10.1126/science.aac4812
Kamat NP, Tobé S, Hill IT, Szostak JW

Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides.

Angew Chem Int Ed Engl. 2015;54(40):11735-11739 - PMID: 26223820 - PMCID: PMC4600236 - DOI: 10.1002/anie.201505742
Graham DB, Becker CE, Doan A, Goel G, Villablanca EJ, Knights D, Mok A, Ng AC, Doench JG, Root DE, Clish CB, Xavier RJ

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.

Nat Commun. 2015;6:7838 - PMID: 26194095 - PMCID: PMC4518307 - DOI: 10.1038/ncomms8838
Groen SC, Humphrey PT, Chevasco D, Ausubel FM, Pierce NE, Whiteman NK

Pseudomonas syringae enhances herbivory by suppressing the reactive oxygen burst in Arabidopsis.

J Insect Physiol. 2016;84:90-102 - PMID: 26205072 - PMCID: PMC4721946 - DOI: 10.1016/j.jinsphys.2015.07.011
Kuo SY, Castoreno AB, Aldrich LN, Lassen KG, Goel G, Dan?ík V, Kuballa P, Latorre I, Conway KL, Sarkar S, Maetzel D, Jaenisch R, Clemons PA, Schreiber SL, Shamji AF, Xavier RJ

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.

Proc Natl Acad Sci U S A. 2015;112(31):E4281-7 - PMID: 26195741 - PMCID: PMC4534235 - DOI: 10.1073/pnas.1512289112
Pringle PL, Stewart KO, Peloquin JM, Sturgeon HC, Nguyen D, Sauk J, Garber JJ, Yajnik V, Ananthakrishnan AN, Chan AT, Xavier RJ, Khalili H

Body Mass Index, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.

Inflamm Bowel Dis. 2015;21(10):2304-2310 - PMID: 26181430 - PMCID: PMC4567407 - DOI: 10.1097/MIB.0000000000000498
Baxt LA, Xavier RJ

Role of Autophagy in the Maintenance of Intestinal Homeostasis.

Gastroenterology. 2015;149(3):553-62 - PMID: 26170139 - PMCID: PMC4550567 - DOI: 10.1053/j.gastro.2015.06.046
Joung JK

Unwanted mutations: Standards needed for gene-editing errors.

Nature. 2015;523(7559):158 - PMID: 26156364 - DOI: 10.1038/523158a
Bakris GL, Pitt B, Weir MR, Freeman MW, Mayo MR, Garza D, Stasiv Y, Zawadzki R, Berman L, Bushinsky DA,

Effect of Patiromer on Serum Potassium Level in Patients With Hyperkalemia and Diabetic Kidney Disease: The AMETHYST-DN Randomized Clinical Trial.

JAMA. 2015;314(2):151-61 - PMID: 26172895 - DOI: 10.1001/jama.2015.7446
Ramezani A, Dubrovsky L, Pushkarsky T, Sviridov D, Karandish S, Raj DS, Fitzgerald ML, Bukrinsky M

Stimulation of Liver X Receptor Has Potent Anti-HIV Effects in a Humanized Mouse Model.

J Pharmacol Exp Ther. 2015;354(3):376-83 - PMID: 26126533 - PMCID: PMC4538872 - DOI: 10.1124/jpet.115.224485
Kleinstiver BP, Prew MS, Tsai SQ, Topkar VV, Nguyen NT, Zheng Z, Gonzales AP, Li Z, Peterson RT, Yeh JJ, Aryee MJ, Joung JK

Engineered CRISPR-Cas9 nucleases with altered PAM specificities.

Nature. 2015;523(7561):481-5 - PMID: 26098369 - PMCID: PMC4540238 - DOI: 10.1038/nature14592
Begun J, Lassen KG, Jijon HB, Baxt LA, Goel G, Heath RJ, Ng A, Tam JM, Kuo SY, Villablanca EJ, Fagbami L, Oosting M, Kumar V, Schenone M, Carr SA, Joosten LA, Vyas JM, Daly MJ, Netea MG, Brown GD, Wijmenga C, Xavier RJ

Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.

Cell Rep. 2015;11(12):1905-1918 - PMID: 26095365 - PMCID: PMC4507440 - DOI: 10.1016/j.celrep.2015.05.045
Wyvekens N, Topkar VV, Khayter C, Joung JK, Tsai SQ

Dimeric CRISPR RNA-guided FokI-dCas9 nucleases (RFNs) directed by truncated gRNAs for highly specific genome editing.

Hum Gene Ther. 2015;26(7):425-431 - PMID: 26068112 - PMCID: PMC4509490 - DOI: 10.1089/hum.2015.084
Rajamuthiah R, Jayamani E, Conery AL, Fuchs BB, Kim W, Johnston T, Vilcinskas A, Ausubel FM, Mylonakis E

A Defensin from the Model Beetle Tribolium castaneum Acts Synergistically with Telavancin and Daptomycin against Multidrug Resistant Staphylococcus aureus.

PLoS One. 2015;10(6):e0128576 - PMID: 26062137 - PMCID: PMC4465704 - DOI: 10.1371/journal.pone.0128576
Quévrain E, Maubert MA, Michon C, Chain F, Marquant R, Tailhades J, Miquel S, Carlier L, Bermúdez-Humarán LG, Pigneur B, Lequin O, Kharrat P, Thomas G, Rainteau D, Aubry C, Breyner N, Afonso C, Lavielle S, Grill JP, Chassaing G, Chatel JM, Trugnan G, Xavier R, Langella P, Sokol H, Seksik P

Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease.

Gut. 2016;65(3):415-25 - PMID: 26045134 - PMCID: PMC5136800 - DOI: 10.1136/gutjnl-2014-307649
Kim W, Conery AL, Rajamuthiah R, Fuchs BB, Ausubel FM, Mylonakis E

Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy.

PLoS One. 2015;10(6):e0127640 - PMID: 26039584 - PMCID: PMC4454602 - DOI: 10.1371/journal.pone.0127640
Causton B, Ramadas RA, Cho JL, Jones K, Pardo-Saganta A, Rajagopal J, Xavier RJ, Medoff BD

CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation.

J Immunol. 2015;195(2):683-94 - PMID: 26041536 - PMCID: PMC4489191 - DOI: 10.4049/jimmunol.1402983
Adamala K, Engelhart AE, Kamat NP, Jin L, Szostak JW

Construction of a liposome dialyzer for the preparation of high-value, small-volume liposome formulations.

Nat Protoc. 2015;10(6):927-938 - PMID: 26020615 - PMCID: PMC4982460 - DOI: 10.1038/nprot.2015.054
Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, Riedel H, Fisch P, Cantz T, Rudolph C, Mussolino C, Joung JK, Schambach A, Cathomen T

Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.

PLoS Genet. 2015;11(5):e1005239 - PMID: 26000857 - PMCID: PMC4441453 - DOI: 10.1371/journal.pgen.1005239
Khor B, Gagnon JD, Goel G, Roche MI, Conway KL, Tran K, Aldrich LN, Sundberg TB, Paterson AM, Mordecai S, Dombkowski D, Schirmer M, Tan PH, Bhan AK, Roychoudhuri R, Restifo NP, O'Shea JJ, Medoff BD, Shamji AF, Schreiber SL, Sharpe AH, Shaw SY, Xavier RJ

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.

Elife. 2015;4:ePub - PMID: 25998054 - PMCID: PMC4441007 - DOI: 10.7554/eLife.05920
Hwang WY, Fu Y, Reyon D, Gonzales AP, Joung JK, Yeh JR

Targeted Mutagenesis in Zebrafish Using CRISPR RNA-Guided Nucleases.

Methods Mol Biol. 2015;1311:317-34 - PMID: 25981483 - DOI: 10.1007/978-1-4939-2687-9_21
Smith MB, Rocha AM, Smillie CS, Olesen SW, Paradis C, Wu L, Campbell JH, Fortney JL, Mehlhorn TL, Lowe KA, Earles JE, Phillips J, Techtmann SM, Joyner DC, Elias DA, Bailey KL, Hurt RA, Preheim SP, Sanders MC, Yang J, Mueller MA, Brooks S, Watson DB, Zhang P, He Z, Dubinsky EA, Adams PD, Arkin AP, Fields MW, Zhou J, Alm EJ, Hazen TC

Natural bacterial communities serve as quantitative geochemical biosensors.

MBio. 2015;6(3):e00326-15 - PMID: 25968645 - PMCID: PMC4436078 - DOI: 10.1128/mBio.00326-15
Haney CH, Samuel BS, Bush J, Ausubel FM

Associations with rhizosphere bacteria can confer an adaptive advantage to plants.

Nat Plants. 2015;1(6):ePub - PMID: 27019743 - PMCID: PMC4806546 - DOI: 10.1038/nplants.2015.51
Haney CH, Samuel BS, Bush J, Ausubel FM

Associations with rhizosphere bacteria can confer an adaptive advantage to plants.

Nat Plants. 2015;1:15051 - PMID: 27250003
Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y

PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles.

Nucleic Acids Res. 2015;43(W1):W154-W159 - PMID: 25958392 - PMCID: PMC4489270 - DOI: 10.1093/nar/gkv452
Total: 2467