Publications for All Faculty

Sort by:
Reset

O'Connell DJ, Kolde R, Sooknah M, Graham DB, Sundberg TB, Latorre IJ, Mikkelsen TS, Xavier RJ

Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing.
Cell Syst. 2016;2(5):323-334 - PMID: 27211859 - PMCID: PMC5032147 - DOI: 10.1016/j.cels.2016.04.011

Frydman GH, Bendapudi PK, Marini RP, Vanderburg CR, Tompkins RG, Fox JG

Coagulation Biomarkers in Healthy Chinese-Origin Rhesus Macaques (Macaca mulatta).
J Am Assoc Lab Anim Sci. 2016;55(3):252-9 - PMID: 27177557 - PMCID: PMC4865685

Ueki R, Liu L, Kashiwagi S, Kaneki M, Khan M, Hirose M, Tompkins RG, Martyn JA, Yasuhara S

Role of Elevated Fibrinogen in Burn-Induced Mitochondrial Dysfunction: Protective Effects of Glycyrrhizin.
Shock. 2016;46(4):382-9 - PMID: 27172157 - PMCID: PMC5026541 - DOI: 10.1097/SHK.0000000000000602

Lamas B, Richard ML, Leducq V, Pham HP, Michel ML, Da Costa G, Bridonneau C, Jegou S, Hoffmann TW, Natividad JM, Brot L, Taleb S, Couturier-Maillard A, Nion-Larmurier I, Merabtene F, Seksik P, Bourrier A, Cosnes J, Ryffel B, Beaugerie L, Launay JM, Langella P, Xavier RJ, Sokol H

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.
Nat Med. 2016;22(6):598-605 - PMID: 27158904 - PMCID: PMC5087285 - DOI: 10.1038/nm.4102

Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, Virgin HW, Mazmanian SK

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.
Science. 2016;352(6289):1116-20 - PMID: 27230380 - PMCID: PMC4996125 - DOI: 10.1126/science.aad9948

Taleban S, Stewart KO, Li DK, Singh P, Pardi DS, Sturgeon HC, Yajnik V, Xavier RJ, Ananthakrishnan AN, Khalili H

Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn's Disease Phenotypes.
Dig Dis Sci. 2016;61(9):2627-35 - PMID: 27142671 - PMCID: PMC4982770 - DOI: 10.1007/s10620-016-4180-8

Tsai SQ, Topkar VV, Joung JK, Aryee MJ

Open-source guideseq software for analysis of GUIDE-seq data.
Nat Biotechnol. 2016;34(5):483 - PMID: 27153277 - DOI: 10.1038/nbt.3534

Peloquin JM, Goel G, Villablanca EJ, Xavier RJ

Mechanisms of Pediatric Inflammatory Bowel Disease.
Annu Rev Immunol. 2016;34:31-64 - PMID: 27168239 - DOI: 10.1146/annurev-immunol-032414-112151

Zhernakova A, Kurilshikov A, Bonder MJ, Tigchelaar EF, Schirmer M, Vatanen T, Mujagic Z, Vila AV, Falony G, Vieira-Silva S, Wang J, Imhann F, Brandsma E, Jankipersadsing SA, Joossens M, Cenit MC, Deelen P, Swertz MA, , Weersma RK, Feskens EJ, Netea MG, Gevers D, Jonkers D, Franke L, Aulchenko YS, Huttenhower C, Raes J, Hofker MH, Xavier RJ, Wijmenga C, Fu J

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.
Science. 2016;352(6285):565-9 - PMID: 27126040 - PMCID: PMC5240844 - DOI: 10.1126/science.aad3369

Vatanen T, Kostic AD, d'Hennezel E, Siljander H, Franzosa EA, Yassour M, Kolde R, Vlamakis H, Arthur TD, Hämäläinen AM, Peet A, Tillmann V, Uibo R, Mokurov S, Dorshakova N, Ilonen J, Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H, Huttenhower C, Gevers D, Cullen TW, Knip M, DIABIMMUNE Study Group, Xavier RJ

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
Cell. 2016;165(4):842-53 - PMID: 27133167 - PMCID: PMC4950857 - DOI: 10.1016/j.cell.2016.04.007

Vatanen T, Kostic AD, d'Hennezel E, Siljander H, Franzosa EA, Yassour M, Kolde R, Vlamakis H, Arthur TD, Hämäläinen AM, Peet A, Tillmann V, Uibo R, Mokurov S, Dorshakova N, Ilonen J, Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H, Huttenhower C, Gevers D, Cullen TW, Knip M, , Xavier RJ

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
Cell. 2016;165(4):842-53 - PMID: 27133167 - PMCID: PMC4950857 - DOI: 10.1016/j.cell.2016.04.007

Prywes N, Michaels YS, Pal A, Oh SS, Szostak JW

Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying.
Chem Commun (Camb). 2016;52(39):6529-32 - PMID: 27109314 - DOI: 10.1039/c6cc02692c

Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, O'Neill LA, Xavier RJ

Trained immunity: A program of innate immune memory in health and disease.
Science. 2016;352(6284):aaf1098 - PMID: 27102489 - PMCID: PMC5087274 - DOI: 10.1126/science.aaf1098

Zimmer S, Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Björkhem I, Gustafsson JÅ, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, Lütjohann D, Latz E

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming.
Sci Transl Med. 2016;8(333):333ra50 - PMID: 27053774 - PMCID: PMC4878149 - DOI: 10.1126/scitranslmed.aad6100

Tsai SQ, Joung JK

Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases.
Nat Rev Genet. 2016;17(5):300-12 - PMID: 27087594 - PMCID: PMC7225572 - DOI: 10.1038/nrg.2016.28

Abrams JA, Xavier RJ, Rustgi AK

Timothy C. Wang, MD: Our next AGA President.
Gastroenterology. 2016;150(5):1231-1236 - PMID: 27018487 - DOI: 10.1053/j.gastro.2016.03.021

Adamala KP, Engelhart AE, Szostak JW

Collaboration between primitive cell membranes and soluble catalysts.
Nat Commun. 2016;7:11041 - PMID: 26996603 - PMCID: PMC4802160 - DOI: 10.1038/ncomms11041

Li L, Lelyveld VS, Prywes N, Szostak JW

Experimental and computational evidence for a loose transition state in phosphoroimidazolide hydrolysis.
J Am Chem Soc. 2016;138(12):3986-9 - PMID: 26974265 - PMCID: PMC7547882 - DOI: 10.1021/jacs.6b00784

Engelhart AE, Adamala KP, Szostak JW

A simple physical mechanism enables homeostasis in primitive cells.
Nat Chem. 2016;8(5):448-53 - PMID: 27102678 - PMCID: PMC4929987 - DOI: 10.1038/nchem.2475

Acharya M, Sokolovska A, Tam JM, Conway KL, Stefani C, Raso F, Mukhopadhyay S, Feliu M, Paul E, Savill J, Hynes RO, Xavier RJ, Vyas JM, Stuart LM, Lacy-Hulbert A

?v Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells.
Nat Commun. 2016;7:10917 - PMID: 26965188 - PMCID: PMC4792966 - DOI: 10.1038/ncomms10917

Kazis LE, Lee AF, Rose M, Liang MH, Li NC, Ren XS, Sheridan R, Gilroy-Lewis J, Stoddard F, Hinson M, Warden G, Stubbs K, Blakeney P, Meyer W, McCauley R, Herndon D, Palmieri T, Mooney K, Wood D, Pidcock F, Reilly D, Cullen M, Calvert C, Ryan CM, Schneider JC, Soley-Bori M, Tompkins RG

Recovery Curves for Pediatric Burn Survivors: Advances in Patient-Oriented Outcomes.
JAMA Pediatr. 2016;170(6):534-42 - PMID: 26953515 - DOI: 10.1001/jamapediatrics.2015.4722

Schwerd T, Pandey S, Yang HT, Bagola K, Jameson E, Jung J, Lachmann RH, Shah N, Patel SY, Booth C, Runz H, Düker G, Bettels R, Rohrbach M, Kugathasan S, Chapel H, Keshav S, Elkadri A, Platt N, Muise AM, Koletzko S, Xavier RJ, Marquardt T, Powrie F, Wraith JE, Gyrd-Hansen M, Platt FM, Uhlig HH

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.
Gut. 2017;66(6):1060-1073 - PMID: 26953272 - PMCID: PMC5532464 - DOI: 10.1136/gutjnl-2015-310382

Liu S, Bartnikas LM, Volko SM, Ausubel FM, Tang D

Mutation of the Glucosinolate Biosynthesis Enzyme Cytochrome P450 83A1 Monooxygenase Increases Camalexin Accumulation and Powdery Mildew Resistance.
Front Plant Sci. 2016;7:227 - PMID: 26973671 - PMCID: PMC4774424 - DOI: 10.3389/fpls.2016.00227

Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, Tachibana M, Younkin L, Kurti A, Carrasquillo MM, Zou F, Sevlever D, Bisceglio G, Gan M, Fol R, Knight P, Wang M, Han X, Fryer JD, Fitzgerald ML, Ohyagi Y, Younkin SG, Bu G, Kanekiyo T

ABCA7 Deficiency Accelerates Amyloid-? Generation and Alzheimer's Neuronal Pathology.
J Neurosci. 2016;36(13):3848-59 - PMID: 27030769 - PMCID: PMC4812140 - DOI: 10.1523/JNEUROSCI.3757-15.2016

Bambouskova M, Polakovicova I, Halova I, Goel G, Draberova L, Bugajev V, Doan A, Utekal P, Gardet A, Xavier RJ, Draber P

New Regulatory Roles of Galectin-3 in the High-affinity IgE Receptor Signaling.
Mol Cell Biol. 2016;36(9):1366-82 - PMID: 26929198 - PMCID: PMC4836217 - DOI: 10.1128/MCB.00064-16
Total: 2489