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Pal A, Das RS, Zhang W, Lang M, McLaughlin LW, Szostak JW

Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension.
Chem Commun (Camb). 2016;52(80):11905-11907 - PMID: 27722518 - DOI: 10.1039/c6cc06925h

Szostak JW

On the origin of life.
Medicina (B Aires). 2016;76(4):199-203 - PMID: 27576276

Zhang D, Gomez JE, Chien JY, Haseley N, Desjardins CA, Earl AM, Hsueh PR, Hung DT

Genomic analysis of the evolution of fluoroquinolone resistance in Mycobacterium tuberculosis prior to tuberculosis diagnosis.
Antimicrob Agents Chemother. 2016;60(11):6600-6608 - PMID: 27572408 - PMCID: PMC5075065 - DOI: 10.1128/AAC.00664-16

Walton T, Szostak JW

A highly reactive imidazolium-bridged dinucleotide intermediate in nonenzymatic RNA primer extension.
J Am Chem Soc. 2016;138(36):11996-2002 - PMID: 27552367 - PMCID: PMC6326528 - DOI: 10.1021/jacs.6b07977

Peloquin JM, Goel G, Kong L, Huang H, Haritunians T, Sartor RB, Daly MJ, Newberry RD, McGovern DP, Yajnik V, Lira SA, Xavier RJ

Characterization of candidate genes in inflammatory bowel disease-associated risk loci.
JCI Insight. 2016;1(13):e87899 - PMID: 27668286 - PMCID: PMC5033062 - DOI: 10.1172/jci.insight.87899

Lehrbach NJ, Ruvkun G

Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.
Elife. 2016;5:ePub - PMID: 27528192 - PMCID: PMC4987142 - DOI: 10.7554/eLife.17721

Kashiwagi S, Khan MA, Yasuhara S, Goto T, Tompkins RG, Kaneki M, Martyn JA

Prevention of Burn-Induced Inflammatory Responses and Muscle Wasting By GTS-21, A Specific Agonist for ?7 Nicotinic Acetylcholine Receptors.
Shock. 2017;47(1):61-69 - PMID: 27529131 - PMCID: PMC5167674 - DOI: 10.1097/SHK.0000000000000729

Rivas MA, Graham D, Sulem P, Stevens C, Desch AN, Goyette P, Gudbjartsson D, Jonsdottir I, Thorsteinsdottir U, Degenhardt F, Mucha S, Kurki MI, Li D, D'Amato M, Annese V, Vermeire S, Weersma RK, Halfvarson J, Paavola-Sakki P, Lappalainen M, Lek M, Cummings B, Tukiainen T, Haritunians T, Halme L, Koskinen LL, Ananthakrishnan AN, Luo Y, Heap GA, Visschedijk MC, , , MacArthur DG, Neale BM, Ahmad T, Anderson CA, Brant SR, Duerr RH, Silverberg MS, Cho JH, Palotie A, Saavalainen P, Kontula K, Färkkilä M, McGovern DP, Franke A, Stefansson K, Rioux JD, Xavier RJ, Daly MJ, Barrett J, de Lane K, Edwards C, Hart A, Hawkey C, Jostins L, Kennedy N, Lamb C, Lee J, Lees C, Mansfield J, Mathew C, Mowatt C, Newman B, Nimmo E, Parkes M, Pollard M, Prescott N, Randall J, Rice D, Satsangi J, Simmons A, Tremelling M, Uhlig H, Wilson D, Abraham C, Achkar JP, Bitton A, Boucher G, Croitoru K, Fleshner P, Glas J, Kugathasan S, Limbergen JV, Milgrom R, Proctor D, Regueiro M, Schumm PL, Sharma Y, Stempak JM, Targan SR, Wang MH

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.
Nat Commun. 2016;7:12342 - PMID: 27503255 - PMCID: PMC4980482 - DOI: 10.1038/ncomms12342

Netea MG, Joosten LA, Li Y, Kumar V, Oosting M, Smeekens S, Jaeger M, Ter Horst R, Schirmer M, Vlamakis H, Notebaart R, Pavelka N, Aguirre-Gamboa RR, Swertz MA, Tunjungputri RN, van de Heijden W, Franzosa EA, Ng A, Graham D, Lassen K, Schraa K, Netea-Maier R, Smit J, de Mast Q, van de Veerdonk F, Kullberg BJ, Tack C, van de Munckhof I, Rutten J, van der Graaf J, Franke L, Hofker M, Jonkers I, Platteel M, Maatman A, Fu J, Zhernakova A, van der Meer JW, Dinarello CA, van der Ven A, Huttenhouwer C, Koenen H, Joosten I, Xavier RJ, Wijmenga C

Understanding human immune function using the resources from the Human Functional Genomics Project.
Nat Med. 2016;22(8):831-3 - PMID: 27490433 - DOI: 10.1038/nm.4140

Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Büning C, Schumm LP, Klei L, Ananthakrishnan A, Aumais G, Baidoo L, Dubinsky M, Fiocchi C, Glas J, Milgrom R, Proctor DD, Regueiro M, Simms LA, Stempak JM, Targan SR, Törkvist L, Sharma Y, Devlin B, Borneman J, Hakonarson H, Xavier RJ, Daly M, Brant SR, Rioux JD, Silverberg MS, Cho JH, Braun J, McGovern DP, Duerr RH

A pleiotropic missense variant in SLC39A8 is associated with Crohn's disease and human gut microbiome composition.
Gastroenterology. 2016;151(4):724-32 - PMID: 27492617 - PMCID: PMC5037008 - DOI: 10.1053/j.gastro.2016.06.051

Outterson K, Rex JH, Jinks T, Jackson P, Hallinan J, Karp S, Hung DT, Franceschi F, Merkeley T, Houchens C, Dixon DM, Kurilla MG, Aurigemma R, Larsen J

Accelerating global innovation to address antibacterial resistance: introducing CARB-X.
Nat Rev Drug Discov. 2016;15(9):589-590 - PMID: 27469032 - DOI: 10.1038/nrd.2016.155

Avraham R, Haseley N, Fan A, Bloom-Ackermann Z, Livny J, Hung DT

A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes.
Nat Protoc. 2016;11(8):1477-91 - PMID: 27442864 - DOI: 10.1038/nprot.2016.090

Li L, Sheen J

Dynamic and diverse sugar signaling.
Curr Opin Plant Biol. 2016;33:116-125 - PMID: 27423125 - PMCID: PMC5050104 - DOI: 10.1016/j.pbi.2016.06.018

Shaw KA, Bertha M, Hofmekler T, Chopra P, Vatanen T, Srivatsa A, Prince J, Kumar A, Sauer C, Zwick ME, Satten GA, Kostic AD, Mulle JG, Xavier RJ, Kugathasan S

Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease.
Genome Med. 2016;8(1):75 - PMID: 27412252 - PMCID: PMC4944441 - DOI: 10.1186/s13073-016-0331-y

Syrkina O, Hales CH, Bonab AA, Hamrahi V, Paul K, Jung WJ, Tompkins RG, Fischman AJ, Carter EA

Molecular Imaging of Smoke-Induced Changes in Nuclear Factor-Kappa B Expression in Murine Tissues Including the Lung.
J Burn Care Res. 2016;37(6):335-342 - PMID: 27437954 - DOI: 10.1097/BCR.0000000000000394

Brito IL, Yilmaz S, Huang K, Xu L, Jupiter SD, Jenkins AP, Naisilisili W, Tamminen M, Smillie CS, Wortman JR, Birren BW, Xavier RJ, Blainey PC, Singh AK, Gevers D, Alm EJ

Mobile genes in the human microbiome are structured from global to individual scales.
Nature. 2016;535(7612):435-439 - PMID: 27409808 - PMCID: PMC4983458 - DOI: 10.1038/nature18927

Li Y, Oosting M, Deelen P, Ricaño-Ponce I, Smeekens S, Jaeger M, Matzaraki V, Swertz MA, Xavier RJ, Franke L, Wijmenga C, Joosten LA, Kumar V, Netea MG

Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.
Nat Med. 2016;22(8):952-960 - PMID: 27376574 - PMCID: PMC5084084 - DOI: 10.1038/nm.4139

Newman M, Ausubel FM

Introduction to Gene Editing and Manipulation Using CRISPR/Cas9 Technology.
Curr Protoc Mol Biol. 2016;115:31.4.1-6 - PMID: 27366890 - PMCID: PMC4963815 - DOI: 10.1002/cpmb.14

Dowen RH, Breen PC, Tullius T, Conery AL, Ruvkun G

A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport.
Genes Dev. 2016;30(13):1515-28 - PMID: 27401555 - PMCID: PMC4949325 - DOI: 10.1101/gad.283895.116

DeJesus R, Moretti F, McAllister G, Wang Z, Bergman P, Liu S, Frias E, Alford J, Reece-Hoyes JS, Lindeman A, Kelliher J, Russ C, Knehr J, Carbone W, Beibel M, Roma G, Ng A, Tallarico JA, Porter JA, Xavier RJ, Mickanin C, Murphy LO, Hoffman GR, Nyfeler B

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62.
Elife. 2016;5:ePub - PMID: 27351204 - PMCID: PMC4924995 - DOI: 10.7554/eLife.17290

Prywes N, Blain JC, Del Frate F, Szostak JW

Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides.
Elife. 2016;5:ePub - PMID: 27351102 - PMCID: PMC4959843 - DOI: 10.7554/eLife.17756

Kleinstiver BP, Tsai SQ, Prew MS, Nguyen NT, Welch MM, Lopez JM, McCaw ZR, Aryee MJ, Joung JK

Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells.
Nat Biotechnol. 2016;34(8):869-874 - PMID: 27347757 - PMCID: PMC4980201 - DOI: 10.1038/nbt.3620

Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW

Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication.
Nat Chem. 2016;8(10):915-21 - PMID: 27657866 - PMCID: PMC5061144 - DOI: 10.1038/nchem.2551

Xavier RJ

Microbiota as Therapeutic Targets.
Dig Dis. 2016;34(5):558-65 - PMID: 27331403 - DOI: 10.1159/000445263

Samuel BS, Rowedder H, Braendle C, Félix MA, Ruvkun G

Caenorhabditis elegans responses to bacteria from its natural habitats.
Proc Natl Acad Sci U S A. 2016;113(27):E3941-9 - PMID: 27317746 - PMCID: PMC4941482 - DOI: 10.1073/pnas.1607183113
Total: 2498