Publications for All Faculty

Sort by:
Reset

Seetharaman A, Galagali H, Linarte E, Liu MHX, Cohen JD, Chetal K, Sadreyev R, Tate AJ, Montgomery TA, Ruvkun G

Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans.
PLoS Biol. 2025;23(1):e3002748 - PMID: 39879188 - PMCID: PMC11778786 - DOI: 10.1371/journal.pbio.3002748

Jimena B, Kazimierczyk D, Kazimierczyk S, Moya H, Shin E, Li L, Korgaonkar P, Porter C, Seed B, Cherayil BJ, Jain N

Prenatal maternal infection promotes maternal microchimeric cells to alter infection risk in male offspring.
bioRxiv. 2025;:ePub - PMID: 39896468 - PMCID: PMC11785123 - DOI: 10.1101/2025.01.17.633596

Brown EM, Nguyen PNU, Xavier RJ

Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis.
Cell Chem Biol. 2025;32(1):12-24 - PMID: 39168118 - PMCID: PMC11741937 - DOI: 10.1016/j.chembiol.2024.07.012

Bang S, Shin YH, Park SM, Deng L, Williamson RT, Graham DB, Xavier RJ, Clardy J

Unusual Phospholipids from Morganella morganii Linked to Depression.
J Am Chem Soc. 2025;147(4):2998-3002 - PMID: 39818770 - PMCID: PMC11783507 - DOI: 10.1021/jacs.4c15158

Patange O, Breen P, Arsuffi G, Ruvkun G

Hydrogen sulfide mediates the interaction between C. elegans and Actinobacteria from its natural microbial environment.
Cell Rep. 2025;44(1):115170 - PMID: 39786993 - DOI: 10.1016/j.celrep.2024.115170

Tan ZY, Adade JKA, Gu X, Hecht CJS, Salcius M, Tong B, Liu S, Hwang S, Zécri FJ, Graham DB, Schreiber SL, Xavier RJ

Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator.
Cell Chem Biol. 2025;32(3):498-510.e35 - PMID: 39753134 - PMCID: PMC11928285 - DOI: 10.1016/j.chembiol.2024.12.002

Poulsen BE, Warrier T, Barkho S, Bagnall J, Romano KP, White T, Yu X, Kawate T, Nguyen PH, Raines K, Ferrara K, Golas AL, FitzGerald M, Boeszoermenyi A, Kaushik V, Serrano-Wu M, Shoresh N, Hung DT

Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen.
Cell Chem Biol. 2024;32(2):307-324.e15 - PMID: 39732052 - PMCID: PMC12117999 - DOI: 10.1016/j.chembiol.2024.12.001

Lin Z, Guo Y, Zhang R, Li Y, Wu Y, Sheen J, Liu KH

ABA-activated low-nanomolar Ca2+-CPK signalling controls root cap cycle plasticity and stress adaptation.
Nat Plants. 2024;11(1):90-104 - PMID: 39578615 - PMCID: PMC11757075 - DOI: 10.1038/s41477-024-01865-y

Mayassi T, Li C, Segerstolpe Åsa, Brown EM, Weisberg R, Nakata T, Yano H, Herbst P, Artis D, Graham DB, Xavier RJ

Spatially restricted immune and microbiota-driven adaptation of the gut.
Nature. 2024;636(8042):447-456 - PMID: 39567686 - PMCID: PMC11816900 - DOI: 10.1038/s41586-024-08216-z

Ogasawara D, Konrad DB, Tan ZY, Carey KL, Luo J, Won SJ, Li H, Carter TR, DeMeester KE, Njomen E, Schreiber SL, Xavier RJ, Melillo B, Cravatt BF

Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes.
Cell Chem Biol. 2024;31(12):2138-2155.e32 - PMID: 39547236 - PMCID: PMC11837778 - DOI: 10.1016/j.chembiol.2024.10.005

Romano KP, Bagnall J, Warrier T, Sullivan J, Ferrara K, Orzechowski M, Nguyen PH, Raines K, Livny J, Shoresh N, Hung DT

Perturbation-specific transcriptional mapping for unbiased target elucidation of antibiotics.
Proc Natl Acad Sci U S A. 2024;121(45):e2409747121 - PMID: 39467118 - PMCID: PMC11551328 - DOI: 10.1073/pnas.2409747121

Meirelles LA, Vayena E, Debache A, Schmidt E, Rossy T, Distler T, Hatzimanikatis V, Persat A

Pseudomonas aeruginosa faces a fitness trade-off between mucosal colonization and antibiotic tolerance during airway infection.
Nat Microbiol. 2024;9(12):3284-3303 - PMID: 39455898 - PMCID: 10.1038/s41564-024-01842-3 - DOI: 10.1038/s41564-024-01842-3

Furuichi M, Kawaguchi T, Pust MM, Yasuma-Mitobe K, Plichta DR, Hasegawa N, Ohya T, Bhattarai SK, Sasajima S, Aoto Y, Tuganbaev T, Yaginuma M, Ueda M, Okahashi N, Amafuji K, Kiridoshi Y, Sugita K, Stražar M, Avila-Pacheco J, Pierce K, Clish CB, Skelly AN, Hattori M, Nakamoto N, Caballero S, Norman JM, Olle B, Tanoue T, Suda W, Arita M, Bucci V, Atarashi K, Xavier RJ, Honda K

Commensal consortia decolonize Enterobacteriaceae via ecological control.
Nature. 2024;633(8031):878-886 - PMID: 39294375 - PMCID: PMC11424487 - DOI: 10.1038/s41586-024-07960-6

Zhang Y, Cao Y, Jiang W, Ma Q, Shin J, Sun H, Cui J, Chen Y, Giraldo JP, Strano MS, Lowry GV, Sheen J, Marelli B

Polymeric Nanocarriers Autonomously Cross the Plant Cell Wall and Enable Protein Delivery for Stress Sensing.
Adv Mater. 2024;36(41):e2409356 - PMID: 39149770 - PMCID: PMC11466712 - DOI: 10.1002/adma.202409356

Chou WM, Lin WL, Sheen JF

Determination of chlorothalonil in vegetables/fruits using liquid chromatography-tandem mass spectrometry with a discharge adapter interface.
Rapid Commun Mass Spectrom. 2024;38(15):e9770 - PMID: 38773864 - DOI: 10.1002/rcm.9770

Deguine J, Xavier RJ

B cell tolerance and autoimmunity: Lessons from repertoires.
J Exp Med. 2024;221(9):ePub - PMID: 39093312 - PMCID: PMC11296956 - DOI: 10.1084/jem.20231314

Shehadeh F, Felix L, Kalligeros M, Shehadeh A, Fuchs BB, Ausubel FM, Sotiriadis PP, Mylonakis E

Machine learning-assisted high-throughput screening for Anti-MRSA compounds.
IEEE/ACM Trans Comput Biol Bioinform. 2024;21(6):1911-1921 - PMID: 39058605 - DOI: 10.1109/TCBB.2024.3434340

Neale I, Reddy C, Tan ZY, Li B, Nag PP, Park J, Park J, Carey KL, Graham DB, Xavier RJ

Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation.
Sci Adv. 2024;10(29):eadn2339 - PMID: 39028811 - PMCID: PMC11259170 - DOI: 10.1126/sciadv.adn2339

Seetharaman A, Galagali H, Linarte E, Liu MHX, Cohen JD, Chetal K, Sadreyev R, Tate AJ, Montgomery TA, Ruvkun G

Caenorhabditis elegans SynMuv B gene activity is down-regulated during a viral infection to enhance RNA interference.
bioRxiv. 2024;:ePub - PMID: 39071373 - PMCID: PMC11275910 - DOI: 10.1101/2024.07.12.603258

Yanagi KS, Jochim B, Kunjo SO, Breen P, Ruvkun G, Lehrbach N

Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans.
PLoS Biol. 2024;22(7):e3002720 - PMID: 38991033 - PMCID: PMC11265709 - DOI: 10.1371/journal.pbio.3002720

Trsan T, Peng V, Krishna C, Ohara TE, Beatty WL, Sudan R, Kanai M, Krishnamoorthy P, Rodrigues PF, Fachi JL, Grajales-Reyes G, Jaeger N, Fitzpatrick JAJ, Cella M, Gilfillan S, Nakata T, Jaiswal A, Stappenbeck TS, Daly MJ, Xavier RJ, Colonna M

The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells.
Dev Cell. 2024;59(18):2460-2476.e10 - PMID: 38942017 - PMCID: PMC11421975 - DOI: 10.1016/j.devcel.2024.06.001

Parada-Kusz M, Clatworthy AE, Goering ER, Blackwood SM, Shigeta JY, Mashin E, Salm EJ, Choi C, Combs S, Lee JSW, Rodriguez-Osorio C, Clish C, Tomita S, Hung DT

3-Hydroxykynurenine targets kainate receptors to promote defense against infection.
Nat Chem Biol. 2024;20(12):1586-1596 - PMID: 38898166 - PMCID: PMC12204212 - DOI: 10.1038/s41589-024-01635-z

Kumbhari A, Cheng TNH, Ananthakrishnan AN, Kochar B, Burke KE, Shannon K, Lau H, Xavier RJ, Smillie CS

Discovery of disease-adapted bacterial lineages in inflammatory bowel diseases.
Cell Host Microbe. 2024;32(7):1147-1162.e12 - PMID: 38917808 - PMCID: PMC11239293 - DOI: 10.1016/j.chom.2024.05.022

Meisel JD, Wiesenthal PP, Mootha VK, Ruvkun G

CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene.
Curr Biol. 2024;34(12):2728-2738.e6 - PMID: 38810637 - PMCID: PMC11265314 - DOI: 10.1016/j.cub.2024.04.079

Romano KP, Bagnall J, Warrier T, Sullivan J, Ferrara K, Orzechowski M, Nguyen PH, Raines K, Livny J, Shoresh N, Hung DT

Perturbation-Specific Transcriptional Mapping facilitates unbiased target elucidation of antibiotics.
bioRxiv. 2024;:ePub - PMID: 38712067 - PMCID: PMC11071498 - DOI: 10.1101/2024.04.25.590978
Total: 2498