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Ambros V, Ruvkun G

Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs.
Genetics. 2018;209(3):651-673 - PMID: 29967059 - PMCID: PMC6028246 - DOI: 10.1534/genetics.118.300291

Yassour M, Jason E, Hogstrom LJ, Arthur TD, Tripathi S, Siljander H, Selvenius J, Oikarinen S, Hyöty H, Virtanen SM, Ilonen J, Ferretti P, Pasolli E, Tett A, Asnicar F, Segata N, Vlamakis H, Lander ES, Huttenhower C, Knip M, Xavier RJ

Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.
Cell Host Microbe. 2018;24(1):146-154.e4 - PMID: 30001517 - PMCID: PMC6091882 - DOI: 10.1016/j.chom.2018.06.007

Graham DB, Jasso GJ, Mok A, Goel G, Ng ACY, Kolde R, Varma M, Doench JG, Root DE, Clish CB, Carr SA, Xavier RJ

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.
Cell Rep. 2018;24(4):838-850 - PMID: 30044981 - PMCID: PMC6156773 - DOI: 10.1016/j.celrep.2018.06.081

Schirmer M, Kumar V, Netea MG, Xavier RJ

The causes and consequences of variation in human cytokine production in health.
Curr Opin Immunol. 2018;54:50-58 - PMID: 29913309 - DOI: 10.1016/j.coi.2018.05.012

Zhang W, Walton T, Li L, Szostak JW

Crystallographic observation of nonenzymatic RNA primer extension.
Elife. 2018;7:ePub - PMID: 29851379 - PMCID: PMC5980232 - DOI: 10.7554/eLife.36422

Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM, Kurki M, Ganna A, Graham D, Glaser B, Peter I, Atzmon G, Barzilai N, Levine AP, Schiff E, Pontikos N, Weisburd B, Lek M, Karczewski KJ, Bloom J, Minikel EV, Petersen BS, Beaugerie L, Seksik P, Cosnes J, Schreiber S, Bokemeyer B, Bethge J, International IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-GENES Consortium, Heap G, Ahmad T, Plagnol V, Segal AW, Targan S, Turner D, Saavalainen P, Farkkila M, Kontula K, Palotie A, Brant SR, Duerr RH, Silverberg MS, Rioux JD, Weersma RK, Franke A, Jostins L, Anderson CA, Barrett JC, MacArthur DG, Jalas C, Sokol H, Xavier RJ, Pulver A, Cho JH, McGovern DPB, Daly MJ

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.
PLoS Genet. 2018;14(5):e1007329 - PMID: 29795570 - PMCID: PMC5967709 - DOI: 10.1371/journal.pgen.1007329

Bakker OB, Aguirre-Gamboa R, Sanna S, Oosting M, Smeekens SP, Jaeger M, Zorro M, Võsa U, Withoff S, Netea-Maier RT, Koenen HJPM, Joosten I, Xavier RJ, Franke L, Joosten LAB, Kumar V, Wijmenga C, Netea MG, Li Y

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses.
Nat Immunol. 2018;19(7):776-786 - PMID: 29784908 - PMCID: PMC6022810 - DOI: 10.1038/s41590-018-0121-3

Pitt B, Bakris GL, Weir MR, Freeman MW, Lainscak M, Mayo MR, Garza D, Zawadzki R, Berman L, Bushinsky DA

Long-term effects of patiromer for hyperkalaemia treatment in patients with mild heart failure and diabetic nephropathy on angiotensin-converting enzymes/angiotensin receptor blockers: results from AMETHYST-DN.
ESC Heart Fail. 2018;5(4):592-602 - PMID: 29767459 - PMCID: PMC6073017 - DOI: 10.1002/ehf2.12292

Pontefract A, Hachey J, Zuber MT, Ruvkun G, Carr CE

Sequencing nothing: Exploring failure modes of nanopore sensing and implications for life detection.
Life Sci Space Res (Amst). 2018;18:80-86 - PMID: 30100151 - DOI: 10.1016/j.lssr.2018.05.004

Newman MA, Ji F, Fischer SEJ, Anselmo A, Sadreyev RI, Ruvkun G

The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes.
Genes Dev. 2018;32(9-10):670-681 - PMID: 29739806 - PMCID: PMC6004069 - DOI: 10.1101/gad.311514.118

Burke KE, Khalili H, Garber JJ, Haritunians T, McGovern DPB, Xavier RJ, Ananthakrishnan AN

Genetic Markers Predict Primary Nonresponse and Durable Response to Anti-Tumor Necrosis Factor Therapy in Ulcerative Colitis.
Inflamm Bowel Dis. 2018;24(8):1840-1848 - PMID: 29718226 - PMCID: PMC6128143 - DOI: 10.1093/ibd/izy083

Kasotakis G, Starr N, Nelson E, Sarkar B, Burke PA, Remick DG, Tompkins RG, Inflammation and Host Response to Injury Investigators

Platelet transfusion increases risk for acute respiratory distress syndrome in non-massively transfused blunt trauma patients.
Eur J Trauma Emerg Surg. 2019;45(4):671-679 - PMID: 29627883 - DOI: 10.1007/s00068-018-0953-4

O'Flaherty DK, Kamat NP, Mirza FN, Li L, Prywes N, Szostak JW

Copying of mixed sequence RNA templates inside model protocells.
J Am Chem Soc. 2018;140(15):5171-5178 - PMID: 29608310 - PMCID: PMC7547884 - DOI: 10.1021/jacs.8b00639

Brown EM, Xavier RJ

Without Adaptive Immunity, There's a Cost to Responding STAT.
Cell Metab. 2018;27(4):705-707 - PMID: 29617636 - DOI: 10.1016/j.cmet.2018.03.011

Canver MC, Joung JK, Pinello L

Impact of Genetic Variation on CRISPR-Cas Targeting.
CRISPR J. 2018;1:159-170 - PMID: 31021199 - PMCID: PMC6319324 - DOI: 10.1089/crispr.2017.0016

Lareau CA, Clement K, Hsu JY, Pattanayak V, Joung JK, Aryee MJ, Pinello L

Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".
Nat Methods. 2018;15(4):238-239 - PMID: 29600992 - PMCID: PMC7784551 - DOI: 10.1038/nmeth.4541

Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N, Conery AL, Shen S, Pan W, Lee K, Rajamuthiah R, Fuchs BB, Vlahovska PM, Wuest WM, Gilmore MS, Gao H, Ausubel FM, Mylonakis E

A new class of synthetic retinoid antibiotics effective against bacterial persisters.
Nature. 2018;556(7699):103-107 - PMID: 29590091 - PMCID: PMC6462414 - DOI: 10.1038/nature26157

Verma MS, Fink MJ, Salmon GL, Fornelos N, Ohara TE, Ryu SH, Vlamakis H, Xavier RJ, Stappenbeck TS, Whitesides GM

A common mechanism links activities of butyrate in the colon.
ACS Chem Biol. 2018;13(5):1291-1298 - PMID: 29584955 - DOI: 10.1021/acschembio.8b00073

Mojarro A, Hachey J, Ruvkun G, Zuber MT, Carr CE

CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing.
BMC Bioinformatics. 2018;19(1):108 - PMID: 29587645 - PMCID: PMC5872496 - DOI: 10.1186/s12859-018-2124-3

Clatworthy AE, Romano KP, Hung DT

Whole-organism phenotypic screening for anti-infectives promoting host health.
Nat Chem Biol. 2018;14(4):331-341 - PMID: 29556098 - PMCID: PMC9843822 - DOI: 10.1038/s41589-018-0018-3

Johns NI, Gomes ALC, Yim SS, Yang A, Blazejewski T, Smillie CS, Smith MB, Alm EJ, Kosuri S, Wang HH

Metagenomic mining of regulatory elements enables programmable species-selective gene expression.
Nat Methods. 2018;15(5):323-329 - PMID: 30052624 - PMCID: PMC6065261 - DOI: 10.1038/nmeth.4633

Haller S, Franchet A, Hakkim A, Chen J, Drenkard E, Yu S, Schirmeier S, Li Z, Martins N, Ausubel FM, Liégeois S, Ferrandon D

Quorum-sensing regulator RhlR but not its autoinducer RhlI enablesPseudomonasto evade opsonization.
EMBO Rep. 2018;19(5):ePub - PMID: 29523648 - PMCID: PMC5934776 - DOI: 10.15252/embr.201744880

Jin L, Kamat NP, Jena S, Szostak JW

Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution.
Small. 2018;14(15):e1704077 - PMID: 29479815 - PMCID: PMC6278924 - DOI: 10.1002/smll.201704077

Yuen GJ, Ausubel FM

Both live and dead Enterococci activate Caenorhabditis elegans host defense via immune and stress pathways.
Virulence. 2018;9(1):0 - PMID: 29436902 - PMCID: PMC5955442 - DOI: 10.1080/21505594.2018.1438025

Jin L, Engelhart AE, Adamala KP, Szostak JW

Preparation, Purification, and Use of Fatty Acid-containing Liposomes.
J Vis Exp. 2018;(132):ePub - PMID: 29553563 - PMCID: PMC5912384 - DOI: 10.3791/57324
Total: 2498