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Warnhoff K, Ruvkun G

Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification.
Nat Chem Biol. 2019;15(5):480-488 - PMID: 30911177 - PMCID: PMC6470025 - DOI: 10.1038/s41589-019-0249-y

Bhattacharyya RP, Walker M, Boykin R, Son SS, Liu J, Hachey AC, Ma P, Wu L, Choi K, Cummins KC, Benson M, Skerry J, Ryu H, Wong SY, Goldberg MB, Han J, Pierce VM, Cosimi LA, Shoresh N, Livny J, Beechem J, Hung DT

Rapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA.
Sci Rep. 2019;9(1):4516 - PMID: 30872641 - PMCID: PMC6418090 - DOI: 10.1038/s41598-019-40792-3

Strom KR, Szostak JW, Prywes N

Transfer of Sequence Information and Replication of Diimine Duplexes.
J Org Chem. 2019;84(7):3754-3761 - PMID: 30855962 - PMCID: PMC7547894 - DOI: 10.1021/acs.joc.9b00095

Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HM

Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential: (Trends Endocrinol. Metab. 29, 723-735, 2018).
Trends Endocrinol Metab. 2019;30(6):407 - PMID: 30837108 - DOI: 10.1016/j.tem.2019.01.009

Lander ES, Baylis F, Zhang F, Charpentier E, Berg P, Bourgain C, Friedrich B, Joung JK, Li J, Liu D, Naldini L, Nie JB, Qiu R, Schoene-Seifert B, Shao F, Terry S, Wei W, Winnacker EL

Adopt a moratorium on heritable genome editing.
Nature. 2019;567(7747):165-168 - PMID: 30867611 - DOI: 10.1038/d41586-019-00726-5

Clement K, Rees H, Canver MC, Gehrke JM, Farouni R, Hsu JY, Cole MA, Liu DR, Joung JK, Bauer DE, Pinello L

CRISPResso2 provides accurate and rapid genome editing sequence analysis.
Nat Biotechnol. 2019;37(3):224-226 - PMID: 30809026 - PMCID: PMC6533916 - DOI: 10.1038/s41587-019-0032-3

Mao K, Ji F, Breen P, Sewell A, Han M, Sadreyev R, Ruvkun G

Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes.
Cell Metab. 2019;29(5):1182-1191.e4 - PMID: 30799287 - PMCID: PMC6506380 - DOI: 10.1016/j.cmet.2019.01.022

Kleinstiver BP, Sousa AA, Walton RT, Tak YE, Hsu JY, Clement K, Welch MM, Horng JE, Malagon-Lopez J, Scarfò I, Maus MV, Pinello L, Aryee MJ, Joung JK

Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing.
Nat Biotechnol. 2019;37(3):276-282 - PMID: 30742127 - PMCID: PMC6401248 - DOI: 10.1038/s41587-018-0011-0

Yudanin NA, Schmitz F, Flamar AL, Thome JJC, Tait Wojno E, Moeller JB, Schirmer M, Latorre IJ, Xavier RJ, Farber DL, Monticelli LA, Artis D

Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity.
Immunity. 2019;50(2):505-519.e4 - PMID: 30770247 - PMCID: PMC6594374 - DOI: 10.1016/j.immuni.2019.01.012

Kniazeva M, Ruvkun G

Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells.
Proc Natl Acad Sci U S A. 2019;116(9):3784-3792 - PMID: 30808764 - PMCID: PMC6397575 - DOI: 10.1073/pnas.1815656116

Wu Y, Shi L, Li L, Fu L, Liu Y, Xiong Y, Sheen J

Integration of nutrient, energy, light and hormone signalling via TOR in plants.
J Exp Bot. 2019;70(8):2227-2238 - PMID: 30715492 - PMCID: PMC6463029 - DOI: 10.1093/jxb/erz028

Collij V, Imhann F, Vich Vila A, Fu J, Dijkstra G, Festen EAM, Voskuil MD, Daly MJ, Xavier RJ, Wijmenga C, Zhernakova A, Weersma RK

SLC39A8 missense variant is associated with Crohn's disease but does not have a major impact on gut microbiome composition in healthy subjects.
PLoS One. 2019;14(1):e0211328 - PMID: 30703110 - PMCID: PMC6354981 - DOI: 10.1371/journal.pone.0211328

Penaranda C, Hung DT

Single-Cell RNA Sequencing to Understand Host-Pathogen Interactions.
ACS Infect Dis. 2019;5(3):336-344 - PMID: 30702856 - DOI: 10.1021/acsinfecdis.8b00369

Matsushita-Ishiodori Y, Hanczyc MM, Wang A, Szostak JW, Yomo T

Using Imaging Flow Cytometry to Quantify and Optimize Giant Vesicle Production by Water-in-oil Emulsion Transfer Methods.
Langmuir. 2019;35(6):2375-2382 - PMID: 30645943 - DOI: 10.1021/acs.langmuir.8b03635

Raymond SL, Hawkins RB, Wang Z, Mira JC, Stortz JA, Han F, Lanz JD, Hennessy LV, Brumback BA, Baker HV, Efron PA, Brakenridge SC, Xiao W, Tompkins RG, Cuschieri J, Moore FA, Maier RV, Moldawer LL

Prospective Validation of a Transcriptomic Metric in Severe Trauma.
Ann Surg. 2020;271(5):802-810 - PMID: 30688688 - PMCID: PMC6656642 - DOI: 10.1097/SLA.0000000000003204

Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y, Narushima S, Vlamakis H, Motoo I, Sugita K, Shiota A, Takeshita K, Yasuma-Mitobe K, Riethmacher D, Kaisho T, Norman JM, Mucida D, Suematsu M, Yaguchi T, Bucci V, Inoue T, Kawakami Y, Olle B, Roberts B, Hattori M, Xavier RJ, Atarashi K, Honda K

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity.
Nature. 2019;565(7741):600-605 - PMID: 30675064 - DOI: 10.1038/s41586-019-0878-z

Lavoie S, Conway KL, Lassen KG, Jijon HB, Pan H, Chun E, Michaud M, Lang JK, Gallini Comeau CA, Dreyfuss JM, Glickman JN, Vlamakis H, Ananthakrishnan A, Kostic A, Garrett WS, Xavier RJ

The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response.
Elife. 2019;8:ePub - PMID: 30666959 - PMCID: PMC6342529 - DOI: 10.7554/eLife.39982

Strecker J, Jones S, Koopal B, Schmid-Burgk J, Zetsche B, Gao L, Makarova KS, Koonin EV, Zhang F

Engineering of CRISPR-Cas12b for human genome editing.
Nat Commun. 2019;10(1):212 - PMID: 30670702 - PMCID: PMC6342934 - DOI: 10.1038/s41467-018-08224-4

Jia M, Liu X, Xue H, Wu Y, Shi L, Wang R, Chen Y, Xu N, Zhao J, Shao J, Qi Y, An L, Sheen J, Yu F

Noncanonical ATG8-ABS3 interaction controls senescence in plants.
Nat Plants. 2019;5(2):212-224 - PMID: 30664732 - PMCID: PMC6368864 - DOI: 10.1038/s41477-018-0348-x

Nakazawa H, Ikeda K, Shinozaki S, Yasuhara S, Yu YM, Martyn JAJ, Tompkins RG, Yorozu T, Inoue S, Kaneki M

Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle.
FEBS Open Bio. 2019;9(2):348-363 - PMID: 30761259 - PMCID: PMC6356165 - DOI: 10.1002/2211-5463.12580

Xiaofang Jiang, A. Brantley Hall, Timothy D. Arthur, Damian R. Plichta, Christian T. Covington, Mathilde Poyet, Jessica Crothers, Peter L. Moses, Andrew C. Tolonen, Hera Vlamakis, Eric J. Alm, Ramnik J. Xavier

Invertible promoters mediate bacterial phase variation, antibiotic resistance, and host adaptation in the gut
Science. 2019;363, Issue 6423:181-187 - PMID: 30630933 - PMCID: PMC6543533 - DOI: 10.1126/science.aau5238

Wang A, Chan Miller C, Szostak JW

Core-Shell Modeling of Light Scattering by Vesicles: Effect of Size, Contents, and Lamellarity.
Biophys J. 2019;116(4):659-669 - PMID: 30686489 - PMCID: PMC6382849 - DOI: 10.1016/j.bpj.2019.01.006

Haberman Y, Karns R, Dexheimer PJ, Schirmer M, Somekh J, Jurickova I, Braun T, Novak E, Bauman L, Collins MH, Mo A, Rosen MJ, Bonkowski E, Gotman N, Marquis A, Nistel M, Rufo PA, Baker SS, Sauer CG, Markowitz J, Pfefferkorn MD, Rosh JR, Boyle BM, Mack DR, Baldassano RN, Shah S, Leleiko NS, Heyman MB, Grifiths AM, Patel AS, Noe JD, Aronow BJ, Kugathasan S, Walters TD, Gibson G, Thomas SD, Mollen K, Shen-Orr S, Huttenhower C, Xavier RJ, Hyams JS, Denson LA

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response.
Nat Commun. 2019;10(1):38 - PMID: 30604764 - PMCID: PMC6318335 - DOI: 10.1038/s41467-018-07841-3

Walton T, Pazienza L, Szostak JW

Template-directed catalysis of a multi-step reaction pathway for nonenzymatic RNA primer extension.
Biochemistry. 2019;58(6):755-762 - PMID: 30566332 - PMCID: PMC7547881 - DOI: 10.1021/acs.biochem.8b01156

Vatanen T, Plichta DR, Somani J, Münch PC, Arthur TD, Hall AB, Rudolf S, Oakeley EJ, Ke X, Young RA, Haiser HJ, Kolde R, Yassour M, Luopajärvi K, Siljander H, Virtanen SM, Ilonen J, Uibo R, Tillmann V, Mokurov S, Dorshakova N, Porter JA, McHardy AC, Lähdesmäki H, Vlamakis H, Huttenhower C, Knip M, Xavier RJ

Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life.
Nat Microbiol. 2019;4(3):470-479 - PMID: 30559407 - PMCID: PMC6384140 - DOI: 10.1038/s41564-018-0321-5
Total: 2481