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Khader R, Tharmalingam N, Mishra B, Felix L, Ausubel FM, Kelso MJ, Mylonakis E

Characterization of Five Novel Anti-MRSA Compounds Identified Using a Whole-Animal Caenorhabditis elegans/Galleria mellonella Sequential-Screening Approach.
Antibiotics (Basel). 2020;9(8):ePub - PMID: 32726955 - PMCID: PMC7459823 - DOI: 10.3390/antibiotics9080449

Gomes ALC, Johns NI, Yang A, Velez-Cortes F, Smillie CS, Smith MB, Alm EJ, Wang HH

Genome and sequence determinants governing the expression of horizontally acquired DNA in bacteria.
ISME J. 2020;14(9):2347-2357 - PMID: 32514119 - PMCID: PMC7608860 - DOI: 10.1038/s41396-020-0696-1

Strecker J, Ladha A, Makarova KS, Koonin EV, Zhang F

Response to Comment on "RNA-guided DNA insertion with CRISPR-associated transposases".
Science. 2020;368(6495):ePub - PMID: 32499411 - DOI: 10.1126/science.abb2920

Grünewald J, Zhou R, Lareau CA, Garcia SP, Iyer S, Miller BR, Langner LM, Hsu JY, Aryee MJ, Joung JK

A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing.
Nat Biotechnol. 2020;38(7):861-864 - PMID: 32483364 - PMCID: PMC7723518 - DOI: 10.1038/s41587-020-0535-y

Zhou L, O'Flaherty DK, Szostak JW

Template-directed copying of RNA by non-enzymatic ligation.
Angew Chem Int Ed Engl. 2020;59(36):15682-15687 - PMID: 32558121 - PMCID: PMC7496532 - DOI: 10.1002/anie.202004934

Kenny DJ, Plichta DR, Shungin D, Koppel N, Hall AB, Fu B, Vasan RS, Shaw SY, Vlamakis H, Balskus EP, Xavier RJ

Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level.
Cell Host Microbe. 2020;28(2):245-257.e6 - PMID: 32544460 - PMCID: PMC7435688 - DOI: 10.1016/j.chom.2020.05.013

Varma M, Kadoki M, Lefkovith A, Conway KL, Gao K, Mohanan V, Tusi BK, Graham DB, Latorre IJ, Tolonen AC, Khor B, Ng A, Xavier RJ

Cell Type- and Stimulation-Dependent Transcriptional Programs Regulated by Atg16L1 and Its Crohn's Disease Risk Variant T300A.
J Immunol. 2020;205(2):414-424 - PMID: 32522834 - PMCID: PMC7364322 - DOI: 10.4049/jimmunol.1900750

Kim W, Zou G, Pan W, Fricke N, Faizi HA, Kim SM, Khader R, Li S, Lee K, Escorba I, Vlahovska PM, Gao H, Ausubel FM, Mylonakis E

The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus.
MBio. 2020;11(3):ePub - PMID: 32605985 - PMCID: PMC7327171 - DOI: 10.1128/mBio.01140-20

Kindt JT, Szostak JW, Wang A

Bulk Self-Assembly of Giant, Unilamellar Vesicles.
ACS Nano. 2020;14(11):14627-14634 - PMID: 32602696 - PMCID: PMC8172239 - DOI: 10.1021/acsnano.0c03125

Slyper M, Porter CBM, Ashenberg O, Waldman J, Drokhlyansky E, Wakiro I, Smillie C, Smith-Rosario G, Wu J, Dionne D, Vigneau S, Jané-Valbuena J, Tickle TL, Napolitano S, Su MJ, Patel AG, Karlstrom A, Gritsch S, Nomura M, Waghray A, Gohil SH, Tsankov AM, Jerby-Arnon L, Cohen O, Klughammer J, Rosen Y, Gould J, Nguyen L, Hofree M, Tramontozzi PJ, Li B, Wu CJ, Izar B, Haq R, Hodi FS, Yoon CH, Hata AN, Baker SJ, Suvà ML, Bueno R, Stover EH, Clay MR, Dyer MA, Collins NB, Matulonis UA, Wagle N, Johnson BE, Rotem A, Rozenblatt-Rosen O, Regev A

A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors.
Nat Med. 2020;26(5):792-802 - PMID: 32405060 - PMCID: PMC7220853 - DOI: 10.1038/s41591-020-0844-1

Duzdevich D, Carr CE, Szostak JW

Deep sequencing of non-enzymatic RNA primer extension.
Nucleic Acids Res. 2020;48(12):e70 - PMID: 32427335 - PMCID: PMC7337528 - DOI: 10.1093/nar/gkaa400

Ernst CM, Braxton JR, Rodriguez-Osorio CA, Zagieboylo AP, Li L, Pironti A, Manson AL, Nair AV, Benson M, Cummins K, Clatworthy AE, Earl AM, Cosimi LA, Hung DT

Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae.
Nat Med. 2020;26(5):705-711 - PMID: 32284589 - PMCID: PMC9194776 - DOI: 10.1038/s41591-020-0825-4

Todd ZR, Fahrenbach AC, Ranjan S, Magnani CJ, Szostak JW, Sasselov DD

Ultraviolet-Driven Deamination of Cytidine Ribonucleotides Under Planetary Conditions.
Astrobiology. 2020;20(7):878-888 - PMID: 32267736 - PMCID: PMC9634989 - DOI: 10.1089/ast.2019.2182

Ackerman CM, Myhrvold C, Thakku SG, Freije CA, Metsky HC, Yang DK, Ye SH, Boehm CK, Kosoko-Thoroddsen TF, Kehe J, Nguyen TG, Carter A, Kulesa A, Barnes JR, Dugan VG, Hung DT, Blainey PC, Sabeti PC

Massively multiplexed nucleic acid detection with Cas13.
Nature. 2020;582(7811):277-282 - PMID: 32349121 - PMCID: PMC7332423 - DOI: 10.1038/s41586-020-2279-8

Lelyveld VS, Zhang W, Szostak JW

Synthesis of phosphoramidate-linked DNA by a modified DNA polymerase.
Proc Natl Acad Sci U S A. 2020;117(13):7276-7283 - PMID: 32188786 - PMCID: PMC7132125 - DOI: 10.1073/pnas.1922400117

Borren NZ, Plichta D, Joshi AD, Bonilla G, Peng V, Colizzo FP, Luther J, Khalili H, Garber JJ, van der Woude CJ, Sadreyev R, Vlamakis H, Xavier RJ, Ananthakrishnan AN

Alterations in Fecal Microbiomes and Serum Metabolomes of Fatigued Patients With Quiescent Inflammatory Bowel Diseases.
Clin Gastroenterol Hepatol. 2021;19(3):519-527.e5 - PMID: 32184182 - DOI: 10.1016/j.cgh.2020.03.013

Frydman GH, Tessier SN, Wong KHK, Vanderburg CR, Fox JG, Toner M, Tompkins RG, Irimia D

Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis.
Sci Rep. 2020;10(1):4621 - PMID: 32165642 - PMCID: PMC7067782 - DOI: 10.1038/s41598-020-61309-3

Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E

Defining trained immunity and its role in health and disease.
Nat Rev Immunol. 2020;20(6):375-388 - PMID: 32132681 - PMCID: PMC7186935 - DOI: 10.1038/s41577-020-0285-6

Fischer SEJ, Ruvkun G

Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons.
Proc Natl Acad Sci U S A. 2020;117(11):5987-5996 - PMID: 32123111 - PMCID: PMC7084138 - DOI: 10.1073/pnas.1919028117

Walton T, DasGupta S, Duzdevich D, Oh SS, Szostak JW

In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole-activated substrates.
Proc Natl Acad Sci U S A. 2020;117(11):5741-5748 - PMID: 32123094 - PMCID: PMC7084097 - DOI: 10.1073/pnas.1914367117

Graham DB, Xavier RJ

Pathway paradigms revealed from the genetics of inflammatory bowel disease.
Nature. 2020;578(7796):527-539 - PMID: 32103191 - PMCID: PMC7871366 - DOI: 10.1038/s41586-020-2025-2

Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC

Global chemical effects of the microbiome include new bile-acid conjugations.
Nature. 2020;579(7797):123-129 - PMID: 32103176 - PMCID: PMC7252668 - DOI: 10.1038/s41586-020-2047-9

Reyes M, Filbin MR, Bhattacharyya RP, Billman K, Eisenhaure T, Hung DT, Levy BD, Baron RM, Blainey PC, Goldberg MB, Hacohen N

An immune-cell signature of bacterial sepsis.
Nat Med. 2020;26(3):333-340 - PMID: 32066974 - PMCID: PMC7235950 - DOI: 10.1038/s41591-020-0752-4

Liu KH, Diener A, Lin Z, Liu C, Sheen J

Primary nitrate responses via calcium signalling and diverse protein phosphorylation.
J Exp Bot. 2020;71(15):4428-4441 - PMID: 31985788 - PMCID: PMC7382375 - DOI: 10.1093/jxb/eraa047

Ennamorati M, Vasudevan C, Clerkin K, Halvorsen S, Verma S, Ibrahim S, Prosper S, Porter C, Yeliseyev V, Kim M, Gardecki J, Sassi S, Tearney G, Cherayil BJ, Bry L, Seed B, Jain N

Intestinal microbes influence development of thymic lymphocytes in early life.
Proc Natl Acad Sci U S A. 2020;117(5):2570-2578 - PMID: 31964813 - PMCID: PMC7007548 - DOI: 10.1073/pnas.1915047117
Total: 2498